LOCUS       NM_001191110            9034 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus cadherin, EGF LAG seven-pass G-type receptor 2
            (Celsr2), mRNA.
ACCESSION   NM_001191110 XM_001076220
VERSION     NM_001191110.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9034)
  AUTHORS   Zhou,X., Zhan,Z., Tang,C., Li,J., Zheng,X., Zhu,S. and Qi,J.
  TITLE     Silencing Celsr2 inhibits the proliferation and migration of
            Schwann cells through suppressing the Wnt/beta-catenin signaling
            pathway
  JOURNAL   Biochem Biophys Res Commun 533 (4), 623-630 (2020)
   PUBMED   32988580
  REMARK    GeneRIF: Silencing Celsr2 inhibits the proliferation and migration
            of Schwann cells through suppressing the Wnt/beta-catenin signaling
            pathway.
REFERENCE   2  (bases 1 to 9034)
  AUTHORS   Vogel,P., Read,R.W., Hansen,G.M., Payne,B.J., Small,D., Sands,A.T.
            and Zambrowicz,B.P.
  TITLE     Congenital hydrocephalus in genetically engineered mice
  JOURNAL   Vet Pathol 49 (1), 166-181 (2012)
   PUBMED   21746835
REFERENCE   3  (bases 1 to 9034)
  AUTHORS   Qu,Y., Glasco,D.M., Zhou,L., Sawant,A., Ravni,A., Fritzsch,B.,
            Damrau,C., Murdoch,J.N., Evans,S., Pfaff,S.L., Formstone,C.,
            Goffinet,A.M., Chandrasekhar,A. and Tissir,F.
  TITLE     Atypical cadherins Celsr1-3 differentially regulate migration of
            facial branchiomotor neurons in mice
  JOURNAL   J Neurosci 30 (28), 9392-9401 (2010)
   PUBMED   20631168
REFERENCE   4  (bases 1 to 9034)
  AUTHORS   Tissir,F., Qu,Y., Montcouquiol,M., Zhou,L., Komatsu,K., Shi,D.,
            Fujimori,T., Labeau,J., Tyteca,D., Courtoy,P., Poumay,Y., Uemura,T.
            and Goffinet,A.M.
  TITLE     Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis,
            leading to fatal hydrocephalus
  JOURNAL   Nat Neurosci 13 (6), 700-707 (2010)
   PUBMED   20473291
REFERENCE   5  (bases 1 to 9034)
  AUTHORS   Shima,Y., Kawaguchi,S.Y., Kosaka,K., Nakayama,M., Hoshino,M.,
            Nabeshima,Y., Hirano,T. and Uemura,T.
  TITLE     Opposing roles in neurite growth control by two seven-pass
            transmembrane cadherins
  JOURNAL   Nat Neurosci 10 (8), 963-969 (2007)
   PUBMED   17618280
  REMARK    GeneRIF: The Celsr2 enhanced neurite growth of neuron in
            hippocampus of rat.
REFERENCE   6  (bases 1 to 9034)
  AUTHORS   Shima,Y., Kengaku,M., Hirano,T., Takeichi,M. and Uemura,T.
  TITLE     Regulation of dendritic maintenance and growth by a mammalian
            7-pass transmembrane cadherin
  JOURNAL   Dev Cell 7 (2), 205-216 (2004)
   PUBMED   15296717
REFERENCE   7  (bases 1 to 9034)
  AUTHORS   Morgan,R., El-Kadi,A.M. and Theokli,C.
  TITLE     Flamingo, a cadherin-type receptor involved in the Drosophila
            planar polarity pathway, can block signaling via the canonical wnt
            pathway in Xenopus laevis
  JOURNAL   Int J Dev Biol 47 (4), 245-252 (2003)
   PUBMED   12755329
REFERENCE   8  (bases 1 to 9034)
  AUTHORS   Vincent,J.B., Skaug,J. and Scherer,S.W.
  TITLE     The human homologue of flamingo, EGFL2, encodes a brain-expressed
            large cadherin-like protein with epidermal growth factor-like
            domains, and maps to chromosome 1p13.3-p21.1
  JOURNAL   DNA Res 7 (3), 233-235 (2000)
   PUBMED   10907856
REFERENCE   9  (bases 1 to 9034)
  AUTHORS   Johnson,K.J., Patel,S.R. and Boekelheide,K.
  TITLE     Multiple cadherin superfamily members with unique expression
            profiles are produced in rat testis
  JOURNAL   Endocrinology 141 (2), 675-683 (2000)
   PUBMED   10650949
REFERENCE   10 (bases 1 to 9034)
  AUTHORS   Nakayama,M., Nakajima,D., Nagase,T., Nomura,N., Seki,N. and
            Ohara,O.
