LOCUS       NM_001401250            3961 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus CUGBP, Elav-like family member 4 (Celf4), mRNA.
ACCESSION   NM_001401250 XM_039096903
VERSION     NM_001401250.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3961)
  AUTHORS   Wilson R, Geyer SH, Reissig L, Rose J, Szumska D, Hardman E, Prin
            F, McGuire C, Ramirez-Solis R, White J, Galli A, Tudor C, Tuck E,
            Mazzeo CI, Smith JC, Robertson E, Adams DJ, Mohun T and Weninger
            WJ.
  TITLE     Highly variable penetrance of abnormal phenotypes in embryonic
            lethal knockout mice
  JOURNAL   Wellcome Open Res 1, 1 (2017)
   PUBMED   27996060
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3961)
  AUTHORS   Karunakaran DK, Congdon S, Guerrette T, Banday AR, Lemoine C,
            Chhaya N and Kanadia R.
  TITLE     The expression analysis of Sfrs10 and Celf4 during mouse retinal
            development
  JOURNAL   Gene Expr Patterns 13 (8), 425-436 (2013)
   PUBMED   23932931
REFERENCE   3  (bases 1 to 3961)
  AUTHORS   Zheng S, Damoiseaux R, Chen L and Black DL.
  TITLE     A broadly applicable high-throughput screening strategy identifies
            new regulators of Dlg4 (Psd-95) alternative splicing
  JOURNAL   Genome Res 23 (6), 998-1007 (2013)
   PUBMED   23636947
REFERENCE   4  (bases 1 to 3961)
  AUTHORS   Wagnon JL, Mahaffey CL, Sun W, Yang Y, Chao HT and Frankel WN.
  TITLE     Etiology of a genetically complex seizure disorder in Celf4 mutant
            mice
  JOURNAL   Genes Brain Behav 10 (7), 765-777 (2011)
   PUBMED   21745337
REFERENCE   5  (bases 1 to 3961)
  AUTHORS   Kino Y, Washizu C, Oma Y, Onishi H, Nezu Y, Sasagawa N, Nukina N
            and Ishiura S.
  TITLE     MBNL and CELF proteins regulate alternative splicing of the
            skeletal muscle chloride channel CLCN1
  JOURNAL   Nucleic Acids Res 37 (19), 6477-6490 (2009)
   PUBMED   19720736
REFERENCE   6  (bases 1 to 3961)
  AUTHORS   Wang J, Gao QS, Wang Y, Lafyatis R, Stamm S and Andreadis A.
  TITLE     Tau exon 10, whose missplicing causes frontotemporal dementia, is
            regulated by an intricate interplay of cis elements and trans
            factors
  JOURNAL   J Neurochem 88 (5), 1078-1090 (2004)
   PUBMED   15009664
REFERENCE   7  (bases 1 to 3961)
  AUTHORS   Ladd AN, Charlet N and Cooper TA.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000299.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001401250.2.
            
            On Feb 4, 2022 this sequence version replaced XM_039096903.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-678               JACYVU010000299.1  6506400-6507077     c
            679-761             JACYVU010000299.1  6431953-6432035     c
            762-840             JACYVU010000299.1  6289288-6289366     c
            841-969             JACYVU010000299.1  6256234-6256362     c
            970-1049            JACYVU010000299.1  6255807-6255886     c
            1050-1193           JACYVU010000299.1  6255434-6255577     c
            1194-1341           JACYVU010000299.1  6254286-6254433     c
            1342-1491           JACYVU010000299.1  6252574-6252723     c
            1492-1557           JACYVU010000299.1  6248780-6248845     c
            1558-1641           JACYVU010000299.1  6247440-6247523     c
            1642-1725           JACYVU010000299.1  6242031-6242114     c
            1726-1897           JACYVU010000299.1  6237945-6238116     c
            1898-3961           JACYVU010000299.1  6228752-6230815     c
FEATURES             Location/Qualifiers
     source          1..3961
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..3961
                     /gene="Celf4"
                     /gene_synonym="Brunol4"
                     /note="CUGBP, Elav-like family member 4"
                     /db_xref="GeneID:307540"
                     /db_xref="RGD:1307630"
     exon            1..678
                     /gene="Celf4"
