LOCUS       NM_001033860            3573 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus CEA cell adhesion molecule 1 (Ceacam1),
            transcript variant 1, mRNA.
ACCESSION   NM_001033860
VERSION     NM_001033860.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3573)
  AUTHORS   Huff,L.P., Kikuchi,D.S., Faidley,E., Forrester,S.J., Tsai,M.Z.,
            Lassegue,B. and Griendling,K.K.
  TITLE     Polymerase-delta-interacting protein 2 activates the RhoGEF
            epithelial cell transforming sequence 2 in vascular smooth muscle
            cells
  JOURNAL   Am J Physiol Cell Physiol 316 (5), C621-C631 (2019)
   PUBMED   30726115
REFERENCE   2  (bases 1 to 3573)
  AUTHORS   Bonsor,D.A., Gunther,S., Beadenkopf,R., Beckett,D. and
            Sundberg,E.J.
  TITLE     Diverse oligomeric states of CEACAM IgV domains
  JOURNAL   Proc Natl Acad Sci U S A 112 (44), 13561-13566 (2015)
   PUBMED   26483485
REFERENCE   3  (bases 1 to 3573)
  AUTHORS   Huang,Y.H., Zhu,C., Kondo,Y., Anderson,A.C., Gandhi,A., Russell,A.,
            Dougan,S.K., Petersen,B.S., Melum,E., Pertel,T., Clayton,K.L.,
            Raab,M., Chen,Q., Beauchemin,N., Yazaki,P.J., Pyzik,M.,
            Ostrowski,M.A., Glickman,J.N., Rudd,C.E., Ploegh,H.L., Franke,A.,
            Petsko,G.A., Kuchroo,V.K. and Blumberg,R.S.
  TITLE     CEACAM1 regulates TIM-3-mediated tolerance and exhaustion
  JOURNAL   Nature 517 (7534), 386-390 (2015)
   PUBMED   25363763
  REMARK    Erratum:[Nature. 2016 Aug 18;536(7616):359. doi:
            10.1038/nature17421.. PMID: 26982724]
REFERENCE   4  (bases 1 to 3573)
  AUTHORS   Heckt,T., Bickert,T., Jeschke,A., Seitz,S., Schulze,J., Ito,W.D.,
            Zimmermann,W., Amling,M., Schinke,T., Horst,A.K. and Keller,J.
  TITLE     Increased osteoclastogenesis in mice lacking the carcinoembryonic
            antigen-related cell adhesion molecule 1
  JOURNAL   PLoS One 9 (12), e114360 (2014)
   PUBMED   25490771
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3573)
  AUTHORS   Singer,B.B., Opp,L., Heinrich,A., Schreiber,F.,
            Binding-Liermann,R., Berrocal-Almanza,L.C., Heyl,K.A., Muller,M.M.,
            Weimann,A., Zweigner,J. and Slevogt,H.
  TITLE     Soluble CEACAM8 interacts with CEACAM1 inhibiting TLR2-triggered
            immune responses
  JOURNAL   PLoS One 9 (4), e94106 (2014)
   PUBMED   24743304
  REMARK    GeneRIF: CEACAM8 interacts with CEACAM1 inhibiting TLR2-triggered
            immune responses
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3573)
  AUTHORS   Culic,O., Huang,Q.H., Flanagan,D., Hixson,D. and Lin,S.H.
  TITLE     Molecular cloning and expression of a new rat liver cell-CAM105
            isoform. Differential phosphorylation of isoforms
  JOURNAL   Biochem J 285 (Pt 1) (Pt 1), 47-53 (1992)
   PUBMED   1637321
REFERENCE   7  (bases 1 to 3573)
  AUTHORS   McCuaig,K., Turbide,C. and Beauchemin,N.
  TITLE     mmCGM1a: a mouse carcinoembryonic antigen gene family member,
            generated by alternative splicing, functions as an adhesion
            molecule
  JOURNAL   Cell Growth Differ 3 (3), 165-174 (1992)
   PUBMED   1633107
REFERENCE   8  (bases 1 to 3573)
  AUTHORS   Dveksler,G.S., Pensiero,M.N., Cardellichio,C.B., Williams,R.K.,
            Jiang,G.S., Holmes,K.V. and Dieffenbach,C.W.
