LOCUS       NM_001421086            7512 bp    mRNA    linear   ROD 01-JUL-2024
DEFINITION  Rattus norvegicus centromere protein E (Cenpe), mRNA.
ACCESSION   NM_001421086 XM_006233350
VERSION     NM_001421086.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7512)
  AUTHORS   Zhang,J.L., Xu,M.F., Chen,J., Wei,Y.L. and She,Z.Y.
  TITLE     Kinesin-7 CENP-E mediates chromosome alignment and spindle assembly
            checkpoint in meiosis I
  JOURNAL   Chromosoma 133 (2), 149-168 (2024)
   PUBMED   38456964
  REMARK    GeneRIF: Kinesin-7 CENP-E mediates chromosome alignment and spindle
            assembly checkpoint in meiosis I.
REFERENCE   2  (bases 1 to 7512)
  AUTHORS   Xiao,T., Wongtrakoongate,P., Trainor,C. and Felsenfeld,G.
  TITLE     CTCF Recruits Centromeric Protein CENP-E to the
            Pericentromeric/Centromeric Regions of Chromosomes through Unusual
            CTCF-Binding Sites
  JOURNAL   Cell Rep 12 (10), 1704-1714 (2015)
   PUBMED   26321640
REFERENCE   3  (bases 1 to 7512)
  AUTHORS   Barisic,M., Silva e Sousa,R., Tripathy,S.K., Magiera,M.M.,
            Zaytsev,A.V., Pereira,A.L., Janke,C., Grishchuk,E.L. and Maiato,H.
  TITLE     Mitosis. Microtubule detyrosination guides chromosomes during
            mitosis
  JOURNAL   Science 348 (6236), 799-803 (2015)
   PUBMED   25908662
REFERENCE   4  (bases 1 to 7512)
  AUTHORS   Milev,M.P., Hasaj,B., Saint-Dic,D., Snounou,S., Zhao,Q. and
            Sacher,M.
  TITLE     TRAMM/TrappC12 plays a role in chromosome congression, kinetochore
            stability, and CENP-E recruitment
  JOURNAL   J Cell Biol 209 (2), 221-234 (2015)
   PUBMED   25918224
REFERENCE   5  (bases 1 to 7512)
  AUTHORS   Iemura,K. and Tanaka,K.
  TITLE     Chromokinesin Kid and kinetochore kinesin CENP-E differentially
            support chromosome congression without end-on attachment to
            microtubules
  JOURNAL   Nat Commun 6, 6447 (2015)
   PUBMED   25743205
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7512)
  AUTHORS   Van Hooser,A.A., Ouspenski,I.I., Gregson,H.C., Starr,D.A.,
            Yen,T.J., Goldberg,M.L., Yokomori,K., Earnshaw,W.C., Sullivan,K.F.
            and Brinkley,B.R.
  TITLE     Specification of kinetochore-forming chromatin by the histone H3
            variant CENP-A
  JOURNAL   J Cell Sci 114 (Pt 19), 3529-3542 (2001)
   PUBMED   11682612
REFERENCE   7  (bases 1 to 7512)
  AUTHORS   Uren,A.G., Wong,L., Pakusch,M., Fowler,K.J., Burrows,F.J.,
            Vaux,D.L. and Choo,K.H.
  TITLE     Survivin and the inner centromere protein INCENP show similar
            cell-cycle localization and gene knockout phenotype
  JOURNAL   Curr Biol 10 (21), 1319-1328 (2000)
   PUBMED   11084331
REFERENCE   8  (bases 1 to 7512)
  AUTHORS   Chan,G.K., Schaar,B.T. and Yen,T.J.
  TITLE     Characterization of the kinetochore binding domain of CENP-E
            reveals interactions with the kinetochore proteins CENP-F and
            hBUBR1
  JOURNAL   J Cell Biol 143 (1), 49-63 (1998)
   PUBMED   9763420
REFERENCE   9  (bases 1 to 7512)
  AUTHORS   Thrower,D.A., Jordan,M.A., Schaar,B.T., Yen,T.J. and Wilson,L.
