LOCUS       NM_012552               1107 bp    mRNA    linear   ROD 08-APR-2024
DEFINITION  Rattus norvegicus chymotrypsin like elastase 1 (Cela1), mRNA.
ACCESSION   NM_012552
VERSION     NM_012552.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1107)
  AUTHORS   Liu,S., Young,S.M. and Varisco,B.M.
  TITLE     Dynamic expression of chymotrypsin-like elastase 1 over the course
            of murine lung development
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 306 (12), L1104-L1116 (2014)
   PUBMED   24793170
REFERENCE   2  (bases 1 to 1107)
  AUTHORS   Wells,J.M., Esni,F., Boivin,G.P., Aronow,B.J., Stuart,W., Combs,C.,
            Sklenka,A., Leach,S.D. and Lowy,A.M.
  TITLE     Wnt/beta-catenin signaling is required for development of the
            exocrine pancreas
  JOURNAL   BMC Dev Biol 7, 4 (2007)
   PUBMED   17222338
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1107)
  AUTHORS   Hinojos,C.A., Boerwinkle,E., Fornage,M. and Doris,P.A.
  TITLE     Combined genealogical, mapping, and expression approaches to
            identify spontaneously hypertensive rat hypertension candidate
            genes
  JOURNAL   Hypertension 45 (4), 698-704 (2005)
   PUBMED   15710778
REFERENCE   4  (bases 1 to 1107)
  AUTHORS   Ryvnyak,V.V. and Dulgieru,O.F.
  TITLE     Elastase involvement in extracellular and intracellular collagen
            degradation during postpartum involution of the uterus
  JOURNAL   Bull Exp Biol Med 136 (2), 206-208 (2003)
   PUBMED   14631512
  REMARK    GeneRIF: Results describe the location of elastase in rat uterus
            during its postpartum involution.
REFERENCE   5  (bases 1 to 1107)
  AUTHORS   Ryvnyak,V.V., Gudumak,V.S. and Dulgieru,O.F.
  TITLE     Electron-histochemical location of cathepsin D and elastase in the
            uterus
  JOURNAL   Bull Exp Biol Med 136 (2), 199-201 (2003)
   PUBMED   14631510
  REMARK    GeneRIF: Data show that both cathepsin D and elastase are present
            in lysosomes of smooth-muscle cells, macrophages, and fibroblasts
            of the myometrium.
REFERENCE   6  (bases 1 to 1107)
  AUTHORS   Swift,G.H., Craik,C.S., Stary,S.J., Quinto,C., Lahaie,R.G.,
            Rutter,W.J. and MacDonald,R.J.
  TITLE     Structure of the two related elastase genes expressed in the rat
            pancreas
  JOURNAL   J Biol Chem 259 (22), 14271-14278 (1984)
   PUBMED   6094548
REFERENCE   7  (bases 1 to 1107)
  AUTHORS   Largman,C.
  TITLE     Isolation and characterization of rat pancreatic elastase
  JOURNAL   Biochemistry 22 (16), 3763-3770 (1983)
   PUBMED   6555050
REFERENCE   8  (bases 1 to 1107)
  AUTHORS   MacDonald,R.J., Swift,G.H., Quinto,C., Swain,W., Pictet,R.L.,
            Nikovits,W. and Rutter,W.J.
