LOCUS       NM_021741               2455 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus centrosomal protein 78 (Cep78), mRNA.
ACCESSION   NM_021741
VERSION     NM_021741.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2455)
  AUTHORS   Nikopoulos,K., Farinelli,P., Giangreco,B., Tsika,C.,
            Royer-Bertrand,B., Mbefo,M.K., Bedoni,N., Kjellstrom,U., El
            Zaoui,I., Di Gioia,S.A., Balzano,S., Cisarova,K., Messina,A.,
            Decembrini,S., Plainis,S., Blazaki,S.V., Khan,M.I., Micheal,S.,
            Boldt,K., Ueffing,M., Moulin,A.P., Cremers,F.P.M., Roepman,R.,
            Arsenijevic,Y., Tsilimbaris,M.K., Andreasson,S. and Rivolta,C.
  TITLE     Mutations in CEP78 Cause Cone-Rod Dystrophy and Hearing Loss
            Associated with Primary-Cilia Defects
  JOURNAL   Am J Hum Genet 99 (3), 770-776 (2016)
   PUBMED   27588451
REFERENCE   2  (bases 1 to 2455)
  AUTHORS   Brunk,K., Zhu,M., Barenz,F., Kratz,A.S., Haselmann-Weiss,U.,
            Antony,C. and Hoffmann,I.
  TITLE     Cep78 is a new centriolar protein involved in Plk4-induced
            centriole overduplication
  JOURNAL   J Cell Sci 129 (14), 2713-2718 (2016)
   PUBMED   27246242
REFERENCE   3  (bases 1 to 2455)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1 and X99330.1.
            
            On Oct 16, 2007 this sequence version replaced NM_021741.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by a combination of transcript alignments and orthologous
            data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.4824.1,
                                           SRR26643293.8125.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-212               JAXUCZ010000001.1  222701748-222701959 c
            213-1809            X99330.1           1-1597
            1810-1863           JAXUCZ010000001.1  222674767-222674820 c
            1864-2455           X99330.1           1598-2189
FEATURES             Location/Qualifiers
     source          1..2455
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..2455
                     /gene="Cep78"
                     /gene_synonym="Ip63"
                     /note="centrosomal protein 78"
                     /db_xref="GeneID:60347"
                     /db_xref="RGD:620464"
     CDS             1..2370
                     /gene="Cep78"
                     /gene_synonym="Ip63"
                     /note="centrosomal protein 78kDa"
                     /codon_start=1
                     /product="centrosomal protein of 78 kDa"
                     /protein_id="NP_068509.2"
                     /db_xref="GeneID:60347"
                     /db_xref="RGD:620464"
                     /translation="MIDSVKLRRDCATDFFSHYEYLCALQDSAPLPAVRACLRDGVLD
                     FNADRLRAVDWAPLLSSLRVNRDLPLVAIKSSFQPWLGESVLRSGGADAHRVCRNRVP
                     SVRSKDISFQLCKALKGCLSVSGVLRNLELNGLILRERDLTSLTKGLSKSASLVHLSL
                     ANCPVGDGGLEIICQGIKNSVTLKTVNFTGCNLTWQGASHMAKILKYQTMRRHEETWA
                     ESLRYRRPDLDCMAGLRRITLNCNTLIGDQGASAFADSLSEDLWLRALDLQQCGLTSE
                     GAKALLEALETNRTLVVLDIRKNPLIDHSMMKAVIRKVLQNGRSATSEYQWVTSPSLK
                     ELPKTTKQKKKTIVLGSSRKGKATIRVGLATKKPVSNGRKHGLSKDSYAPDPLPPGAS
                     GFLPWRTAERARRNRSFPLIKTHDLSNHLQQSDFPVTVTVESPSSSETDESEDSSESV
                     HEVPQKTSIRQETLQEKLEECLKQLKEERVTRLKTDKRISELEHENAQLRNINFSLSE
                     ALQAQSLTSMILDDEGVLGSIENSFQKFHAFLDLLKDAGLGQLATMAGIDQSDFHLLG
                     RPQMSSTVNTPVEEQKGLEDENLDLKQTAVGQMQDIGFQKITSDPMVPLPLDTNQVPA
                     STQEAAGSSRDHLGVVALEQQEGSAVGFIAITGSPSADGISGGRSLEEVVLSKHSRSS
                     SGKGSTASEPSRRQSAERHSRKDLHSDSDSPVNSKGKGPGEKRSLLNEPIKSESLKKC
                     VSIKKENRIVTVSSKSIKSKPNLLEHSESDTIGSDFEFQEHDHSSAHLT"
     exon            1..268
                     /gene="Cep78"
                     /gene_synonym="Ip63"
                     /inference="alignment:Splign:2.1.0"
     exon            269..441
                     /gene="Cep78"
                     /gene_synonym="Ip63"
                     /inference="alignment:Splign:2.1.0"
     exon            442..514
                     /gene="Cep78"
                     /gene_synonym="Ip63"
                     /inference="alignment:Splign:2.1.0"
     exon            515..618
                     /gene="Cep78"
                     /gene_synonym="Ip63"
                     /inference="alignment:Splign:2.1.0"
     exon            619..793
                     /gene="Cep78"
                     /gene_synonym="Ip63"
