LOCUS       NM_031242               1972 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus CDP-diacylglycerol synthase 1 (Cds1), mRNA.
ACCESSION   NM_031242
VERSION     NM_031242.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1972)
  AUTHORS   Xu,Y., Mak,H.Y., Lukmantara,I., Li,Y.E., Hoehn,K.L., Huang,X.,
            Du,X. and Yang,H.
  TITLE     CDP-DAG synthase 1 and 2 regulate lipid droplet growth through
            distinct mechanisms
  JOURNAL   J Biol Chem 294 (45), 16740-16755 (2019)
   PUBMED   31548309
REFERENCE   2  (bases 1 to 1972)
  AUTHORS   Blunsom,N.J., Gomez-Espinosa,E., Ashlin,T.G. and Cockcroft,S.
  TITLE     Sustained phospholipase C stimulation of H9c2 cardiomyoblasts by
            vasopressin induces an increase in CDP-diacylglycerol synthase 1
            (CDS1) through protein kinase C and cFos
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1864 (7), 1072-1082
            (2019)
   PUBMED   30862571
  REMARK    GeneRIF: vasopressin stimulates CDS1 mRNA through phospholipase C,
            protein kinase C and cFos and provides a potential mechanism for
            maintenance of phosphatidylinositol levels during long-term
            phospholipase C signalling.
REFERENCE   3  (bases 1 to 1972)
  AUTHORS   Blunsom,N.J., Gomez-Espinosa,E., Ashlin,T.G. and Cockcroft,S.
  TITLE     Mitochondrial CDP-diacylglycerol synthase activity is due to the
            peripheral protein, TAMM41 and not due to the integral membrane
            protein, CDP-diacylglycerol synthase 1
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1863 (3), 284-298 (2018)
   PUBMED   29253589
  REMARK    GeneRIF: CDS activity present in mitochondria is mainly due to
            TAMM41, which is required for normal mitochondrial function.
REFERENCE   4  (bases 1 to 1972)
  AUTHORS   Qi,Y., Kapterian,T.S., Du,X., Ma,Q., Fei,W., Zhang,Y., Huang,X.,
            Dawes,I.W. and Yang,H.
  TITLE     CDP-diacylglycerol synthases regulate the growth of lipid droplets
            and adipocyte development
  JOURNAL   J Lipid Res 57 (5), 767-780 (2016)
   PUBMED   26946540
REFERENCE   5  (bases 1 to 1972)
  AUTHORS   D'Souza,K., Kim,Y.J., Balla,T. and Epand,R.M.
  TITLE     Distinct properties of the two isoforms of CDP-diacylglycerol
            synthase
  JOURNAL   Biochemistry 53 (47), 7358-7367 (2014)
   PUBMED   25375833
REFERENCE   6  (bases 1 to 1972)
  AUTHORS   Lykidis,A., Jackson,P.D., Rock,C.O. and Jackowski,S.
  TITLE     The role of CDP-diacylglycerol synthetase and phosphatidylinositol
            synthase activity levels in the regulation of cellular
            phosphatidylinositol content
  JOURNAL   J Biol Chem 272 (52), 33402-33409 (1997)
   PUBMED   9407135
REFERENCE   7  (bases 1 to 1972)
  AUTHORS   Monaco,M.E. and Feldman,M.
  TITLE     Extraction and stabilization of mammalian CDP-diacylglycerol
            synthase activity
  JOURNAL   Biochem Biophys Res Commun 239 (1), 166-170 (1997)
   PUBMED   9345289
REFERENCE   8  (bases 1 to 1972)
  AUTHORS   Saito,S., Goto,K., Tonosaki,A. and Kondo,H.
  TITLE     Gene cloning and characterization of CDP-diacylglycerol synthase
            from rat brain
  JOURNAL   J Biol Chem 272 (14), 9503-9509 (1997)
   PUBMED   9083091
REFERENCE   9  (bases 1 to 1972)
  AUTHORS   Heacock,A.M., Uhler,M.D. and Agranoff,B.W.
