LOCUS       NM_001395117            4360 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Rattus norvegicus centrosome assembly and centriole elongation
            protein (Cpap), mRNA.
ACCESSION   NM_001395117 XM_039093310
VERSION     NM_001395117.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4360)
  AUTHORS   Chang,C.W., Hsu,W.B., Tsai,J.J., Tang,C.J. and Tang,T.K.
  TITLE     CEP295 interacts with microtubules and is required for centriole
            elongation
  JOURNAL   J Cell Sci 129 (13), 2501-2513 (2016)
   PUBMED   27185865
REFERENCE   2  (bases 1 to 4360)
  AUTHORS   Bazzi,H. and Anderson,K.V.
  TITLE     Acentriolar mitosis activates a p53-dependent apoptosis pathway in
            the mouse embryo
  JOURNAL   Proc Natl Acad Sci U S A 111 (15), E1491-E1500 (2014)
   PUBMED   24706806
REFERENCE   3  (bases 1 to 4360)
  AUTHORS   Hatzopoulos,G.N., Erat,M.C., Cutts,E., Rogala,K.B., Slater,L.M.,
            Stansfeld,P.J. and Vakonakis,I.
  TITLE     Structural analysis of the G-box domain of the microcephaly protein
            CPAP suggests a role in centriole architecture
  JOURNAL   Structure 21 (11), 2069-2077 (2013)
   PUBMED   24076405
REFERENCE   4  (bases 1 to 4360)
  AUTHORS   Wu,K.S. and Tang,T.K.
  TITLE     CPAP is required for cilia formation in neuronal cells
  JOURNAL   Biol Open 1 (6), 559-565 (2012)
   PUBMED   23213448
REFERENCE   5  (bases 1 to 4360)
  AUTHORS   McIntyre,R.E., Lakshminarasimhan Chavali,P., Ismail,O.,
            Carragher,D.M., Sanchez-Andrade,G., Forment,J.V., Fu,B., Del
            Castillo Velasco-Herrera,M., Edwards,A., van der Weyden,L.,
            Yang,F., Ramirez-Solis,R., Estabel,J., Gallagher,F.A., Logan,D.W.,
            Arends,M.J., Tsang,S.H., Mahajan,V.B., Scudamore,C.L., White,J.K.,
            Jackson,S.P., Gergely,F. and Adams,D.J.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Disruption of mouse Cenpj, a regulator of centriole biogenesis,
            phenocopies Seckel syndrome
  JOURNAL   PLoS Genet 8 (11), e1003022 (2012)
   PUBMED   23166506
REFERENCE   6  (bases 1 to 4360)
  AUTHORS   Bond,J., Roberts,E., Springell,K., Lizarraga,S.B., Scott,S.,
            Higgins,J., Hampshire,D.J., Morrison,E.E., Leal,G.F., Silva,E.O.,
            Costa,S.M., Baralle,D., Raponi,M., Karbani,G., Rashid,Y., Jafri,H.,
            Bennett,C., Corry,P., Walsh,C.A. and Woods,C.G.
  TITLE     A centrosomal mechanism involving CDK5RAP2 and CENPJ controls brain
            size
  JOURNAL   Nat Genet 37 (4), 353-355 (2005)
   PUBMED   15793586
  REMARK    Erratum:[Nat Genet. 2005 May;37(5):555. Lizarraga, Sophia
            [corrected to Lizarraga, Sofia B]]
REFERENCE   7  (bases 1 to 4360)
  AUTHORS   Hung,L.Y., Chen,H.L., Chang,C.W., Li,B.R. and Tang,T.K.
  TITLE     Identification of a novel microtubule-destabilizing motif in CPAP
            that binds to tubulin heterodimers and inhibits microtubule
            assembly
  JOURNAL   Mol Biol Cell 15 (6), 2697-2706 (2004)
   PUBMED   15047868
REFERENCE   8  (bases 1 to 4360)
  AUTHORS   Peng,B., Sutherland,K.D., Sum,E.Y., Olayioye,M., Wittlin,S.,
            Tang,T.K., Lindeman,G.J. and Visvader,J.E.