  TITLE     Identification of high-molecular-weight proteins with multiple
            EGF-like motifs by motif-trap screening
  JOURNAL   Genomics 51 (1), 27-34 (1998)
   PUBMED   9693030
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Jul 17, 2010 this sequence version replaced XM_001076220.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB011529.1, SRR26360194.2129060.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3310              JAXUCZ010000002.1  198738073-198741382 c
            3311-3958           JAXUCZ010000002.1  198732907-198733554 c
            3959-4181           JAXUCZ010000002.1  198730719-198730941 c
            4182-4297           JAXUCZ010000002.1  198730270-198730385 c
            4298-4386           JAXUCZ010000002.1  198730000-198730088 c
            4387-4544           JAXUCZ010000002.1  198729634-198729791 c
            4545-4708           JAXUCZ010000002.1  198729115-198729278 c
            4709-4834           JAXUCZ010000002.1  198728834-198728959 c
            4835-5001           JAXUCZ010000002.1  198728324-198728490 c
            5002-5289           JAXUCZ010000002.1  198727787-198728074 c
            5290-5464           JAXUCZ010000002.1  198727528-198727702 c
            5465-5606           JAXUCZ010000002.1  198727197-198727338 c
            5607-5727           JAXUCZ010000002.1  198726921-198727041 c
            5728-5911           JAXUCZ010000002.1  198726332-198726515 c
            5912-6013           JAXUCZ010000002.1  198726068-198726169 c
            6014-6108           JAXUCZ010000002.1  198725390-198725484 c
            6109-6318           JAXUCZ010000002.1  198724866-198725075 c
            6319-6502           JAXUCZ010000002.1  198724052-198724235 c
            6503-6631           JAXUCZ010000002.1  198723818-198723946 c
            6632-6812           JAXUCZ010000002.1  198723546-198723726 c
            6813-6980           JAXUCZ010000002.1  198723261-198723428 c
            6981-7107           JAXUCZ010000002.1  198723031-198723157 c
            7108-7308           JAXUCZ010000002.1  198722734-198722934 c
            7309-7483           JAXUCZ010000002.1  198722326-198722500 c
            7484-7596           JAXUCZ010000002.1  198721940-198722052 c
            7597-7676           JAXUCZ010000002.1  198721719-198721798 c
            7677-7803           JAXUCZ010000002.1  198721480-198721606 c
            7804-7926           JAXUCZ010000002.1  198721277-198721399 c
            7927-8054           JAXUCZ010000002.1  198720604-198720731 c
            8055-8143           JAXUCZ010000002.1  198720313-198720401 c
            8144-8326           JAXUCZ010000002.1  198720027-198720209 c
            8327-8497           JAXUCZ010000002.1  198719740-198719910 c
            8498-8732           JAXUCZ010000002.1  198719410-198719644 c
            8733-9034           JAXUCZ010000002.1  198718763-198719064 c
FEATURES             Location/Qualifiers
     source          1..9034
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..9034
                     /gene="Celsr2"
                     /gene_synonym="Megf3"
                     /note="cadherin, EGF LAG seven-pass G-type receptor 2"
                     /db_xref="GeneID:83465"
                     /db_xref="RGD:69237"
     CDS             1..8760
                     /gene="Celsr2"
                     /gene_synonym="Megf3"
                     /note="flamingo-like protein celsr2; seven-pass
                     transmembrane cadherin; multiple epidermal growth
                     factor-like domains 3; multiple EGF-like domains protein
