LOCUS       NM_001401003            9084 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus centrosomal protein 290 (Cep290), transcript
            variant 1, mRNA.
ACCESSION   NM_001401003
VERSION     NM_001401003.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9084)
  AUTHORS   Dharmat,R., Eblimit,A., Robichaux,M.A., Zhang,Z., Nguyen,T.T.,
            Jung,S.Y., He,F., Jain,A., Li,Y., Qin,J., Overbeek,P., Roepman,R.,
            Mardon,G., Wensel,T.G. and Chen,R.
  TITLE     SPATA7 maintains a novel photoreceptor-specific zone in the distal
            connecting cilium
  JOURNAL   J Cell Biol 217 (8), 2851-2865 (2018)
   PUBMED   29899041
REFERENCE   2  (bases 1 to 9084)
  AUTHORS   Wang,C., Li,J., Takemaru,K.I., Jiang,X., Xu,G. and Wang,B.
  TITLE     Centrosomal protein Dzip1l binds Cby, promotes ciliary bud
            formation, and acts redundantly with Bromi to regulate ciliogenesis
            in the mouse
  JOURNAL   Development 145 (6) (2018)
   PUBMED   29487109
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9084)
  AUTHORS   Fleming,L.R., Doherty,D.A., Parisi,M.A., Glass,I.A., Bryant,J.,
            Fischer,R., Turkbey,B., Choyke,P., Daryanani,K., Vemulapalli,M.,
            Mullikin,J.C., Malicdan,M.C., Vilboux,T., Sayer,J.A., Gahl,W.A. and
            Gunay-Aygun,M.
  TITLE     Prospective Evaluation of Kidney Disease in Joubert Syndrome
  JOURNAL   Clin J Am Soc Nephrol 12 (12), 1962-1973 (2017)
   PUBMED   29146704
REFERENCE   4  (bases 1 to 9084)
  AUTHORS   Zhang,B., Wang,G., Xu,X., Yang,S., Zhuang,T., Wang,G., Ren,H.,
            Cheng,S.Y., Jiang,Q. and Zhang,C.
  TITLE     DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like
            Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of
            the BBSome Protein during the Cell Cycle
  JOURNAL   J Biol Chem 292 (4), 1351-1360 (2017)
   PUBMED   27979967
REFERENCE   5  (bases 1 to 9084)
  AUTHORS   Nechipurenko,I.V., Olivier-Mason,A., Kazatskaya,A., Kennedy,J.,
            McLachlan,I.G., Heiman,M.G., Blacque,O.E. and Sengupta,P.
  TITLE     A Conserved Role for Girdin in Basal Body Positioning and
            Ciliogenesis
  JOURNAL   Dev Cell 38 (5), 493-506 (2016)
   PUBMED   27623382
REFERENCE   6  (bases 1 to 9084)
  AUTHORS   Perrault,I., Delphin,N., Hanein,S., Gerber,S., Dufier,J.L.,
            Roche,O., Defoort-Dhellemmes,S., Dollfus,H., Fazzi,E., Munnich,A.,
            Kaplan,J. and Rozet,J.M.
  TITLE     Spectrum of NPHP6/CEP290 mutations in Leber congenital amaurosis
            and delineation of the associated phenotype
  JOURNAL   Hum Mutat 28 (4), 416 (2007)
   PUBMED   17345604
REFERENCE   7  (bases 1 to 9084)
  AUTHORS   den Hollander,A.I., Koenekoop,R.K., Yzer,S., Lopez,I., Arends,M.L.,
            Voesenek,K.E., Zonneveld,M.N., Strom,T.M., Meitinger,T.,
            Brunner,H.G., Hoyng,C.B., van den Born,L.I., Rohrschneider,K. and
            Cremers,F.P.
  TITLE     Mutations in the CEP290 (NPHP6) gene are a frequent cause of Leber
            congenital amaurosis
  JOURNAL   Am J Hum Genet 79 (3), 556-561 (2006)
   PUBMED   16909394
REFERENCE   8  (bases 1 to 9084)
  AUTHORS   Chang,B., Khanna,H., Hawes,N., Jimeno,D., He,S., Lillo,C.,
            Parapuram,S.K., Cheng,H., Scott,A., Hurd,R.E., Sayer,J.A.,
            Otto,E.A., Attanasio,M., O'Toole,J.F., Jin,G., Shou,C.,
            Hildebrandt,F., Williams,D.S., Heckenlively,J.R. and Swaroop,A.
