LOCUS       NM_053643               1567 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus CDP-diacylglycerol synthase 2 (Cds2), mRNA.
ACCESSION   NM_053643
VERSION     NM_053643.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1567)
  AUTHORS   Xu,Y., Mak,H.Y., Lukmantara,I., Li,Y.E., Hoehn,K.L., Huang,X.,
            Du,X. and Yang,H.
  TITLE     CDP-DAG synthase 1 and 2 regulate lipid droplet growth through
            distinct mechanisms
  JOURNAL   J Biol Chem 294 (45), 16740-16755 (2019)
   PUBMED   31548309
REFERENCE   2  (bases 1 to 1567)
  AUTHORS   Blunsom,N.J., Gomez-Espinosa,E., Ashlin,T.G. and Cockcroft,S.
  TITLE     Mitochondrial CDP-diacylglycerol synthase activity is due to the
            peripheral protein, TAMM41 and not due to the integral membrane
            protein, CDP-diacylglycerol synthase 1
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1863 (3), 284-298 (2018)
   PUBMED   29253589
REFERENCE   3  (bases 1 to 1567)
  AUTHORS   Qi,Y., Kapterian,T.S., Du,X., Ma,Q., Fei,W., Zhang,Y., Huang,X.,
            Dawes,I.W. and Yang,H.
  TITLE     CDP-diacylglycerol synthases regulate the growth of lipid droplets
            and adipocyte development
  JOURNAL   J Lipid Res 57 (5), 767-780 (2016)
   PUBMED   26946540
REFERENCE   4  (bases 1 to 1567)
  AUTHORS   D'Souza,K., Kim,Y.J., Balla,T. and Epand,R.M.
  TITLE     Distinct properties of the two isoforms of CDP-diacylglycerol
            synthase
  JOURNAL   Biochemistry 53 (47), 7358-7367 (2014)
   PUBMED   25375833
REFERENCE   5  (bases 1 to 1567)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 1567)
  AUTHORS   Inglis-Broadgate,S.L., Ocaka,L., Banerjee,R., Gaasenbeek,M.,
            Chapple,J.P., Cheetham,M.E., Clark,B.J., Hunt,D.M. and Halford,S.
  TITLE     Isolation and characterization of murine Cds (CDP-diacylglycerol
            synthase) 1 and 2
  JOURNAL   Gene 356, 19-31 (2005)
   PUBMED   16023307
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Dec 8, 2020 this sequence version replaced NM_053643.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB052898.1, SRR26643290.13341.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-170               JAXUCZ010000003.1  139967870-139968039
            171-307             JAXUCZ010000003.1  139993380-139993516
            308-404             JAXUCZ010000003.1  139994389-139994485
            405-502             JAXUCZ010000003.1  139995549-139995646
            503-642             JAXUCZ010000003.1  139997100-139997239
            643-701             JAXUCZ010000003.1  139997511-139997569
            702-784             JAXUCZ010000003.1  139998435-139998517
            785-872             JAXUCZ010000003.1  140000730-140000817
            873-941             JAXUCZ010000003.1  140001451-140001519
            942-1094            JAXUCZ010000003.1  140002286-140002438
            1095-1214           JAXUCZ010000003.1  140005472-140005591
            1215-1318           JAXUCZ010000003.1  140005890-140005993
            1319-1567           JAXUCZ010000003.1  140006211-140006459
FEATURES             Location/Qualifiers
     source          1..1567
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..1567
                     /gene="Cds2"
                     /note="CDP-diacylglycerol synthase 2"
                     /db_xref="GeneID:114101"
                     /db_xref="RGD:621186"
     exon            1..170
                     /gene="Cds2"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..1451
                     /gene="Cds2"
                     /EC_number="2.7.7.41"
                     /note="CDS 2; CDP-DAG synthase 2; CDP-DG synthetase 2;
                     CDP-diglyceride synthetase 2; CDP-diglyceride
                     pyrophosphorylase 2; CTP:phosphatidate
                     cytidylyltransferase 2; CDP-DG synthase 2; CDP-diglyceride
                     synthase 2; CDP-diacylglycerol synthase (phosphatidate
                     cytidylyltransferase) 2"
                     /codon_start=1
                     /product="phosphatidate cytidylyltransferase 2"