  TITLE     Primary structure of two distinct rat pancreatic preproelastases
            determined by sequence analysis of the complete cloned messenger
            ribonucleic acid sequences
  JOURNAL   Biochemistry 21 (6), 1453-1463 (1982)
   PUBMED   6918221
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Apr 13, 2016 this sequence version replaced NM_012552.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ227752.1, V01234.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760476,
                                           SAMN06680412 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                JAXUCZ010000007.1  133665000-133665061 c
            63-145              JAXUCZ010000007.1  133664265-133664347 c
            146-246             JAXUCZ010000007.1  133662321-133662421 c
            247-372             JAXUCZ010000007.1  133661940-133662065 c
            373-509             JAXUCZ010000007.1  133660172-133660308 c
            510-655             JAXUCZ010000007.1  133658587-133658732 c
            656-805             JAXUCZ010000007.1  133652838-133652987 c
            806-1107            JAXUCZ010000007.1  133651941-133652242 c
FEATURES             Location/Qualifiers
     source          1..1107
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..1107
                     /gene="Cela1"
                     /gene_synonym="Ela1; ELAI1; RATELAI1"
                     /note="chymotrypsin like elastase 1"
                     /db_xref="GeneID:24331"
                     /db_xref="RGD:2547"
     exon            1..62
                     /gene="Cela1"
                     /gene_synonym="Ela1; ELAI1; RATELAI1"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..823
                     /gene="Cela1"
                     /gene_synonym="Ela1; ELAI1; RATELAI1"
                     /EC_number="3.4.21.36"
                     /note="elastase-1; elastase 1, pancreatic;
                     chymotrypsin-like elastase family, member 1"
                     /codon_start=1
                     /product="chymotrypsin-like elastase family member 1
                     precursor"
                     /protein_id="NP_036684.1"
                     /db_xref="GeneID:24331"
                     /db_xref="RGD:2547"
                     /translation="MLRFLVFASLVLYGHSTQDFPETNARVVGGAEARRNSWPSQISL
                     QYLSGGSWYHTCGGTLIRRNWVMTAAHCVSSQMTFRVVVGDHNLSQNDGTEQYVSVQK
                     IVVHPNWNSNNVAAGYDIALLRLAQSVTLNNYVQLAVLPQEGTILANNNPCYITGWGR
                     TRTNGQLSQTLQQAYLPSVDYSICSSSSYWGSTVKTTMVCAGGDGVRSGCQGDSGGPL
                     HCLVNGQYSVHGVTSFVSSMGCNVSRKPTVFTRVSAYISWMNNVIAYN"
     exon            63..145
                     /gene="Cela1"
                     /gene_synonym="Ela1; ELAI1; RATELAI1"
                     /inference="alignment:Splign:2.1.0"
     exon            146..246
                     /gene="Cela1"
                     /gene_synonym="Ela1; ELAI1; RATELAI1"
                     /inference="alignment:Splign:2.1.0"
     exon            247..372
                     /gene="Cela1"
                     /gene_synonym="Ela1; ELAI1; RATELAI1"
                     /inference="alignment:Splign:2.1.0"
     exon            373..509
                     /gene="Cela1"
                     /gene_synonym="Ela1; ELAI1; RATELAI1"
                     /inference="alignment:Splign:2.1.0"
     exon            510..655
                     /gene="Cela1"
                     /gene_synonym="Ela1; ELAI1; RATELAI1"
                     /inference="alignment:Splign:2.1.0"
     exon            656..805
                     /gene="Cela1"
                     /gene_synonym="Ela1; ELAI1; RATELAI1"
                     /inference="alignment:Splign:2.1.0"
     exon            806..1107
                     /gene="Cela1"
                     /gene_synonym="Ela1; ELAI1; RATELAI1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtggtctac tctctccaca acatgctgcg cttcctggtg ttcgcttccc tggtcctgta
       61 tggacacagt acccaggact ttccggaaac taatgcccgc gtggttggag gggctgaagc
      121 ccggaggaac tcctggccat ctcagatttc cctccagtac ctgtccggag gatcatggta
      181 ccacacctgt ggagggaccc tcatccgacg caactgggtg atgaccgctg cccactgtgt
      241 gagcagccag atgactttcc gagtggtcgt cggagaccac aacctgagtc agaatgacgg
      301 cacggagcag tacgtgagcg tgcagaagat cgtggtgcac cccaactgga acagcaacaa
      361 tgtggctgca ggctatgaca tcgccctatt gcgcttggcc cagagtgtca cactcaataa
      421 ctacgtccag ctggctgttt tgccccagga gggaaccatc ctggctaaca acaatccctg
      481 ctatatcaca ggctggggga gaaccagaac caatgggcag ctgtctcaga ccctgcagca
      541 ggcgtacctg cccagcgtgg actacagcat ctgctccagc tcctcttact ggggctccac
      601 ggtgaagacg accatggtgt gtgctggtgg agacggagtc cgctctgggt gccagggtga
      661 ttctggggga cccctccatt gcttggtgaa cggccagtat tctgtccacg gagtgaccag
      721 ctttgtgtcc agtatgggct gtaatgtctc caggaagccc acagtcttca cccgagtctc
      781 tgcttacatt tcctggatga acaatgtcat tgcctacaac tgaacgtctt cctgagtcca
      841 gtggcctccc caagatggtg cttagctctg caataagatc tgaagtaagc gagaaggagt
      901 tagggctggg gttatcgctc agcggcagaa cactttctaa tatgtgcgaa gccctgggtt
      961 ccatccctaa tactgcagcg ggggcagggg agtgctgctg gtgtctctct gctctttctc
     1021 cagtatctgg ggcaaaggtg gttaatgaaa aacagctctg agactgagcc agatacagaa
     1081 aggcaaataa aactcaatgt gttatca
//