  TITLE     In-frame deletion in a novel centrosomal/ciliary protein
            CEP290/NPHP6 perturbs its interaction with RPGR and results in
            early-onset retinal degeneration in the rd16 mouse
  JOURNAL   Hum Mol Genet 15 (11), 1847-1857 (2006)
   PUBMED   16632484
REFERENCE   9  (bases 1 to 9084)
  AUTHORS   Sayer,J.A., Otto,E.A., O'Toole,J.F., Nurnberg,G., Kennedy,M.A.,
            Becker,C., Hennies,H.C., Helou,J., Attanasio,M., Fausett,B.V.,
            Utsch,B., Khanna,H., Liu,Y., Drummond,I., Kawakami,I., Kusakabe,T.,
            Tsuda,M., Ma,L., Lee,H., Larson,R.G., Allen,S.J., Wilkinson,C.J.,
            Nigg,E.A., Shou,C., Lillo,C., Williams,D.S., Hoppe,B., Kemper,M.J.,
            Neuhaus,T., Parisi,M.A., Glass,I.A., Petry,M., Kispert,A., Gloy,J.,
            Ganner,A., Walz,G., Zhu,X., Goldman,D., Nurnberg,P., Swaroop,A.,
            Leroux,M.R. and Hildebrandt,F.
  TITLE     The centrosomal protein nephrocystin-6 is mutated in Joubert
            syndrome and activates transcription factor ATF4
  JOURNAL   Nat Genet 38 (6), 674-681 (2006)
   PUBMED   16682973
REFERENCE   10 (bases 1 to 9084)
  AUTHORS   Andersen,J.S., Wilkinson,C.J., Mayor,T., Mortensen,P., Nigg,E.A.
            and Mann,M.
  TITLE     Proteomic characterization of the human centrosome by protein
            correlation profiling
  JOURNAL   Nature 426 (6966), 570-574 (2003)
   PUBMED   14654843
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               JAXUCZ010000007.1  37196783-37196954
            173-302             JAXUCZ010000007.1  37197489-37197618
            303-380             JAXUCZ010000007.1  37197774-37197851
            381-450             JAXUCZ010000007.1  37198539-37198608
            451-497             JAXUCZ010000007.1  37199407-37199453
            498-641             JAXUCZ010000007.1  37201553-37201696
            642-695             JAXUCZ010000007.1  37202316-37202369
            696-716             JAXUCZ010000007.1  37203001-37203021
            717-869             JAXUCZ010000007.1  37203185-37203337
            870-1052            JAXUCZ010000007.1  37204074-37204256
            1053-1142           JAXUCZ010000007.1  37205145-37205234
            1143-1265           JAXUCZ010000007.1  37207350-37207472
            1266-1389           JAXUCZ010000007.1  37208467-37208590
            1390-1562           JAXUCZ010000007.1  37210638-37210810
            1563-1725           JAXUCZ010000007.1  37217585-37217747
            1726-1826           JAXUCZ010000007.1  37219226-37219326
            1827-1914           JAXUCZ010000007.1  37219395-37219482
            1915-2027           JAXUCZ010000007.1  37221301-37221413
            2028-2786           JAXUCZ010000007.1  37224781-37225539
            2787-2879           JAXUCZ010000007.1  37225767-37225859
            2880-2964           JAXUCZ010000007.1  37226121-37226205
            2965-3107           JAXUCZ010000007.1  37226795-37226937
            3108-3272           JAXUCZ010000007.1  37227611-37227775
            3273-3422           JAXUCZ010000007.1  37228633-37228782
            3423-3538           JAXUCZ010000007.1  37230186-37230301
            3539-3641           JAXUCZ010000007.1  37233753-37233855
            3642-3872           JAXUCZ010000007.1  37233944-37234174
            3873-4046           JAXUCZ010000007.1  37237412-37237585
            4047-4158           JAXUCZ010000007.1  37241860-37241971
            4159-4364           JAXUCZ010000007.1  37243411-37243616
            4365-4516           JAXUCZ010000007.1  37244547-37244698
            4517-4628           JAXUCZ010000007.1  37245852-37245963