  TITLE     Cloning of the mouse hepatitis virus (MHV) receptor: expression in
            human and hamster cell lines confers susceptibility to MHV
  JOURNAL   J Virol 65 (12), 6881-6891 (1991)
   PUBMED   1719235
REFERENCE   9  (bases 1 to 3573)
  AUTHORS   Lin,S.H., Culic,O., Flanagan,D. and Hixson,D.C.
  TITLE     Immunochemical characterization of two isoforms of rat liver
            ecto-ATPase that show an immunological and structural identity with
            a glycoprotein cell-adhesion molecule with Mr 105,000
  JOURNAL   Biochem J 278 (Pt 1) (Pt 1), 155-161 (1991)
   PUBMED   1831973
REFERENCE   10 (bases 1 to 3573)
  AUTHORS   Williams,R.K., Jiang,G.S. and Holmes,K.V.
  TITLE     Receptor for mouse hepatitis virus is a member of the
            carcinoembryonic antigen family of glycoproteins
  JOURNAL   Proc Natl Acad Sci U S A 88 (13), 5533-5536 (1991)
   PUBMED   1648219
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M92848.1, J04963.1, BC061740.1 and JAXUCZ010000001.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061740.1, J04963.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN16676784,
                                           SAMN16676785 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                M92848.1           1-29
            30-1655             J04963.1           37-1662
            1656-1723           BC061740.1         1642-1709
            1724-1873           J04963.1           1726-1875
            1874-2178           BC061740.1         1848-2152
            2179-3573           JAXUCZ010000001.1  90171401-90172795   c
FEATURES             Location/Qualifiers
     source          1..3573
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..3573
                     /gene="Ceacam1"
                     /gene_synonym="Bgp; BGPR; Ccam1; CD66a"
                     /note="CEA cell adhesion molecule 1"
                     /db_xref="GeneID:81613"
                     /db_xref="RGD:67396"
     exon            1..121
                     /gene="Ceacam1"
                     /gene_synonym="Bgp; BGPR; Ccam1; CD66a"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1617
                     /gene="Ceacam1"
                     /gene_synonym="Bgp; BGPR; Ccam1; CD66a"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; GP110; pp120; C-CAM 105; ecto-ATPase; cell-CAM
                     105; ATP-dependent taurocolate-carrier protein; bone
                     gamma-carboxyglutamic acid (Gla) protein; osteocalcin;
                     CEA-related cell adhesion molecule 1 (bone
                     gamma-carboxyglutamic acid (Gla) protein) (osteocalcin);
                     carcinoembryonic antigen-related cell adhesion molecule 1
                     (biliary glycoprotein); pp120/ecto-ATPase;
                     carcinoembryonic antigen related cell adhesion molecule 1;
                     cell adhesion molecule CEACAM1"
                     /codon_start=1
                     /product="cell adhesion molecule CEACAM1 isoform 1
                     precursor"
                     /protein_id="NP_001029032.1"
                     /db_xref="GeneID:81613"
                     /db_xref="RGD:67396"
                     /translation="MELASARLLRGQIPWRGLLLTASLLTYWSPLTTAQVTVDAVPPN