                     3; multiple epidermal growth factor-like domains protein
                     3; cadherin EGF LAG seven-pas G-type receptor 2;
                     Flamingo1; cadherin, EGF LAG seven-pass G-type receptor 2
                     (flamingo homolog, Drosophila)"
                     /codon_start=1
                     /product="cadherin EGF LAG seven-pass G-type receptor 2
                     precursor"
                     /protein_id="NP_001178039.1"
                     /db_xref="GeneID:83465"
                     /db_xref="RGD:69237"
                     /translation="MRSRAASAPLPTPLLPLLLLLLLLPPSPLLGDQVGPCRSLGSGG
                     RGSSGACAPVGWLCPASASNLWLYTSRCRDSGIELTGHLVPHHDGLRVWCPESGAHIP
                     LPPSSEGCPWSCRLLGIGGHLSPQGTLTLPQEHPCLKAPRLRCQSCKLAQAPGLRAGE
                     GSREESMGGRRKRNVNTAPQFQPPSYQATVPENQPAGTSVASLRAIDPDEGEAGRLEY
                     TMDALFDSRSNHFFSLDPITGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLT
                     ILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGPGG
                     SPSEVFEIDPRSGVIRTRGPVDREEVESYKLIVEASDQGRDPGPRSSTAVVFLSVEDD
                     NDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNALVHYSIMSGNARGQFYLD
                     AQTGALDVVSPLDYETTKEYTLRIRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVST
                     PFQATVLESVPLGYLVLHVQAIDADAGENARLEYSLAGVGHDFPFTINNGTGWISVAA
                     ELDREEVDFYSFGVEARDHGTPALTASASVSVTILDVNDNNPTFTQPEYTVRLNEDAA
                     VGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYV
                     LAVTASDGTRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDED
                     TGENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDT
                     TYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQG
                     GDDGDGDFIVESTSGIVRTLRRLDRENVAQYILRAYAVDKGMPPARTPMEVTVTVLDV
                     NDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLD
                     IFSGELTALVDLDYEDRPEYILVIQATSAPLVSRATVHVRLLDRNDNPPVLGNFEILF
                     NNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELRLSRAL
                     DNNRPLEAIMSVLVSDGVHSVTAQCSLRVTIITDEMLTHSITLRLEDMSPERFLSPLL
                     GLFIQAVAATLATPPDHVVVFNVQRDTDAPGGHILNVSLSVGQPPGPGGGPPFLPSED
                     LQERLYLNRSLLTAISAQRVLPFDDNICLREPCENYMRCVSVLRFDSSAPFIASSSVL
                     FRPIHPVGGLRCRCPPGFTGDYCETEVDLCYSRPCGPHGHCRSREGGYTCLCRDGYTG
                     EHCEVSARSGRCTPGVCKNGGTCVNLLVGGFKCDCPSGDFEKPFCQVTTRSFPARSFI
                     TFRGLRQRFHFTLALSFATKERDGLLLYNGRFNEKHDFVALEVIQEQVQLTFSAGEST
                     TTVSPFVPGGVSDGQWHTVQLKYYNKPLLGQTGLPQGPSEQKVAVVSVDGCDTGVALR
                     FGAMLGNYSCAAQGTQGGSKKSLDLTGPLLLGGVPDLPESFPVRMRHFVGCMKNLQVD
                     SRHVDMADFIANNGTVPGCPTKKNVCDSNTCHNGGTCVNQWDAFSCECPLGFGGKSCA
                     QEMANPQRFLGSSLVAWHGLSLPISQPWHLSLMFRTRQADGVLLQAVTRGRSTITLQL
                     RAGHVVLSVEGTGLQASSLRLEPGRANDGDWHHAQLSLGASGGPGHAILSFDYGQQKA
                     EGNLGPRLHGLHLSNMTVGGVPGPASSVARGFRGCLQGVRVSETPEGVSSLDPSRGES
                     INVEPGCSWPDPCDSNPCPTNSYCSNDWDSYSCSCDPGYYGDNCTNVCDLNPCEHQSV
                     CTRKPSAPHGYICECLPNYLGPYCETRIDQPCPRGWWGHPTCGPCNCDVSKGFDPDCN
                     KTSGECHCKENHYRPPSSPTCLLCDCYPTGSLSRVCDPEDGQCPCKPGVIGRQCDRCD
                     NPFAEVTTNGCEVNYDSCPRAIEAGIWWPRTRFGLPAAAPCPKGSFGTAVRHCDEHRG
                     WLPPNLFNCTSVTFSELKGFAERLQRNESGLDSGRSQRLALLLRNATQHTSGYFGSDV
                     KVAYQLATRLLAHESAQRGFGLSATQDVHFTENLLRVGSALLDAANKRHWELIQQTEG
                     GTAWLLQHYEAYASALAQNMRHTYLSPFTIVTPNIVISVVRLDKGNFAGTKLPRYEAL