  TITLE     Mitotic HeLa cells contain a CENP-E-associated minus end-directed
            microtubule motor
  JOURNAL   EMBO J 14 (5), 918-926 (1995)
   PUBMED   7889940
REFERENCE   10 (bases 1 to 7512)
  AUTHORS   Yen,T.J., Compton,D.A., Wise,D., Zinkowski,R.P., Brinkley,B.R.,
            Earnshaw,W.C. and Cleveland,D.W.
  TITLE     CENP-E, a novel human centromere-associated protein required for
            progression from metaphase to anaphase
  JOURNAL   EMBO J 10 (5), 1245-1254 (1991)
   PUBMED   2022189
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On May 10, 2023 this sequence version replaced XM_006233350.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                JAXUCZ010000002.1  226311057-226311141
            86-177              JAXUCZ010000002.1  226313387-226313478
            178-267             JAXUCZ010000002.1  226314667-226314756
            268-386             JAXUCZ010000002.1  226314899-226315017
            387-506             JAXUCZ010000002.1  226315624-226315743
            507-588             JAXUCZ010000002.1  226316624-226316705
            589-656             JAXUCZ010000002.1  226316877-226316944
            657-722             JAXUCZ010000002.1  226317027-226317092
            723-774             JAXUCZ010000002.1  226320566-226320617
            775-862             JAXUCZ010000002.1  226322636-226322723
            863-992             JAXUCZ010000002.1  226323584-226323713
            993-1112            JAXUCZ010000002.1  226325120-226325239
            1113-1271           JAXUCZ010000002.1  226326381-226326539
            1272-1428           JAXUCZ010000002.1  226327883-226328039
            1429-1517           JAXUCZ010000002.1  226328764-226328852
            1518-1685           JAXUCZ010000002.1  226330579-226330746
            1686-1760           JAXUCZ010000002.1  226331324-226331398
            1761-1880           JAXUCZ010000002.1  226331604-226331723
            1881-2003           JAXUCZ010000002.1  226332480-226332602
            2004-2160           JAXUCZ010000002.1  226332695-226332851
            2161-2315           JAXUCZ010000002.1  226333104-226333258
            2316-2567           JAXUCZ010000002.1  226335077-226335328
            2568-2840           JAXUCZ010000002.1  226335478-226335750
            2841-2996           JAXUCZ010000002.1  226335865-226336020
            2997-3197           JAXUCZ010000002.1  226336801-226337001
            3198-3356           JAXUCZ010000002.1  226338043-226338201
            3357-3647           JAXUCZ010000002.1  226339151-226339441
            3648-3803           JAXUCZ010000002.1  226339576-226339731
            3804-4091           JAXUCZ010000002.1  226340725-226341012
            4092-4250           JAXUCZ010000002.1  226343431-226343589
            4251-4535           JAXUCZ010000002.1  226343704-226343988
            4536-4817           JAXUCZ010000002.1  226344221-226344502
            4818-5099           JAXUCZ010000002.1  226345443-226345724
            5100-5258           JAXUCZ010000002.1  226346752-226346910
            5259-5519           JAXUCZ010000002.1  226348256-226348516
            5520-5624           JAXUCZ010000002.1  226349525-226349629
            5625-5843           JAXUCZ010000002.1  226350451-226350669
            5844-6038           JAXUCZ010000002.1  226353363-226353557
            6039-6242           JAXUCZ010000002.1  226354167-226354370
