LOCUS       NM_001025421            2002 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus CUGBP, Elav-like family member 1 (Celf1), mRNA.
ACCESSION   NM_001025421 XM_342461
VERSION     NM_001025421.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2002)
  AUTHORS   Yan,J.K., Zhang,T., Dai,L.N., Gu,B.L., Zhu,J., Yan,W.H., Cai,W. and
            Wang,Y.
  TITLE     CELF1/p53 axis: a sustained antiproliferative signal leading to
            villus atrophy under total parenteral nutrition
  JOURNAL   FASEB J 33 (3), 3378-3391 (2019)
   PUBMED   30514107
  REMARK    GeneRIF: A sustained suppression of IEC proliferation evoked by
            CELF1/p53 axis.
REFERENCE   2  (bases 1 to 2002)
  AUTHORS   Liu,Y., Wang,H., Wang,J., Wei,B., Zhang,X., Zhang,M., Cao,D.,
            Dai,J., Wang,Z., Nyirimigabo,E. and Ji,G.
  TITLE     A positive feedback regulation of Heme oxygenase 1 by CELF1 in
            cardiac myoblast cells
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1862 (2), 209-218 (2019)
   PUBMED   30508596
REFERENCE   3  (bases 1 to 2002)
  AUTHORS   Bai,Z., Chai,X.R., Yoon,M.J., Kim,H.J., Lo,K.A., Zhang,Z.C., Xu,D.,
            Siang,D.T.C., Walet,A.C.E., Xu,S.H., Chia,S.Y., Chen,P., Yang,H.,
            Ghosh,S. and Sun,L.
  TITLE     Dynamic transcriptome changes during adipose tissue energy
            expenditure reveal critical roles for long noncoding RNA regulators
  JOURNAL   PLoS Biol 15 (8), e2002176 (2017)
   PUBMED   28763438
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2002)
  AUTHORS   Blech-Hermoni,Y. and Ladd,A.N.
  TITLE     Identification of transcripts regulated by CUG-BP, Elav-like family
            member 1 (CELF1) in primary embryonic cardiomyocytes by RNA-seq
  JOURNAL   Genom Data 6, 74-76 (2015)
   PUBMED   26366374
REFERENCE   5  (bases 1 to 2002)
  AUTHORS   Yang,L., Zhang,J., Chen,J., Jin,H., Liu,J., Huang,S. and Cui,Z.
  TITLE     The Expression of CUGBP1 After Spinal Cord Injury in Rats
  JOURNAL   Neurochem Res 40 (9), 1966-1975 (2015)
   PUBMED   26283512
  REMARK    GeneRIF: demonstrated that CUGBP1 expression was positively
            correlated with PCNA expression, and the p27 expression was
            negatively correlated with CUGBP1 expression following LPS
            stimulation
REFERENCE   6  (bases 1 to 2002)
  AUTHORS   Karagiannides,I., Thomou,T., Tchkonia,T., Pirtskhalava,T.,
            Kypreos,K.E., Cartwright,A., Dalagiorgou,G., Lash,T.L.,
            Farmer,S.R., Timchenko,N.A. and Kirkland,J.L.
  TITLE     Increased CUG triplet repeat-binding protein-1 predisposes to
            impaired adipogenesis with aging
  JOURNAL   J Biol Chem 281 (32), 23025-23033 (2006)
   PUBMED   16754681
  REMARK    GeneRIF: CUG triplet repeat-binding protein-1 has a role in
            adipogenesis with aging
REFERENCE   7  (bases 1 to 2002)
  AUTHORS   Ladd,A.N., Stenberg,M.G., Swanson,M.S. and Cooper,T.A.
  TITLE     Dynamic balance between activation and repression regulates
            pre-mRNA alternative splicing during heart development
  JOURNAL   Dev Dyn 233 (3), 783-793 (2005)
   PUBMED   15830352
REFERENCE   8  (bases 1 to 2002)
  AUTHORS   Iakova,P., Wang,G.L., Timchenko,L., Michalak,M.,
            Pereira-Smith,O.M., Smith,J.R. and Timchenko,N.A.