                     /inference="alignment:Splign:2.1.0"
     exon            794..907
                     /gene="Cep78"
                     /gene_synonym="Ip63"
                     /inference="alignment:Splign:2.1.0"
     exon            908..972
                     /gene="Cep78"
                     /gene_synonym="Ip63"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1084
                     /gene="Cep78"
                     /gene_synonym="Ip63"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1220
                     /gene="Cep78"
                     /gene_synonym="Ip63"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1266
                     /gene="Cep78"
                     /gene_synonym="Ip63"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1395
                     /gene="Cep78"
                     /gene_synonym="Ip63"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1473
                     /gene="Cep78"
                     /gene_synonym="Ip63"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1640
                     /gene="Cep78"
                     /gene_synonym="Ip63"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1809
                     /gene="Cep78"
                     /gene_synonym="Ip63"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..2437
                     /gene="Cep78"
                     /gene_synonym="Ip63"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgatcgact ctgtgaagct ccgtcgcgac tgcgcgaccg acttcttctc gcactatgag
       61 tacctgtgcg cgctgcagga ctcggcgccg ctgcccgccg tgcgcgcctg cctgcgggat
      121 ggcgtgctgg acttcaatgc cgaccggctg cgcgcggtgg actgggcacc gctgctcagc
      181 tcgctcaggg tgaaccgtga cctgccgctg gtggccatca agagctcctt ccagccgtgg
      241 ctcggggagt cagttctacg gtccggaggt gctgatgcac acagagtttg tagaaatcga
      301 gttccttcag taagatccaa agacataagc ttccagttat gtaaggctct taaaggctgc
      361 ttaagtgtat caggcgtgct cagaaatctg gagctaaatg ggctgattct gagagagaga
      421 gatttgacta gtctaacaaa gggattgagt aaatcagcct ctttggtgca cctgtctctt
      481 gcaaactgtc cagttggaga tggaggttta gaaattattt gtcaaggtat aaagaactcc
      541 gtcactctca agaccgtcaa cttcacagga tgcaatctga cgtggcaagg agccagtcat
      601 atggccaaga tcttaaagta tcaaaccatg agaagacatg aagagacctg ggctgagagt
      661 cttcgctaca ggaggccgga tcttgactgc atggccggct taaggcgcat cacactgaat
      721 tgcaacacac tcattggtga ccagggtgca agtgcttttg cagactctct cagtgaggat
      781 ttatggcttc gggcacttga cctgcagcag tgcggcctta ccagtgaagg ggcgaaggct
      841 ttactggagg ccttggaaac caacagaacc ctggtcgttc tggatataag gaaaaaccca
      901 cttattgatc attctatgat gaaagcagtt atcagaaagg ttctccagaa cggaaggagt
      961 gcaacttcag agtaccagtg ggtaacgtcc ccgtcactga aggaactgcc caaaaccact
     1021 aagcagaaaa agaaaacgat cgtcctagga agcagtcgaa aaggaaaagc tactattcga
     1081 gttggtttag ctacaaagaa acctgtgagt aatgggagaa aacatgggct cagtaaagac
     1141 tcctatgctc ccgaccctct gcctccaggc gcgtctggtt tcttgccctg gcgcacggca
     1201 gaacgtgcaa gaagaaacag gagttttcca ttaatcaaaa ctcatgatct gtctaatcac
     1261 ctgcagcaat cagatttccc tgtgactgtg acagtagaaa gtccttcatc ctcagaaact
     1321 gacgagtctg aggattcttc agaaagtgtc catgaagtgc ctcagaaaac cagcataaga
     1381 caagaaacat tacaggagaa gctggaggag tgcctaaagc agctaaagga ggagagagtg
     1441 acccgcctca aaactgacaa gcgcatcagt gagctggaac atgaaaatgc ccagctaaga
     1501 aatataaatt tctccctgtc tgaagccctt caagcacagt cattgacgag catgatcctg
     1561 gacgatgaag gagtcttggg cagcatcgag aattcttttc agaagttcca cgcctttttg
     1621 gatctcctta aagatgctgg gctcgggcag cttgccacta tggctggtat agatcagtca
     1681 gatttccacc tgttaggtcg tccccagatg agttctacgg ttaacacacc tgtggaagaa
     1741 cagaaaggac ttgaagatga aaatctggat ctgaagcaga ctgctgtagg acaaatgcag
     1801 gacatcggtt ttcagaagat tacaagtgat cctatggttc ctttacctct cgacaccaac
     1861 caggttccag cttccacaca agaggcagca ggatcttctc gagaccacct gggggttgta
     1921 gccctggagc agcaggaggg ctctgcagtg ggattcattg ctataacagg ctctccttca
     1981 gcagatggca tttcaggagg cagaagtcta gaagaggtgg tgttgtcaaa gcacagcagg
     2041 tcttcttcag gcaaagggag cacagcaagc gagccctcca gaaggcagtc tgctgagaga
     2101 cactccagga aggacctgca ttccgactcc gactcccctg tgaactcaaa aggcaaagga
     2161 cctggggaaa agaggtcttt gcttaatgag ccaattaaaa gtgaatcttt gaaaaaatgt
     2221 gtttctatca agaaagaaaa tagaatagtg actgtatcat caaagagtat caaaagtaaa
     2281 cccaatctgc tagaacattc tgaaagtgat actattgggt ctgattttga atttcaagag
     2341 catgaccatt cgtcagcaca cctgacctga cataggtcta accttttgaa attatgattt
     2401 ttgccttaaa attttaataa attttcttat gtttttaaaa aaaaaaaaaa aaaaa
//