  TITLE     CPAP is a novel stat5-interacting cofactor that augments
            stat5-mediated transcriptional activity
  JOURNAL   Mol Endocrinol 16 (9), 2019-2033 (2002)
   PUBMED   12198240
REFERENCE   9  (bases 1 to 4360)
  AUTHORS   Tchernev,V.T., Mansfield,T.A., Giot,L., Kumar,A.M., Nandabalan,K.,
            Li,Y., Mishra,V.S., Detter,J.C., Rothberg,J.M., Wallace,M.R.,
            Southwick,F.S. and Kingsmore,S.F.
  TITLE     The Chediak-Higashi protein interacts with SNARE complex and signal
            transduction proteins
  JOURNAL   Mol Med 8 (1), 56-64 (2002)
   PUBMED   11984006
REFERENCE   10 (bases 1 to 4360)
  AUTHORS   Hung,L.Y., Tang,C.J. and Tang,T.K.
  TITLE     Protein 4.1 R-135 interacts with a novel centrosomal protein (CPAP)
            which is associated with the gamma-tubulin complex
  JOURNAL   Mol Cell Biol 20 (20), 7813-7825 (2000)
   PUBMED   11003675
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Jun 3, 2021 this sequence version replaced XM_039093310.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR21887622.1476015.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA5760383,
                                    SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               JAXUCZ010000015.1  34802309-34802421   c
            114-612             JAXUCZ010000015.1  34795167-34795665   c
            613-736             JAXUCZ010000015.1  34794448-34794571   c
            737-1021            JAXUCZ010000015.1  34788156-34788440   c
            1022-1133           JAXUCZ010000015.1  34784696-34784807   c
            1134-1236           JAXUCZ010000015.1  34782912-34783014   c
            1237-2857           JAXUCZ010000015.1  34781181-34782801   c
            2858-2990           JAXUCZ010000015.1  34779077-34779209   c
            2991-3156           JAXUCZ010000015.1  34772480-34772645   c
            3157-3399           JAXUCZ010000015.1  34753890-34754132   c
            3400-3484           JAXUCZ010000015.1  34751187-34751271   c
            3485-3549           JAXUCZ010000015.1  34749043-34749107   c
            3550-3663           JAXUCZ010000015.1  34748718-34748831   c
            3664-3804           JAXUCZ010000015.1  34747276-34747416   c
            3805-3889           JAXUCZ010000015.1  34747117-34747201   c
            3890-4010           JAXUCZ010000015.1  34746916-34747036   c
            4011-4360           JAXUCZ010000015.1  34742838-34743187   c
FEATURES             Location/Qualifiers
     source          1..4360
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p12"
     gene            1..4360
                     /gene="Cpap"
                     /gene_synonym="Cenpj"
                     /note="centrosome assembly and centriole elongation
                     protein"
                     /db_xref="GeneID:305909"
                     /db_xref="RGD:1310464"
     exon            1..113
                     /gene="Cpap"
                     /gene_synonym="Cenpj"
                     /inference="alignment:Splign:2.1.0"
     exon            114..612
                     /gene="Cpap"
                     /gene_synonym="Cenpj"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..4203
                     /gene="Cpap"
                     /gene_synonym="Cenpj"
                     /codon_start=1