            4629-5084           JAXUCZ010000007.1  37246521-37246976
            5085-5249           JAXUCZ010000007.1  37248050-37248214
            5250-5357           JAXUCZ010000007.1  37249128-37249235
            5358-5492           JAXUCZ010000007.1  37249463-37249597
            5493-5759           JAXUCZ010000007.1  37250346-37250612
            5760-5867           JAXUCZ010000007.1  37251215-37251322
            5868-6067           JAXUCZ010000007.1  37251829-37252028
            6068-6281           JAXUCZ010000007.1  37253253-37253466
            6282-6419           JAXUCZ010000007.1  37260930-37261067
            6420-6641           JAXUCZ010000007.1  37263191-37263412
            6642-6764           JAXUCZ010000007.1  37263707-37263829
            6765-6910           JAXUCZ010000007.1  37265645-37265790
            6911-7066           JAXUCZ010000007.1  37266106-37266261
            7067-7190           JAXUCZ010000007.1  37268648-37268771
            7191-7325           JAXUCZ010000007.1  37271221-37271355
            7326-7412           JAXUCZ010000007.1  37273072-37273158
            7413-7577           JAXUCZ010000007.1  37274066-37274230
            7578-7700           JAXUCZ010000007.1  37274927-37275049
            7701-7873           JAXUCZ010000007.1  37276130-37276302
            7874-8015           JAXUCZ010000007.1  37279555-37279696
            8016-8089           JAXUCZ010000007.1  37280543-37280616
            8090-8184           JAXUCZ010000007.1  37281385-37281479
            8185-8264           JAXUCZ010000007.1  37284268-37284347
            8265-9084           JAXUCZ010000007.1  37285136-37285955
FEATURES             Location/Qualifiers
     source          1..9084
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q21"
     gene            1..9084
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /note="centrosomal protein 290"
                     /db_xref="GeneID:314787"
                     /db_xref="RGD:1311640"
     exon            1..172
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            173..302
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..8492
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /note="isoform 1 is encoded by transcript variant 1;
                     centrosomal protein 290kDa; centrosomal protein of 290
                     kDa"
                     /codon_start=1
                     /product="centrosomal protein of 290 kDa isoform 1"
                     /protein_id="NP_001387932.1"
                     /db_xref="GeneID:314787"
                     /db_xref="RGD:1311640"
                     /translation="MPPNIKWKELIKVDPDELPRQEELADKLLISLSKVEVNELKNED
                     QENMIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQ
                     QSAGGRDTRFLRDEIRQLEKQLEQKDRELEDMEKELDKEKKVNEQLALRNEEAENENS
                     KLRRENKRLKKKNEQLRQDIIDYQKQIDSQKESLLSRRGEDSDYRSQLSKKNYELVQY
                     LDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDTVMDQIKK
                     ENEHYRLQVRELTDLLKAKDEEDDPVMMAVNAKVEEWKLILSSKDDEIIEYQQMLQSL
                     RGKLKNAQLDADKSNIMALKQGIQERDSQIKMLTEQVEQYTKEMEKNTFIIEDLKNEL
                     RKDKGTSNIYQQTHYMKIHSKVQILEEKTKEAERTAELAEADAREKDKELVEALKRLK
                     DYESGVYGLEDAVIEIKNYKAQIKIRDGEIEVLTKEINKLEMKINDVLDENEALRERA
                     GLEPKTMIDLTEFRNSKRVKQQQYRAENQILLKEIESLEEERLDLKRKIRQMAQERGK
                     RSAASGLTIDDLNLTETFSHGDKIGERKLNFISFNNMNETQSKITSSANTELLHRRPS
                     FSVVQSDRSETEENLTTRSLSRMLSGIHHSVDSAVEPVVSLTRCSSFMQLKDSNTTPE
                     AITIREIFKAPCLRSLRNLESLVSTFSKDSSEELSEYLCSLSDDCVKRGSGNHRALEK