  TITLE     Competition of CUGBP1 and calreticulin for the regulation of p21
            translation determines cell fate
  JOURNAL   EMBO J 23 (2), 406-417 (2004)
   PUBMED   14726956
REFERENCE   9  (bases 1 to 2002)
  AUTHORS   Ladd,A.N., Charlet,N. and Cooper,T.A.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   10 (bases 1 to 2002)
  AUTHORS   Good,P.J., Chen,Q., Warner,S.J. and Herring,D.C.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            [WARNING] On Oct 26, 2024 this sequence was replaced by
            NM_001025421.3.
            
            On Nov 27, 2020 this sequence version replaced NM_001025421.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098012.1, SRR23984936.65258.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               JAXUCZ010000003.1  97435136-97435326
            192-274             JAXUCZ010000003.1  97437333-97437415
            275-323             JAXUCZ010000003.1  97437789-97437837
            324-458             JAXUCZ010000003.1  97439360-97439494
            459-538             JAXUCZ010000003.1  97439973-97440052
            539-700             JAXUCZ010000003.1  97440959-97441120
            701-776             JAXUCZ010000003.1  97442917-97442992
            777-905             JAXUCZ010000003.1  97444302-97444430
            906-1019            JAXUCZ010000003.1  97445302-97445415
            1020-1205           JAXUCZ010000003.1  97446368-97446553
            1206-1349           JAXUCZ010000003.1  97448488-97448631
            1350-1516           JAXUCZ010000003.1  97449019-97449185
            1517-2002           JAXUCZ010000003.1  97452306-97452791
FEATURES             Location/Qualifiers
     source          1..2002
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..2002
                     /gene="Celf1"
                     /gene_synonym="Cugbp1"
                     /note="CUGBP, Elav-like family member 1"
                     /db_xref="GeneID:362160"
                     /db_xref="RGD:1307721"
     exon            1..191
                     /gene="Celf1"
                     /gene_synonym="Cugbp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1477
                     /gene="Celf1"
                     /gene_synonym="Cugbp1"
                     /note="CUG-BP- and ETR-3-like factor 1; CELF-1; CUG-BP1;
                     bruno-like protein 2; RNA-binding protein BRUNOL-2; CUG
                     triplet repeat RNA-binding protein 1"
                     /codon_start=1
                     /product="CUGBP Elav-like family member 1"
                     /protein_id="NP_001020592.1"
                     /db_xref="GeneID:362160"
                     /db_xref="RGD:1307721"
                     /translation="MNGTLDHPDQPDLDAIKMFVGQVPRTWSEKDLRELFEQYGAVYE
                     INILRDRSQNPPQSKGCCFVTFYTRKAALEAQNALHNMKVLPGMHHPIQMKPADSEKN
                     NAVEDRKLFIGMISKKCTENDIRVMFSSFGQIEECRILRGPDGLSRGCAFVTFTTRTM
                     AQTAIKAMHQAQTMEGCSSPMVVKFADTQKDKEQKRMAQQLQQQMQQISAASVWGNLA
                     GLNTLGPQYLALYLQLLQQTANSGNLNTLSSLHPMGGLNAMQLQNLAALAAAASAAQN
                     TPSGTNALTTSSSPLSVLTSSAGSSPSSSSSNSVNPIASLGALQTLAGATAGLNVGSL
                     AGMAALNGGLGSSGLSNGTGSTMEALTQAYSGIQQYAAAALPTLYNQNLLTQQSIGAA
                     GSQKEGPEGANLFIYHLPQEFGDQDLLQMFMPFGNVVSAKVFIDKQTNLSKCFGFVSY
                     DNPVSAQAAIQSMNGFQIGMKRLKVQLKRSKNDSKPY"
     exon            192..274
                     /gene="Celf1"
                     /gene_synonym="Cugbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            275..323
                     /gene="Celf1"
                     /gene_synonym="Cugbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            324..458
                     /gene="Celf1"
                     /gene_synonym="Cugbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            459..538