                     /product="centromere protein J"
                     /protein_id="NP_001382046.1"
                     /db_xref="GeneID:305909"
                     /db_xref="RGD:1310464"
                     /translation="MKMFLMPTSSELNTGQNFLTQWMTSPSRAGVILNREFPILDADE
                     KQAATTVSASFPVKAAHFSSSFSISSEEDSFHEEQTLEAGRPYKPRSEDPEAHPVSAS
                     VRREPIASCQDAPGCQEGNRNAATPDLKSEFKEVANKNPLFKKLEQLKEIQQKKQEQL
                     KRQQLEQLQRLMEEQEKLLTMVSGQHMFPGSLLPDELSQKHRSPGDSASGERATLSPP
                     SYPNPTQDNSRASSLLPDEQSNFCRATQQDSVLTSKNASDLFHESQYHEAHVRRNDLK
                     EESHNHPSGEGALPCWEKKMGKSQEGKDVNLQRSRDSSGVVNIEERPIKAAIREKQQT
                     FEDYLEEQIRLEERELRQKQLQEAEGPLLTKMKPKQPFLKRGEGLARFTNAKCKFQKG
                     KESKLASTQSPSEQQSVPKVDRQHLQRKTALINRDLCADTTSVKKDSKARSKAGSASL
                     RQKPKVTKTNRRDSLSPPGRKVQTGKKCDGQFRPQVKLERNVPTNNKENVPAYIKPWG
                     AGCKVWNKTQGRDRLPLSTGPVGCVVSRSLVPETDRQTESSLDISLQKKLENWEREKE
                     KENLELDEFLFLERAADEISFSSNSSFVLKILERDQQIYEGHRLSSTPVKAVQPQKAQ
                     QADPWGQSNHSEVPRPSVAHEDESEFEAMLLSRGSGSPGLRELSCKLSKKAFQNSTSE
                     NQGRWDAGDGDVANSDSSSESEEHDITIKPSTEAEDRVFSNREDSPQVCDAKGPSRDT
                     GAQEDQWRDADLDLSDKECSSDESVTVESLSSQVLEPLRLPSSHDGSKVDFDDERSWA
                     DLEENPHEHGVVPREEAMSGTSQTHCHSTSEGCVLDKTIKRKIAPVKKGEDFSKSDRS
                     VSPPPSDLMVKFFPSLKPKPKLDSHVENEPKLSLSQDQPPGDSVRSQVLREKVIELES
                     EIEKFKAENTSLAKLRIERESALEKLRKEIADFEQQKARELARIEEYKKEETRKLQKE
                     RKVFEKYTAAARTFPDKKEREEIQALKQQIQELQEDLKRKETKWSSTHGRLRSQIEML
                     VKENTDLREEIKVMERFRLEAWKRAEAIENSPKACQYIMATKKDESMNSSIQFQKSHA
                     SLGVQGEKYKKKYLPAQGNSSRRSKSVPPRDLGSLDKGQAALPREPLQPVNFPDLEYK
                     NKEEKEEEIQGEINHPDGKVEKVYKNGCRVVLFPNGTRKEVSADGKSITVTFFNGDVK
                     QVMPDERVVYYYAAAQTTHTTYPEGLEVLHFSSGQIEKHFPDGRKEITFPDQTIKTLF
                     ADGQEESIFPDGTIVRVQRDGNKIIEFNNGQRELHTAQFKRREYPDGTVKTVYANGHQ
                     ETKYTSGRVRVKDKDGNVLMDTEM"
     exon            613..736
                     /gene="Cpap"
                     /gene_synonym="Cenpj"
                     /inference="alignment:Splign:2.1.0"
     exon            737..1021
                     /gene="Cpap"
                     /gene_synonym="Cenpj"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1133
                     /gene="Cpap"
                     /gene_synonym="Cenpj"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1236
                     /gene="Cpap"
                     /gene_synonym="Cenpj"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..2857
                     /gene="Cpap"
                     /gene_synonym="Cenpj"
                     /inference="alignment:Splign:2.1.0"
     exon            2858..2990
                     /gene="Cpap"
                     /gene_synonym="Cenpj"
                     /inference="alignment:Splign:2.1.0"
     exon            2991..3156
                     /gene="Cpap"
                     /gene_synonym="Cenpj"
                     /inference="alignment:Splign:2.1.0"
     exon            3157..3399
                     /gene="Cpap"
                     /gene_synonym="Cenpj"
                     /inference="alignment:Splign:2.1.0"
     exon            3400..3484
