LOCUS       XP_006242229            3064 aa            linear   ROD 22-FEB-2024
DEFINITION  cadherin EGF LAG seven-pass G-type receptor 1 isoform X1 [Rattus
            norvegicus].
ACCESSION   XP_006242229
VERSION     XP_006242229.1
DBLINK      BioProject: PRJNA1074393
DBSOURCE    REFSEQ: accession XM_006242167.5
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_086025) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_036323735.1-RS_2024_02
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 02/09/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..3064
                     /organism="Rattus norvegicus"
                     /strain="BN/NHsdMcwi"
                     /bio_material="RGD 61498"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /sex="male"
                     /tissue_type="kidney, spleen, liver"
                     /geo_loc_name="USA: Wisconsin, Milwaukee"
                     /lat_lon="43.05 N 88.04 W"
                     /collected_by="Rebecca Schilling, Melinda Dwinell"
     Protein         1..3064
                     /product="cadherin EGF LAG seven-pass G-type receptor 1
                     isoform X1"
                     /calculated_mol_wt=333721
     Region          264..364
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(271..272,327,329,360,362..363)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          372..470
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(379..380,431,433,466,468..469)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          479..576
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(485..486,538,540,572,574..575)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          584..698
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(591..592,661,663,694,696..697)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          706..800
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(713..714,766,768,796,798..799)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          808..903
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(815..816,866,868,899,901..902)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          912..1010
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(918..919,972,974,1006,1008..1009)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          1018..1112
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(1025..1026,1078,1080,1108,1110..1111)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          1132..1213
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Region          1379..1414
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          1422..1456
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          1459..1642
                     /region_name="LamG"
                     /note="Laminin G domain; Laminin G-like domains are
                     usually Ca++ mediated receptors that can have binding
                     sites for steroids, beta1 integrins, heparin, sulfatides,
                     fibulin-1, and alpha-dystroglycans. Proteins that contain
                     LamG domains serve a variety of...; cd00110"
                     /db_xref="CDD:238058"
     Region          1666..1700
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          1734..1864
                     /region_name="Laminin_G_2"
                     /note="Laminin G domain; pfam02210"
                     /db_xref="CDD:460494"
     Region          1889..1923
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
                     /db_xref="CDD:238011"
     Region          1923..1961
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain; smart00179"
                     /db_xref="CDD:214542"
     Region          <1930..2026
                     /region_name="TNFRSF"
                     /note="Tumor necrosis factor receptor superfamily
                     (TNFRSF); cl22855"
                     /db_xref="CDD:473981"
     Region          2017..>2055
                     /region_name="EGF_Lam"
                     /note="Laminin-type epidermal growth factor-like domain;
                     laminins are the major noncollagenous components of
                     basement membranes that mediate cell adhesion, growth
                     migration, and differentiation; the laminin-type epidermal
                     growth factor-like module occurs in...; cd00055"
                     /db_xref="CDD:238012"
     Site            order(2018,2020,2030,2037,2039,2048)
                     /site_type="active"
                     /note="EGF-like motif [active]"
                     /db_xref="CDD:238012"
     Region          2067..2128
                     /region_name="HormR"
                     /note="Domain present in hormone receptors; smart00008"
                     /db_xref="CDD:214468"
     Region          2145..2396
                     /region_name="GAIN"
                     /note="GPCR-Autoproteolysis INducing (GAIN) domain;
                     pfam16489"
                     /db_xref="CDD:465137"
     Region          2422..2475
                     /region_name="GPS"
