LOCUS       NM_001244805            2205 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus centrosomal protein 63 (Cep63), transcript
            variant 2, mRNA.
ACCESSION   NM_001244805
VERSION     NM_001244805.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2205)
  AUTHORS   Kodani,A., Yu,T.W., Johnson,J.R., Jayaraman,D., Johnson,T.L.,
            Al-Gazali,L., Sztriha,L., Partlow,J.N., Kim,H., Krup,A.L.,
            Dammermann,A., Krogan,N.J., Walsh,C.A. and Reiter,J.F.
  TITLE     Centriolar satellites assemble centrosomal microcephaly proteins to
            recruit CDK2 and promote centriole duplication
  JOURNAL   Elife 4, e07519 (2015)
   PUBMED   26297806
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2205)
  AUTHORS   Marjanovic,M., Sanchez-Huertas,C., Terre,B., Gomez,R., Scheel,J.F.,
            Pacheco,S., Knobel,P.A., Martinez-Marchal,A., Aivio,S.,
            Palenzuela,L., Wolfrum,U., McKinnon,P.J., Suja,J.A., Roig,I.,
            Costanzo,V., Luders,J. and Stracker,T.H.
  TITLE     CEP63 deficiency promotes p53-dependent microcephaly and reveals a
            role for the centrosome in meiotic recombination
  JOURNAL   Nat Commun 6, 7676 (2015)
   PUBMED   26158450
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2205)
  AUTHORS   Zhao,H., Zhu,L., Zhu,Y., Cao,J., Li,S., Huang,Q., Xu,T., Huang,X.,
            Yan,X. and Zhu,X.
  TITLE     The Cep63 paralogue Deup1 enables massive de novo centriole
            biogenesis for vertebrate multiciliogenesis
  JOURNAL   Nat Cell Biol 15 (12), 1434-1444 (2013)
   PUBMED   24240477
REFERENCE   4  (bases 1 to 2205)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   5  (bases 1 to 2205)
  AUTHORS   Andersen,J.S., Wilkinson,C.J., Mayor,T., Mortensen,P., Nigg,E.A.
            and Mann,M.
  TITLE     Proteomic characterization of the human centrosome by protein
            correlation profiling
  JOURNAL   Nature 426 (6966), 570-574 (2003)
   PUBMED   14654843
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC161815.1.
            
            Transcript Variant: This variant (2) contains a different segment
            for its 5' end which results in the use of a downstream start
            codon, compared to variant 1. The resulting protein (isoform 2) is
            shorter when it is compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC161815.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2205              BC161815.1         1-2205
FEATURES             Location/Qualifiers
     source          1..2205
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..2205
                     /gene="Cep63"
                     /note="centrosomal protein 63"
                     /db_xref="GeneID:300963"
                     /db_xref="RGD:1561183"
     exon            1..273
                     /gene="Cep63"
                     /inference="alignment:Splign:2.1.0"
     exon            274..342
                     /gene="Cep63"
                     /inference="alignment:Splign:2.1.0"
     CDS             299..1915
                     /gene="Cep63"
                     /note="isoform 2 is encoded by transcript variant 2;
                     centrosomal protein of 63 kDa; centrosomal protein 63kDa"
                     /codon_start=1
                     /product="centrosomal protein of 63 kDa isoform 2"
                     /protein_id="NP_001231734.1"
                     /db_xref="GeneID:300963"
                     /db_xref="RGD:1561183"
                     /translation="MEALLEGIQTRGHSGGFLTSCEAELQELMKQIDIMVAHKKSEWE
                     GQTHALETCLDMRDRELKALRSQLDMKHKEVGILHQQIEEQEKTKQEMALEYKEELMK
                     LQEELSRLKRSYEKLQKKQLREFRGNTKSLREDRSEIERLTGKIEEFRQKSLDWEKQR
                     LIYQQQVSSLEAQRKALAEQSEIIQAQLANRKQKLESVELSSQSEIQHLSSKLERAKD
                     TICANELEIERLNIRVKDLMGTNVTILQEQRQKEEKLRESEKLLEALQEEQKELKASL
                     QAQESFILDAKMQEKLQTKLKAVDTKHSVERSLEDCQVERKYSSSGQGVLDNVLSQLD
                     ISHSSEELLQAEVTRLEGSLESVSTTCKQLSQELMEKYEELKRMEGHNNEYRTEIKKL
                     KEQILQADQTYSSALEGMKTEISQLTRELHQRDITIASAKCSSSDMERQLKAEMQKAE