            6243-6452           JAXUCZ010000002.1  226355790-226355999
            6453-6565           JAXUCZ010000002.1  226360390-226360502
            6566-6663           JAXUCZ010000002.1  226361865-226361962
            6664-6844           JAXUCZ010000002.1  226364892-226365072
            6845-7131           JAXUCZ010000002.1  226367076-226367362
            7132-7512           JAXUCZ010000002.1  226369256-226369636
FEATURES             Location/Qualifiers
     source          1..7512
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q43"
     gene            1..7512
                     /gene="Cenpe"
                     /note="centromere protein E"
                     /db_xref="GeneID:362044"
                     /db_xref="RGD:1307115"
     exon            1..85
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..7223
                     /gene="Cenpe"
                     /codon_start=1
                     /product="centromere-associated protein E"
                     /protein_id="NP_001408015.1"
                     /db_xref="GeneID:362044"
                     /db_xref="RGD:1307115"
                     /translation="MAEEAAVAVCVRVRPLNSREEELGEASHIYWKTDKNAIYQSDGG
                     KSFQFDRVFHSNETTKNVYEEIAVPIISSAIQGYNGTIFAYGQTASGKTHTMMGSEDC
                     LGVIPRAIHDIFQRIKKFPEREFLLRVSYMEIYNETITDLLCNTQKVKPLIIREDINR
                     NVYVADLTEEVVYTAEMALKWLATGEKNRHYGITKMNQRSSRSHTIFRMILESREKAE
                     SSNCDGSIKVSHLNLVDLAGSERAAQTGAEGMRLKEGCYINRNLLILGQVIKKLSDGQ
                     VGGFINYRDSKLTRILQNSLGGNAKTRIICTITPASLDETLTTLQFASTAKYMKNTPY
                     VNEVSNDEALLKRYRREIVDLKKQLEEVNTKTRAQEIEKDQLAQLLDEKDLLQKVQDE
                     KIQNLKRMLVTSSSIALQQELEIKKKRRVTWCFGKMKDSNYVKEFKIPTNITTRTRKT
                     SVTPLRENSLMKLGESALSWESEVFDNTLEPLAEAEWSSATALLSEENLESELTSLNT
                     QYNNLVLDYEQLRRENEDLKLKLKEKNELEEFEFLEQREEKDQELQLMHEVSNLKNLI
                     KHAEEYNQDLENELSSKVELLKEKEDQIKELQRYIDAQKSETTKTDLSYSSEATEDLK
                     QAMRTLSDLDTVALDAKRESAFLRSENLELKERINELSDSCKQMENGIQMYQRQLEAK
                     KQVQADLEKELQLAFQEISKLSALVDGKGLLSNLELEKRITDLQKELNKEVEEKETLQ
                     KEVHLLSELKSLPSEVETLRRELHEKSEELCVITTEREKLFSEMAHKDSRIQGLLEEI
                     GNTKDDLAASQLSQRSSDEECQALKSLHVELKHRQEEVLEESERVKQELSQKTQELAQ
                     KTAEGQEMLNQMEELREKLERRDSSLQSAEKEKNLLTEKLQQTLEEVRALTQEKNDLK
                     QLQESLQTERDQLRSDIQDTVNMNIDTQEQLLNALESLKQHQETINMLKMKATEEMSD
                     HLPIKGREGSSDEVEQKLDGIDEENLLAESAHTVVGSGEDHGETEEQRKIDSLLQENS
                     RLQQTLESIIAEKEQLKMDLKENIEMSVENQEELRILRDELKRQQEIAAQEKDHVTEK
                     SEELSRAHERLAEIEEKLKEKNQKLQETQQQLVSIQEAMSEMQAKVTDLENLQNEFRN
                     QALALERVETERLELAQKLHENYEKMESITKERNDLKELQESFEIEKKQLKEYAREME
                     SAGLQTKEQLNIAHANLKEYQEIIKELRGSISEKEAQASSTQDTGKTNPASQGETPVP
                     REQELLPDAEEARASAEKGSELEPVEEHSRTAHSLTTEGIEMEILALTKKLEESQKEI
                     SCLTKERSDLRRTQEALQVECAQLKDDARRTLANHLETEEELSLARCCLKEQENKIDS
                     LIVSLSQKEAELSSVRVQLEVTTGELERKVQELCEKQEQLNIKETSEVQGKMSELDHI
                     RALLLTKDSALQSVESDRLRLNKQLEESQEEIKILIKEREELRRAQEALHVEREQQQE
                     SIKEISTRLQELQDKEYEYLVMKSLNETQGNKCEDLNQQLEAQKSSLEKVEMQNVNLT
                     QRLNETLEEMKSVAKERDELRSVEERLTADRDQLKKSLEETITKNQELQEKGHQLSQV
                     KADLRETMDQMEQLKEQLEAQNSTLESIEIEKLKLTQQLNENLKEMTLVAKENDDLKI
