LOCUS       NM_017197               2049 bp    mRNA    linear   ROD 31-JAN-2024
DEFINITION  Rattus norvegicus CUGBP, Elav-like family member 2 (Celf2),
            transcript variant 1, mRNA.
ACCESSION   NM_017197
VERSION     NM_017197.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2049)
  AUTHORS   Liu,Y., Wang,H., Wang,J., Wei,B., Zhang,X., Zhang,M., Cao,D.,
            Dai,J., Wang,Z., Nyirimigabo,E. and Ji,G.
  TITLE     A positive feedback regulation of Heme oxygenase 1 by CELF1 in
            cardiac myoblast cells
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1862 (2), 209-218 (2019)
   PUBMED   30508596
REFERENCE   2  (bases 1 to 2049)
  AUTHORS   Bai,Z., Chai,X.R., Yoon,M.J., Kim,H.J., Lo,K.A., Zhang,Z.C., Xu,D.,
            Siang,D.T.C., Walet,A.C.E., Xu,S.H., Chia,S.Y., Chen,P., Yang,H.,
            Ghosh,S. and Sun,L.
  TITLE     Dynamic transcriptome changes during adipose tissue energy
            expenditure reveal critical roles for long noncoding RNA regulators
  JOURNAL   PLoS Biol 15 (8), e2002176 (2017)
   PUBMED   28763438
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2049)
  AUTHORS   Del Pino Sans,J., Krishnan,S., Aggison,L.K., Adams,H.L.,
            Shrikant,M.M., Lopez-Giraldez,F. and Petersen,S.L.
  TITLE     Microarray analysis of neonatal rat anteroventral periventricular
            transcriptomes identifies the proapoptotic Cugbp2 gene as
            sex-specific and regulated by estradiol
  JOURNAL   Neuroscience 303, 312-322 (2015)
   PUBMED   26166732
  REMARK    GeneRIF: This study demonstrated that Cugbp2 regulates splicing and
            translation of mRNAs linked to sexual differentiation in rats.
REFERENCE   4  (bases 1 to 2049)
  AUTHORS   Moraes,K.C., Monteiro,C.J. and Pacheco-Soares,C.
  TITLE     A novel function for CUGBP2 in controlling the pro-inflammatory
            stimulus in H9c2 cells: subcellular trafficking of messenger
            molecules
  JOURNAL   Cell Biol Int 37 (10), 1129-1138 (2013)
   PUBMED   23661609
  REMARK    GeneRIF: a regulatory connection between COX-2 and CUGBP2 in the
            cardiac cells, was demonstrated.
REFERENCE   5  (bases 1 to 2049)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 2049)
  AUTHORS   Mukhopadhyay,D., Houchen,C.W., Kennedy,S., Dieckgraefe,B.K. and
            Anant,S.
  TITLE     Coupled mRNA stabilization and translational silencing of
            cyclooxygenase-2 by a novel RNA binding protein, CUGBP2
  JOURNAL   Mol Cell 11 (1), 113-126 (2003)
   PUBMED   12535526
  REMARK    GeneRIF: These findings identify a novel paradigm for RNA binding
            proteins such as CUGBP2 in facilitating opposing functions of mRNA
            stability and translation inhibition and reveal a mechanism for
            inhibiting cyclooxygenase-2 expression in cancer cells.
REFERENCE   7  (bases 1 to 2049)
  AUTHORS   Zhang,W., Liu,H., Han,K. and Grabowski,P.J.
  TITLE     Region-specific alternative splicing in the nervous system:
            implications for regulation by the RNA-binding protein NAPOR
  JOURNAL   RNA 8 (5), 671-685 (2002)
   PUBMED   12022233
  REMARK    GeneRIF: tissue-specific distribution of NAPOR, CUG-BP, and other
            highly related proteins within the nervous system
REFERENCE   8  (bases 1 to 2049)
  AUTHORS   Levers,T.E., Tait,S., Birling,M.C., Brophy,P.J. and Price,D.J.
  TITLE     Etr-r3/mNapor, encoding an ELAV-type RNA binding protein, is
            expressed in differentiating cells in the developing rodent
            forebrain
  JOURNAL   Mech Dev 112 (1-2), 191-193 (2002)
   PUBMED   11850193
  REMARK    GeneRIF: Etr-r3/mNapor, encoding an ELAV-type RNA binding protein,
            is expressed in differentiating cells in the developing rodent
            forebrain
REFERENCE   9  (bases 1 to 2049)
  AUTHORS   Ladd,A.N., Charlet,N. and Cooper,T.A.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   10 (bases 1 to 2049)
  AUTHORS   Choi,D.K., Ito,T., Tsukahara,F., Hirai,M. and Sakaki,Y.
