LOCUS       NM_001399511            2317 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus corneodesmosin (Cdsn), mRNA.
ACCESSION   NM_001399511 XM_039099154
VERSION     NM_001399511.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2317)
  AUTHORS   Valentin,F., Oji,V., Hausser,I., Liebau,E., Tarinski,T., Metze,D.,
            Breitkreutz,D., Traupe,H., Jonca,N. and Terheyden,P.
  TITLE     Increased expression of caspase-1 and interleukin-18 in peeling
            skin disease, and a novel mutation of corneodesmosin
  JOURNAL   Acta Derm Venereol 95 (8), 1019-1021 (2015)
   PUBMED   26014679
REFERENCE   2  (bases 1 to 2317)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   3  (bases 1 to 2317)
  AUTHORS   Broccardo,C.J., Mahaffey,S., Schwarz,J., Wruck,L., David,G.,
            Schlievert,P.M., Reisdorph,N.A. and Leung,D.Y.
  TITLE     Comparative proteomic profiling of patients with atopic dermatitis
            based on history of eczema herpeticum infection and Staphylococcus
            aureus colonization
  JOURNAL   J Allergy Clin Immunol 127 (1), 186-193 (2011)
   PUBMED   21211653
REFERENCE   4  (bases 1 to 2317)
  AUTHORS   Oji,V., Eckl,K.M., Aufenvenne,K., Natebus,M., Tarinski,T.,
            Ackermann,K., Seller,N., Metze,D., Nurnberg,G., Folster-Holst,R.,
            Schafer-Korting,M., Hausser,I., Traupe,H. and Hennies,H.C.
  TITLE     Loss of corneodesmosin leads to severe skin barrier defect,
            pruritus, and atopy: unraveling the peeling skin disease
  JOURNAL   Am J Hum Genet 87 (2), 274-281 (2010)
   PUBMED   20691404
REFERENCE   5  (bases 1 to 2317)
  AUTHORS   Caubet,C., Jonca,N., Lopez,F., Esteve,J.P., Simon,M. and Serre,G.
  TITLE     Homo-oligomerization of human corneodesmosin is mediated by its
            N-terminal glycine loop domain
  JOURNAL   J Invest Dermatol 122 (3), 747-754 (2004)
   PUBMED   15086562
REFERENCE   6  (bases 1 to 2317)
  AUTHORS   Levy-Nissenbaum,E., Betz,R.C., Frydman,M., Simon,M., Lahat,H.,
            Bakhan,T., Goldman,B., Bygum,A., Pierick,M., Hillmer,A.M.,
            Jonca,N., Toribio,J., Kruse,R., Dewald,G., Cichon,S., Kubisch,C.,
            Guerrin,M., Serre,G., Nothen,M.M. and Pras,E.
  TITLE     Hypotrichosis simplex of the scalp is associated with nonsense
            mutations in CDSN encoding corneodesmosin
  JOURNAL   Nat Genet 34 (2), 151-153 (2003)
   PUBMED   12754508
REFERENCE   7  (bases 1 to 2317)
  AUTHORS   Jonca,N., Guerrin,M., Hadjiolova,K., Caubet,C., Gallinaro,H.,
            Simon,M. and Serre,G.
  TITLE     Corneodesmosin, a component of epidermal corneocyte desmosomes,
            displays homophilic adhesive properties
  JOURNAL   J Biol Chem 277 (7), 5024-5029 (2002)
   PUBMED   11739386
REFERENCE   8  (bases 1 to 2317)
  AUTHORS   Simon,M., Jonca,N., Guerrin,M., Haftek,M., Bernard,D., Caubet,C.,
            Egelrud,T., Schmidt,R. and Serre,G.
  TITLE     Refined characterization of corneodesmosin proteolysis during
            terminal differentiation of human epidermis and its relationship to
            desquamation
  JOURNAL   J Biol Chem 276 (23), 20292-20299 (2001)
   PUBMED   11279026
  REMARK    Erratum:[J Biol Chem 2001 Dec 14;276(50):47742-3]
REFERENCE   9  (bases 1 to 2317)
  AUTHORS   Simon,M., Montezin,M., Guerrin,M., Durieux,J.J. and Serre,G.
  TITLE     Characterization and purification of human corneodesmosin, an
            epidermal basic glycoprotein associated with corneocyte-specific
            modified desmosomes
  JOURNAL   J Biol Chem 272 (50), 31770-31776 (1997)
   PUBMED   9395522
REFERENCE   10 (bases 1 to 2317)
  AUTHORS   Montezin,M., Simon,M., Guerrin,M. and Serre,G.