  TITLE     Cloning of CDP-diacylglycerol synthase from a human neuronal cell
            line
  JOURNAL   J Neurochem 67 (5), 2200-2203 (1996)
   PUBMED   8863531
REFERENCE   10 (bases 1 to 1972)
  AUTHORS   Ballas,L.M. and Bell,R.M.
  TITLE     Topography of glycerolipid synthetic enzymes. Synthesis of
            phosphatidylserine, phosphatidylinositol and glycerolipid
            intermediates occurs on the cytoplasmic surface of rat liver
            microsomal vesicles
  JOURNAL   Biochim Biophys Acta 665 (3), 586-595 (1981)
   PUBMED   6271231
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC127492.1.
            
            On Jun 10, 2007 this sequence version replaced NM_031242.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC127492.1, AB009999.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1972
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..1972
                     /gene="Cds1"
                     /note="CDP-diacylglycerol synthase 1"
                     /db_xref="GeneID:81925"
                     /db_xref="RGD:621185"
     exon            1..176
                     /gene="Cds1"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1445
                     /gene="Cds1"
                     /EC_number="2.7.7.41"
                     /note="CDS 1; CDP-DAG synthase 1; CDP-DG synthetase 1;
                     CDP-diglyceride synthetase 1; CDP-diglyceride
                     pyrophosphorylase 1; CTP:phosphatidate
                     cytidylyltransferase 1; CDP-DG synthase 1; CDP-diglyceride
                     synthase 1; CDP-diacylglycerol synthase (phosphatidate
                     cytidylyltransferase) 1"
                     /codon_start=1
                     /product="phosphatidate cytidylyltransferase 1"
                     /protein_id="NP_112521.2"
                     /db_xref="GeneID:81925"
                     /db_xref="RGD:621185"
                     /translation="MLELRHRGGCPGPGGAGTPPPREGEAAGGDHETESTSDKETDID
                     DRYGDLDARGDSDVPEVPPSSDRTPEILKKALSGLSSRWKNWWIRGILTLTMISLFFL
                     IIYMGSFMLMLLVLGIQVKCFQEIITIGYRVYHSYDLPWFRTLSWYFLLCVNYFFYGE
                     TVADYFATFVQREEQLQFLIRYHRFISFALYLAGFCMFVLSLVKKHYRLQFYMFAWTH
                     VTLLITVTQSHLVIQNLFEGMIWFLVPISSVICNDITAYLFGFFFGRTPLIKLSPKKT
                     WEGFIGGFFSTVIFGFIAAYVLSKYQYFVCPVEYRSDVNSFVTECEPSELFQLQNYSL
                     PPFLQAVLSRETVSLYPFQIHSIALSTFASLIGPFGGFFASGFKRAFKIKDFANTIPG
                     HGGIMDRFDCQYLMATFVHVYITSFIRGPNPSKVLQQLLVLQPEQQLNIYRTLKIHLT
                     EKGILQPTWKV"
     exon            177..304
                     /gene="Cds1"
                     /inference="alignment:Splign:2.1.0"
     exon            305..401
                     /gene="Cds1"
                     /inference="alignment:Splign:2.1.0"
     exon            402..499
                     /gene="Cds1"
                     /inference="alignment:Splign:2.1.0"
     exon            500..639
                     /gene="Cds1"
                     /inference="alignment:Splign:2.1.0"
     exon            640..698
                     /gene="Cds1"
                     /inference="alignment:Splign:2.1.0"