                     TRFLQKRSSSFPASPIAAELMQRYSHRQSSAVFPQQSYAHEVHKVTSEGDQAHSQIKY
                     ADLSLKDNKRQSESSSQTEMSRSKSQINLSGLVPVIAQSRASLVHPREKLLGQLQREL
                     VLLRSQNETIAQDLSIQEEQSRNAHLDLDHQRSQEEQNEFLSRELIEKEKDLERSRTV
                     ITKFQNKLKELVEENKQLEEGMKEILQAIKDMPKDSDVKGSETSLIIPSLERLVNAME
                     SKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAVNYSQQLVKANLKIDHLEK
                     ETDLLRQSSGSNVVYKGIDLPDGIAPSSAYIINSQNEYLIHLLQELDNKEKKLKHLED
                     SLEDYNRKFAVIRHQQSLLYKEYLSEKDVWKADSEMIKEEKRKLEDQAQQDAVKVKEY
                     NNLLNALQMDSNEMKKMLSENSRKITVLQVNEKSLIRQYTTLVEIERQLRKENGKHKN
                     DVISMEAEVTEKIGNLQRFKEMATFRIAALQKVVDNSVSLSELELANKQYSELTAKYR
                     DVLQKDNMLVQRASNLEHLACENASLKEQMEGLSKELEITKEKLHTIEQAWEQETKLG
                     NESNMDKAKKSMTNSDIVSISKKITVLEMKELNERQRAEHCQKMYEHLRTSLKHMEER
                     NFELETKFTELTKINLDAQKVEQMLRDELADSVNKAVSDADRQRILELEKREVELKVE
                     VSKLREISDIAKRQVDFLNSQQQSREKEVESLRMQLLDFQAQSDEKALIAKLHQHVVS
                     LQISEATALGKLESVTSKLQKMEACNLRLEQKLDEKEQALYYARLEGRNRANHLRQTI
                     QSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKL
                     KGLEELISTLKDARGAQKVINWHVKIEELRLQELKLNRELVKGKEEIKYLNNIISEYE
                     HTISSLEEDIVQQSKFHEERQMAWDQREVELERQLDIFDRQQNEILSAAQKFEDATGS
                     MPDPSLPLPNQLEIALRKIKENIQIILKTQATCKSLEEKLKEKESALRLAEQNILSRD
                     KVINELRLQLPATADREKLIAELNRTELEPKSHHTMKIAHQTIANMQARLNHKEEVLK
                     KYQHLLEKAREEQREIVKKHEEDLHVLHHKLEQQADNSLSKFKQTAQDLIKQSPAPVP
                     TNKHFIRLAEMEQTVAEQDDSLSSLLTKLKRVSRDLERQKEVTEFKVREFETTKLRLQ
                     ETHANEVKKVKAEVEDLRHALAQAQKDSQNLKSELQAQKEANSRAPTTTMRNLVDRLK
                     SQLALKEKQQKALSRALLELRSEMTAAAEERIIAVTSQKEANLNVQQVVERHTKELKS
                     QIEDLNENLLKLKEALKTSKNKENSLADDLNDLNNELQKKQKAYNKILREKDGIDQEN
                     DELRRQIKRLSSGLQSKTLIDNKQSLIDELQKKVKKLESQLERQVDDVDIKPIKEKSG
                     KEELIRWEEGKKWQTKVEGMRNKLKEKEGEVHSLTKQLSTLKELFAKADKEKLTLQKK
                     LKTTGMTVDQVLGVRALESEKELEELKRRNLDLENDIVYMRTHQALPRDSVVEDLHLQ
                     NRYLQEKLHTLENKLSKDAYSQSLTSEIESDDHCQKEQELQRENLKLSSENIELKFQL
                     EQAKKDLPRLKNQVRDLKEMCEILKKGKMELERKLGQVRGSGRSGKTIPELEKTIGLM
                     KKVVEKVQRENEQLKKASGLLTSEKMATLEEENGKLKAELEKLKAHFGRQLSMQFESK
                     SKGTERIMAENERLRKELKKEMQASEKLRIAKNNLELVNDKMAGQLEETGKRLQFAES
                     RGPQLEGADSQSWKSIVVSRIYDTKIKDLESDIAKKNQSITDLKQLVREATEREQKAK
                     KYTEDLEQQIEILKNVPEGAETEQELIQQLQLLRLANNQLDKEKAELIHQIEVIKDQT
                     GAESSTPDSDQLKKKINDLETHLRKSEPEKQHLKEEIKKLKKELENFDPSFFEEIEDL
                     KYNYKEEVKKNILLEEKLNKLSEQFGFELPSPLAASEQREDGESPNGVPIY"
     exon            303..380
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            381..450
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            451..497
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            498..641
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            642..695
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            696..716
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            717..869
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1052
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1142
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1265
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1389
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1562
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1725
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1826
