LOCUS       NM_024125               1475 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Rattus norvegicus CCAAT/enhancer binding protein beta (Cebpb),
            transcript variant 1, mRNA.
ACCESSION   NM_024125
VERSION     NM_024125.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1475)
  AUTHORS   Zhu,Y.L., Meng,L.L., Ma,J.H., Yuan,X., Chen,S.W., Yi,X.R., Li,X.Y.,
            Wang,Y., Tang,Y.S., Xue,M., Zhu,M.Z., Peng,J., Lu,X.J., Huang,J.Z.,
            Song,Z.C., Wu,C., Zheng,K.Z., Dai,Q.Q., Huang,F. and Fang,H.S.
  TITLE     Loss of LBP triggers lipid metabolic disorder through H3K27
            acetylation-mediated C/EBPbeta- SCD activation in non-alcoholic
            fatty liver disease
  JOURNAL   Zool Res 45 (1), 79-94 (2024)
   PUBMED   38114435
  REMARK    GeneRIF: Loss of LBP triggers lipid metabolic disorder through
            H3K27 acetylation-mediated C/EBPbeta- SCD activation in
            non-alcoholic fatty liver disease.
REFERENCE   2  (bases 1 to 1475)
  AUTHORS   Hu,B., Liu,T., Wu,Z. and Phan,S.H.
  TITLE     P53 regulates CCAAT/Enhancer binding protein beta gene expression
  JOURNAL   Gene 884, 147675 (2023)
   PUBMED   37541559
  REMARK    GeneRIF: P53 regulates CCAAT/Enhancer binding protein beta gene
            expression.
REFERENCE   3  (bases 1 to 1475)
  AUTHORS   Pena-Altamira,E., Polazzi,E., Moretto,E., Lauriola,M. and Monti,B.
  TITLE     The transcription factor CCAAT enhancer-binding protein beta
            protects rat cerebellar granule neurons from apoptosis through its
            transcription-activating isoforms
  JOURNAL   Eur J Neurosci 39 (2), 176-185 (2014)
   PUBMED   24438488
  REMARK    GeneRIF: Data demonstrate, that in neurons, C/EBP beta isoforms are
            differently modulated in apoptosis
REFERENCE   4  (bases 1 to 1475)
  AUTHORS   Pomerance,M., Mockey,M., Young,J., Quillard,J. and Blondeau,J.P.
  TITLE     Expression, hormonal regulation, and subcellular localization of
            CCAAT/enhancer-binding protein-beta in rat and human thyrocytes
  JOURNAL   Thyroid 15 (3), 197-204 (2005)
   PUBMED   15785238
  REMARK    GeneRIF: This factor plays important roles in the regulation of
            thyroid specific genes.
REFERENCE   5  (bases 1 to 1475)
  AUTHORS   Calkhoven,C.F., Muller,C. and Leutz,A.
  TITLE     Translational control of C/EBPalpha and C/EBPbeta isoform
            expression
  JOURNAL   Genes Dev 14 (15), 1920-1932 (2000)
   PUBMED   10921906
REFERENCE   6  (bases 1 to 1475)
  AUTHORS   Lincoln,A.J., Monczak,Y., Williams,S.C. and Johnson,P.F.
  TITLE     Inhibition of CCAAT/enhancer-binding protein alpha and beta
            translation by upstream open reading frames
  JOURNAL   J Biol Chem 273 (16), 9552-9560 (1998)
   PUBMED   9545285
REFERENCE   7  (bases 1 to 1475)
  AUTHORS   Ossipow,V., Descombes,P. and Schibler,U.
  TITLE     CCAAT/enhancer-binding protein mRNA is translated into multiple
            proteins with different transcription activation potentials
  JOURNAL   Proc Natl Acad Sci U S A 90 (17), 8219-8223 (1993)
   PUBMED   8367486
REFERENCE   8  (bases 1 to 1475)
  AUTHORS   Thomassin,H., Hamel,D., Bernier,D., Guertin,M. and Belanger,L.
  TITLE     Molecular cloning of two C/EBP-related proteins that bind to the
            promoter and the enhancer of the alpha 1-fetoprotein gene. Further
            analysis of C/EBP beta and C/EBP gamma
  JOURNAL   Nucleic Acids Res 20 (12), 3091-3098 (1992)
   PUBMED   1377818
REFERENCE   9  (bases 1 to 1475)
  AUTHORS   Descombes,P. and Schibler,U.
  TITLE     A liver-enriched transcriptional activator protein, LAP, and a
            transcriptional inhibitory protein, LIP, are translated from the
            same mRNA
  JOURNAL   Cell 67 (3), 569-579 (1991)
   PUBMED   1934061
REFERENCE   10 (bases 1 to 1475)
  AUTHORS   Descombes,P., Chojkier,M., Lichtsteiner,S., Falvey,E. and
            Schibler,U.
  TITLE     LAP, a novel member of the C/EBP gene family, encodes a
            liver-enriched transcriptional activator protein
  JOURNAL   Genes Dev 4 (9), 1541-1551 (1990)
   PUBMED   2253878
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from JAXUCZ010000003.1 and
            BC129071.1.
            
            On Sep 11, 2014 this sequence version replaced NM_024125.4.
            