                     MDEALREERDQLRESLRQTEASDLEKQEKLRIAHLDLKEHQETIERLMGSVAKRTEEV
                     SDMNMELERANTRLQEKVQELKASELQLLKSKVEAGETKKQLKEQGLALSKIEMENLN
                     LAQQIHQNLEEMKSISKERDDLKRMEEILRMEKDQLKDSLREAKFKAHQNYEETVQYG
                     KGLLCGGEQHCTGRLREKCLRIEKLLKRYSEMANDYECLNRFSLDLEKETKTQKELSV
                     TIKTKLSLPYTQTKEIEKLLTANQRCSMEFHRILKKLKYVLSYITRIKEEQHEFINKF
                     EMAFIQEVEKQNELQIKIQSLSQTSNIPSRDSQSKLSQEMDLHIEEILKDFSENDFLT
                     IKTEVKQVLSNRKEITEFLEKWLNTHFDTENLKSSIQKENKSIGLVNNFYHSKITAMV
                     NESTEFEERCAARAKDLERHLKALTETTEQLSKVYQSLTVSWSIVRPSTQDSKDPRVA
                     LEAEQLTSKDKNALGAMPYKEEIEDLKMQLVKIDLEKKAKAKEFEKEMLAIKATVEHQ
                     EEVIRLLRENLRRNQQAQDTSMLSEQDSHPLRKPLTCGGGSGIVQSTKALILKSEYKK
                     MESEISKLKQQNEQLRKQKNQLLCDNSQLSKEVKSWEERTLRRDSYREASHENPPKSP
                     AVTGMESKRRQNTASQCKERNFQDPVPKDSPKSSFFDSRSKSLPAPPPIRYFDNSSLG
                     LCPEEPAEIENVDPKANLCQASSGKDVSECKMQ"
     exon            86..177
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            178..267
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            268..386
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            387..506
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            507..588
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            589..656
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            657..722
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            723..774
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            775..862
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            863..992
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1112
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1271
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1428
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1517
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1685
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1760
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1880
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2003
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2160
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2315
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2567
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2840
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            2841..2996
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            2997..3197
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            3198..3356
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            3357..3647
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            3648..3803
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            3804..4091
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            4092..4250
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            4251..4535
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            4536..4817
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            4818..5099
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            5100..5258
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            5259..5519
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            5520..5624