                     VVEEKSVLLLAHNLPQEFQVFYWYKGTTLNPDSEIARYIRSDNMSKTGPAYSGRETIY
                     SNGSLFFQNVNKTDERAYTLSVFDQQFNPIQTSVQFRVYPALQKPNVTGNNSNPMEGE
                     PFVSLMCEPYTNNTSYLWSRNGESLSEGDRVTFSEGNRTLTLLNVRRTDKGYYECEAR
                     NPATFNRSDPFNLDVIYGPDAPVISPPDIYLHQGSNLNLSCHADSNPPAQYFWLINEK
                     LQTSSQELFISNITTNNSGTYACFVNNTVTGLSRTTVKNITVFEPVTQPSIQITNTTV
                     KELGSVTLTCFSKDTGVSVRWLFNSQSLQLTDRMTLSQDNSTLRIDPIKREDAGDYQC
                     EISNPVSFRISHPIKLDVIPDPTQGNSGLSEGAIAGIVIGSVAGVALIAALAYFLYSR
                     KTGGGSDHRDLTEHKPSTSSHNLGPSDDSPNKVDDVSYSVLNFNAQQSKRPTSASSSP
                     TETVYSVVKKK"
     exon            122..481
                     /gene="Ceacam1"
                     /gene_synonym="Bgp; BGPR; Ccam1; CD66a"
                     /inference="alignment:Splign:2.1.0"
     exon            482..760
                     /gene="Ceacam1"
                     /gene_synonym="Bgp; BGPR; Ccam1; CD66a"
                     /inference="alignment:Splign:2.1.0"
     exon            761..1015
                     /gene="Ceacam1"
                     /gene_synonym="Bgp; BGPR; Ccam1; CD66a"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1291
                     /gene="Ceacam1"
                     /gene_synonym="Bgp; BGPR; Ccam1; CD66a"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1418
                     /gene="Ceacam1"
                     /gene_synonym="Bgp; BGPR; Ccam1; CD66a"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1471
                     /gene="Ceacam1"
                     /gene_synonym="Bgp; BGPR; Ccam1; CD66a"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1503
                     /gene="Ceacam1"
                     /gene_synonym="Bgp; BGPR; Ccam1; CD66a"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..3573
                     /gene="Ceacam1"
                     /gene_synonym="Bgp; BGPR; Ccam1; CD66a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccgtgttg gagccaaatc tcttccccag agaagaacct agcaggcagc agagactatg
       61 gagctagcct cggctcgtct cctcagaggg cagattccct ggaggggact actgctcaca
      121 gcctcacttt taacctactg gagccctctc accactgccc aagtcaccgt agacgctgtg
      181 ccacccaacg ttgttgagga gaagagcgtt cttttactcg ctcacaatct gccgcaggag
      241 ttccaagtct tttactggta caagggaacc actttgaatc cagacagtga aattgcacga
      301 tatataagat ccgataatat gagtaaaaca ggacctgcat acagcggcag agagacaata
      361 tacagcaatg gatccttgtt cttccaaaat gtcaacaaga ctgacgagag agcctacaca
      421 ctatctgtgt ttgatcaaca atttaatcct atacaaacgt ctgtgcaatt tcgtgtatac
      481 cccgcattac aaaagcccaa cgtcacaggt aacaactcca atcccatgga gggtgagccc
      541 ttcgtatcat taatgtgtga accgtacact aacaatacca gctacctgtg gagcagaaat
      601 ggtgaaagcc tctcagaagg tgacagggtg acgttctctg agggcaacag gactctcact
      661 ttactcaacg tcaggaggac tgacaaagga tactatgagt gtgaagcccg gaacccagcg
      721 actttcaatc gaagtgaccc attcaacctg gacgttatct atggtccgga cgccccagtt
      781 atatcccctc cagatattta tttgcatcaa gggtcaaacc tcaacctctc ctgccatgca
      841 gactctaacc ctcccgcaca gtacttttgg cttatcaatg agaagctcca gacatcctcc
      901 caagagctct ttatctccaa catcactact aacaatagcg gaacctatgc ctgcttcgtc
      961 aataacactg tcactggcct cagtcgcacc acagtcaaga acattacagt ctttgagcca