                     RGERPPDLETTVILPESVFREMPPMVRSAGPGEAQETEELARRQRRHPELSQGEAVAS
                     VIIYHTLAGLLPHNYDPDKRSLRVPKRPVINTPVVSISVHDDEELLPRALDKPVTVQF
                     RLLETEERTKPICVFWNHSILVSGTGGWSARGCEVVFRNESHVSCQCNHMTSFAVLMD
                     VSRRENGEILPLKTLTYVALGVTLAALMITFLFLTLLRALRSNQHGIRRNLTAALGLA
                     QLVFLLGINQADLPFACTVIAILLHFLYLCTFSWALLEALHLYRALTEVRDVNASPMR
                     FYYMLGWGVPAFITGLAVGLDPEGYGNPDFCWLSIYDTLIWSFAGPVAFAVSMSVFLY
                     ILSARASCAAQRQGFEKKGPVSGLRSSFTVLLLLSATWLLALLSVNSDTLLFHYLFAA
                     CNCVQGPFIFLSYVVLSKEVRKALKFACSRKPSPDPALTTKSTLTSSYNCPSPYADGR
                     LYQPYGDSAGSLHSASRSGKSQPSYIPFLLREESTLNPGQVPPGLGDPSGLFMEGQAQ
                     QHDPDTDSDSDLSLEDDQSGSYASTHSSDSEEEEEEAAFPGEQGWDSLLGPGAERLPL
                     HSTPKDGGPGSGKVPWPGDFGTTTKENSGSGPLEERPRENGDALTREGSLGPLPGPST
                     QPHKGILKKKCLPTISEKSSLLRLPLEQGTGSSRGSTASEGSRNGPPPRPPPRQSLQE
                     QLNGVMPIAMSIKAGTVDEDSSGSEFLFFNFLH"
     exon            1..3310
                     /gene="Celsr2"
                     /gene_synonym="Megf3"
                     /inference="alignment:Splign:2.1.0"
     exon            3311..3958
                     /gene="Celsr2"
                     /gene_synonym="Megf3"
                     /inference="alignment:Splign:2.1.0"
     exon            3959..4181
                     /gene="Celsr2"
                     /gene_synonym="Megf3"
                     /inference="alignment:Splign:2.1.0"
     exon            4182..4297
                     /gene="Celsr2"
                     /gene_synonym="Megf3"
                     /inference="alignment:Splign:2.1.0"
     exon            4298..4386
                     /gene="Celsr2"
                     /gene_synonym="Megf3"
                     /inference="alignment:Splign:2.1.0"
     exon            4387..4544
                     /gene="Celsr2"
                     /gene_synonym="Megf3"
                     /inference="alignment:Splign:2.1.0"
     exon            4545..4708
                     /gene="Celsr2"
                     /gene_synonym="Megf3"
                     /inference="alignment:Splign:2.1.0"
     exon            4709..4834
                     /gene="Celsr2"
                     /gene_synonym="Megf3"
                     /inference="alignment:Splign:2.1.0"
     exon            4835..5001
                     /gene="Celsr2"
                     /gene_synonym="Megf3"
                     /inference="alignment:Splign:2.1.0"
     exon            5002..5289
                     /gene="Celsr2"
                     /gene_synonym="Megf3"
                     /inference="alignment:Splign:2.1.0"
     exon            5290..5464
                     /gene="Celsr2"
                     /gene_synonym="Megf3"
                     /inference="alignment:Splign:2.1.0"
     exon            5465..5606
                     /gene="Celsr2"
                     /gene_synonym="Megf3"
                     /inference="alignment:Splign:2.1.0"
     exon            5607..5727
                     /gene="Celsr2"
                     /gene_synonym="Megf3"
                     /inference="alignment:Splign:2.1.0"
     exon            5728..5911
                     /gene="Celsr2"
                     /gene_synonym="Megf3"
                     /inference="alignment:Splign:2.1.0"
     exon            5912..6013
                     /gene="Celsr2"
                     /gene_synonym="Megf3"
                     /inference="alignment:Splign:2.1.0"
     exon            6014..6108
                     /gene="Celsr2"
                     /gene_synonym="Megf3"
