LOCUS       NM_001106192            2239 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus chromatin licensing and DNA replication factor 1
            (Cdt1), mRNA.
ACCESSION   NM_001106192 XM_001079374 XM_226545
VERSION     NM_001106192.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2239)
  AUTHORS   Franz A, Pirson PA, Pilger D, Halder S, Achuthankutty D, Kashkar H,
            Ramadan K and Hoppe T.
  TITLE     Chromatin-associated degradation is defined by UBXN-3/FAF1 to
            safeguard DNA replication fork progression
  JOURNAL   Nat Commun 7, 10612 (2016)
   PUBMED   26842564
  REMARK    Erratum:[Nat Commun. 2016 May 17;7:11593. PMID: 27186651]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2239)
  AUTHORS   Mosammaparast N, Kim H, Laurent B, Zhao Y, Lim HJ, Majid MC, Dango
            S, Luo Y, Hempel K, Sowa ME, Gygi SP, Steen H, Harper JW, Yankner B
            and Shi Y.
  TITLE     The histone demethylase LSD1/KDM1A promotes the DNA damage response
  JOURNAL   J Cell Biol 203 (3), 457-470 (2013)
   PUBMED   24217620
REFERENCE   3  (bases 1 to 2239)
  AUTHORS   Varma D, Chandrasekaran S, Sundin LJ, Reidy KT, Wan X, Chasse DA,
            Nevis KR, DeLuca JG, Salmon ED and Cook JG.
  TITLE     Recruitment of the human Cdt1 replication licensing protein by the
            loop domain of Hec1 is required for stable kinetochore-microtubule
            attachment
  JOURNAL   Nat Cell Biol 14 (6), 593-603 (2012)
   PUBMED   22581055
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2239)
  AUTHORS   Miotto B and Struhl K.
  TITLE     JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone
            acetylase and blocks replication licensing in response to stress
  JOURNAL   Mol Cell 44 (1), 62-71 (2011)
   PUBMED   21856198
REFERENCE   5  (bases 1 to 2239)
  AUTHORS   Sugimoto N, Tatsumi Y, Tsurumi T, Matsukage A, Kiyono T, Nishitani
            H and Fujita M.
  TITLE     Cdt1 phosphorylation by cyclin A-dependent kinases negatively
            regulates its function without affecting geminin binding
  JOURNAL   J Biol Chem 279 (19), 19691-19697 (2004)
   PUBMED   14993212
REFERENCE   6  (bases 1 to 2239)
  AUTHORS   Cook JG, Chasse DA and Nevins JR.
  TITLE     The regulated association of Cdt1 with minichromosome maintenance
            proteins and Cdc6 in mammalian cells
  JOURNAL   J Biol Chem 279 (10), 9625-9633 (2004)
   PUBMED   14672932
REFERENCE   7  (bases 1 to 2239)
  AUTHORS   Yanagi K, Mizuno T, You Z and Hanaoka F.
  TITLE     Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a
            novel intrinsic Cdt1 DNA binding activity
  JOURNAL   J Biol Chem 277 (43), 40871-40880 (2002)
   PUBMED   12192004
REFERENCE   8  (bases 1 to 2239)
  AUTHORS   Arentson E, Faloon P, Seo J, Moon E, Studts JM, Fremont DH and Choi
            K.
  TITLE     Oncogenic potential of the DNA replication licensing protein CDT1
  JOURNAL   Oncogene 21 (8), 1150-1158 (2002)
   PUBMED   11850834
REFERENCE   9  (bases 1 to 2239)
  AUTHORS   Wohlschlegel JA, Dwyer BT, Dhar SK, Cvetic C, Walter JC and Dutta
            A.
  TITLE     Inhibition of eukaryotic DNA replication by geminin binding to Cdt1
  JOURNAL   Science 290 (5500), 2309-2312 (2000)
   PUBMED   11125146
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473972.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_226545.4, XM_001079374.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2239
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..2239
                     /gene="Cdt1"
                     /gene_synonym="Ris2"
                     /note="chromatin licensing and DNA replication factor 1"
                     /db_xref="GeneID:292071"
                     /db_xref="RGD:1309211"
     exon            1..257
                     /gene="Cdt1"
                     /gene_synonym="Ris2"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1712
                     /gene="Cdt1"
                     /gene_synonym="Ris2"
                     /note="retroviral integration site 2"
                     /codon_start=1
                     /product="DNA replication factor Cdt1"
                     /protein_id="NP_001099662.1"
                     /db_xref="GeneID:292071"
                     /db_xref="RGD:1309211"
                     /translation="MAQSRVTDFYACRRPGLAIPRAKSTCLTPSPGGLVAPEFTRSSS
                     RKRVRPHAEPGSDQPAPPARRRLRLPGLDSCPSFPADPSSPADPSSPADPSSSVCPSP
                     VCPSPVKRTKSTTVSRGPQQSKVPSQDSISELQSCLRQARKLGAQARALRARVQENVV
                     EPSTPDTKEPTEQPCVDKAPAYQRFHALAQPGLPGLVLPYKYQVLAEMFRSMDTIVSM