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1914
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2027
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2786
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            2787..2879
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            2880..2964
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            2965..3107
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            3108..3272
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            3273..3422
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            3423..3538
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            3539..3641
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            3642..3872
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            3873..4046
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            4047..4158
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            4159..4364
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            4365..4516
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            4517..4628
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            4629..5084
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            5085..5249
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            5250..5357
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            5358..5492
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            5493..5759
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            5760..5867
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            5868..6067
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            6068..6281
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            6282..6419
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            6420..6641
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            6642..6764
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            6765..6910
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            6911..7066
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            7067..7190
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            7191..7325
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            7326..7412
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            7413..7577
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            7578..7700
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            7701..7873
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            7874..8015
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            8016..8089
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            8090..8184
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            8185..8264
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
     exon            8265..9084
                     /gene="Cep290"
                     /gene_synonym="RGD1311640"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtggtgtc gcctagcagc cggcgccgct tcggcttgtt tgggaagagt tggcgggagc
       61 agcttgagtg cgcgaggaca gctattggaa gcgagaggcc caggcggtgg ccgaacccgg
      121 acgtgatcgc tgtagatgag tgactgctgc tgttttgccc gtcttggttt aggaactgag
      181 aggcagtgaa agaattcaag atgccaccta atataaaatg gaaagaatta atcaaagttg
      241 atccagatga actgccacgt caagaagagt tggcagataa attattgata tccttatcca
      301 aggtggaagt aaatgaacta aaaaatgaag atcaagaaaa catgatacat ctgttcagaa
      361 ttactcagtc actaatgaag atgaaagctc aagaagtgga gctggccttg gaagaagttg