                     /note="G-protein-coupled receptor proteolytic site domain;
                     smart00303"
                     /db_xref="CDD:197639"
     Region          2480..2733
                     /region_name="7tm_GPCRs"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; cl28897"
                     /db_xref="CDD:475119"
     Region          2483..2507
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:410628"
     Region          2516..2537
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:410628"
     Region          2547..2569
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:410628"
     Region          2588..2604
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410628"
     Region          2623..2646
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410628"
     Region          2669..2691
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:410628"
     Region          2695..2720
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:410628"
     CDS             1..3064
                     /gene="Celsr1"
                     /coded_by="XM_006242167.5:464..9658"
                     /db_xref="GeneID:300128"
                     /db_xref="RGD:1560078"
ORIGIN      
        1 mapssprvls alvllaaaal palglgaaaw elrvpggara falgpgwiys ldttrtprel
       61 ldvsregpaa dqllglgagt rgcarlagrl lplqvrlvar gaptapslvl raraygarcg
      121 vrvlsrsarg telrsrairs vpglgdalcf pasgggaasl tsvleaitnf pacscppvag
      181 trcrrgpicl rpggsaglrl vcalgraaga vwvelvveat sgtpsespsv spsslnqsqp
      241 ragvvrrsrr gagsstspqf plpsyqvsvp enepagtavi elrahdpdeg eagrlsyqme
      301 alfdersngy flidattgav ttaraldret kdthvlkvsa vdhgsprrsa atyltvtvsd
      361 tndhspvfeq seyreriren levgyevlti ratdgdapsn anmryrlleg aggvfeidar
      421 sgvvrtravv dreeaaeyql lveandqgrn pgplsasatv hivvedendn ypqfsekryv
      481 vqvpedvavn tpvlrvqatd rdqgqnaaih ysivsgnlkg qfylhslsgs ldvinpldfe
      541 aireytlrik aqdggrppli nssglvsvqv ldvndnapif vsspfqaavl envplghsvl
      601 hiqavdadag enarlqyrlv dtastilggs sidsenpvsa pdfpfqihns sgwitvcael
      661 drellehysf gveavdhgsp pmsssasvsi tvldvndndp vftqpvyelr lnedaavgss
      721 vltlrardrd ansvityqlt ggntrnrfal ssqsggglit lalpldykqe rqyvlavtas
      781 dgtrshtaqv finvtdanth rpvfqsshyt vsvsedrpvg tsiatisatd edtgenarit
      841 yvledpvpqf ridpdtgtiy tmteldyedq aaytlaitaq dngipqksdt tsleililda
      901 ndnaprflrd fyqgsvfeda ppstsvlqvs atdrdsgpng rllytfqggd dgdgdfyiep
      961 tsgvirtqrr ldrenvavyn lwalavdrgn pnplsasvev qvtvldindn ppvfekdele
     1021 lfveenspvg svvarirand pdegpnaqim yqivegnvpe vfqldllsgd lralveldfe
     1081 vrrdymlvvq atsaplvsra tvhirlldqn dnppelpdfq ilfnnyvtnk snsfpsgvig
     1141 ripahdpdls dslnytflqg nelslllldp atgelqlsrd ldnnrpleal mevsvsdgvh
     1201 svtalctlrv tiitddmltn sitvrlenms qerflsplls lfvegvatvl sttkddifvf
     1261 niqndtdvss nilnvtfsal lpggargrff psedlqeqiy lnrtllttis aqrvlpfddn
     1321 iclrepceny mkcvsvlrfd ssapfisstt vlfrpihpit glrcrcppgf tgdyceteid
     1381 lcysnpcgan grcrsreggy tcecfedftg ehcqvnvrsg rcasgvckng gtcvnlligg
     1441 fhcvcppgey ehpycevstr sfppqsfvtf rglrqrfhft vslafatqdr nalllyngrf
     1501 nekhdfiale iveeqlqltf sagettttvt pqvpggvsdg rwhsvlvqyy nkpnighlgl
     1561 phgpsgekva vvtvddcdaa vavhfgsyvg nyscaaqgtq sgskksldlt gplllggvpn
     1621 lpedfpvhsr qfvgcmrnls idgrivdmaa fianngtrag casqrnfcdg tlcqnggtcv
     1681 nrwntylcec plrfggknce qamphpqrft gesivswsdl ditisvpwyl glmfrtrked
     1741 gvlmeatagt ssklhlqiln syirfevshg psdvasmqls ktrvtdggwh hllielrsak
     1801 egkdikylai mtldygmdqs tvqignqlpg lkmrtivigg vsedkvsvrh gfrgcmqgvr
     1861 vgetstniat lnmndalkvr vkdgcdvedp casspcpphs hcrdtwdsys cicdrgyfgk
     1921 kcvdacllnp ckhvaacvrs pntprgysce cgpghygqyc enkvdlpcpk gwwgnpvcgp
     1981 chcavsqgfd pdcnktngqc qckenyykpp aqdaclpcdc fphgshsrac dmdtgqcack
     2041 pgvigrqcnr cdnpfaevts lgceviyngc prafeagiww pqtkfgqpaa vpcpkgsvgn
     2101 avrhcsgekg wlppelfnct sgffvdlkam neklsrnetr mdgnrslrla kalrnatqrn
     2161 stlfgndvrt ayqllarilq hesqqqgfdl aatreanfhe dvvhtgssll apdteaaweq
     2221 iqrseagaaq llrhfeayfs nvarnvkrty lrpfiivtdn milavdifdk lnftgaqvpr
     2281 fqdvqeefpr elessvsfpa dtfkppekke gpmvrltnrr tapltaqpep rteretsfsr
     2341 qrrhpdepgq favalvviyr tlgqllpehy dpdhrslrlp nrpvintpvv namvysegtp
     2401 fpsslqrpvl vefslletee rskpvcvfwn hsldiggtgg wsakgcells rnrthvtcqc
     2461 shsascavlm disrrehgev lplkiityaa lslslvallv sfvllslvrt lrsnlhsihk
     2521 nliaalffsq lvflvginqt enpflctvva illhyvsmgt fawtlvenlh vyrmltevrn
     2581 idtgpmrfyh vvgwgipaiv tglavgldpq gygnpdfcwl slqdtliwsf agpvgtvvii
     2641 ntvifvlsak vscqrkhhyy erkgvvsmlr taflllllvt atwllgllav nsdtlifhyl
     2701 faafsclqgi fvllfhcvth revrkhlrav lagkklhldd sattratllt rslncnntys
     2761 egpdmlrtgl gestasldst trdegvqkls vssgpargnh gepdssfipr nskkahgpds
     2821 dsdselslde hsssyassht sdseddggea edkwnpaggp ahstpkadal anhvpagwpe
     2881 eslagsdsee ldtephlkve tkvsvelhrq aqgnhygdra sdlesgvlak pvavlssqpq
     2941 eqrkgilknk vtyppplpeq plkcrlrekl adceqsptss rtsslgsgdg vhatdcviti
     3001 ktprrepgre hlngvamnvc tgsaqadgsd sekphgtvnl tdcqsspqal kpgtaaygas
     3061 npla
//