                     /inference="alignment:Splign:2.1.0"
     exon            6109..6318
                     /gene="Celsr2"
                     /gene_synonym="Megf3"
                     /inference="alignment:Splign:2.1.0"
     exon            6319..6502
                     /gene="Celsr2"
                     /gene_synonym="Megf3"
                     /inference="alignment:Splign:2.1.0"
     exon            6503..6631
                     /gene="Celsr2"
                     /gene_synonym="Megf3"
                     /inference="alignment:Splign:2.1.0"
     exon            6632..6812
                     /gene="Celsr2"
                     /gene_synonym="Megf3"
                     /inference="alignment:Splign:2.1.0"
     exon            6813..6980
                     /gene="Celsr2"
                     /gene_synonym="Megf3"
                     /inference="alignment:Splign:2.1.0"
     exon            6981..7107
                     /gene="Celsr2"
                     /gene_synonym="Megf3"
                     /inference="alignment:Splign:2.1.0"
     exon            7108..7308
                     /gene="Celsr2"
                     /gene_synonym="Megf3"
                     /inference="alignment:Splign:2.1.0"
     exon            7309..7483
                     /gene="Celsr2"
                     /gene_synonym="Megf3"
                     /inference="alignment:Splign:2.1.0"
     exon            7484..7596
                     /gene="Celsr2"
                     /gene_synonym="Megf3"
                     /inference="alignment:Splign:2.1.0"
     exon            7597..7676
                     /gene="Celsr2"
                     /gene_synonym="Megf3"
                     /inference="alignment:Splign:2.1.0"
     exon            7677..7803
                     /gene="Celsr2"
                     /gene_synonym="Megf3"
                     /inference="alignment:Splign:2.1.0"
     exon            7804..7926
                     /gene="Celsr2"
                     /gene_synonym="Megf3"
                     /inference="alignment:Splign:2.1.0"
     exon            7927..8054
                     /gene="Celsr2"
                     /gene_synonym="Megf3"
                     /inference="alignment:Splign:2.1.0"
     exon            8055..8143
                     /gene="Celsr2"
                     /gene_synonym="Megf3"
                     /inference="alignment:Splign:2.1.0"
     exon            8144..8326
                     /gene="Celsr2"
                     /gene_synonym="Megf3"
                     /inference="alignment:Splign:2.1.0"
     exon            8327..8497
                     /gene="Celsr2"
                     /gene_synonym="Megf3"
                     /inference="alignment:Splign:2.1.0"
     exon            8498..8732
                     /gene="Celsr2"
                     /gene_synonym="Megf3"
                     /inference="alignment:Splign:2.1.0"
     exon            8733..9034
                     /gene="Celsr2"
                     /gene_synonym="Megf3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcggagcc gggctgccag cgcccccctc ccaacgccac tgctgccgct gctactgctg
       61 ttgctgctgc tgccgccgtc gccactactg ggagatcaag tggggccctg tcgttctctg
      121 gggtccgggg gacgcggctc ctctggggcc tgcgcccccg tgggctggct ctgcccagcc
      181 tctgcttcga acctctggct ctacaccagc cgctgcagag attcgggcat tgagctgacc
      241 ggccacctgg tgccccatca cgatggcctg agggtttggt gtccagaatc aggggctcat
      301 atccctcttc cgccatcctc tgaaggctgc ccctggagct gtcgactcct gggtatcgga
      361 ggacaccttt ctccacaagg cacgctgacc ctgcctcaag aacacccttg cttaaaggcc