                     /gene="Celf1"
                     /gene_synonym="Cugbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            539..700
                     /gene="Celf1"
                     /gene_synonym="Cugbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            701..776
                     /gene="Celf1"
                     /gene_synonym="Cugbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            777..905
                     /gene="Celf1"
                     /gene_synonym="Cugbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1019
                     /gene="Celf1"
                     /gene_synonym="Cugbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1205
                     /gene="Celf1"
                     /gene_synonym="Cugbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1349
                     /gene="Celf1"
                     /gene_synonym="Cugbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1516
                     /gene="Celf1"
                     /gene_synonym="Cugbp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..2002
                     /gene="Celf1"
                     /gene_synonym="Cugbp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagctcaaag aaaatgaacg gcaccctgga ccacccagac caaccagatc ttgatgctat
       61 caagatgttt gtgggccagg ttccaaggac ctggtcggag aaagacttga gggagctttt
      121 tgagcagtat ggtgctgtct atgaaatcaa catcctaagg gataggagcc aaaaccctcc
      181 tcagagcaaa gggtgctgtt ttgttacatt ttacacccgt aaagctgcat tagaagctca
      241 gaatgctctc cacaacatga aggttctacc tgggatgcat caccctatac agatgaaacc
      301 cgcggacagt gagaagaaca acgctgtgga agacaggaag ctgtttattg gtatgatttc
      361 caagaagtgt actgaaaatg acatccgagt catgttttct tcgtttggac agattgaaga
      421 gtgccggata ttgcggggac ctgatggctt gagcagaggt tgtgcatttg tgacttttac
      481 aacaagaacc atggcacaga cagctatcaa agcaatgcac caagcacaga ccatggaggg
      541 ttgctcatcc cccatggtgg taaagtttgc tgacacccag aaggacaaag aacagaagag
      601 aatggcccag cagctccagc agcagatgca gcagattagt gcagcgtctg tgtgggggaa
      661 cctggctggt ctgaacacac ttgggcccca gtacttagca ctttatttgc agctccttca
      721 gcagactgcc aactctggga acctcaacac cctgagcagc ctccacccaa tgggagggtt
      781 aaatgcaatg cagctccaga atttggctgc actggctgct gcagctagtg cagctcagaa
      841 tacaccaagt ggtaccaatg ctctcactac atccagcagt cccctcagcg tactcaccag
      901 ttcagcaggg tcttcaccga gctccagcag cagtaattct gtcaacccca tagcctcact
      961 tggagcgctg caaacattag ccggagcaac agctggcctc aacgttggct cattggcagg
     1021 aatggctgct ttgaatggag gtttgggcag cagtggcctt tccaatggca ctgggagtac
     1081 catggaagcc ctcacccagg cgtattctgg tatccagcaa tatgctgctg cagccctccc
     1141 tactctgtac aaccagaatc tgttgacaca gcagagtatt ggtgctgctg gaagccagaa
     1201 ggaaggtcca gaaggagcca acctgttcat ctatcacctg ccccaagagt ttggagacca
     1261 ggacttactg cagatgttta tgccctttgg gaatgtcgtg tctgccaagg ttttcataga
     1321 caagcagacc aacctgagca agtgttttgg ttttgtaagt tatgacaatc ctgtctcagc
     1381 tcaagctgcc atccagtcca tgaacggctt tcaaattgga atgaagaggc ttaaagtgca
     1441 gctcaaacgt tcgaagaatg atagtaagcc ctactgatcg tgctcccctc tgagactgga
     1501 gtgagaagat cttctgattc ctgccgtttg ttcatcgttg tgcctaaagc atgtcgatgt
     1561 ggcgtcaagt acatcgtcca aatccctgtc tcttcagctt ctctgatgct tgaactctca
     1621 cctttgacct tgtgttgacc tttgatgctg atgtgtattt tattatgttt gtttctttct
     1681 ttgttttttc ttttttcttt cttttttttc ccttttgtgc tgccaaaatt ggttttgcta
     1741 gaacgactgc tgaagggaaa atatttaaac ttgcatttga atataaaaaa aatctatttt
     1801 tctagaactt cctaagataa ccacttgatt ttgtgattcc aattctttgt aactgtctca
     1861 gagcagccct actagcacat gccgtgtggt gtttgtatcc ttgtgaacac acagccagtc
     1921 cgcttccagg ctttcttcct ctgtgtgctt cgttttaaag acagctttga aataaacaat
     1981 gaaataaaag atgtcactaa aa
//