                     /gene="Cpap"
                     /gene_synonym="Cenpj"
                     /inference="alignment:Splign:2.1.0"
     exon            3485..3549
                     /gene="Cpap"
                     /gene_synonym="Cenpj"
                     /inference="alignment:Splign:2.1.0"
     exon            3550..3663
                     /gene="Cpap"
                     /gene_synonym="Cenpj"
                     /inference="alignment:Splign:2.1.0"
     exon            3664..3804
                     /gene="Cpap"
                     /gene_synonym="Cenpj"
                     /inference="alignment:Splign:2.1.0"
     exon            3805..3889
                     /gene="Cpap"
                     /gene_synonym="Cenpj"
                     /inference="alignment:Splign:2.1.0"
     exon            3890..4010
                     /gene="Cpap"
                     /gene_synonym="Cenpj"
                     /inference="alignment:Splign:2.1.0"
     exon            4011..4360
                     /gene="Cpap"
                     /gene_synonym="Cenpj"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggctctgg ctgcggcggt ggttgtggcg gctctttcgt aaatgccggg cctgctcaaa
       61 ggtgacttta tcactggtcg aagcggtctg aaccgctgtg tcttcgtgga acggtggtgg
      121 aagccagtag gtgttgagga cttcccagtg ttcagattgg gtcattagat gaaaatgttc
      181 ctgatgccaa cctcttcaga attaaacact gggcagaact tcctcaccca gtggatgact
      241 agtccttctc gggctggggt catattaaat cgagaatttc ctattttgga tgccgatgag
      301 aagcaagcag ctacaactgt ttctgccagc tttcccgtga aagccgccca tttttcaagt
      361 agcttcagta ttagtagtga agaggattca tttcatgaag aacagacgct ggaggctgga
      421 agaccttata aaccacggtc agaagacccg gaagctcatc cagtctctgc ttcagtcaga
      481 agggagccaa tagcatcatg tcaggatgcc ccaggatgcc aggagggtaa cagaaatgcc
      541 gctacgcctg atctcaagag tgaattcaaa gaagtggcta ataaaaaccc actttttaaa
      601 aaactggagc agctgaaaga aatacagcag aagaagcagg aacagctgaa gaggcagcag
      661 cttgaacaac tgcagaggct catggaggag caagagaagc tgctcaccat ggtgtctggg
      721 cagcacatgt ttccaggttc attactgcct gatgagctga gccagaagca tcgctctcca
      781 ggagactcag cctcaggaga gagggccacc ctgtcaccac ccagctaccc aaatccaacc
      841 caagacaact cccgtgcttc cagccttcta ccagatgaac aaagtaactt ctgtagagcc
      901 actcaacaag attctgtttt aacttcaaaa aatgcttctg atttgtttca tgagtcacaa
      961 tatcatgaag cacatgtgag aagaaatgat ttaaaggagg aaagccataa ccatccttca
     1021 ggggaaggtg ctttgccatg ctgggaaaag aagatgggga agagccagga agggaaggat
     1081 gtgaacttac aaagaagtag agattcctca ggagtggtta atattgaaga gaggccaatc
     1141 aaagctgcca ttagagagaa gcagcagaca ttcgaggact acttagagga gcagatccga
     1201 ctggaagagc gagaactgag acagaagcag ctgcaggaag cagaaggacc attactaacg
     1261 aaaatgaaac ccaagcagcc atttttaaaa cgaggagaag gtttagcgag gtttactaat
     1321 gctaaatgta aatttcagaa ggggaaagaa agcaagctag cgagtaccca gagcccgtca
     1381 gagcagcagt ctgtgcctaa agtagacaga cagcacttgc agaggaaaac cgcgctcata
     1441 aacagggacc tgtgtgcaga caccacctct gttaaaaagg acagtaaagc taggtccaag
     1501 gctggctcgg cctcactcag gcagaaaccc aaagtgacca agaccaatag gagggacagt
     1561 ctatccccgc cgggacggaa agtacagacg gggaagaaat gtgatggaca atttagaccc
     1621 caggtcaaat tagagagaaa tgtgcccacc aataataagg aaaatgtacc tgcgtacata
     1681 aagccctggg gtgctggctg caaggtgtgg aataagacac aggggagaga cagacttcct