      421 ccacggctca gatgccagtc ttgcaagctg gcacaggccc cagggctcag ggctggggaa
      481 ggatcacgag aggaatctat gggtgggcgc aggaaaagga atgtgaatac agctccccag
      541 ttccagcctc ccagctacca ggccacagtg cccgagaacc agcctgctgg tacctctgtt
      601 gcctccttaa gagccattga tcccgatgag ggtgaggcgg gtcgacttga gtacaccatg
      661 gatgccctct ttgatagccg ctccaatcat ttcttctcct tggacccaat cactggtgct
      721 gtcaccacag ctgaggagct ggatcgggag accaagagca cccatgtctt cagggtcacc
      781 gcacaggatc atggtatgcc ccgacggagt gccttggcca cacttactat cttagtgact
      841 gacaccaatg atcacgaccc tgtttttgag cagcaagaat acaaggagag cctcagggag
      901 aacctggagg ttggctatga ggtgcttaca gtcagggcca ccgatggcga tgcccctcct
      961 aatgccaaca ttctgtaccg cctgctggag gggcctggag gcagcccctc agaagtcttt
     1021 gagatcgatc ctcgctctgg ggtgatccga acccgcggcc ccgtagatcg ggaagaagtg
     1081 gaatcctaca aattgatagt ggaggcgagt gaccagggtc gggacccagg cccacggagc
     1141 tccacagctg tcgtcttcct gtctgtggaa gatgataatg acaacgcccc ccagtttagc
     1201 gagaagcgct acgtggttca ggtgcgggag gatgtgaccc caggagcccc cgttctccga
     1261 gtcacggcct cggacagaga caagggcagc aacgccctgg tgcactatag tatcatgagc
     1321 ggcaacgctc ggggacagtt ctatctggat gctcagactg gagccctgga tgtggtgagc
     1381 ccactcgact atgagacaac caaagaatat acactgcgga tccgggccca ggatggtggc
     1441 cggcctccac tttccaacgt ctccggtcta gtaaccgtgc aggtcctaga catcaatgac
     1501 aacgccccca tctttgtcag cacccctttc caggccacgg tcctagagag tgtaccttta
     1561 ggctacctgg ttctgcatgt ccaagcgatt gatgctgatg ccggagagaa cgcccgcctc
     1621 gaatacagcc tggctggggt tgggcacgac ttccccttca ccattaacaa cggcacaggc
     1681 tggatctcgg tggccgcgga gttggaccgg gaagaggttg atttctacag cttcggagta
     1741 gaagccaggg accacggcac cccagcactc accgcctcag ccagtgtcag tgtaaccatc
     1801 ctggatgtca atgacaacaa cccaaccttt acgcagccgg agtacacggt gcggctcaac
     1861 gaggacgcgg ctgtgggcac cagtgtggtg acggtgtcag ccgtggatcg agatgctcac
     1921 agtgtcatta cctaccagat caccagcggc aacacccgca accgcttctc tatcaccagc
     1981 caaagcgggg gtggcctggt ctccctggcc ttaccgctgg actacaaact cgagcggcag
     2041 tatgtgctgg ccgtgactgc ctcggatggc acaaggcagg acacagctca gatcgtggtg
     2101 aatgtcactg atgccaacac ccatcgtccc gtcttccaga gctcccacta tacggtgaat
     2161 gttaatgaag accggccagc aggcaccaca gtggtgctga tcagtgctac agacgaggac
     2221 acaggggaga atgcccgaat cacctacttt atggaggaca gcatccctca gttccgcatc
     2281 gatgcagaca ctggggccgt caccacccag gctgagctgg actatgaaga tcaggtgtct
     2341 tacaccctgg ccatcaccgc tcgggacaat ggcatccccc agaagtcgga cacaacctac
     2401 ctggagatcc tggtaaatga cgtgaatgac aatgcccccc agttcctcag agattcctac
     2461 caggggagtg tctatgagga tgtgccaccc ttcaccagcg tcctgcagat ctcagccacc
     2521 gatcgcgact ccggtctgaa cggcagggtt ttctacacct tccaaggagg ggacgatgga
     2581 gatggtgact ttattgtaga gtccacatca ggcatcgtgc gcacactgcg gaggctggat
     2641 cgtgagaatg tggcccagta catcttgaga gcgtacgcgg tggacaaggg gatgccgcca
     2701 gcccgcacac ccatggaagt gacagttact gtactggatg tgaatgacaa tccccccgtc
     2761 tttgaacagg atgagtttga tgtatttgtg gaagagaaca gccccatcgg actggctgtg
     2821 gcccgggtca cagccaccga cccagacgaa gggaccaatg cacagatcat gtaccagata
     2881 gtggagggca atatccctga ggtctttcag ctggacatct tctcgggcga gctaacggcc
     2941 ctcgtagatt tggactacga ggaccgacct gaatatatcc tggtcatcca ggctacgtct
     3001 gctcccttgg tgagcagggc tactgtccat gtccgcctcc tcgaccgcaa tgataacccg
     3061 ccagtgctgg gcaactttga gattcttttc aacaactatg tcaccaaccg ctcgagcagc
     3121 ttccctgggg gtgctatagg ccgcgtgcct gcccatgacc ccgatatctc agacagcctg
     3181 acgtacagct ttgagcgagg aaatgaactc agcctggtcc tactcaatgc ctccaccggt
     3241 gagctgagac tgagccgggc actggacaac aaccggcccc tggaagccat catgagtgtg