     1021 gtgactcagc cctccatcca aatcaccaac accacagtca aagaactagg ctctgtgacc
     1081 ctgacctgct tctcaaagga cactggagtc tccgtccgat ggcttttcaa tagccagagt
     1141 ctgcagctca cagacaggat gacgctctcc caggacaaca gcaccctcag aatagaccct
     1201 attaagagag aagatgccgg ggactatcag tgtgagatct ccaacccggt cagtttcagg
     1261 ataagtcacc caatcaagct ggacgtaata cctgatccaa cacaaggaaa ttctggcctc
     1321 tcagagggtg ccattgcagg cattgtgatt ggatctgtgg ctggagtggc cctaatagca
     1381 gcgctggcat acttccttta ttccaggaag actggcgggg gaagtgacca tcgagatctc
     1441 acagagcaca aaccctcaac ctccagccac aatctgggtc cttctgacga ctctcctaac
     1501 aaggtggatg acgtctcata ctctgtcctg aacttcaatg cccagcaatc caaacgacca
     1561 acttcagcct cttcaagccc cacagaaaca gtttattcgg tagtcaaaaa gaagtgacat
     1621 tgtctgtcct gctgactgca ccagtgatgc attcccagat tctctccctc acgggagagt
     1681 ccctgcacac acgcgcacgt gcgcgtgcac acacacacac acacacacac acatgcacac
     1741 acacacgcac acacgcacgc acacacacac atgcacacac gcacacacac atgtatacac
     1801 tctattgact ccttccgtgt taatagaaga aaaggtgtat cctggagcct acagaaaacc
     1861 caaccctttc taggcattaa aatttggccg agagagagga accaaaacgg cccacccctt
     1921 cacttttctg ttttaaattg atgtattctg agcacattca ctcctccacc caactccaag
     1981 tcctgccctg tcagagtctg acttgaattt cgataaacct cggaggtcac ctaagtgctt
     2041 atgccaaaaa ccacaaaacc aaacaaagca aaacagaagc aggaaatggc cgatcccatg
     2101 tcttaaggct gatgcgaagc caccacacat gaagatcaaa gccataggca ttcgttcgct
     2161 gggcagtccg cacaccagcc aactgtcaca tttactgtga cattagagtc tctgaaccat
     2221 gggtcttcac gcctgagccc ttctccagga aacccactca gagcaactag agaaacccct
     2281 tggcagcaaa caccagcaat tgctaagcag ggtgcagaag aaaagacgac atttctcaca
     2341 tctaccagga tggcgcccag gaaagcaggg ctggcggttt tggactgaga gacatatgga
     2401 atttgaaaag ggaacagaga gatacccttt gaggagtgtc gaaattattt taaaagaagc
     2461 catatttgga ggcgttggaa ttttcctctt cctaagacaa tccactattt gacatttgta
     2521 gctgctgact ttcctttcgc tgggcgagct gatcagtttg ccttagggca actaaatctc
     2581 acgtctccct tggccccccg cacgcaagcc ctttggatcg tgagctccaa accaaaaata
     2641 aataagtgaa tcgtgaggcg gtcccttgca gaaccactgt catgggtcag gctcctactt
     2701 ttctgtatta gtcaagaaaa gcctgagttt tcctttctcg tttttatcct gtcgttctgg
     2761 ccacagcccg gacagtcttc ctctgagatc tctagcttgt ctaccttctt gtgtttcttt
     2821 taaactctca cgaaactgct taacttcaaa aagtaaaata ataactttcc tcatctacac
     2881 cagaaagaga cccaactccg tttctggaaa cctaggatca gcctccagct gccctctgaa
     2941 ctttctgcct tgtttcccct ttcttttgac tctaatacct catgcagtgt cctacctgtt
     3001 aggatgacag cacaggccac taggcctggc cacccgtaca ttctgtctgc cctgcactct
     3061 caggaaacct tggcctctgt ctgtttggtt catgtgaagt gtgcccttaa aggaacagtc
     3121 actcataccg gaggcattgt ttacagcctg gaacattcta cacagtgcat cactggaaat
     3181 gggctgctag cagggttctc gtacccagcc atggcctttc tgtagcctcg gaaacctgcc
     3241 tttccaccag ggatgagtcc cagcagcgga gaaaaggcaa atgtagtctc aggaacccgc
     3301 tgttcaaagg cacaccctct gtgcctgtta accaaaggtt gtatttgata tcgagtattt
     3361 ggtctcatgc catgcctaac aggcttctga gagaattgtt tagttctccc actcagggat
     3421 ttctttcagg gatttccagc cctaacatga cctgtgtata ttttgcttca cccacgcaat
     3481 gctgggttac ttcattttgc ccggctaaag ccaaatcgga gttatttgta aatttgctct
     3541 atgttcataa taaaaattta tatatcactg ata
//
