LOCUS       NM_017095               1208 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus CCAAT/enhancer binding protein epsilon (Cebpe),
            mRNA.
ACCESSION   NM_017095
VERSION     NM_017095.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1208)
  AUTHORS   Chumakov,A.M., Kubota,T., Walter,S. and Koeffler,H.P.
  TITLE     Identification of murine and human XCP1 genes as
            C/EBP-epsilon-dependent members of FIZZ/Resistin gene family
  JOURNAL   Oncogene 23 (19), 3414-3425 (2004)
   PUBMED   15064728
REFERENCE   2  (bases 1 to 1208)
  AUTHORS   Tavor,S., Vuong,P.T., Park,D.J., Gombart,A.F., Cohen,A.H. and
            Koeffler,H.P.
  TITLE     Macrophage functional maturation and cytokine production are
            impaired in C/EBP epsilon-deficient mice
  JOURNAL   Blood 99 (5), 1794-1801 (2002)
   PUBMED   11861297
REFERENCE   3  (bases 1 to 1208)
  AUTHORS   Gombart,A.F., Shiohara,M., Kwok,S.H., Agematsu,K., Komiyama,A. and
            Koeffler,H.P.
  TITLE     Neutrophil-specific granule deficiency: homozygous recessive
            inheritance of a frameshift mutation in the gene encoding
            transcription factor CCAAT/enhancer binding protein--epsilon
  JOURNAL   Blood 97 (9), 2561-2567 (2001)
   PUBMED   11313242
REFERENCE   4  (bases 1 to 1208)
  AUTHORS   Lekstrom-Himes,J.A., Dorman,S.E., Kopar,P., Holland,S.M. and
            Gallin,J.I.
  TITLE     Neutrophil-specific granule deficiency results from a novel
            mutation with loss of function of the transcription factor
            CCAAT/enhancer binding protein epsilon
  JOURNAL   J Exp Med 189 (11), 1847-1852 (1999)
   PUBMED   10359588
REFERENCE   5  (bases 1 to 1208)
  AUTHORS   Verbeek,W., Gombart,A.F., Chumakov,A.M., Muller,C., Friedman,A.D.
            and Koeffler,H.P.
  TITLE     C/EBPepsilon directly interacts with the DNA binding domain of
            c-myb and cooperatively activates transcription of myeloid
            promoters
  JOURNAL   Blood 93 (10), 3327-3337 (1999)
   PUBMED   10233885
REFERENCE   6  (bases 1 to 1208)
  AUTHORS   Lekstrom-Himes,J. and Xanthopoulos,K.G.
  TITLE     CCAAT/enhancer binding protein epsilon is critical for effective
            neutrophil-mediated response to inflammatory challenge
  JOURNAL   Blood 93 (9), 3096-3105 (1999)
   PUBMED   10216107
REFERENCE   7  (bases 1 to 1208)
  AUTHORS   Williams,S.C., Du,Y., Schwartz,R.C., Weiler,S.R., Ortiz,M.,
            Keller,J.R. and Johnson,P.F.
  TITLE     C/EBPepsilon is a myeloid-specific activator of cytokine,
            chemokine, and macrophage-colony-stimulating factor receptor genes
  JOURNAL   J Biol Chem 273 (22), 13493-13501 (1998)
   PUBMED   9593684
REFERENCE   8  (bases 1 to 1208)
  AUTHORS   Safar,J. and Prusiner,S.B.
  TITLE     Molecular studies of prion diseases
  JOURNAL   Prog Brain Res 117, 421-434 (1998)
   PUBMED   9932423
  REMARK    Review article
REFERENCE   9  (bases 1 to 1208)
  AUTHORS   Williams,S.C., Cantwell,C.A. and Johnson,P.F.