  TITLE     Developmentally-regulated expression of mNapor encoding an
            apoptosis-induced ELAV-type RNA binding protein
  JOURNAL   Gene 237 (1), 135-142 (1999)
   PUBMED   10524244
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000294.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_017197.4.
            
            On Feb 2, 2010 this sequence version replaced NM_017197.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ010386.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-284               JACYVU010000294.1  9985572-9985855
            285-481             JACYVU010000294.1  10139438-10139634
            482-564             JACYVU010000294.1  10195520-10195602
            565-613             JACYVU010000294.1  10225382-10225430
            614-748             JACYVU010000294.1  10234616-10234750
            749-828             JACYVU010000294.1  10242607-10242686
            829-987             JACYVU010000294.1  10246365-10246523
            988-1051            JACYVU010000294.1  10250011-10250074
            1052-1186           JACYVU010000294.1  10261615-10261749
            1187-1306           JACYVU010000294.1  10286630-10286749
            1307-1504           JACYVU010000294.1  10293255-10293452
            1505-1648           JACYVU010000294.1  10297717-10297860
            1649-2049           JACYVU010000294.1  10300452-10300852
FEATURES             Location/Qualifiers
     source          1..2049
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.3"
     gene            1..2049
                     /gene="Celf2"
                     /gene_synonym="Brunol3; Cugbp2; Etr3; Napor"
                     /note="CUGBP, Elav-like family member 2"
                     /db_xref="GeneID:29428"
                     /db_xref="RGD:68347"
     exon            1..284
                     /gene="Celf2"
                     /gene_synonym="Brunol3; Cugbp2; Etr3; Napor"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..1776
                     /gene="Celf2"
                     /gene_synonym="Brunol3; Cugbp2; Etr3; Napor"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RNA-binding protein Brunol3; Cugbp- and Etr3-like factor
                     2; CUG-BP- and ETR-3-like factor 2; bruno-like protein 3;
                     neuroblastoma apoptosis-related RNA-binding protein;
                     RNA-binding protein BRUNOL-3; elav-type RNA-binding
                     protein 3; CUG triplet repeat, RNA binding protein 2"
                     /codon_start=1
                     /product="CUGBP Elav-like family member 2 isoform 1"
                     /protein_id="NP_058893.2"
                     /db_xref="GeneID:29428"
                     /db_xref="RGD:68347"
                     /translation="MFERTSELAFVETISVESMRCPKSAVTMRNEELLLSNGTANKMN
                     GALDHSDQPDPDAIKMFVGQIPRSWSEKELKELFEPYGAVYQINVLRDRSQNPPQSKG
                     CCFVTFYTRKAALEAQNALHNIKTLPGMHHPIQMKPADSEKSNAVEDRKLFIGMVSKK
                     CNENDIRVMFSPFGQIEECRILRGPDGLSRGCAFVTFSTRAMAQNAIKAMHQSQTMEG
                     CSSPIVVKFADTQKDKEQRRLQQQLAQQMQQLNTATWGNLTGLGGLTPQYLALLQQAT
                     SSSNLGAFSGIQQMAGMNALQLQNLATLAAAAAAAQTSATSTNANPLSSTSSALGALT
                     SPVAASTPNSTAGAAMNSLTSLGTLQGLAGATVGLNNINALAVAQMLSGMAALNGGLG
                     ATGLTNGTAGTMDALTQAYSGIQQYAAAALPTLYSQSLLQQQSAAGSQKEGPEGANLF
                     IYHLPQEFGDQDILQMFMPFGNVISAKVFIDKQTNLSKCFGFVSYDNPVSAQAAIQAM
                     NGFQIGMKRLKVQLKRSKNDSKPY"
     exon            285..481
                     /gene="Celf2"
                     /gene_synonym="Brunol3; Cugbp2; Etr3; Napor"
                     /inference="alignment:Splign:2.1.0"
     exon            482..564
                     /gene="Celf2"
                     /gene_synonym="Brunol3; Cugbp2; Etr3; Napor"
                     /inference="alignment:Splign:2.1.0"
     exon            565..613
                     /gene="Celf2"
                     /gene_synonym="Brunol3; Cugbp2; Etr3; Napor"
                     /inference="alignment:Splign:2.1.0"
     exon            614..748