      421 aaaaggctgg ggaagaacaa gcaaaatttg aaaatcaatt aaagacaaaa gtaatgaaac
      481 tggaaaatga actggagatg gctcagcagt ctgcaggtgg acgtgacact cggtttttac
      541 gtgatgaaat tcgccaactt gaaaagcagt tggaacaaaa agatagagaa ttagaggata
      601 tggaaaaaga actggataaa gaaaagaaag ttaatgaaca attggccctt cgaaacgagg
      661 aggcagaaaa tgaaaacagc aaattaagaa gagagaacaa acgtctaaag aaaaagaatg
      721 aacagcttcg tcaggacatt attgactacc agaaacaaat agattcacaa aaagaatcac
      781 ttctgtcaag gagaggagag gacagtgact accgatcaca gttatctaaa aagaactatg
      841 aacttgttca atatctggac gaaatacaga ccttaacaga agctaatgag aaaattgaag
      901 ttcagaacca agaaatgaga aaaaacctag aagagtctgt acaggaaatg gagaagatga
      961 ctgatgaata taacaggatg aaagcgattg tgcatcagac agatactgtt atggaccaga
     1021 tcaaaaaaga gaatgagcac taccgccttc aagtgcgaga actcacagat cttctgaaag
     1081 caaaggatga agaggatgat cccgtcatga tggctgtcaa tgcaaaagtg gaggaatgga
     1141 agttaatttt gtcttctaaa gatgatgaaa tcattgaata ccagcaaatg ttacagagtc
     1201 tgagagggaa acttaaaaat gcccagcttg atgctgataa aagtaacatt atggctctga
     1261 agcagggtat ccaggaacga gacagtcaaa ttaagatgct tactgaacaa gtagaacagt
     1321 atacgaaaga aatggaaaaa aatactttta ttattgaaga tttgaaaaat gagctccgaa
     1381 aagacaaagg tacttcaaac atttatcagc agactcatta tatgaaaatc cactcaaagg
     1441 tacaaatttt agaagagaaa acaaaagagg ccgagagaac agctgagctg gctgaggctg
     1501 atgctaggga gaaggacaaa gaattggttg aggctctgaa gagattaaaa gattatgaat
     1561 ctggagtata tggcttagaa gatgcggtta ttgaaataaa gaattataaa gcccaaatta
     1621 aaataagaga tggagagatt gaagtgttga ccaaggagat caataagctt gagatgaaga
     1681 tcaatgatgt ccttgatgaa aatgaagctc ttagagagcg ggccggcctt gaacccaaga
     1741 caatgattga tctgactgaa tttagaaata gtaaacgcgt aaagcagcag cagtacagag
     1801 ctgagaacca gattcttttg aaagagatcg aaagtctaga ggaagaacgt cttgacttga
     1861 agagaaaaat tcgtcaaatg gctcaagaaa gaggcaaaag gagtgcagcc tcaggattaa
     1921 ccattgatga tctgaaccta actgaaacct tttctcacgg ggataaaata ggagaaagaa
     1981 agctaaattt tataagcttc aataatatga atgaaacaca atcaaagatt acgagttcag
     2041 ctaacacaga gctgctccat aggagaccat cattcagtgt tgtgcagtca gatcgcagtg
     2101 agacagagga gaatctgacc acacgctcac tgtcaagaat gctctctgga attcaccata
     2161 gcgtagacag tgcagtggag cctgtcgtct ctttaactcg atgctcctca tttatgcagc
     2221 tgaaagacag caatacaact ccagaagcta ttacaataag ggagattttt aaagcaccat
     2281 gtctccgatc tttgagaaac ctagaatcgt tagtcagtac cttcagtaag gacagcagtg
     2341 aagaactaag tgaatactta tgctccctct ctgatgactg tgtgaagaga ggctcaggaa
     2401 accatcgagc gctagagaaa accaggttct tacagaagcg cagttcatct tttccagcat
     2461 caccaatagc tgctgaatta atgcagagat attcacatag gcagagctct gcagtatttc
     2521 ctcaacagtc gtatgcacat gaagtgcata aagtaacatc agaaggtgac caggcccact
     2581 ctcaaataaa gtatgctgat ctcagtttga aagacaataa aagacaaagt gaatcatcct
     2641 cccaaactga gatgtcgaga agtaagagcc aaattaatct ttcaggtctt gtgcctgtca
     2701 ttgctcagtc cagagcatct ctggtacatc cccgtgaaaa gcttctaggg cagctacaga
     2761 gagagctagt actccttaga tctcagaatg aaaccatagc acaggattta tcaatccaag
     2821 aagagcagag tagaaatgca cacttagacc ttgaccatca gagaagccag gaagaacaga
     2881 atgaatttct ttcaagagaa ttgattgaaa aggaaaaaga tttagaaaga agtaggacag
     2941 taattactaa atttcagaat aaactaaaag aattagttga agaaaataag caacttgaag
     3001 aaggtatgaa ggaaattttg caagccatta aggacatgcc aaaggattct gatgtgaaag
     3061 gaagtgaaac atctttaatc atcccaagtc ttgaaagact ggttaatgct atggaatcaa
     3121 agaatgcaga aggaatcttc gatgctagtt tgcatctgaa agcccaagtt gatcaactta
     3181 caggaaggaa tgaagaatta aggcaagaac tcagggaatc tcggaaagaa gcagtaaatt
     3241 attcccagca gttggtaaaa gcaaacttaa agattgatca ccttgagaaa gaaacagacc
