LOCUS       NM_001025646            2481 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus centrosomal protein 55 (Cep55), mRNA.
ACCESSION   NM_001025646 XM_220034
VERSION     NM_001025646.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2481)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2481)
  AUTHORS   Frosk,P., Arts,H.H., Philippe,J., Gunn,C.S., Brown,E.L.,
            Chodirker,B., Simard,L., Majewski,J., Fahiminiya,S., Russell,C.,
            Liu,Y.P., Hegele,R., Katsanis,N., Goerz,C., Del Bigio,M.R. and
            Davis,E.E.
  CONSRTM   FORGE Canada Consortium; Canadian Rare Diseases: Models &
            Mechanisms Network,
  TITLE     A truncating mutation in CEP55 is the likely cause of MARCH, a
            novel syndrome affecting neuronal mitosis
  JOURNAL   J Med Genet 54 (7), 490-501 (2017)
   PUBMED   28264986
REFERENCE   3  (bases 1 to 2481)
  AUTHORS   Tsai,C.Y., Chen,C.H., Chang,A.Y., Chan,J.Y. and Chan,S.H.
  TITLE     Upregulation of FLJ10540, a PI3K-association protein, in rostral
            ventrolateral medulla impairs brain stem cardiovascular regulation
            during mevinphos intoxication
  JOURNAL   Biochem Pharmacol 93 (1), 34-41 (2015)
   PUBMED   25449601
  REMARK    GeneRIF: Upregulation of Cep55 in the rostral ventrolateral medulla
            elicits impairment of brain stem cardiovascular regulation.
REFERENCE   4  (bases 1 to 2481)
  AUTHORS   Hadders,M.A., Agromayor,M., Obita,T., Perisic,O., Caballe,A.,
            Kloc,M., Lamers,M.H., Williams,R.L. and Martin-Serrano,J.
  TITLE     ESCRT-III binding protein MITD1 is involved in cytokinesis and has
            an unanticipated PLD fold that binds membranes
  JOURNAL   Proc Natl Acad Sci U S A 109 (43), 17424-17429 (2012)
   PUBMED   23045692
REFERENCE   5  (bases 1 to 2481)
  AUTHORS   Kuo,T.C., Chen,C.T., Baron,D., Onder,T.T., Loewer,S., Almeida,S.,
            Weismann,C.M., Xu,P., Houghton,J.M., Gao,F.B., Daley,G.Q. and
            Doxsey,S.
  TITLE     Midbody accumulation through evasion of autophagy contributes to
            cellular reprogramming and tumorigenicity
  JOURNAL   Nat Cell Biol 13 (10), 1214-1223 (2011)
   PUBMED   21909099
  REMARK    Erratum:[Nat Cell Biol. 2011 Dec;13(12):1467]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2481)
  AUTHORS   Iwamori,T., Iwamori,N., Ma,L., Edson,M.A., Greenbaum,M.P. and
            Matzuk,M.M.
  TITLE     TEX14 interacts with CEP55 to block cell abscission
  JOURNAL   Mol Cell Biol 30 (9), 2280-2292 (2010)
   PUBMED   20176808
REFERENCE   7  (bases 1 to 2481)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   8  (bases 1 to 2481)
  AUTHORS   van der Horst,A. and Khanna,K.K.
  TITLE     The peptidyl-prolyl isomerase Pin1 regulates cytokinesis through
            Cep55
  JOURNAL   Cancer Res 69 (16), 6651-6659 (2009)
   PUBMED   19638580
REFERENCE   9  (bases 1 to 2481)
  AUTHORS   Carlton,J.G., Agromayor,M. and Martin-Serrano,J.
  TITLE     Differential requirements for Alix and ESCRT-III in cytokinesis and
            HIV-1 release
  JOURNAL   Proc Natl Acad Sci U S A 105 (30), 10541-10546 (2008)
   PUBMED   18641129
REFERENCE   10 (bases 1 to 2481)
  AUTHORS   Morita,E., Sandrin,V., Chung,H.Y., Morham,S.G., Gygi,S.P.,
            Rodesch,C.K. and Sundquist,W.I.