     exon            699..781
                     /gene="Cds1"
                     /inference="alignment:Splign:2.1.0"
     exon            782..869
                     /gene="Cds1"
                     /inference="alignment:Splign:2.1.0"
     exon            870..938
                     /gene="Cds1"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1091
                     /gene="Cds1"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1211
                     /gene="Cds1"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1315
                     /gene="Cds1"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1947
                     /gene="Cds1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcggctccg cggtggcggg gcgctagtcg acgccagccc agcgacgcga gagcgggaca
       61 tgctggagct gcggcaccgc gggggctgcc ccggccccgg gggagcgggg acgccgccac
      121 cccgcgaggg agaggcggcc ggcggcgacc acgaaaccga gagcaccagc gacaaagaaa
      181 cagatattga tgacaggtat ggagatctcg atgccagagg agattccgat gttcctgagg
      241 tcccaccatc ctcagacagg acccccgaga ttctcaagaa agccctgtct ggactgtcat
      301 caagatggaa gaactggtgg attcgtggga tcctcaccct gaccatgatc tccctcttct
      361 tcctgatcat ctatatgggg tccttcatgc tgatgcttct ggttctgggc atccaggtga
      421 agtgcttcca ggagatcata accatcgggt acagggtcta ccactcctac gacctcccgt
      481 ggtttagaac actaagttgg tacttcctcc tatgtgtgaa ctacttcttc tatggagaga
      541 cagtggcaga ttacttcgcc acgttcgttc agagggagga gcagctgcag ttcctcattc
      601 gctaccacag gttcatatcc ttcgccctct acctggcagg tttctgcatg ttcgtcctga
      661 gcttggtgaa gaaacactac cgactacagt tctatatgtt cgcatggact cacgtcactt
      721 tactgataac cgtcactcag tcacatcttg tcatccaaaa tctgtttgaa ggcatgatat
      781 ggttccttgt ccccatatca agcgtcatct gcaatgatat cacggcttac ctttttggat
      841 ttttttttgg aagaactcct ttaattaagc tgtctcctaa gaagacctgg gaaggattca
      901 ttggtggttt cttctccaca gtcatatttg gattcattgc tgcctatgtg ttgtccaagt
      961 atcagtactt tgtgtgcccg gtggagtacc gaagcgacgt caactccttc gtgacagaat
     1021 gtgagccctc agaactgttc cagcttcaga attactccct ccctccgttc ctacaggcag
     1081 tgctgagccg ggagaccgtg agcttgtacc ccttccagat acacagcatt gccctttcaa
     1141 catttgcatc actgatcggc ccattcggag gcttcttcgc cagtggattc aaaagagctt
     1201 tcaaaatcaa ggactttgca aacactattc ctgggcatgg agggataatg gacaggttcg
     1261 attgtcagta tttgatggcg acgttcgtgc acgtgtacat caccagcttc atcaggggtc
     1321 cgaatcccag caaagtgctc cagcagctcc tagtgcttca gccagagcag cagttaaaca
     1381 tctacagaac cctgaagata catctcacgg agaaaggcat cctgcagccc acctggaagg
     1441 tgtagctgtc ctgaggggac agactgctga ggaggaagga gctcacagag cagctccgac
     1501 tgaagtcttg cactgagcca gcctggggct agaaactcag tagatgcagg ttttgcagat
     1561 acgaatgttt ctctttctct gaaattactg tgaatattta acaaacacga gatctgagac
     1621 gagtgcgcat cagtcgccgc cgtgaaagat ccgtgctttt ctaagatgta ttttccaatg
     1681 ttaagttctc cgcccttact ggccgggctc catgatgtag gaggtttaaa gagtcaagca
     1741 ctgtcacctg aggctgaggc ccccttaggc tcgtgcctgg cagtgtgatc cttctcacaa
     1801 acactgacct ttgcactgac tgggagctgc ctctctgtgg ctggggatgc tcagcaggca
     1861 ccctgggaag cgaggcctag ggcttcctcc tctactgacc tcaggcattt ctgcaggctg
     1921 agttagatta aaaaagaaag aaaaagaaaa aaaaaaaaaa aaaaaaaaaa aa
//