                     /gene_synonym="Brunol4"
                     /inference="alignment:Splign:2.1.0"
     CDS             393..1853
                     /gene="Celf4"
                     /gene_synonym="Brunol4"
                     /note="CUG-BP- and ETR-3-like factor 4"
                     /codon_start=1
                     /product="CUGBP Elav-like family member 4"
                     /protein_id="NP_001388179.1"
                     /db_xref="GeneID:307540"
                     /db_xref="RGD:1307630"
                     /translation="MYIKMATLANGQADNASLSTNGLGSSPGSAGHMNGLSHSPGNPS
                     TIPMKDHDAIKLFIGQIPRNLDEKDLKPLFEEFGKIYELTVLKDRFTGMHKGCAFLTY
                     CERESALKAQSALHEQKTLPGMNRPIQVKPADSESRGGSSCLRQPPSQDRKLFVGMLN
                     KQQSEDDVRRLFEAFGNIEECTILRGPDGNSKGCAFVKYSSHAEAQAAINALHGSQTM
                     PGASSSLVVKFADTDKERTMRRMQQMAGQMGMFNPMAIPFGAYGAYAQALMQQQAALM
                     ASVAQGGYLNPMAAFAAAQMQQMAALNMNGLAAAPMTPTSGGSTPPGITAPAVPSIPS
                     PIGVNGFTGLPPQANGQPAAEAVFANGIHPYPAQSPTAADPLQQAYAGVQQYAGPAAY
                     PAAYGQISQAFPQPPPMIPQQQREGPEGCNLLIYHLPQEFGDAELMQMFLPFGFVSFD
                     NPASAQTAIQAMNGFQIGMKRLKVQLKRPKDANRPY"
     exon            679..761
                     /gene="Celf4"
                     /gene_synonym="Brunol4"
                     /inference="alignment:Splign:2.1.0"
     exon            762..840
                     /gene="Celf4"
                     /gene_synonym="Brunol4"
                     /inference="alignment:Splign:2.1.0"
     exon            841..969
                     /gene="Celf4"
                     /gene_synonym="Brunol4"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1049
                     /gene="Celf4"
                     /gene_synonym="Brunol4"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1193
                     /gene="Celf4"
                     /gene_synonym="Brunol4"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1341
                     /gene="Celf4"
                     /gene_synonym="Brunol4"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1491
                     /gene="Celf4"
                     /gene_synonym="Brunol4"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1557
                     /gene="Celf4"
                     /gene_synonym="Brunol4"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1641
                     /gene="Celf4"
                     /gene_synonym="Brunol4"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1725
                     /gene="Celf4"
                     /gene_synonym="Brunol4"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1897
                     /gene="Celf4"
                     /gene_synonym="Brunol4"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..3961
                     /gene="Celf4"
                     /gene_synonym="Brunol4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accgagagag agagaaagag agagagagag agagagagag agagagagag agagagagag
       61 agagagaaga caggagagga gagaggagga gagagaagag gaagagagag aagagagaga
      121 aatagaacga gagcccagag cagatcaagg tgtaggaaac caaaggggag agaacccgag
      181 tgtgtgcgtg tgtgtgtgag tgtgtgtgag tgtgtgtgtg tgtgtgtgcg tgtgtgagtg
      241 tgtgagtgtg tgagtgtgtg agagagtgtg tgtgtgcgtg tgtgtgtgta tgtgtgtgtg
      301 tgtgcgtgtg cgtgtgtgag cgcgagcgag cgagtgaggg agaggagcga gagagtgcga
      361 gcgagaaaga ataaaaggaa agatttttct ctatgtatat aaagatggcc acgttagcaa
      421 acggacaggc tgacaacgcg agcctcagta ccaacgggct aggcagcagc ccgggcagcg
      481 ccgggcatat gaacggatta agccacagcc cggggaaccc gtcgaccatt cctatgaagg
      541 accacgatgc catcaagctg ttcattgggc agatcccccg aaacctggat gagaaggacc
      601 tcaagcccct cttcgaagag ttcggcaaga tctacgagct tacggttctg aaggacaggt
      661 tcacaggcat gcacaaaggc tgcgctttcc tcacctactg cgagcgtgag tcagcgctga
      721 aggcccagag cgcgctgcac gagcagaaga ccctgcccgg gatgaaccgg ccgatccagg
      781 tgaagcctgc ggacagcgag agccgaggag gtagtagctg cctgcgccag cccccttcac