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            5625..5843
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            5844..6038
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            6039..6242
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            6243..6452
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            6453..6565
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            6566..6663
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            6664..6844
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            6845..7131
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
     exon            7132..7512
                     /gene="Cenpe"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attttccttc ctgggcggca gcagacagga tggccgagga ggctgcagtg gctgtctgtg
       61 ttcgagtgcg acccctcaac agcagagaag aagaacttgg agaagcctcc cacatttatt
      121 ggaaaaccga taagaatgct atttatcaga gcgacggggg taaatccttc caatttgatc
      181 gtgtctttca cagtaatgag accactaaga atgtgtatga agagatcgca gtgccaatca
      241 tcagctctgc catacaaggc tacaacggta ccatctttgc ctatgggcaa actgcatctg
      301 ggaaaacaca taccatgatg ggctctgaag attgtttggg agttattccc agggcaattc
      361 atgacatttt ccaaaggatt aagaagtttc ctgagagaga gtttctccta cgggtttctt
      421 acatggagat ctacaacgaa accattacag acttactctg taatactcaa aaagtgaaac
      481 ctttgataat tcgggaagac atcaatagga atgtatatgt tgctgacctc acagaagaag
      541 tggtttatac agcagaaatg gctttgaaat ggcttgcaac aggagagaag aacagacatt
      601 atggaataac caaaatgaat caaagaagca gtcgttctca tacaattttt aggatgattt
      661 tggaaagcag ggaaaaggct gagtcttcta attgtgatgg gtctatcaag gtgtctcatc
      721 tgaatttggt tgatcttgca ggcagtgaaa gagctgctca aacaggagct gaaggtatgc
      781 gattgaagga aggctgttac ataaatcgga acttacttat tttgggacaa gtgattaaga
      841 aacttagtga tgggcaggtt ggtggtttca taaattaccg agatagcaag ttaacacgaa
      901 ttcttcagaa ctccttggga ggaaatgcga agactcgtat catctgcaca atcactccag
      961 cgtcgcttga tgaaacactg accacgctcc agtttgccag cactgccaag tacatgaaga
     1021 atactcctta tgttaatgaa gtgtcaaatg atgaagctct cttaaaaaga tacagaagag
     1081 aaatagtgga tcttaaaaaa caattagagg aggtaaatac aaagactcgg gcgcaggaaa
     1141 tagaaaaaga ccaactggcc cagctcctgg atgaaaaaga cttgcttcag aaagttcagg
     1201 atgagaaaat tcagaacctg aagcggatgc tggtgacatc gtcttctatt gcactgcagc
     1261 aggaactaga gattaagaag aaacgcaggg ttacgtggtg ctttggcaaa atgaaggatt
     1321 caaactatgt aaaggaattt aaaattccaa caaacataac aacgagaaca cgtaaaactt
     1381 ccgtgactcc tttgagagaa aattctctca tgaagttggg agagagcgca ctgtcctggg
     1441 agtctgaagt gttcgataac acactcgagc cattggctga ggcagagtgg agctcagcaa
     1501 cagccctcct cagtgaggaa aacttagaaa gtgagttgac ctcacttaat actcaatata
     1561 ataatctagt attagactat gaacagctaa gaagagaaaa tgaagacttg aaattgaaat
     1621 taaaagaaaa aaatgagtta gaggaatttg agtttctaga acaaagagaa gaaaaagatc
     1681 aagagctaca actaatgcat gaagtttcca acttaaagaa tttaattaaa catgcagaag
     1741 aatataatca agatcttgag aacgaactga gttcaaaagt ggagcttctt aaagagaaag
     1801 aggaccagat taaggagctg cagagataca tagacgccca gaagtcagaa acgacaaaga
     1861 cagacctgtc atactcatcg gaagccactg aagacctgaa acaggcaatg cgcactctgt
     1921 ctgatctgga cacagtggcc ctggacgcca agagggagtc cgccttcctt agaagtgaga
     1981 acctggagct gaaggagagg attaatgagc tttcagattc ttgtaagcag atggaaaatg
     2041 gcattcagat gtatcagcgc cagctggagg cgaaaaagca agtgcaggct gacctggaga