            Summary: This intronless gene encodes a member of the transcription
            factor family whose members contain a basic leucine-zipper domain.
            The encoded protein functions as a homodimer but can also form
            heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and
            gamma. The encoded protein plays important roles in several
            cellular processes and in various diseases, including regulating
            cell proliferation, differentiation, apoptosis and
            neuroinflammation, and being involved in brain injury and
            inflammatory progression. The use of alternative in-frame AUG start
            codons results in multiple protein isoforms, each with different
            cellular localizations and distinct biological functions. [provided
            by RefSeq, Sep 2014].
            
            Transcript Variant: This variant (1) encodes multiple isoforms
            through the use of alternative translation initiation codons. The
            isoform (LAP1, also known as LAP* or p38) represented in this
            RefSeq results from translation initiation at the 5' most AUG start
            codon and is the longest isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC129071.1, M57235.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                JAXUCZ010000003.1  176817005-176817014
            11-1475             BC129071.1         1-1465
FEATURES             Location/Qualifiers
     source          1..1475
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..1475
                     /gene="Cebpb"
                     /gene_synonym="Il6dbp; NF-IL6; TCF5"
                     /note="CCAAT/enhancer binding protein beta"
                     /db_xref="GeneID:24253"
                     /db_xref="RGD:2327"
     exon            1..1432
                     /gene="Cebpb"
                     /gene_synonym="Il6dbp; NF-IL6; TCF5"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..947
                     /gene="Cebpb"
                     /gene_synonym="Il6dbp; NF-IL6; TCF5"
                     /note="isoform LAP1 is encoded by transcript variant 1;
                     CCAAT/enhancer binding protein (C/EBP), beta; SF-B;
                     IL-6DBP; silencer factor B;
                     interleukin-6-dependent-binding protein; nuclear
                     factor-IL6; C/EBP beta"
                     /codon_start=1
                     /product="CCAAT/enhancer-binding protein beta isoform
                     LAP1"
                     /protein_id="NP_077039.3"
                     /db_xref="GeneID:24253"
                     /db_xref="RGD:2327"
                     /translation="MHRLLAWDAACLPPPPAAFRPMEVANFYYEPDCLAYGAKAARAA
                     PRAPAAEPAIGEHERAIDFSPYLEPLAPAAADFAAPAPAHHDFLSDLFADDYGAKPSK
                     KPSDYGYVSLGRAGAKAAPPACFPPPPPAALKAEPGFEPADCKRADDAPAMAAGFPFA
                     LRAYLGYQATPSGSSGSLSTSSSSSPPGTPSPADAKAAPAACFAGPPAAPAKAKAKKA
                     VDKLSDEYKMRRERNNIAVRKSRDKAKMRNLETQHKVLELTAENERLQKKVEQLSREL
                     STLRNLFKQLPEPLLASAGHC"
ORIGIN      
        1 gtccgagccg cgcacgggac cgggacgcag cggagcccgc gggccccgcg ttcatgcacc
       61 gcctgctggc ctgggacgca gcatgcctcc cgccgccgcc cgccgccttt agacccatgg
      121 aagtggccaa cttctactac gagcccgact gcctggccta cggggccaag gcggcccgcg
      181 ccgcgccgcg cgcccccgcc gccgagccgg ccatcggcga gcacgagcgc gccatcgact
      241 tcagccccta cctggagccg ctcgcgcccg ccgccgcgga cttcgccgcg cccgcgcccg
      301 cgcaccacga cttcctttcc gacctcttcg ccgacgacta cggcgccaag ccgagcaaga
      361 agccgtccga ctacggttac gtgagcctcg gccgcgcggg cgccaaggcc gcaccgcccg
      421 cctgcttccc gccgccgcct cccgccgcac tcaaggccga gccgggcttc gaacccgcgg
      481 actgcaagcg cgcggacgac gcgcccgcca tggcggccgg cttcccgttc gccctgcgcg
      541 cctacctggg ctaccaggcg acgccgagcg gcagcagcgg cagcctgtcc acgtcgtcgt
      601 cgtccagccc gcccgggacg ccgagccccg ccgacgccaa ggccgcgccc gccgcctgct
      661 tcgcggggcc gccggccgcg cccgccaagg ccaaggccaa gaaggcggtg gacaagctga
      721 gcgacgagta caagatgcgg cgcgagcgca acaacatcgc ggtgcgcaag agccgcgaca
      781 aggccaagat gcgcaacctg gagacgcagc acaaggtgct ggagctgacg gcggagaacg
      841 agcggctgca gaagaaggtg gagcagctgt cgcgagagct cagcacgctg cggaacttgt
      901 tcaagcagct gcccgagccg ctgctggcct cggcgggtca ctgctagccc ggcgggggtg
      961 gcgtgggggc gccgcggcca ccctgggcac cgtgcgccct gccccgcgcg ctccgtcccc
     1021 gcgcgcgccc ggggcaccgt gcgtgcaccg cgcgcacctg cacctgcacc gaggggacac
     1081 cgtgggcacc gcgcgcacgc acctgcaccg cgcaccgggt ttcgggactt gatgcaatcc
     1141 ggatcaaacg tggctgagcg cgtgtggaca cgggactgac gcaacacacg tgtaactgtc
     1201 agccgggccc tgagtaatca cttaaagatg ttcctgcggg gttgttgctg ttgatgtttt
     1261 tgtttttgtt ttttgttttt tgtttttttt ttggtcttat tatttttttg tattatataa
     1321 aaaagttcta tttctatgag aaaagaggcg tatgtatatt ttgagaacct tttccgtttc
     1381 gagcattaaa gtgaagacat tttaataaac ttttttggag aatgtttaaa aaaaaaaaaa
     1441 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