                     EKAVEHKEILSQLESLRLENRRLSETVMKLELGLHECSMPVSPLGLIATRFLEEEELR
                     SHHILERLDAHIEELKRESEKTVRQFTALV"
     exon            343..520
                     /gene="Cep63"
                     /inference="alignment:Splign:2.1.0"
     exon            521..616
                     /gene="Cep63"
                     /inference="alignment:Splign:2.1.0"
     exon            617..739
                     /gene="Cep63"
                     /inference="alignment:Splign:2.1.0"
     exon            740..853
                     /gene="Cep63"
                     /inference="alignment:Splign:2.1.0"
     exon            854..1087
                     /gene="Cep63"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1218
                     /gene="Cep63"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1356
                     /gene="Cep63"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1471
                     /gene="Cep63"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1669
                     /gene="Cep63"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1756
                     /gene="Cep63"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..2180
                     /gene="Cep63"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaaggggga ggtcgagcgt cgccatgggt gctccgttcc actccgcaca gcgtgcagta
       61 aagaagtggc tctgaaggtc ggttgagagt accggcctgc gcttctggaa gcgctgaacg
      121 actctgaagt cgagggcgaa cgcttggcta ctctcagaaa cccgggcggc gggcgcgaaa
      181 aacccttacc cacagagcgc gcgtcggctt cctccgggcc ccgcccttct tccgggtcac
      241 gtgacgcacg gcgctctcat accccgtatg tagttgccaa aacaaagggg atttggcgat
      301 ggaggccttg ttggaaggaa tacaaactcg ggggcatagt gggggatttt tgacatcctg
      361 tgaagcagaa ttgcaagagc tcatgaaaca gatcgatata atggtggctc ataagaaatc
      421 tgagtgggag gggcagacac atgctctgga gacttgtttg gacatgcgcg atcgggagct
      481 gaaggctctg aggagtcagc tggacatgaa gcacaaagag gttggaatat tgcatcagca
      541 gatagaagaa caagaaaaaa ccaagcaaga aatggccctg gagtacaagg aggagttaat
      601 gaagctgcag gaggaattaa gcagactgaa gagaagctat gaaaaactgc agaaaaagca
      661 actaagagaa tttagaggaa ataccaaaag tctgcgagag gatcggtctg agattgagag
      721 gctgactgga aaaatagagg aattccgaca gaagtctttg gactgggaga agcagcgtct
      781 gatttatcag caacaggtat cttctctgga agcacagagg aaggctctag ctgagcagtc
      841 agagataatc caggctcagc ttgccaaccg gaaacagaaa ttagagtctg tggaactgtc
      901 tagccagtca gaaattcagc acctgagcag taagcttgag cgggctaagg acaccatctg
      961 tgccaatgag ctggaaatag agcgccttaa tataagggtc aaggacctga tgggaaccaa
     1021 cgtgactatc ctgcaggagc agcggcaaaa ggaggagaaa ctgagggagt ctgaaaagtt
     1081 actagaggct ctgcaggaag aacagaaaga gttgaaggca agtcttcaag ctcaagaaag
     1141 cttcattctt gatgcaaaaa tgcaggagaa actgcaaacg aaactaaagg cagttgacac
     1201 taagcactca gtagaaaggt ctctggagga ctgtcaggtg gagaggaagt acagctcttc
     1261 agggcaggga gtcttggata atgtgctctc ccagttggac ataagccaca gcagtgaaga
     1321 actcctacag gcagaggtga ctcgtcttga aggcagtttg gaatctgtga gtacaacatg
     1381 taaacagctg agccaagaac tgatggagaa gtacgaagag ctgaagagga tggaagggca
     1441 taacaatgag taccggacag agataaagaa gctgaaggaa cagattctgc aggctgatca
     1501 gacttacagc tctgccctgg aaggaatgaa gacggaaatc tcccagctaa cccgggagtt
     1561 gcaccagcga gatatcacta ttgcttctgc caagtgttcc tcctcagaca tggaaaggca
     1621 gctgaaggca gagatgcaga aggcggaaga aaaggccgta gagcataagg agattctgag
     1681 tcagctggaa tctctcagat tagaaaatcg ccgtctctct gaaacagtga tgaagctgga
     1741 actgggcttg cacgagtgct cgatgcccgt ctctccactg ggattgatag ctaccaggtt
     1801 tctagaagag gaggagctga ggtctcacca cattctagag cgcctggacg cccacattga
     1861 agaactgaaa agagagagtg agaagacggt gaggcagttc acagccctcg tgtagtgctg
     1921 agcagccaca cacagaagac tggttctaaa gatctaagag caatggctgc aagagcagca
     1981 ctgaggaatc tgcagatcgg gcacttaggt attttcactg gctcatttga aggactgctt
     2041 ccagtagtaa cctgtgagaa taaactacct tgcagacttt ctcacatgaa tatttattac
     2101 cacagagcaa taccttttct tcctgactta catgtgaata gctgtgtact aattaaaata
     2161 aagattttgc tatactgttt aaaaaaaaaa aaaaaaaaaa aaaaa
//