  TITLE     A family of C/EBP-related proteins capable of forming covalently
            linked leucine zipper dimers in vitro
  JOURNAL   Genes Dev 5 (9), 1553-1567 (1991)
   PUBMED   1884998
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Sep 13, 2022 this sequence version replaced NM_017095.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CA505506.1, SRR26643284.17737.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN06680412
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-698               JAXUCZ010000015.1  32140779-32141476   c
            699-1208            JAXUCZ010000015.1  32139716-32140225   c
FEATURES             Location/Qualifiers
     source          1..1208
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p13"
     gene            1..1208
                     /gene="Cebpe"
                     /gene_synonym="C/EPBe; CRP1"
                     /note="CCAAT/enhancer binding protein epsilon"
                     /db_xref="GeneID:25410"
                     /db_xref="RGD:2329"
     exon            1..698
                     /gene="Cebpe"
                     /gene_synonym="C/EPBe; CRP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..1034
                     /gene="Cebpe"
                     /gene_synonym="C/EPBe; CRP1"
                     /note="c/EBP epsilon; c/EBP-related protein 1;
                     CCAAT/enhancer binding protein, epsilon; CCAAT/enhancer
                     binding protein (C/EBP), epsilon"
                     /codon_start=1
                     /product="CCAAT/enhancer-binding protein epsilon"
                     /protein_id="NP_058791.1"
                     /db_xref="GeneID:25410"
                     /db_xref="RGD:2329"
                     /translation="MSHGTYYECEPRGGQQPLEFSGGRAGPGELGDMCEHEASIDLSA
                     YIESGEEQLLSDLFAMKPTPEARSLKGPGTPSFPHYLPADPRPFAYPSHTFGPDRKAL
                     GPGIYSNPGSYDPRAVAVKEEPRGPEGNRGTGRGSYNPLQYQVAHCGQTAVHLPPTLA
                     APGQPLRVLKAPVAAAAPPCSPLLKAPSPAGPSHKGKKAVNKDSLEYRLRRERNNIAV
                     RKSRDKAKRRIMETQQKVLEYMAENERLRSRVDQLTQELDTLRNLFRQIPEAASLIKG
                     VGGCS"
     exon            699..1208
                     /gene="Cebpe"
                     /gene_synonym="C/EPBe; CRP1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagaaggaa agggaagcag aggaggagag aagccacgta ggagttggtg acagagaaga
       61 ccagagaggg cagacctagg gcaaatctag gacaggggga gatcaagaga gggcaggctg
      121 agcatcccaa cgtgggagcg cccctgagca caggacccag gggcggggag ccaaggggcg
      181 ggccggccat gtcccacggg acctactatg aatgcgagcc tcggggtggc cagcagccac
      241 ttgagttctc agggggtcga gctgggcccg gggagctggg ggacatgtgt gagcatgagg
      301 cctccattga cctctccgcc tacatcgagt ctggggaaga acagctactt tctgacctct
      361 ttgccatgaa gccaacgcct gaagcccgaa gccttaaggg cccaggaaca ccttcatttc
      421 ctcactacct gccggctgac cctcggccat ttgcctatcc ctcacacaca tttggcccag
      481 ataggaaggc tttgggacct ggcatctaca gcaacccagg gagctacgac cccagggctg
      541 tggcggtgaa agaggagcct cgagggccag agggcaaccg aggcaccggc agaggcagct
      601 acaatcccct gcagtaccaa gtggcacact gtgggcagac agcagtgcac ctccccccga
      661 ccctggcagc acctggccag cccctgcgcg tcctcaaggc ccctgtggcg gctgctgccc
      721 ctccctgcag cccccttctc aaggcaccct cccctgctgg cccctcgcac aagggcaaga
      781 aggcagtgaa caaagatagc ctggagtacc ggctgcgacg cgaacgcaac aacatcgcag
      841 tgcgcaagag ccgggacaaa gccaagaggc gcattatgga gacacagcag aaggtgttag
      901 agtacatggc ggaaaatgag cgtctgcgca gccgcgtgga ccagctcacc caggagttag
      961 acactctccg caacctcttc cgccagatcc ccgaggctgc cagcctcatc aagggtgtcg
     1021 ggggctgcag ctgagcctgc ctggcagact atgggcaccg ggccctaagg accccgccca
     1081 ccctcctagg tccccagagt cctaaacagg ccaagcctga aaaagagatc atggacaatg
     1141 gcagccagta actgggaaag tcgggaccaa aatgattctg tggctgaata aattgcactg
     1201 tgacttga
//