  TITLE     Corneodesmosin, a corneodesmosome-specific basic protein, is
            expressed in the cornified epithelia of the pig, guinea pig, rat,
            and mouse
  JOURNAL   Exp Cell Res 231 (1), 132-140 (1997)
   PUBMED   9056420
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Jan 10, 2022 this sequence version replaced XM_039099154.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.673579.1,
                                           SRR26643293.80897.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               JAXUCZ010000020.1  3188851-3188962     c
            113-2317            JAXUCZ010000020.1  3184142-3186346     c
FEATURES             Location/Qualifiers
     source          1..2317
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..2317
                     /gene="Cdsn"
                     /note="corneodesmosin"
                     /db_xref="GeneID:682408"
                     /db_xref="RGD:1598543"
     exon            1..112
                     /gene="Cdsn"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..1650
                     /gene="Cdsn"
                     /codon_start=1
                     /product="corneodesmosin precursor"
                     /protein_id="NP_001386440.1"
                     /db_xref="GeneID:682408"
                     /db_xref="RGD:1598543"
                     /translation="MGSSRAPRMGRVGGHGLMALLMAGFILPGTLAKSIGPFSDPCKD
                     PTRITSPNDPCLIGKTGSNSISSHGGTSSISSQGGSSSISSHGGTSSISSQGGSSSSQ
                     GSSSGSLIFKPGTGYSQSSYSFGSGGSQTGSSGSQTGSSGSQTGSSGYQSGNSGYQSG
                     SSGSQSGRWVSSSSQWVSSSSQSGSSGSSREGPGNGSALPTDDNSSRLTSGTVQSGGS
                     YTSKSSSSNQRPCSSNVPDSPCSGGPVITHSGPYISGSHTVSGGQRPVVVVVEQHGSG
                     GPGGFQGMPCSNGGPSGKPCPPITSVQKPYGGYEVVGGSADSYLVPGMTYSGGKIYPV
                     GYFTKDNPIRGSPGSPSFAAGPPISEGKYFSSNPIIPSRSSNAYPSGIVFQPVGSGGV
                     QPCGTGSIGSKGPCSGTRIQITSSGSSTSYHPCSGGASQGPCSSPGTNSISGGSSSVS
                     TGKIVLQPCGSKSSSSGYPCLSVPSSTLNGGLNGSPQPVPSVVLKPCGPNSPGRVPCR
                     SIRDILTQVKPLGPQLMDPQVFLPQGEPLDKS"
     exon            113..2317
                     /gene="Cdsn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcagtcagg aggccacacg gtgcacaatg ggttcctctc gggcacccag gatggggcgt
       61 gtgggagggc acgggctgat ggcattgctg atggccggtt tcatcctgcc aggaaccttg
      121 gctaagagca ttgggccctt ctcggacccc tgtaaggacc ccacgaggat cacctctccg
      181 aatgaccctt gtctcattgg aaagactggc tccaacagca tcagcagcca cggaggcaca
      241 agcagcatca gcagccaggg tggatccagc agcatcagca gccacggagg cacaagcagc
      301 atcagcagcc agggtggatc cagcagctcc cagggaagtt cttcaggatc cttgatattt
      361 aaaccaggga cagggtattc ccagagtagc tattcttttg gttctggcgg ctcccagaca
      421 ggaagcagcg gctctcagac aggaagcagt ggttctcaga caggaagcag cggctatcag
      481 tcaggaaaca gcggctatca gtcaggaagc agcggctctc agtcaggaag atgggtaagc
      541 agcagttctc aatgggtaag cagtagttct cagtccggaa gttcaggaag cagccgagag
      601 ggaccaggaa atggctctgc tctcccgacg gatgacaatt cttcccgcct gacatcaggc
      661 actgtccagt ctggaggctc gtatacttct aagagcagca gctccaacca gcggccttgt
      721 agctccaacg tgcccgactc tccctgcagc ggggggcctg tcatcacaca ctcagggccc
      781 tacatctccg gttcccacac cgtttcgggt ggccagagac ctgtagtggt ggtggtggag
      841 caacatggct ctggtggccc tggagggttt caaggcatgc cctgtagcaa tggcggcccc
      901 tcaggcaagc cctgccctcc catcacctct gtccagaaac cctatggcgg ctatgaggtg
      961 gtaggtggct ctgccgacag ttatctggtc cccggcatga cctacagtgg gggtaaaatt
     1021 taccccgtgg gctacttcac taaggacaac cctatcagag gctcgccagg gtccccctcc
     1081 tttgccgctg ggcccccaat ctctgagggc aagtacttct ctagcaatcc catcattccc
     1141 agccgcagct ccaatgccta cccatcgggc atagtgttcc agcccgtggg ctctggcggg
     1201 gtccagccct gtggcactgg ctcgatcggc tctaaggggc cttgctctgg tacgagaatt
     1261 cagatcacct ccagcggctc cagtacctcc taccacccct gcagtggtgg tgcctcccag
     1321 gggccctgct cctcaccggg caccaactct attagcgggg gaagctcttc cgtctccact
     1381 ggcaaaatcg tccttcagcc ctgcggcagc aaatctagct cttccggcta cccctgcctt
     1441 tctgttccct cctccacatt gaatgggggt ctgaatggct ctcctcagcc tgtcccctca
     1501 gtggttctca agccctgtgg ccccaacagc cctggaagag tgccgtgccg ttccatccgc
     1561 gacattctga cccaagtgaa gcctttgggg ccccagttaa tggatcccca agtctttctg
     1621 ccacagggcg agccacttga caagtcttaa gccgtgcgtg cgagctattt tccaattgcc
     1681 agccacctcc cgactggaag acgttcaggg gcccagtttc ccaccctcct cccgggaaag
     1741 ctgcctcacg tgctgcagtt agcccgatga tgctcttgac tgttttcggc actcgaaatg
     1801 gtggactcca tccttctcct cctcctcctc ctttcctggt gcttccacac cacgccactg
     1861 gggtgccctc tctgcccgat tacctgcctg gaaacgcact ttttcaagtc cttgactggg
     1921 aagtcctcga agcacacctc aaccttgggt gccgggataa gtcaaagcgt gcctctgccg
     1981 gtttgccgat taaggcaaaa tccaatcagt cacctgagaa ccaaagtgca tttctcagcg
     2041 acgcctcctc cagccctcat ctaaatcgtt gggttcccac catgcatcat gagtctcacc
     2101 gcgccctacc agacccattt ccaaaacaca cccgtgcctc cccctaccca gctctccatg
     2161 ccactttctg cctggttgcc acttcacccg aacgaagcac aggtgttgct gtatgtgtgc
     2221 gtgtgtgtac ccccggggca tccacagact ctggcacaga ttccccggct ctctctggac
     2281 ttggacaggg ctcaataaac gttgtgaact ttgtgca
//
