LOCUS       NP_001099662             556 aa            linear   ROD 20-MAR-2023
DEFINITION  DNA replication factor Cdt1 [Rattus norvegicus].
ACCESSION   NP_001099662 XP_001079374 XP_226545
VERSION     NP_001099662.1
DBSOURCE    REFSEQ: accession NM_001106192.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 556)
  AUTHORS   Franz A, Pirson PA, Pilger D, Halder S, Achuthankutty D, Kashkar H,
            Ramadan K and Hoppe T.
  TITLE     Chromatin-associated degradation is defined by UBXN-3/FAF1 to
            safeguard DNA replication fork progression
  JOURNAL   Nat Commun 7, 10612 (2016)
   PUBMED   26842564
  REMARK    Erratum:[Nat Commun. 2016 May 17;7:11593. PMID: 27186651]
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 556)
  AUTHORS   Mosammaparast N, Kim H, Laurent B, Zhao Y, Lim HJ, Majid MC, Dango
            S, Luo Y, Hempel K, Sowa ME, Gygi SP, Steen H, Harper JW, Yankner B
            and Shi Y.
  TITLE     The histone demethylase LSD1/KDM1A promotes the DNA damage response
  JOURNAL   J Cell Biol 203 (3), 457-470 (2013)
   PUBMED   24217620
REFERENCE   3  (residues 1 to 556)
  AUTHORS   Varma D, Chandrasekaran S, Sundin LJ, Reidy KT, Wan X, Chasse DA,
            Nevis KR, DeLuca JG, Salmon ED and Cook JG.
  TITLE     Recruitment of the human Cdt1 replication licensing protein by the
            loop domain of Hec1 is required for stable kinetochore-microtubule
            attachment
  JOURNAL   Nat Cell Biol 14 (6), 593-603 (2012)
   PUBMED   22581055
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 556)
  AUTHORS   Miotto B and Struhl K.
  TITLE     JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone
            acetylase and blocks replication licensing in response to stress
  JOURNAL   Mol Cell 44 (1), 62-71 (2011)
   PUBMED   21856198
REFERENCE   5  (residues 1 to 556)
  AUTHORS   Sugimoto N, Tatsumi Y, Tsurumi T, Matsukage A, Kiyono T, Nishitani
            H and Fujita M.
  TITLE     Cdt1 phosphorylation by cyclin A-dependent kinases negatively
            regulates its function without affecting geminin binding
  JOURNAL   J Biol Chem 279 (19), 19691-19697 (2004)
   PUBMED   14993212
REFERENCE   6  (residues 1 to 556)
  AUTHORS   Cook JG, Chasse DA and Nevins JR.
  TITLE     The regulated association of Cdt1 with minichromosome maintenance
            proteins and Cdc6 in mammalian cells
  JOURNAL   J Biol Chem 279 (10), 9625-9633 (2004)
   PUBMED   14672932
REFERENCE   7  (residues 1 to 556)
  AUTHORS   Yanagi K, Mizuno T, You Z and Hanaoka F.
  TITLE     Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a
            novel intrinsic Cdt1 DNA binding activity
  JOURNAL   J Biol Chem 277 (43), 40871-40880 (2002)
   PUBMED   12192004
REFERENCE   8  (residues 1 to 556)
  AUTHORS   Arentson E, Faloon P, Seo J, Moon E, Studts JM, Fremont DH and Choi
            K.
  TITLE     Oncogenic potential of the DNA replication licensing protein CDT1
  JOURNAL   Oncogene 21 (8), 1150-1158 (2002)
   PUBMED   11850834
REFERENCE   9  (residues 1 to 556)
  AUTHORS   Wohlschlegel JA, Dwyer BT, Dhar SK, Cvetic C, Walter JC and Dutta
            A.
  TITLE     Inhibition of eukaryotic DNA replication by geminin binding to Cdt1
  JOURNAL   Science 290 (5500), 2309-2312 (2000)
   PUBMED   11125146
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473972.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_226545.4, XP_001079374.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..556
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     Protein         1..556
                     /product="DNA replication factor Cdt1"
                     /note="retroviral integration site 2"
                     /calculated_mol_wt=61252
     Region          180..363
                     /region_name="Cdt1_m"
                     /note="The middle winged helix fold of replication
                     licensing factor Cdt1 binds geminin to inhibit binding of
                     the MCM complex to origins of replication and DNA;
                     cd08674"
                     /db_xref="CDD:176571"
     Site            order(180..182,184..185,188..191,194,210,240,298..300,303,
                     306,325,334,338..345)
                     /site_type="active"
                     /note="Cdt1-Geminin inhibitory interaction site [active]"
                     /db_xref="CDD:176571"
     Site            order(181..182,184..185,188..191,193,334,338..345,347)
                     /site_type="active"
                     /note="Cdt1-Geminin permissive interaction site [active]"
                     /db_xref="CDD:176571"
     Region          426..548
                     /region_name="Cdt1_c"
                     /note="The C-terminal fold of replication licensing factor
                     Cdt1 is essential for Cdt1 activity and directly interacts
                     with MCM2-7 helicase; cd08767"
                     /db_xref="CDD:176572"
     Site            order(440,444,480..481,485,507,511,515,522,524,527,545,
                     548)
                     /site_type="active"
                     /note="putative Cdt1-MCM complex binding site [active]"
                     /db_xref="CDD:176572"
     CDS             1..556
                     /gene="Cdt1"
                     /gene_synonym="Ris2"
                     /coded_by="NM_001106192.1:42..1712"
                     /db_xref="GeneID:292071"
                     /db_xref="RGD:1309211"
ORIGIN      
        1 maqsrvtdfy acrrpglaip rakstcltps pgglvapeft rsssrkrvrp haepgsdqpa
       61 pparrrlrlp gldscpsfpa dpsspadpss padpsssvcp spvcpspvkr tksttvsrgp
      121 qqskvpsqds iselqsclrq arklgaqara lrarvqenvv epstpdtkep teqpcvdkap
      181 ayqrfhalaq pglpglvlpy kyqvlaemfr smdtivsmlh nrsetvtfak vkqgvqemir
      241 krfeernmgq iktvypesys frqecnvptf kdsikrsdyq ltiepllgqe aggatqltat
      301 gllqrrqvfr qnlvervkeh hkvflaslnp pmtvpedqlt rwhprfnvde vpdiepaelp
      361 qppvtekltt aqevlararn lmtpkmekal snlalrsaep gspgtsspal patppatppa
      421 aspsalkgvs qallerirak evqkqlarmt rcpekelrlq rlerlpelar vlrgvfvser
      481 kpaltmevvc armvdssraa lspgemekhl lllaellpdw lslhrvrtdt yvkldkaadl
      541 agltaklarq vhaegl
//