     1741 ctttccacag ggccggttgg ctgtgtggtc tccaggagtt tggtacctga gacagataga
     1801 cagacagaat cttcccttga tatttctctt cagaaaaaat tagagaattg ggagagagaa
     1861 aaagaaaagg aaaacttgga actagatgaa tttttatttt tggaacgggc tgctgatgaa
     1921 atatcatttt ctagtaattc ctcttttgtt ctgaaaatct tagaaaggga ccaacagatc
     1981 tatgaaggtc acaggctgtc ttccacccct gtcaaagctg tgcagcccca gaaggcacag
     2041 caggcagatc cttgggggca gagtaaccac agtgaggttc cccgccccag tgttgcacat
     2101 gaggatgaga gtgagtttga ggccatgctc ttgtctcggg gttcagggtc acctggcttg
     2161 agggaactgt cctgtaaact tagtaagaaa gccttccaaa acagcacttc tgagaaccag
     2221 ggccgatggg atgcagggga tggtgacgtt gccaacagcg acagtagctc tgagtctgag
     2281 gagcatgaca ttaccatcaa accgtccacc gaggctgagg acagggtctt cagcaacaga
     2341 gaggatagtc cacaagtctg tgacgccaaa ggaccttctc gggacaccgg ggctcaagaa
     2401 gatcagtgga gagacgcaga cctggatctg tctgataaag agtgtagcag tgacgagtct
     2461 gtcacagttg aaagtctgag cagtcaagta ttggagccgc tgagactgcc ctcctctcac
     2521 gacgggagta aagtcgactt cgatgatgaa agatcttggg cagaccttga ggagaatcca
     2581 catgaacatg gtgttgttcc cagagaggaa gccatgtctg gtacttccca gacacactgc
     2641 cacagtacaa gtgaaggatg tgttctggac aaaacaataa aaaggaagat tgcaccagtc
     2701 aagaagggag aagacttcag caagtctgac aggagcgtaa gtcctcctcc atctgacttg
     2761 atggtaaaat tcttcccttc tttgaaacca aagccaaaat tagattcaca cgtagaaaat
     2821 gaacccaagt taagcctgag tcaagatcaa ccaccaggtg acagtgttcg atctcaggtc
     2881 ttaagagaga aagttattga actggaatca gaaatagaaa aatttaaagc tgagaacaca
     2941 tctttagcta aacttcgtat tgaacgagaa agtgccttgg aaaaactgag gaaagaaatt
     3001 gctgactttg agcaacaaaa agcaagagaa ctggctcgaa tagaagagta taaaaaggag
     3061 gagacgagga aactacaaaa ggagcgcaaa gtcttcgaga agtacacagc agctgcaaga
     3121 acattcccag ataaaaagga gcgggaagaa atacaggctt tgaaacagca aatacaggaa
     3181 ttacaggaag acttgaaaag gaaggaaaca aaatggtcaa gtacacacgg tcgcctcaga
     3241 agccagatag aaatgctagt caaagagaat acagacctcc gagaagaaat aaaagtaatg
     3301 gaaagattcc gactggaggc ctggaagaga gcagaagcta ttgagaacag tcccaaggcc
     3361 tgccagtaca taatggccac aaaaaaggat gagtccatga actcatcaat tcaatttcaa
     3421 aagagtcatg cttctttagg agtccaggga gaaaaatata agaaaaagta tttgccagca
     3481 caaggaaatt catctagaag atccaagtct gtgccgcctc gtgatttagg cagcttggat
     3541 aaaggacaag ctgccttgcc tagagagcct cttcaaccag tgaacttccc agaccttgaa
     3601 tataaaaaca aagaggaaaa agaggaagaa attcagggag aaatcaatca tcctgatggg
     3661 aaggtagaaa aagtttataa aaatggatgc cgggttgttc tgtttcccaa tggaactcgg
     3721 aaagaagtga gtgcggacgg gaagagcatc acggttacat tcttcaatgg tgacgtcaaa
     3781 caggtcatgc cagatgagag agtggtctac tactatgctg ctgcccagac cacacatacc
     3841 acgtacccag aagggcttga agtcttacat ttctcaagcg ggcaaataga aaagcatttc
     3901 ccagatggaa gaaaagaaat cacatttcct gaccagacca ttaagacttt atttgctgat
     3961 ggtcaagaag agagcatctt tccagatggc acaattgtcc gagtacaacg tgatggcaac
     4021 aaaatcatag agtttaataa tggccaaaga gagctccaca ctgcccagtt caagagacga
     4081 gaataccccg atgggactgt taagactgtc tatgcaaatg gtcatcagga gacaaagtac
     4141 acctctggcc gagtcagagt gaaggacaaa gatggtaatg tgctaatgga cacagaaatg
     4201 tgaaaggtct ttgtgggatt aatcatgaag taacactaaa tggttttctg ttcagaggat
     4261 gtacatttct tatgtgttca gttgtttaat ttatataacg tgtgtctaaa taaaaagatt
     4321 atgtttgaat tttaaaatta aattaaagtt ttgccatata
//
