LOCUS       NM_001004098            3148 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus centromere protein C (Cenpc), mRNA.
ACCESSION   NM_001004098 XM_223310
VERSION     NM_001004098.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3148)
  AUTHORS   Himoto T, Tanaka N, Saito A, Muro Y, Sugiura K, Tani J, Miyoshi H,
            Morishita A, Yoneyama H, Haba R and Masaki T.
  TITLE     Diversity of humoral responses to the centromere proteins among
            HCV-related chronic liver disease, PBC and AIH patients
  JOURNAL   Clin Res Hepatol Gastroenterol 39 (2), 222-229 (2015)
   PUBMED   25220385
REFERENCE   2  (bases 1 to 3148)
  AUTHORS   Gascoigne KE, Takeuchi K, Suzuki A, Hori T, Fukagawa T and
            Cheeseman IM.
  TITLE     Induced ectopic kinetochore assembly bypasses the requirement for
            CENP-A nucleosomes
  JOURNAL   Cell 145 (3), 410-422 (2011)
   PUBMED   21529714
REFERENCE   3  (bases 1 to 3148)
  AUTHORS   Trazzi S, Perini G, Bernardoni R, Zoli M, Reese JC, Musacchio A and
            Della Valle G.
  TITLE     The C-terminal domain of CENP-C displays multiple and critical
            functions for mammalian centromere formation
  JOURNAL   PLoS One 4 (6), e5832 (2009)
   PUBMED   19503796
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3148)
  AUTHORS   De La Fuente R, Viveiros MM, Wigglesworth K and Eppig JJ.
  TITLE     ATRX, a member of the SNF2 family of helicase/ATPases, is required
            for chromosome alignment and meiotic spindle organization in
            metaphase II stage mouse oocytes
  JOURNAL   Dev Biol 272 (1), 1-14 (2004)
   PUBMED   15242786
REFERENCE   5  (bases 1 to 3148)
  AUTHORS   Talbert PB, Bryson TD and Henikoff S.
  TITLE     Adaptive evolution of centromere proteins in plants and animals
  JOURNAL   J Biol 3 (4), 18 (2004)
   PUBMED   15345035
REFERENCE   6  (bases 1 to 3148)
  AUTHORS   Van Hooser AA, Ouspenski II, Gregson HC, Starr DA, Yen TJ, Goldberg
            ML, Yokomori K, Earnshaw WC, Sullivan KF and Brinkley BR.
  TITLE     Specification of kinetochore-forming chromatin by the histone H3
            variant CENP-A
  JOURNAL   J Cell Sci 114 (Pt 19), 3529-3542 (2001)
   PUBMED   11682612
REFERENCE   7  (bases 1 to 3148)
  AUTHORS   Kalitsis P, MacDonald AC, Newson AJ, Hudson DF and Choo KH.
  TITLE     Gene structure and sequence analysis of mouse centromere proteins A
            and C
  JOURNAL   Genomics 47 (1), 108-114 (1998)
   PUBMED   9465302
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY693788.1.
            
            [WARNING] On Oct 11, 2024 this sequence was replaced by
            NM_001004098.2.
            
            On Sep 4, 2004 this sequence version replaced XM_223310.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY693788.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMD00132292
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3148
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p21"
     gene            1..3148
                     /gene="Cenpc"
                     /gene_synonym="Cenpc1"
                     /note="centromere protein C"
                     /db_xref="GeneID:305270"
                     /db_xref="RGD:1303061"
     exon            1..31
                     /gene="Cenpc"
                     /gene_synonym="Cenpc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..2764
                     /gene="Cenpc"
                     /gene_synonym="Cenpc1"
                     /note="centromere autoantigen C; centromere protein C1"
                     /codon_start=1
                     /product="centromere protein C"
                     /protein_id="NP_001004098.1"
                     /db_xref="GeneID:305270"
                     /db_xref="RGD:1303061"
                     /translation="MASFHLDHLKNYHRRFCRPSRAPNIPTKQGQNMLEILQDCFEEQ