                     LHNRSETVTFAKVKQGVQEMIRKRFEERNMGQIKTVYPESYSFRQECNVPTFKDSIKR
                     SDYQLTIEPLLGQEAGGATQLTATGLLQRRQVFRQNLVERVKEHHKVFLASLNPPMTV
                     PEDQLTRWHPRFNVDEVPDIEPAELPQPPVTEKLTTAQEVLARARNLMTPKMEKALSN
                     LALRSAEPGSPGTSSPALPATPPATPPAASPSALKGVSQALLERIRAKEVQKQLARMT
                     RCPEKELRLQRLERLPELARVLRGVFVSERKPALTMEVVCARMVDSSRAALSPGEMEK
                     HLLLLAELLPDWLSLHRVRTDTYVKLDKAADLAGLTAKLARQVHAEGL"
     exon            258..413
                     /gene="Cdt1"
                     /gene_synonym="Ris2"
                     /inference="alignment:Splign:2.1.0"
     exon            414..565
                     /gene="Cdt1"
                     /gene_synonym="Ris2"
                     /inference="alignment:Splign:2.1.0"
     exon            566..763
                     /gene="Cdt1"
                     /gene_synonym="Ris2"
                     /inference="alignment:Splign:2.1.0"
     exon            764..909
                     /gene="Cdt1"
                     /gene_synonym="Ris2"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1007
                     /gene="Cdt1"
                     /gene_synonym="Ris2"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1196
                     /gene="Cdt1"
                     /gene_synonym="Ris2"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1349
                     /gene="Cdt1"
                     /gene_synonym="Ris2"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1551
                     /gene="Cdt1"
                     /gene_synonym="Ris2"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..2239
                     /gene="Cdt1"
                     /gene_synonym="Ris2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaaattgcg cgaaatccgc gggaagtagc tttttggcgc catggcgcag agtcgtgtta
       61 ccgatttcta tgcgtgccgt cgtccgggcc ttgcgattcc gcgagccaag tcgacctgtc
      121 tcaccccgag ccctggtggg ctcgtggctc ctgagttcac ccggagcagc agccgcaagc
      181 gcgtccggcc ccacgccgaa cccgggagcg accagcccgc gccgcccgcg cgccggaggc
      241 tacggctacc tggattggat tcttgtccca gtttcccagc tgaccccagc tctccagctg
      301 accccagctc cccagctgac cccagctcct ccgtttgccc atcccccgtc tgcccatccc
      361 ccgtcaagag aacaaagagt actacagttt ctagaggtcc acagcagagc aaggtcccct
      421 cccaggactc catctccgag ctccagtcct gcctgaggca ggcacgtaag ttgggagccc
      481 aggcaagggc cctgagagcg agagtccaag agaatgttgt ggagccttct accccagata
      541 ccaaggagcc cacagaacaa ccatgtgtcg acaaagctcc tgcctaccag cgcttccatg
      601 ccctggccca gcctggcctc cccggccttg tcctaccata caagtatcag gtgctggccg
      661 agatgttccg cagcatggac accatcgtga gcatgcttca caaccgctct gagaccgtca
      721 cctttgctaa agtcaagcaa ggggttcagg agatgatacg caagcgcttt gaagagcgca
      781 atatgggcca gatcaaaacc gtgtaccccg agtcgtattc cttccgccag gagtgcaacg
      841 tccccacttt caaggacagc atcaagagat ctgattacca gctcaccatc gagcccttgc
      901 tgggccagga ggctggtggt gccacccagc tcacagccac gggtctcctg cagcgccggc
      961 aagtcttccg gcagaacctg gtggaacgtg ttaaggagca tcacaaggtt ttcctggcgt
     1021 ccttaaaccc ccccatgacg gtgcccgaag accagctgac acgctggcac ccgcgtttca
     1081 atgtggatga ggtgcctgat attgagccgg ccgaactgcc ccagcctccc gtgacagaga
     1141 agctcactac tgcccaggaa gtgttggccc gtgcccggaa cttgatgacg cccaagatgg
     1201 agaaggcgtt gagtaacctg gccctgcgct cagctgagcc tggtagccct gggacctcta
     1261 gtccagccct cccagccact ccaccagcca ccccgcccgc tgcctctcct agtgccctga
     1321 agggtgtgtc acaagcactg ctggagcgga taagagccaa ggaggtccag aagcagttgg
     1381 cacggatgac aaggtgccct gagaaggagc ttcggctgca gcggttagaa cgtttgccag
     1441 agctggcccg tgtgctgcgc ggtgtcttcg tgtctgagcg gaagccggcg ctcaccatgg
     1501 aagtggtctg tgcaaggatg gtagacagtt cccgagccgc cctgagccca ggggagatgg
     1561 agaaacacct gttgctcctg gccgagttgc tgccagactg gctcagcctg caccgcgttc
     1621 gcaccgatac ctacgtcaag ctggacaaag ccgctgacct ggctggcctc accgcgaagc
     1681 tggcccgcca ggtccacgcc gaggggctgt gactttgaat tccttgcctg atggcctgtt
     1741 ttctttcatc ggtagacaac gcacttaagc ttccctgtct gcatcacggg tccaaggagg
     1801 gcctgtcgcc cagtatgggc ggctacggtg cccatggatc tcaaagtgct gttgttgcag
     1861 gggttcctgg ggccttgggg taccccagac tcagctatag gggacgtaga ctctggagag
     1921 tagggaatgt tgaatgccct ttccacaaac tgctcaagta ctcatcaagg gccaggtgga
     1981 aggtgaggcc agcatagcct cggctctccg ggcttgggaa agctgcgaga gctcggagcc
     2041 ttaagagttg cacagaactt ggacctctgg cctgatttcg caggacggtg gtgatctgag
     2101 agtgaagttg gaccttctgt aaacatgtgg agtttggttt ctttttaaac cttctatact
     2161 tacacggccc tgcatgtgac tgctagtttt ggctttttaa taaagtcatg taagatttaa
     2221 ataaaatact actgagatt
//