     2101 aggagttaca gctggctttt caagagatat ccaaactcag cgccttggta gacggcaaag
     2161 gtttattgtc taatttggaa ttggagaaaa gaattactga tctccaaaaa gaactaaata
     2221 aagaagttga agagaaagaa actttgcaaa aagaagttca cttgctgtca gagttgaaat
     2281 ctttaccatc tgaggtggag acgctgagga gagagcttca tgagaaatcc gaagagctct
     2341 gtgtaataac aacagaaaga gaaaaactgt tttctgaaat ggctcataaa gacagtagaa
     2401 ttcaaggttt acttgaggaa attggaaaca cgaaagatga ccttgcagct tcccagctga
     2461 gccagaggag cagcgatgag gagtgccaag cactgaaaag cctacacgtg gagctcaagc
     2521 acagacaaga ggaggtcctg gaggagagtg agagggtgaa gcaggagctt tctcagaaga
     2581 ctcaagagct cgcacagaaa acagctgagg gtcaagaaat gctaaatcaa atggaggaac
     2641 tgagagaaaa gttagaaagg agagattcca gtctgcagtc tgcagagaag gagaaaaatc
     2701 tgctcaccga gaagctgcag caaaccttgg aggaagtaag agctttaacc caagaaaaga
     2761 acgacctaaa gcagctccag gagagcctgc aaactgagag ggaccaactc agaagtgaca
     2821 tccaggacac tgtgaacatg aacatagata cccaagaaca gttactaaat gctcttgagt
     2881 ctttgaaaca acaccaagaa acaattaaca tgctgaaaat gaaagctact gaggaaatgt
     2941 cggatcattt gcctataaag ggcagggaag gatctagcga tgaagttgag caaaagctgg
     3001 atggcataga tgaagagaat ctgctggctg aaagtgccca cacagtggtt gggagtggtg
     3061 aggatcatgg ggaaactgag gaacagagga aaattgactc tctactgcag gagaatagca
     3121 gactgcagca gacactggaa agtattatag cagaaaagga acaattgaag atggacctaa
     3181 aggaaaatat tgaaatgagt gtggaaaacc aggaagagtt gagaattctt agagatgaac
     3241 ttaaaaggca acaagagata gctgcacagg aaaaggatca tgtcacagag aagagtgaag
     3301 agctctccag ggcacatgag agattggcag aaatagaaga aaagttaaag gaaaagaacc
     3361 agaaactcca agagacacag cagcaacttg ttagtataca agaagctatg agtgagatgc
     3421 aggcaaaggt gactgacttg gagaacttac agaatgaatt caggaaccaa gcattggcgt
     3481 tggaacgtgt ggaaacagag agactggagt tagctcagaa acttcatgaa aattatgaga
     3541 agatggagtc tatcaccaag gaaagaaacg atctaaaaga attacaggag tcatttgaaa
     3601 tagagaaaaa gcaacttaaa gaatacgcaa gagaaatgga atctgcgggc ctacaaacaa
     3661 aagaacaact aaacattgcc catgcaaatc taaaagaata ccaagaaatc atcaaagagc
     3721 taagaggaag catttctgaa aaagaagctc aagcatcaag cacccaggac acaggaaaaa
     3781 ccaaccctgc atcacaagga gagaccccag tgccgcgaga gcaagagcta cttcctgatg
     3841 cggaagaagc cagggccagt gcagagaagg ggagtgaact ggagccagtg gaagaacatt
     3901 ccagaacagc gcactcatta accacggagg gcatagaaat ggaaatcctt gcactgacca
     3961 agaaacttga agaaagtcag aaggagataa gctgtctcac taaagagaga agtgacctga
     4021 gacgaacaca ggaagcactg caggtcgaat gtgcccagct gaaagacgat gccagaagaa
     4081 ctttggctaa tcatctagaa actgaagagg agctaagcct tgctcgttgt tgcctgaaag
     4141 agcaagagaa caaaattgac tccctaatag tgagcctttc ccagaaggaa gctgagctgt
     4201 cgagcgtgcg ggtgcagctg gaggtgacca ctggtgaact agagagaaag gttcaagaac
     4261 tctgtgagaa acaggaacaa cttaatataa aagaaactag tgaggttcaa gggaagatga
     4321 gtgaacttga ccacatcagg gcgcttctcc ttaccaagga ctcagcactg cagagtgtag
     4381 agagtgacag actccggctg aataaacaac ttgaagaaag tcaagaggaa ataaaaattc
     4441 taattaagga aagagaagag ctgagaagag cacaagaggc ccttcatgtg gagagggagc
     4501 agcagcagga gagcattaag gagatcagca ctaggctgca agaacttcag gacaaagagt
     4561 atgaatatct tgtgatgaag agccttaatg agactcaagg aaataaatgt gaagacttaa
     4621 accagcagtt ggaggcccag aagtcaagtc tggaaaaggt ggaaatgcag aatgtaaact
     4681 tgactcagag acttaatgaa acccttgaag aaatgaaatc cgtagcaaag gaaagagatg
     4741 agcttcgcag tgtggaggag cgcctcacag cagacagaga ccagttgaag aagagccttg