                     NSTESLSCSTPKEKDIYVQSTGKERQASHSESVPISSRRKEASLQVPAKPSDPADEPV
                     QANEVHQKILSTDVVSKSTPDSTKTSSKGVKGHHGASDELYLPGGSPVVLLGARVSGS
                     QKAISSGGQKRVTSRRSADMQSSNTDISFKTRKRLNFEDKVISNTAEIESSASQVEDS
                     ISEEQEGTSSETSQKRDDLSSEIQPQSKKSFSELYLETVNRKSKCSSVVRHTAAVPSP
                     PYPPNDMKLLEDEFIIDGPDRSFSSQPWVVIPRKGHHMPFPENIAVPQGKKSREKPHR
                     LSEKTLVSNTQTDKTGPVEEAQLSVEEKLGTTLTNELENDCRSTENKTHSENAKKPSA
                     RKRTVKQKQRRPSKPNIAQELSMGQNETENRNMSKIGQDKLQINSKRNMEDHEEVRNE
                     PTPKKPVPALGNKKEKDSTQANKEKSRKKCFSRESKRKSVPKEVTLASRRGRRTSQHP
                     SEWWLVKPSEGSVDGNSSKENESSILYPNRKKQTKRNHVSENTEKKPVPSKRKKKEIS
                     SRELKSLNVKGSGGNDDISTSQRKPLQNIDADPTQKSLHCSGPTRGSEDQNSDMISQN
                     VHLKTRSEQHRSKTQMESTSNSEVCKHSVWEESGPSRFKNLEMPGRSNSEVGDEKDQK
                     SLDLKTRSSNMVPNRNLHHKLVLPSNSPNVRRSNRIRLKPLEYWRGERIDYQESSSGR
                     LVLEIVSPASESVKRKAKRNLDKVNKETNKKRIHLDNPTKTKIKVSLDIPLGDPFQAT
                     LAKDPETREIVPMDLIRPRDTYHFFVEQHGLKVYKTLNTTFFSTGKLVLGPHEEKGKQ
                     HVGQDILVFYVNFGDLLCTLHETPYMLTTGDSFYVPSGNHYNIKNLLNVESCLLFTQI
                     KR"
     exon            32..75
                     /gene="Cenpc"
                     /gene_synonym="Cenpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            76..146
                     /gene="Cenpc"
                     /gene_synonym="Cenpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            147..217
                     /gene="Cenpc"
                     /gene_synonym="Cenpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            218..317
                     /gene="Cenpc"
                     /gene_synonym="Cenpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            318..594
                     /gene="Cenpc"
                     /gene_synonym="Cenpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            595..804
                     /gene="Cenpc"
                     /gene_synonym="Cenpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            805..1394
                     /gene="Cenpc"
                     /gene_synonym="Cenpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1568
                     /gene="Cenpc"
                     /gene_synonym="Cenpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1836
                     /gene="Cenpc"
                     /gene_synonym="Cenpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1983
                     /gene="Cenpc"
                     /gene_synonym="Cenpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2066
                     /gene="Cenpc"
                     /gene_synonym="Cenpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2123
                     /gene="Cenpc"
                     /gene_synonym="Cenpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2228
                     /gene="Cenpc"
                     /gene_synonym="Cenpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..2351
                     /gene="Cenpc"
                     /gene_synonym="Cenpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..2447
                     /gene="Cenpc"
                     /gene_synonym="Cenpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..2602
                     /gene="Cenpc"
                     /gene_synonym="Cenpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2603..2693
                     /gene="Cenpc"
                     /gene_synonym="Cenpc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2694..3133
                     /gene="Cenpc"
                     /gene_synonym="Cenpc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgggccgga accatggcct cgttccatct ggatcatcta aagaactacc acagaagatt
       61 ttgccggcct tccagagcac ccaacattcc tacaaagcaa ggccagaaca tgctggaaat