  TITLE     Human ESCRT and ALIX proteins interact with proteins of the midbody
            and function in cytokinesis
  JOURNAL   EMBO J 26 (19), 4215-4227 (2007)
   PUBMED   17853893
  REMARK    Erratum:[EMBO J. 2012 Jul 18;31(14):3228]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098013.1.
            
            On Jul 22, 2005 this sequence version replaced XM_220034.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098013.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2481
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q53"
     gene            1..2481
                     /gene="Cep55"
                     /gene_synonym="RGD1305340"
                     /note="centrosomal protein 55"
                     /db_xref="GeneID:294074"
                     /db_xref="RGD:1305340"
     exon            1..128
                     /gene="Cep55"
                     /gene_synonym="RGD1305340"
                     /inference="alignment:Splign:2.1.0"
     exon            129..323
                     /gene="Cep55"
                     /gene_synonym="RGD1305340"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1529
                     /gene="Cep55"
                     /gene_synonym="RGD1305340"
                     /note="centrosomal protein 55kDa"
                     /codon_start=1
                     /product="centrosomal protein of 55 kDa"
                     /protein_id="NP_001020817.1"
                     /db_xref="GeneID:294074"
                     /db_xref="RGD:1305340"
                     /translation="MSSRSPKDLIKSKWGSRPSSSKSDTALEKFKGEIAAFKTSLDEI
                     TNGKGKVANKDRSKLLEKIQVLEAEREKNVYYLMEKDKEIQRLKDHLRSRYSSSSLLE
                     QLEEKTKECEKKQQLLESLSRETDILKKQLSATTKRLSELESKASTLHLSQSVPANCF
                     NSSMNSIHEKEMQLKDALEKNQQWLVYDQQREAYVKGLLAKIFELEKRTETAAASLPQ
                     QMKKTESEGYLQEEKQKYDHLLENAKKDLEVERQTVTQLRLELDEFRRKYEETQKEVE
                     DLNQLLSSQRKADIQHLEEDKHKTEKIQKLREESSVFKGKLEEERKKSEELLSQVRIL
                     YDSLLKHQEEQSRVALLERQMQACTLDFENEKLDRQNMQHQLYVILKELRKAKSQITQ
                     LESLKQLHGFTFTEQPFPLQGEPENRVKATSPKSPTAVLNESLVECPKCSVQYPATEH
                     RDLLVHVEYCMK"
     exon            324..599
                     /gene="Cep55"
                     /gene_synonym="RGD1305340"
                     /inference="alignment:Splign:2.1.0"
     exon            600..668
                     /gene="Cep55"
                     /gene_synonym="RGD1305340"
                     /inference="alignment:Splign:2.1.0"
     exon            669..819
                     /gene="Cep55"
                     /gene_synonym="RGD1305340"
                     /inference="alignment:Splign:2.1.0"
     exon            820..1130
                     /gene="Cep55"
                     /gene_synonym="RGD1305340"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1202
                     /gene="Cep55"
                     /gene_synonym="RGD1305340"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1328
                     /gene="Cep55"
                     /gene_synonym="RGD1305340"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..2455
                     /gene="Cep55"