     3301 ttctgcgtca atcttcaggc tccaatgtag tttacaaagg catagactta cctgacggga
     3361 tagcaccatc tagtgcctac atcatcaact ctcagaatga gtatttaata catcttttgc
     3421 aggaactaga caataaagaa aagaaattaa agcacttaga agattctctt gaagattata
     3481 acagaaaatt tgcagtgatt cgacatcaac aaagtttatt atataaagaa tatctaagtg
     3541 aaaaggatgt ttggaaagca gattctgaga tgataaaaga ggagaagaga aagctggagg
     3601 atcaggctca gcaggacgct gtgaaagtaa aagagtataa taatttgctc aatgcccttc
     3661 agatggactc gaatgaaatg aagaaaatgc tttcagaaaa cagtaggaaa atcacggttc
     3721 tgcaagtgaa tgagaagtcc ctcatccggc agtatacaac cttagtggag atagagcggc
     3781 aacttagaaa agaaaacggg aaacacaaga atgacgtcat atccatggaa gccgaagtta
     3841 ctgaaaaaat tggaaatttg cagagattta aggaaatggc caccttcagg attgcagctc
     3901 ttcagaaagt tgtagataac agtgtttctt tgtctgaact agaactagcc aataaacagt
     3961 acagtgagct gactgcgaag tacagggacg tcttgcagaa agataacatg cttgttcaga
     4021 gagcaagtaa cttagagcac ctagcgtgtg aaaatgcatc gctgaaagaa cagatggagg
     4081 ggctcagtaa agagctggag atcacaaagg aaaagctcca taccatcgaa caagcctggg
     4141 aacaagaaac gaagttagga aatgaatcaa acatggataa ggcaaagaaa tcaatgacaa
     4201 atagtgacat tgtttctatt tcaaaaaaaa tcactgtgtt ggagatgaaa gaattaaatg
     4261 aaaggcagag ggctgaacac tgtcagaaaa tgtatgagca cctaagaact tcattgaagc
     4321 acatggaaga acgaaacttt gaattggaaa ccaagttcac tgagcttacc aaaatcaacc
     4381 tggatgcaca gaaggtggag cagatgctga gagatgaatt agctgatagt gtgaacaagg
     4441 cagtgagcga cgccgataga cagcggattc tagaactgga gaagcgtgaa gtggagctca
     4501 aagtggaagt gtctaaactg agagagattt ctgatattgc caaaagacaa gttgattttt
     4561 tgaattcaca acaacagtcc agggaaaagg aagtggaatc cctcagaatg cagctgctgg
     4621 acttccaggc acaatctgat gaaaaggcgc taattgccaa attgcaccaa cacgttgtct
     4681 ctcttcaaat tagtgaggcc acagctcttg gtaagttaga gtcagttacg tctaaactcc
     4741 agaagatgga agcctgcaac ttgcgcttag aacagaaact ggacgaaaag gagcaggctc
     4801 tctactacgc ccgcttggag ggtagaaaca gagccaatca cctgcgccag accattcagt
     4861 ctctacgacg acagttcagt ggcgctttac ccttggctca gcaggaaaag ttctccaaaa
     4921 caatgattca gttgcaaaat gacaaactta agataatgca agaaatgaaa aattctcaac
     4981 aagaacacag aaatatggaa aacaaaacat tggaaatgga attaaaatta aaaggcttag
     5041 aagaattaat aagcacttta aaggatgcca ggggagccca gaaggtaatc aattggcatg
     5101 tgaaaataga agaacttcgc cttcaagaac ttaagctaaa tagagagcta gtcaagggta
     5161 aagaagaaat caaatatttg aataatatca tctcggaata tgaacataca atcagcagtc
     5221 tggaggaaga cattgttcag cagagcaagt ttcatgaaga aagacaaatg gcttgggatc
     5281 aaagagaagt tgagctggaa cgccagttag acatttttga tcgtcagcaa aatgaaatac
     5341 tcagtgcagc acaaaagttt gaagacgcga caggatcaat gcctgacccc agcttgcccc
     5401 ttccaaacca acttgaaatt gctctaagaa aaattaagga gaatattcaa ataattctta
     5461 aaacacaagc aacttgcaag tcactagaag agaaactaaa agaaaaagaa tctgctttgc
     5521 ggttggcaga gcaaaatatt ctgtcaagag acaaagtaat caatgaactg aggcttcaat
     5581 tgcctgccac agctgatcga gaaaaactta tagctgagct caacagaaca gagctggagc
     5641 caaaatctca tcacacgatg aaaattgccc atcaaaccat tgccaacatg caggcgaggt
     5701 taaatcacaa ggaagaagta ttgaagaagt accagcatct tttggagaaa gccagagagg
     5761 agcaaagaga aattgttaag aaacatgagg aagaccttca tgttcttcat cacaaattag
     5821 agcaacaggc cgataattca ctcagtaaat tcaaacagac agctcaggat ttaattaagc
     5881 agtctcctgc tccagtaccc accaacaagc atttcattcg cctggccgag atggaacaga
     5941 cagtagcaga acaagatgac tctctctctt cacttttgac caaactgaag agagtatcaa
     6001 gagatttgga aagacaaaaa gaagtcactg agttcaaagt cagagaattt gaaactacca
     6061 aattacggct ccaagaaact catgccaacg aagtaaagaa agtgaaagca gaggtagagg
     6121 acttaaggca tgctctagcc caagcacaga aggactccca gaatttaaag tctgaactcc