      841 aagatagaaa actcttcgtg ggtatgctca acaagcaaca atctgaggac gacgtgcgcc
      901 gcctcttcga ggccttcggg aacatcgagg agtgcactat cctgcgcggg ccggacggca
      961 acagcaaggg gtgcgccttt gtgaagtact cctcccatgc cgaggcacaa gccgccatca
     1021 acgctctaca tggcagccag accatgcctg gagcctcctc cagcctggtg gtcaagtttg
     1081 cagacactga caaggagcgc acaatgcgac ggatgcagca gatggctggc cagatgggca
     1141 tgttcaaccc catggccatc cccttcggag cctatggagc ctacgctcag gcactgatgc
     1201 agcagcaagc agccctcatg gcatcggtcg ctcaaggagg ctacctgaat cccatggctg
     1261 ccttcgctgc cgcccagatg cagcagatgg cggccctcaa catgaatggc ctagcagccg
     1321 cacctatgac cccaacttca ggtggcagca cccctccagg catcactgca ccagctgtgc
     1381 ctagcatccc gtcccccatt ggggtgaacg gcttcaccgg cctcccccca caggccaatg
     1441 ggcagcctgc tgcggaagct gtgtttgcca atggcattca cccttaccca gcacagagcc
     1501 ccaccgcagc ggaccccctg cagcaggcct acgccggagt gcagcagtat gcaggacctg
     1561 ctgcctaccc tgctgcctat ggtcagataa gccaggcctt tcctcagcca ccgccaatga
     1621 ttccccagca acagagagaa gggcccgagg gctgtaacct gctcatctac catctgcccc
     1681 aggagtttgg ggacgctgag ctgatgcaga tgttcctccc tttcggcttc gtgagcttcg
     1741 acaacccggc cagcgcccag accgccatcc aggccatgaa cggcttccag ataggcatga
     1801 agaggctcaa ggtgcagctg aagcggccca aagacgccaa tcgcccgtac tgagcgccgg
     1861 cgggagcgtc ccccggggga gaccaggact cgcacagggc aggatgctga acgggctaca
     1921 ttaaaaacaa acctctttct ctctctattt ataaatgaga actgttggac gacacctttg
     1981 acatatcagc caataccaat caagctgaag actccagaca ctccgtgtga ctgttaacac
     2041 ttcttcaagg aaagtatagc gtctatggag tgcagagggc acgtgtttgg ggaaaaatat
     2101 acatgacata aagatgccga cgacgaagaa gaaaaatgat gtaaagcaag caagcaaaca
     2161 aacaaacaaa caaaaaccct cgactttaaa acgaaataac gtgagcccag ttggggaagc
     2221 tgaggggctg ggcactagga ggagatgctg ctgccaaccg atcctggggc ttttccagcc
     2281 cgtaggcgcc tgaggcaggc aggggcaagt gtacaatggg gcctcgtccc cagcaggcgg
     2341 ctgggaggcc gccactgagc atctctattt gtcattcctt tagctattta gggaccaaag
     2401 gaccaaactt tttatcgcag atgtgtagct ctgtcaatta gaggtggaat ggagaccaac
     2461 ctccttcctg cctcctggct gttcttgaaa cagcttagag cgattctatg aaaatgtaat
     2521 aaaaaaaata aataaaaaaa ataaaaaaga acaaaaaaaa aacaggaaaa aaaataatgc
     2581 ttcaacgctt ttaaaacagc aagatactag ttctttgata ctttgagagg cgctttgatt
     2641 accccgattg aagtctctga aactttccta tggttttctg tattatatgt ctggatggag
     2701 ctgtttagat aaattgattg atggatattt ggggaaagca acaaagatat taagtcagta
     2761 accataaaga gaacaggagg ggaaccaggg gacttcgaag gcaaggtaat tgttgtgaaa
     2821 agtctgtaaa tgcttctaat tcttccccct cttaaaatca taatagttgt acagaatttt
     2881 aaaaggaaaa gtttaaaata cctatatcat agaagaaaaa aaattagagg aaagcaaaaa
     2941 ataaaaaaaa aggaaaaaaa aaccttatag aagttagcgt tatgctaaaa tcccagatgt
     3001 tgtaggactg tacttctgta gagtttagac tgagcatcga tcccgtctcc ctgcgagtgc
     3061 tgtcggactc ggtccccaat ggccaggccg gactgtccag acatgcaggc tccggccgga
     3121 agcgccgctc cggaagcgtc ctgccgcctc tcgcttcgcc ctcctcacct ctgcttcact
     3181 cgccttctgt gcttgttccg gagactttcc aggccaggga gaactgggaa cttttcatct
     3241 tcaaacaact agacaacaca cacacacaca aaaaccttaa acaagagaga gaaaacaaac
     3301 aatctttgaa gaatttctga aactgtttac aaggaatttt gaaaaacagg gatgtttaaa
     3361 tgatgccggc tctgtttttc tgtaaataaa tttgcatatt ttgtaggact tttaattgta
     3421 atgatagaga aaaaacaagg aaaactattt aatgaaagca cgatatttat ctttggtaaa
     3481 tgactttaga gcagttaaag acattgctta aaaaactcag aatcagaaaa acactgaatt
     3541 atttaagaac acatatattt taaagtataa catatttatt ataatttatt tgcacccttg
     3601 ggaagacttg ctttgcattc tgcctcaaga gctcattgat gtccatctgg aggccagggg
     3661 ggtcttggaa ctaccatttt ttttccttta gaacaacaaa attctggttg ctctcaggcc
     3721 tcctaccttt tctttcagtc tattttgttg ttgttttact tctttttttt ctttttcttt
     3781 ctcttgactc ctccttttag gatgtccaga tgttgtaaaa aaaaaaaaaa aaaaaaacag
     3841 ctgcagttca atacaactgc tcttttcaca ctgactccct aaaactcctt gtaaccttct
     3901 gtaactattg gatgacgctt tctccagctt agccctaaat aaagcacagt ttaaaaaaaa
     3961 a
//