                     /protein_id="NP_446095.2"
                     /db_xref="GeneID:114101"
                     /db_xref="RGD:621186"
                     /translation="MTELRQRAVREDAPPEDKESESEAKLDGETASDSESRAETAPPP
                     TSIDDTPEVLNRALSNLSSRWKNWWVRGILTMAMIAFFFIIIYLGPMVLMMIVMCVQI
                     KCFHEIITIGYNVYHSYDLPWFRTLSWYFLLCVNYFFYGETVTDYFFTLVQREEPLRI
                     LSKYHRFISFTLYLTGFCMFVLSLVKKHYRLQFYMFGWTHVTLLIVVTQSHLVIHNLF
                     EGMIWFIVPISCVICNDIMAYMFGFFFGRTPLIKLSPKKTWEGFIGGFFATVVFGLLL
                     SYVMSGYRCFVCPVEYNNDTNSFTVDCEPSDLFRLQEYNIPGVIQSLVGWKTMRMYPF
                     QIHSIALSTFASLIGPFGGFFASGFKRAFKIKDFANTIPGHGGIMDRFDCQYLMATFV
                     NVYIASFIRGPNPSKLIQQFLTLRPDQQLHIFNTLKSHLTDKGILMSALEEE"
     exon            171..307
                     /gene="Cds2"
                     /inference="alignment:Splign:2.1.0"
     exon            308..404
                     /gene="Cds2"
                     /inference="alignment:Splign:2.1.0"
     exon            405..502
                     /gene="Cds2"
                     /inference="alignment:Splign:2.1.0"
     exon            503..642
                     /gene="Cds2"
                     /inference="alignment:Splign:2.1.0"
     exon            643..701
                     /gene="Cds2"
                     /inference="alignment:Splign:2.1.0"
     exon            702..784
                     /gene="Cds2"
                     /inference="alignment:Splign:2.1.0"
     exon            785..872
                     /gene="Cds2"
                     /inference="alignment:Splign:2.1.0"
     exon            873..941
                     /gene="Cds2"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1094
                     /gene="Cds2"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1214
                     /gene="Cds2"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1318
                     /gene="Cds2"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1567
                     /gene="Cds2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgaggcgcgg tggggctgcg aggtgctcgg gcccgccgag aggccgtgca cactgagccg
       61 acctccacag ccaccgcgct gctcactctg ggtgacgtcg cgcccgggtc cccagcatga
      121 ccgagctacg gcagagggct gtccgcgagg acgcacctcc ggaggacaag gaatcagagt
      181 cggaagcaaa gttagatgga gagaccgcat cagacagcga gagtcgagcg gaaacagctc
      241 ccccaccaac ctccatagat gataccccag aggtccttaa cagggccctt tccaacttgt
      301 cctcaagatg gaagaactgg tgggtgcgag gcatcctgac gatggccatg attgcatttt
      361 tcttcattat catttacctg ggaccaatgg ttttgatgat gattgttatg tgtgttcaga
      421 ttaagtgttt ccatgaaata atcactattg gctacaatgt ataccactcc tacgacttgc
      481 cctggttcag gaccctcagc tggtacttcc tcctgtgtgt gaactacttc ttctacgggg
      541 agacagtgac agactacttc ttcactctgg tccagagaga ggagcctttg cgcattctca
      601 gtaaatacca ccggttcatc tcctttaccc tgtatctaac aggattctgc atgtttgttc
      661 tgagtctggt taagaagcat tatcggctgc agttctacat gtttggctgg acccatgtga
      721 ccttgcttat tgtcgtaacg cagtcacatc ttgttatcca taacttgttt gaaggaatga
      781 tatggtttat tgttcccatt tcatgcgtca tctgcaatga tattatggcc tatatgtttg
      841 gctttttctt tggtcggacc ccactcatta agctctctcc aaagaagacc tgggaaggct
      901 tcattggggg cttctttgct actgtggtgt ttggccttct gctctcctac gtgatgtctg
      961 ggtaccgatg cttcgtctgt cctgtggaat acaacaatga caccaacagt ttcactgtgg
     1021 actgtgagcc atctgacctg ttccgcctgc aggagtacaa cattcccggg gtgatccagt
     1081 cgctcgttgg ctggaaaacc atgaggatgt accctttcca gatccacagc attgcgctct
     1141 ccaccttcgc ctcgctcatt ggcccatttg gagggttctt cgcaagtgga ttcaagcggg
     1201 cctttaaaat caaagatttt gccaacacca ttcctggtca tggaggcatc atggatcgct
     1261 ttgactgcca gtacctgatg gccacctttg tcaacgtgta catcgccagc tttatcaggg
     1321 gccccaaccc gagcaaactg attcagcagt ttctgacgtt gcggccggac cagcagcttc
     1381 acatcttcaa cacactcaag tctcacctga ctgacaaggg gattctgatg tctgccttgg
     1441 aagaggagta gtctacccag ggccaggaga gccagaatag gactagagtg aggggcaggt
     1501 caccaaggcc agcccagctg ctgtgactta gataatgaga agcttcaact caccgtcttt
     1561 ttttttt
//