                     /gene="Celf2"
                     /gene_synonym="Brunol3; Cugbp2; Etr3; Napor"
                     /inference="alignment:Splign:2.1.0"
     exon            749..828
                     /gene="Celf2"
                     /gene_synonym="Brunol3; Cugbp2; Etr3; Napor"
                     /inference="alignment:Splign:2.1.0"
     exon            829..987
                     /gene="Celf2"
                     /gene_synonym="Brunol3; Cugbp2; Etr3; Napor"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1051
                     /gene="Celf2"
                     /gene_synonym="Brunol3; Cugbp2; Etr3; Napor"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1186
                     /gene="Celf2"
                     /gene_synonym="Brunol3; Cugbp2; Etr3; Napor"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1306
                     /gene="Celf2"
                     /gene_synonym="Brunol3; Cugbp2; Etr3; Napor"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1504
                     /gene="Celf2"
                     /gene_synonym="Brunol3; Cugbp2; Etr3; Napor"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1648
                     /gene="Celf2"
                     /gene_synonym="Brunol3; Cugbp2; Etr3; Napor"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..2049
                     /gene="Celf2"
                     /gene_synonym="Brunol3; Cugbp2; Etr3; Napor"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ataacttgtc ggcaaggatt atttcttcct agtgagtctg caggagccct tttctgtact
       61 attcagcatc tgaaagagaa gagtggagag agagagagag agagagagag agagagagag
      121 agagagaaga gagagagagg agagggggcg cattagtgaa tagcgactgt ggcattgatg
      181 tttgagcgca cttctgaact ggcttttgtt gagactatca gtgtagaaag catgcgctgt
      241 cccaaatccg ctgttactat gagaaatgag gagctgcttt taagtaacgg cacagccaac
      301 aagatgaacg gagctttgga tcattccgac cagccagacc cagatgccat taagatgttt
      361 gtcggacaga tccctaggtc ctggtcagaa aaggagctga aagaactttt tgagccttat
      421 ggagctgtct accagatcaa cgtcctccgg gaccggagtc agaaccctcc ccagagcaaa
      481 ggttgttgtt tcgtaacatt ttatacaaga aaagctgcac ttgaggccca gaatgcactg
      541 cacaatatta aaactttacc tgggatgcat catcccattc agatgaaacc tgcagatagt
      601 gaaaagtcaa acgctgtgga agaccgaaaa ttgttcatag gaatggtttc caagaagtgt
      661 aacgagaatg acatcagagt gatgttttct cccttcggtc agatagaaga atgccggatt
      721 ctccggggac ctgacgggct gagtcgaggc tgtgcgtttg tcacattttc taccagggca
      781 atggcacaga atgcaatcaa agccatgcat cagtctcaga ccatggaggg ctgctcttca
      841 cctatcgtgg tgaagttcgc tgacactcag aaggacaagg agcaaaggcg cctccagcag
      901 cagcttgcac agcagatgca acagctcaac actgccactt gggggaacct gacaggactg
      961 ggtggactta ccccacagta cctggcgctt ctgcagcagg ccacctcctc cagcaacctg
     1021 ggtgcattca gtggcattca gcaaatggct ggcatgaatg ctttacagtt acagaatctg
     1081 gcaacgctgg ctgcagctgc agctgccgcc caaacctcag ccaccagcac caatgcaaac
     1141 cctctctcca gcacaagcag tgccctgggg gccctcacaa gtcccgtggc tgcttcaacc
     1201 cccaattcta ctgctggtgc agccatgaac tccttgacct ctcttgggac tctgcaagga
     1261 ttggctggag ccactgtcgg attgaataat attaatgcac tagcagttgc tcaaatgctc
     1321 tcaggtatgg cggctctgaa tggaggactt ggcgccacag gcttgacgaa tggtacggct
     1381 ggcaccatgg acgccctcac gcaggcctac tcaggaattc agcagtacgc ggcagctgca
     1441 ctgcccactt tgtacagcca gagcctgctg cagcagcaga gcgctgcagg cagccagaag
     1501 gaaggtccag agggggcaaa cctctttatt taccaccttc cacaggagtt tggagaccag
     1561 gacattctgc agatgttcat gccctttgga aatgttatct ctgctaaagt cttcattgac
     1621 aaacagacca atctgagcaa gtgctttggt tttgttagct atgacaatcc agtctctgca
     1681 caagctgcaa tccaggctat gaacggcttt cagatcggca tgaaacgctt gaaggtgcag
     1741 ctgaagcgct ccaaaaacga cagcaaacct tactgatcct aaccccagaa gctccctgct
     1801 cttattttag ctttcttagg gtaagtccca caagccagcc tgttctcaac agggaaggca
     1861 gaggagggac cacaatgcca acttttacca agagagacgg ttatttttac attaaggcct
     1921 ccgtttcttc cactaatgcc ccacccagtc tgccataatc aaaacctggg ctaccttgtt
     1981 cttattgagt aaaccccacc tccaattgtg ccactgtatt ctccttggtt ttgcaatttg
     2041 aatatcctt
//