     4801 aagagacaat aactaaaaac caagaactcc aggaaaaagg acatcagctt tctcaagtaa
     4861 aggctgatct cagagaaaca atggaccaaa tggagcaatt gaaggagcag ctcgaagccc
     4921 agaattcaac tctggaaagc atagaaatag agaagttaaa actgactcaa caacttaatg
     4981 agaaccttaa agaaatgaca ctagtcgcta aggaaaatga tgacctaaaa attatggatg
     5041 aagccctcag agaagagcga gaccaactaa gggaaagtct gcgacaaaca gaagcaagtg
     5101 atctggaaaa gcaagagaaa ctaagaattg ctcacctgga tctgaaagag caccaagaaa
     5161 ccatcgagag actcatggga agtgtggcta agaggacgga ggaagtgtca gacatgaaca
     5221 tggagctgga aagagcaaac actaggttac aggagaaggt tcaagaactt aaggcaagtg
     5281 agcttcagct tcttaagtca aaagtggaag ccggtgaaac caagaagcag ctcaaggagc
     5341 agggcttagc tctgagtaag atagagatgg agaatttaaa tctggctcag cagattcacc
     5401 agaaccttga agaaatgaaa tctatatcaa aagaaagaga tgatctaaag agaatggagg
     5461 agatactcag gatggagaaa gaccagctca aggacagcct aagagaagcc aagtttaagg
     5521 cccatcagaa ctatgaagag acagtgcaat atggaaaggg gttactatgt ggtggagaac
     5581 agcactgtac aggaagactt cgagaaaagt gcctcaggat agaaaaactc ctgaaaagat
     5641 actcagaaat ggctaatgat tacgagtgct tgaatagatt ctctcttgac ctggagaaag
     5701 aaactaaaac ccaaaaggag ctgtcagtta ccataaaaac aaagctctca cttccataca
     5761 cacaaaccaa agagattgaa aagcttctta ctgcaaacca gagatgttcc atggaattcc
     5821 acagaatcct gaagaaactt aagtatgtgt taagctacat tacaaggata aaggaagaac
     5881 agcatgagtt catcaataaa tttgaaatgg cttttattca ggaagtagaa aagcagaatg
     5941 aattgcaaat taaaatacag agcctttcac agacttccaa tattccatcc agagattcac
     6001 agagcaaact gagccaggaa atggacctcc acattgagga aattctcaaa gacttttcag
     6061 aaaatgactt cctcaccata aaaactgaag tcaaacaagt actaagtaat aggaaagaaa
     6121 taactgagtt tttggaaaaa tggctaaata ctcattttga tacagaaaat cttaaaagta
     6181 gcatccaaaa agaaaacaaa agcatcggcc tagtgaataa cttctaccat agcaaaatca
     6241 ctgccatggt aaatgaatcg acggagtttg aggagagatg tgctgccaga gccaaagatt
     6301 tggagcgtca cctgaaggcg ctgacagaaa caactgagca actgtctaaa gtctaccagt
     6361 cactgactgt ctcttggtcc attgtgcgtc cttccacaca ggacagcaag gatcctcgtg
     6421 ttgcattgga agctgaacaa ctgacctcaa aggacaaaaa tgctttagga gctatgccct
     6481 ataaagaaga aattgaggat ctcaaaatgc agctggtgaa gattgaccta gagaagaagg
     6541 caaaagccaa ggaatttgaa aaggaaatgc ttgctataaa agccactgtt gaacatcaag
     6601 aagaagtgat aaggctactg agagaaaatc ttagaagaaa tcagcaggcc caggatacct
     6661 caatgctctc agaacaagac tcgcatcctc tgaggaaacc tctaacctgt ggcggtggca
     6721 gcggcattgt acaaagcaca aaagctctta ttttgaaaag tgaatataaa aagatggaaa
     6781 gtgaaatttc taagttaaag caacaaaatg agcagctaag aaagcaaaag aatcagctgt
     6841 tatgtgataa ctcccagctc tccaaggagg ttaagagctg ggaggagaga actctcagaa
     6901 gagacagtta cagagaagct tctcatgaga accctccaaa gtctcctgca gtgactggga
     6961 tggagtccaa gaggagacag aacacagctt cccagtgcaa ggagcgaaat ttccaggatc
     7021 cggtgccaaa agattcccca aaatcttcgt ttttcgatag ccggtcaaag tctctaccag
     7081 cacctccccc aatccgctat tttgataact ccagtttagg gctgtgccca gaggaaccag
     7141 ctgaaataga gaatgtggac cctaaggcaa acctttgtca agcctcttca gggaaagatg
     7201 tgtccgagtg caaaatgcag tagacgcccc tcggagcacc ctgtggagcg gctctcttcg
     7261 cgtgtccacc ctgacagcga cgttgcagtc ccgcttcact tcagtctgat tttcacgtat
     7321 aattagaaga tggaggaaca agaaacagat tggttgcaat tacttagaat ggtggccgca
     7381 attccttctg cttgcatttg tgaactgtta attatttata tattgcaaag agtcttgaag
     7441 gaagttttta gtctttccat atggacataa tgtgtataca tttcattaaa gttattcata
     7501 tatgacttag aa
//