     3301 ctggtgtcag atggtgtcca cagtgtgaca gcccagtgct cactccgtgt caccatcatc
     3361 acagacgaga tgctcacaca cagcatcacg ctgcgcttgg aagacatgtc tccagaacgc
     3421 tttctgtccc cactgctggg actcttcatt caggctgtgg cagccacatt ggccacaccc
     3481 ccagatcacg tggtggtctt caatgtgcag agggatactg atgccccagg cggccatatc
     3541 ctcaacgtga gcctgtcagt gggccagccc ccaggacccg ggggtgggcc accctttcta
     3601 ccttcagagg atctgcagga gcgcctgtac ctcaaccgca gcctgctcac cgccatctca
     3661 gctcagcgcg tgctcccctt cgacgacaac atttgcctgc gagaaccctg cgagaattac
     3721 atgcgctgtg tgtccgtgct gcgcttcgac tcctctgcgc cctttatcgc ttcctcttcg
     3781 gtgctcttcc gccccatcca ccctgtcggg ggtctgcgct gtcgctgccc accaggcttc
     3841 acaggcgact actgcgagac tgaggtggac ctctgttact caagaccttg tggaccccat
     3901 gggcactgcc gcagtcgaga gggtggctat acctgcctct gtcgcgatgg ctacacgggg
     3961 gagcactgtg aagtgagtgc ccgctcaggc cgttgtactc caggagtctg caagaatggg
     4021 ggtacctgtg tcaacctgtt ggtgggaggc ttcaaatgtg actgcccatc cggggacttt
     4081 gagaagccct tctgccaggt gaccacacgc agcttcccag cccgctcctt catcaccttc
     4141 cggggccttc gccagcgctt ccacttcacc ctggccctct cgtttgctac caaggagcgt
     4201 gacgggctac tgctgtacaa cgggcgcttc aatgagaagc atgacttcgt agctctcgag
     4261 gtgatccagg agcaggtgca gctcaccttc tctgcagggg aatccaccac cacggtgtct
     4321 ccattcgtgc ctggaggggt cagtgatggc cagtggcata cagtacagct gaagtactac
     4381 aataagccgc tgttgggtca gacaggactt ccacaaggcc catctgagca gaaggtggct
     4441 gtggtgtccg tggatggctg tgacacaggg gtggctctgc gcttcggagc tatgctgggc
     4501 aactactcct gtgctgccca gggcacccaa ggaggcagca agaagtctct ggacctgaca
     4561 gggcccttgt tgctgggtgg ggtgccagat ctgcccgaga gtttccctgt ccgaatgcgg
     4621 cactttgtgg gctgcatgaa gaacctccag gtggatagcc ggcacgtcga catggccgac
     4681 ttcatcgcca acaatggcac tgtgcctggc tgccccacca agaagaacgt gtgtgacagc
     4741 aacacttgcc ataatggtgg cacctgtgtg aaccagtggg acgcattcag ctgcgagtgt
     4801 cccctaggct tcgggggcaa gagctgtgcc caggaaatgg ccaatcccca gcgtttcttg
     4861 ggcagcagcc ttgtggcctg gcatggcctc tctctgccca tctctcagcc ctggcacctc
     4921 agcctcatgt tccgcacacg ccaggcagat ggcgtcctgc tgcaggccgt caccaggggg
     4981 cgcagcacca tcaccctgca gcttcgggca ggccacgtag tgctaagtgt ggagggcaca
     5041 gggctccagg cctcatccct gcgtctggag ccaggccgag ccaatgatgg tgactggcat
     5101 cacgcacagc tgtcactggg agctagcggg ggccctggcc acgccatcct gtcctttgac
     5161 tatgggcaac agaaggcaga gggtaatctg ggccctcggc tgcacgggct gcacctgagc
     5221 aatatgacag tcgggggagt tcccgggcca gccagcagtg tggcccgtgg cttccggggc
     5281 tgtttgcagg gtgtgagggt aagcgagaca cccgagggtg ttagcagtct ggatcccagc
     5341 cgtggggaga gcatcaatgt ggagccaggc tgtagctggc cagatccctg tgactcgaat
     5401 ccatgtccca ccaacagcta ctgcagcaac gactgggaca gctattcttg tagctgtgat
     5461 ccaggttact atggtgacaa ctgtacaaat gtgtgtgacc tgaacccatg cgagcaccag
     5521 tctgtgtgta cccgaaaacc cagtgcaccc cacggctaca tctgcgagtg tttaccaaat
     5581 taccttgggc cctattgtga gaccaggatt gaccaacctt gcccccgtgg ctggtgggga
     5641 caccccacat gtggtccatg caactgcgat gtcagcaaag gctttgaccc agactgcaac
     5701 aagacaagtg gcgagtgcca ctgcaaggag aatcactacc gaccccccag cagccccact
     5761 tgcctcttgt gtgactgtta ccccactggc tctttgtccc gagtctgtga ccctgaggat
     5821 ggccagtgtc catgcaagcc tggagtcatt gggcgtcagt gtgatcgctg tgacaaccct
     5881 tttgctgagg tcaccaccaa tggctgtgaa gtgaattatg acagctgccc acgggccata
     5941 gaggctggga tctggtggcc ccgcacgcgg tttgggctac ctgctgctgc cccctgcccc
     6001 aagggctcct ttgggactgc tgtgcgccac tgtgatgagc acaggggctg gctcccgcca
     6061 aacctcttca actgcacgtc agtcaccttc tcagagctaa agggctttgc cgagcggcta
     6121 cagcgaaacg aatcaggcct ggactcagga cgctcccaga ggctggccct gctcctgcgt