                     /gene_synonym="RGD1305340"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacgcagcga cgcgaccgct gtgtttgtct caggcagtga gtggtccgga ccttggccgg
       61 ggagggaggg gagagcagcc ggagcccgta gccccagggc tggactggac ctctccggag
      121 gagctttgat catctcaaag atgtcttcca gaagtcccaa agatttaatt aaaagcaaat
      181 ggggatcgag gcctagcagc tccaagtcag acactgcgct agagaaattt aagggagaaa
      241 ttgcagcctt caaaacatcc ctggatgaaa tcaccaatgg gaaaggaaaa gtggccaata
      301 aagacagaag caaacttctg gagaaaattc aagttcttga agccgagaga gaaaagaatg
      361 tttattacct catggagaag gacaaagaaa tacagagact caaagaccac ctaaggtcaa
      421 gatatagctc ttcgtcattg ctcgagcagc tggaggagaa aaccaaggag tgtgagaaga
      481 agcagcagtt gctggagtcc ttatccagag agacagatat cctgaaaaag cagttgtctg
      541 ccacgacgaa aagactttcc gaacttgaaa gcaaagccag tacactccac ctatcgcaga
      601 gcgtgcctgc aaactgcttc aactcatcaa tgaatagtat tcatgaaaag gaaatgcagc
      661 tgaaagatgc tctggagaaa aatcagcagt ggcttgtgta cgaccagcag cgagaagcct
      721 acgttaaagg gcttttagca aagatctttg agcttgaaaa gagaacagag actgccgctg
      781 cttccctccc acagcagatg aaaaagactg aatcagaagg ttatcttcaa gaggagaagc
      841 aaaaatatga tcatctcttg gaaaatgcca aaaaagatct tgaagttgag cgacaaaccg
      901 taactcagtt gcgtttagaa ctggatgaat ttcgaaggaa atatgaagaa actcaaaaag
      961 aagttgaaga tttaaaccag ctgttgagtt ctcagcgcaa ggcagacata cagcacctgg
     1021 aagaggacaa gcataagacg gagaaaatcc agaagctcag ggaagagagc agtgtcttca
     1081 aggggaaact ggaagaggag aggaagaagt ctgaagagct tttatctcag gtccgaattc
     1141 tctacgattc tctgttaaag caccaagagg agcagagcag ggtggctctg ctggaacggc
     1201 agatgcaggc atgtactcta gactttgaaa atgaaaaact cgaccgccag aatatgcagc
     1261 atcagctgta tgtgattctt aaggagctcc ggaaagcaaa aagtcaaata acacagttgg
     1321 aatccttgaa gcagctacat ggatttacct tcacagagca gccgttccca ctccagggag
     1381 agcctgaaaa cagagtgaaa gctacctcac ctaagagtcc cactgctgtt ctcaacgaaa
     1441 gcctagtgga atgtcccaag tgcagcgtac agtacccagc caccgaacat cgagacctgc
     1501 ttgtccatgt ggaatactgc atgaagtagc agaaccgttc tcacctttgt actgaaaagt
     1561 ccacactgta ttctgtgttc gtttataggc actttaaatc acacagtaca tctcttaatc
     1621 aatcacacaa gaaactccgt ctacccttgg cactctggca tataagggtg tccttgtatt
     1681 tttctggcca ctttgcattt tccttggtag caactctctg agttggtggc cttcaggctg
     1741 cagtgacaga atgtgctgag cagtggctat ccaaacttct agcacttaac actgttcagt
     1801 aactagcact tcacacggtt ctaatactca ataaacaaga gctatttggg ttattggtta
     1861 tgacttaaag ctactgacca gtcagcaaac attctatgct ttgggggttt taagagactc
     1921 agaaggtgat taaccatgga tcttactgtg ctgatatttt tatgtaagtg ctttgtatgc
     1981 tgacgcttcc acttgatatc tcttgctatt gtagaacggt tactagaaaa gttgggaagt
     2041 tttgtaatct ttagtgctgt taactgttct aagcacaaag caggttttct ttgaagagtc
     2101 ctttaagtag ctgtgctttt tactcatatt atctgaccat aactttgact taaatttcat
     2161 tagtataggt cagtttccaa aaatgccaaa atgaacaaaa cttgagcaaa actatcttgc
     2221 ctcctcattt gatttgcagg gattttattc tgtctttttt gttgttttgt ttttagcact
     2281 cttaaagatg gttgagcagt gtaattatca gatgtttgtt ttctaaatag atatttttat
     2341 atatgctcta tgtgaaccaa aatgtgtttt attctttcag attttctaag atccttacac
     2401 ctgggctact attatcaata tgaaggagga aataataaaa tatttaataa gttttaaaaa
     2461 aaaaaaaaaa aaaaaaaaaa a
//