     6181 aggctcagaa agaagcaaac tccagggcac caacaaccac aatgaggaat ctagtagaca
     6241 ggctaaagag ccagctagct ttgaaagaga agcagcaaaa ggcacttagc cgagccctgt
     6301 tggaacttcg gtcagaaatg acagcagcag ctgaagaacg tataattgct gtaacttctc
     6361 aaaaagaggc aaatctcaat gttcaacaag ttgttgagcg gcatactaaa gaactaaagt
     6421 cacaaattga agatttaaat gaaaatcttt tgaaattaaa agaagctctt aagacaagta
     6481 aaaacaaaga aaattcacta gctgatgact taaatgattt aaataatgaa ctgcaaaaaa
     6541 agcaaaaagc ttataataaa atccttagag agaaagatgg aattgatcaa gaaaatgatg
     6601 aactgagacg acagattaaa agactgtcca gtgggctaca gagcaaaact ctgatagata
     6661 ataagcaaag tttaatcgat gaacttcaga agaaagttaa aaaacttgaa agccaactgg
     6721 aaagacaggt ggatgacgta gacataaagc ctataaagga aaagagtggt aaagaagaat
     6781 taattaggtg ggaagaaggt aagaaatggc aaaccaaagt agagggaatg cgcaacaaat
     6841 taaaggagaa agaaggagag gtccacagcc tgacaaagca gctgagcacc ttaaaggaac
     6901 tttttgccaa agctgataaa gagaagctta ctttgcagaa gaaactgaaa acaacaggaa
     6961 tgactgttga ccaggtctta ggagtgcgag ctttggagtc ggaaaaggag ttggaagagc
     7021 taaaaaggag aaatctggac ttagaaaatg acatagtata tatgaggacc caccaggctc
     7081 ttccacgaga ttctgttgta gaagacttac acttacaaaa tagatacctt caagaaaaac
     7141 ttcatacttt agaaaataaa ctttccaagg atgcatattc tcagtctttg acttcagaaa
     7201 tagaatcaga tgatcattgt caaaaagaac aagagcttca gagggaaaat ttgaaattgt
     7261 catctgaaaa tattgaactg aaatttcaac tggaacaagc aaagaaagac ttgccgagac
     7321 taaagaatca agtaagagat ttgaaggaaa tgtgtgaaat tcttaagaaa gggaaaatgg
     7381 aacttgaacg gaagcttggt caggtcagag ggtctggtag aagtgggaag acaatcccag
     7441 agctagaaaa aactattggg ttaatgaaga aagttgttga aaaagtccaa agagaaaacg
     7501 aacaattgaa aaaggcatca ggactactga ctagtgaaaa aatggctact cttgaggaag
     7561 aaaatggaaa attaaaggct gaattagaaa agctgaaagc tcactttgga cgtcagttga
     7621 gcatgcagtt tgaatctaag agcaaaggga ctgagagaat tatggccgaa aatgagcggc
     7681 ttcggaaaga acttaagaaa gaaatgcaag cttctgagaa actgcgcata gctaagaaca
     7741 acttagagct ggtgaatgac aagatggcgg gtcaactaga agagactggg aagagattgc
     7801 agtttgcaga aagtagaggt ccacagctgg aaggtgctga cagccagagc tggaagtcaa
     7861 ttgtggtttc aagaatatat gacaccaaga taaaagacct cgaaagtgac attgccaaaa
     7921 agaaccaaag tatcaccgac cttaaacagc ttgtaagaga agcaacagag agagaacaga
     7981 aagccaagaa gtacactgaa gaccttgaac aacagattga gatcctcaaa aatgttcctg
     8041 aaggagctga aacagagcaa gagcttatac agcagctcca gcttcttaga ctagccaata
     8101 accagctgga taaagaaaaa gcagagctaa tccatcagat agaagttatc aaggaccaaa
     8161 ctggagccga aagtagcaca cctgattctg atcaactgaa gaaaaagata aatgacctgg
     8221 agacacacct cagaaagtca gagccagaaa agcaacattt gaaggaggaa attaaaaagc
     8281 tgaaaaaaga actggaaaat tttgaccctt cattctttga agaaattgaa gacctgaagt
     8341 acaattataa ggaagaagtg aagaaaaata ttctcttaga agagaagtta aacaaacttt
     8401 ctgaacaatt tggatttgaa ttgcctagcc cacttgctgc ttctgaacaa cgggaagatg
     8461 gagaaagtcc taatggcgtc ccgatttatt aatggcctca tttaaaactg tagatttaaa
     8521 actactgatg acatagaagt ttcagctgga aatcagtctc tgacctacag aatttacctc
     8581 tcaaaatact gtattatttt gcttaaaaat aaaatcatat ttagttttaa cttgttagaa
     8641 aagtatattt ttgaagacct cagtaatttg tgactatata gtatataatg agctacgaca
     8701 aaaatttatg actatatagt atataatgag ctatgataaa tatttcctat tttcatattt
     8761 taaattctct aaaagcataa aggtaagctt ataacaatct tactatttaa aattgattat
     8821 tttatactta tttttgtgtt aagttattca aacctaacga tgatttctat aaatacatag
     8881 aaacatgttt agaagttgac atgtgttttg ccaagcagct aggaaaaata aattgacctg
     8941 tgtaaacatg gcaaacctgt cccaataaaa aaatcacaac agtcccaact attatttcta
     9001 ttttatatat caagggttat atctttgagc ctatcaaatt tctgcttatc tatttttgaa
     9061 aacttattaa acaaagactg gtga
//