     6181 aatgccacac agcacacctc tggctacttc ggcagtgatg tcaaggtggc ctaccagctg
     6241 gccacacgac tgctggctca tgagagtgcc cagcggggct ttgggctgtc cgccacacag
     6301 gatgtgcact tcactgagaa tctgctgagg gtgggcagcg ccctcctgga tgcggccaat
     6361 aagaggcact gggaactgat ccagcagaca gagggtggca ctgcctggct gctccagcac
     6421 tatgaggctt atgccagtgc cctggcccag aatatgcggc atacctacct gagccccttc
     6481 actatcgtca cacccaacat tgtcatctct gtggtgcgcc tggataaggg gaactttgct
     6541 gggaccaagc tgccccgtta tgaggcgtta cgtggggagc gccctccaga tcttgagacc
     6601 acagtcattt tgccagagtc tgtcttcaga gagatgcctc ccatggtgag atctgcagga
     6661 cctggtgaag cccaggagac tgaggagctg gcccggcggc agcggaggca cccagaactg
     6721 agtcagggcg aggcagtggc cagtgtcatc atttaccaca cgctggctgg actgctgccc
     6781 cacaactacg acccagataa gcgtagcctg agagtcccca agcgcccagt catcaacaca
     6841 cctgtggtaa gcatcagtgt ccacgatgat gaggagctcc tgccacgggc actggacaag
     6901 ccagtcacag tgcagttccg actgctggag acggaggagc gaaccaagcc catctgtgtc
     6961 ttctggaacc attcgatcct ggtcagtggc acaggtggct ggtccgccag aggctgcgag
     7021 gttgtcttcc gtaacgagag ccatgtcagc tgccagtgca accatatgac aagctttgct
     7081 gtgctcatgg atgtgtcccg acgagagaat ggtgagattt tgccactgaa gaccctgacg
     7141 tatgtggccc ttggagtcac cttagctgcc ctgatgatca ccttcctctt cctcaccctc
     7201 cttcgagccc ttcgctccaa ccagcatggc atccgacgca acctcacagc tgccctgggc
     7261 ctggcccagc tggtctttct cctggggatc aaccaggctg acctcccttt tgcttgcaca
     7321 gtcattgcca tcctgctgca cttcctgtac ctttgcacct tctcctgggc tctgctggag
     7381 gccttacacc tgtaccgggc gctcacagag gtgcgagacg tcaatgccag ccccatgcgt
     7441 ttctactaca tgctgggctg gggcgttcct gctttcatca caggtctggc tgtgggcttg
     7501 gatcccgaag gctatggaaa ccctgacttc tgctggctct ccatctacga tacgctcatc
     7561 tggagttttg ctggaccagt ggcctttgct gtttcgatga gtgtcttcct gtatatcctg
     7621 tcggcccgag cctcctgtgc tgcccaacgt cagggcttcg agaagaaagg ccctgtctca
     7681 ggcctgcgct cctccttcac tgtcctcctg ctgctgagtg ccacatggct gctggcactg
     7741 ctgtctgtca acagcgacac tctcctcttc cactacctct tcgcggcctg caattgtgtc
     7801 cagggcccct tcatcttcct ctcctacgtg gtgctcagca aggaggtccg gaaagcactc
     7861 aagttcgcct gcagccggaa gcccagccct gaccctgcct tgaccactaa gtctaccctg
     7921 acctcgtcct ataactgccc cagcccctat gcagatggga ggctgtacca gccttacgga
     7981 gattcggccg gctccttgca cagtgccagc cgctcaggca agagtcagcc cagctacatc
     8041 cccttcttgc tgagggagga gtccacgctg aaccctggcc aggttccccc tggcctaggg
     8101 gacccaagtg gcctattcat ggaaggccaa gcccagcaac acgatcccga cacggactct
     8161 gacagtgacc tgtccctgga agatgaccag agtggttcct acgcttctac ccactcatca
     8221 gacagcgagg aagaggagga ggaggccgcc ttccctggcg agcagggctg ggacagcctg
     8281 ctgggtcctg gagctgagag actgcccctt cacagtaccc ccaaggatgg gggtccaggg
     8341 tctgggaagg tcccttggcc aggagacttt gggaccacaa caaaggagaa tagtggtagt
     8401 gggccccttg aagagcggcc acgggagaat ggagatgctc taactcggga agggtctctg
     8461 ggaccccttc cgggcccttc tacccaacct cacaaaggca tcctcaagaa gaagtgtctg
     8521 cccaccatca gcgaaaagag tagcctccta aggttgcccc tggagcaggg cacagggtct
     8581 tcccggggct ccaccgccag tgagggcagc aggaacggac ctcctccacg cccaccaccg
     8641 cgccagtctc tccaggaaca gctgaatggg gtcatgccca tcgccatgag catcaaggca
     8701 ggcactgtgg atgaggactc ttctggctcc gaatttctct tctttaactt cctgcattaa
     8761 ccctgggccg gcgttccttc gtcccctccc cacgctgcgc tcacgcccca atcctgtctt
     8821 ctgctttatc ctgcccctgc tccctacctc ctgcctgcct gcctgcctgc cggagcagca
     8881 gcgacggacc gtccatctga ggagcctggg ccttgcacct ataaggccat ctagtgccaa
     8941 gtctcccccc acccctcaac ctccccttca ctgcactttg gacccttggg ggccaacatc
     9001 tccaagacaa agtttttcag aaaaaaaaaa aaaa
//