      121 cttacaagat tgttttgaag aacagaattc tacagagtca ttgtcttgtt caacacctaa
      181 agagaaagac atttatgttc agtcaacagg caaagagcgc caagcatcac attcagaatc
      241 agttccgatt tcttcaagga ggaaggaagc ttctttgcaa gttcctgcaa aaccaagtga
      301 ccctgctgat gaaccagttc aggctaatga agttcatcag aaaattctgt ctactgatgt
      361 ggtctccaaa agtacaccag actcaaccaa aacatcaagt aaaggagtaa aaggtcacca
      421 tggtgcgtct gatgaattgt acttacctgg tggctcccct gtggttcttc tgggtgcaag
      481 agtgtccggg tcacagaaag ctatttcatc tggtggccaa aaaagagtga cttcaaggcg
      541 ttcagcagat atgcagtctt caaatacaga catttctttt aaaaccagga aaaggctaaa
      601 cttcgaagat aaagttattt cgaacacagc agaaatagag agcagtgcat cacaagtaga
      661 ggatagcata tccgaggaac aagaagggac atcatcagaa acttctcaga agagagacga
      721 tctgagctct gaaattcaac cacaatctaa aaagagcttt tcagagttgt atttagaaac
      781 tgtcaacagg aaaagtaaat gcagttctgt tgttaggcac acagcagcag ttccatctcc
      841 tccgtatcct ccgaatgata tgaaattatt agaagatgaa tttattattg atgggccaga
      901 tagaagcttt tcaagtcaac cttgggtggt gataccaagg aaaggccacc acatgccatt
      961 tcctgaaaac attgcagtgc ctcaaggtaa gaagtcaaga gagaaacctc atcgtctgtc
     1021 cgagaagact ttggtaagta acacacagac tgataagact ggcccagtag aggaagctca
     1081 gctctctgtt gaggaaaaac tgggaactac tttgacaaat gagttggaaa atgattgtag
     1141 atctacagaa aataaaacgc actctgagaa tgcgaaaaaa ccatctgcac ggaaaaggac
     1201 tgtgaaacag aagcagagaa gaccatctaa gcctaacata gctcaagagc tcagtatggg
     1261 acagaatgaa actgaaaata ggaatatgtc aaaaattggc caagacaagt tacaaataaa
     1321 ttcaaaaaga aatatggaag accatgaaga ggtgaggaac gagcctaccc ccaagaaacc
     1381 tgtgcctgct cttggaaata agaaagaaaa ggacagcacc caagctaata aggaaaaatc
     1441 tagaaagaaa tgtttttcta gagagtccaa gaggaaatct gttcccaaag aagtaacttt
     1501 ggcttccagg agaggtcgta gaacttctca gcatccgtct gagtggtggt tggtaaaacc
     1561 aagtgaaggt tctgttgatg gaaattcttc aaaggagaat gaatcatcaa ttttatatcc
     1621 aaatagaaaa aaacagacta agagaaatca cgtatctgag aatactgaga agaaacctgt
     1681 tccatcgaaa agaaagaaga aagagatcag ctcaagagaa ctgaagtctt taaatgtaaa
     1741 gggttctgga ggaaatgatg atatttctac ttcccagagg aagccgttgc aaaacattga
     1801 cgcagatcca actcagaaga gccttcattg ttctggacct accagaggct ctgaagatca
     1861 aaacagtgat atgatatcac agaatgttca tttaaagact cgtagtgagc aacatagaag
     1921 caagacacaa atggaatcta cttcaaattc ggaagtgtgt aaacattcag tgtgggaaga
     1981 aagtggacct tccaggttca agaatcttga aatgcctgga cgcagtaatt ctgaagtggg
     2041 tgacgaaaag gaccagaaga gtttggattt gaaaacaaga agttctaata tggtaccgaa
     2101 taggaattta caccacaaat tagtattgcc ctccaactca ccaaatgttc gtagatctaa
     2161 tagaatacgt ttgaaacctc tggaatattg gcgaggggaa cgaatagatt atcaagaaag
     2221 ctcatcagga agacttgtgc ttgaaatagt gtccccagct tcagaatcag tgaaaagaaa
     2281 ggccaaaaga aatctggaca aagtcaacaa agaaactaac aagaaacgga tccatcttga
     2341 taaccctaca aagactaaga taaaggtgag tctggatatt cctctgggag atcccttcca
     2401 ggcaacattg gcaaaggacc cggaaacaag agagattgtc cccatggatc ttataagacc
     2461 acgagataca taccactttt ttgttgagca acatggtttg aaagtttata aaacattgaa
     2521 tacaacattt ttttctactg gaaaattggt tttaggaccc catgaagaaa aaggaaaaca
     2581 gcatgttggt caagatatat tagtttttta tgttaacttt ggtgaccttc tatgtacatt
     2641 acatgaaaca ccttatatgc taacgaccgg ggattcattc tatgttcctt caggtaatca
     2701 ttacaacatt aaaaacctct tgaatgtgga aagttgtctt ctttttactc aaataaaaag
     2761 gtgaaataaa agtgtatgta tataaaatag attgtttata tgtaaatttt tgtaactgat
     2821 tattttaaag taaaattttt gtttagtttt gcattagtta atcattttat actccttgtt
     2881 aaacatttca tagtcttgta tatgtctttt ggtttttcct cgagtgtaaa tactgtgctt
     2941 actgttgacc attttgttgg tgttgctttg ataatattga aaaaaaaaga acaacaaaag
     3001 aaactaaaat cactgttccc acaatataat atccatctgc tatcaaagag ctgattgatg
     3061 tgtccattca tttgctgtag ttggttccaa atatcaattg taaatcgttg atcattaaat
     3121 aatcgaatag aaaaaaaaaa aaaaaaaa
//
