LOCUS       NP_112521                461 aa            linear   ROD 01-JUN-2024
DEFINITION  phosphatidate cytidylyltransferase 1 [Rattus norvegicus].
ACCESSION   NP_112521
VERSION     NP_112521.2
DBSOURCE    REFSEQ: accession NM_031242.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 461)
  AUTHORS   Xu,Y., Mak,H.Y., Lukmantara,I., Li,Y.E., Hoehn,K.L., Huang,X.,
            Du,X. and Yang,H.
  TITLE     CDP-DAG synthase 1 and 2 regulate lipid droplet growth through
            distinct mechanisms
  JOURNAL   J Biol Chem 294 (45), 16740-16755 (2019)
   PUBMED   31548309
REFERENCE   2  (residues 1 to 461)
  AUTHORS   Blunsom,N.J., Gomez-Espinosa,E., Ashlin,T.G. and Cockcroft,S.
  TITLE     Sustained phospholipase C stimulation of H9c2 cardiomyoblasts by
            vasopressin induces an increase in CDP-diacylglycerol synthase 1
            (CDS1) through protein kinase C and cFos
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1864 (7), 1072-1082
            (2019)
   PUBMED   30862571
  REMARK    GeneRIF: vasopressin stimulates CDS1 mRNA through phospholipase C,
            protein kinase C and cFos and provides a potential mechanism for
            maintenance of phosphatidylinositol levels during long-term
            phospholipase C signalling.
REFERENCE   3  (residues 1 to 461)
  AUTHORS   Blunsom,N.J., Gomez-Espinosa,E., Ashlin,T.G. and Cockcroft,S.
  TITLE     Mitochondrial CDP-diacylglycerol synthase activity is due to the
            peripheral protein, TAMM41 and not due to the integral membrane
            protein, CDP-diacylglycerol synthase 1
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1863 (3), 284-298 (2018)
   PUBMED   29253589
  REMARK    GeneRIF: CDS activity present in mitochondria is mainly due to
            TAMM41, which is required for normal mitochondrial function.
REFERENCE   4  (residues 1 to 461)
  AUTHORS   Qi,Y., Kapterian,T.S., Du,X., Ma,Q., Fei,W., Zhang,Y., Huang,X.,
            Dawes,I.W. and Yang,H.
  TITLE     CDP-diacylglycerol synthases regulate the growth of lipid droplets
            and adipocyte development
  JOURNAL   J Lipid Res 57 (5), 767-780 (2016)
   PUBMED   26946540
REFERENCE   5  (residues 1 to 461)
  AUTHORS   D'Souza,K., Kim,Y.J., Balla,T. and Epand,R.M.
  TITLE     Distinct properties of the two isoforms of CDP-diacylglycerol
            synthase
  JOURNAL   Biochemistry 53 (47), 7358-7367 (2014)
   PUBMED   25375833
REFERENCE   6  (residues 1 to 461)
  AUTHORS   Lykidis,A., Jackson,P.D., Rock,C.O. and Jackowski,S.
  TITLE     The role of CDP-diacylglycerol synthetase and phosphatidylinositol
            synthase activity levels in the regulation of cellular
            phosphatidylinositol content
  JOURNAL   J Biol Chem 272 (52), 33402-33409 (1997)
   PUBMED   9407135
REFERENCE   7  (residues 1 to 461)
  AUTHORS   Monaco,M.E. and Feldman,M.
  TITLE     Extraction and stabilization of mammalian CDP-diacylglycerol
            synthase activity
  JOURNAL   Biochem Biophys Res Commun 239 (1), 166-170 (1997)
   PUBMED   9345289
REFERENCE   8  (residues 1 to 461)
  AUTHORS   Saito,S., Goto,K., Tonosaki,A. and Kondo,H.
  TITLE     Gene cloning and characterization of CDP-diacylglycerol synthase
            from rat brain
  JOURNAL   J Biol Chem 272 (14), 9503-9509 (1997)
   PUBMED   9083091
REFERENCE   9  (residues 1 to 461)
  AUTHORS   Heacock,A.M., Uhler,M.D. and Agranoff,B.W.
  TITLE     Cloning of CDP-diacylglycerol synthase from a human neuronal cell
            line
  JOURNAL   J Neurochem 67 (5), 2200-2203 (1996)
   PUBMED   8863531
REFERENCE   10 (residues 1 to 461)
  AUTHORS   Ballas,L.M. and Bell,R.M.
  TITLE     Topography of glycerolipid synthetic enzymes. Synthesis of
            phosphatidylserine, phosphatidylinositol and glycerolipid
            intermediates occurs on the cytoplasmic surface of rat liver
            microsomal vesicles
  JOURNAL   Biochim Biophys Acta 665 (3), 586-595 (1981)
   PUBMED   6271231
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC127492.1.
            
            On Jun 10, 2007 this sequence version replaced NP_112521.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC127492.1, AB009999.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..461
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     Protein         1..461
                     /product="phosphatidate cytidylyltransferase 1"
                     /EC_number="2.7.7.41"
                     /note="CDS 1; CDP-DAG synthase 1; CDP-DG synthetase 1;
                     CDP-diglyceride synthetase 1; CDP-diglyceride
                     pyrophosphorylase 1; CTP:phosphatidate
                     cytidylyltransferase 1; CDP-DG synthase 1; CDP-diglyceride
                     synthase 1; CDP-diacylglycerol synthase (phosphatidate
                     cytidylyltransferase) 1"
                     /calculated_mol_wt=52839
     Region          1..68
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O35052.2)"
     Site            7
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:P98191; propagated from
                     UniProtKB/Swiss-Prot (O35052.2)"
     Site            35
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (O35052.2)"
     Site            37
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (O35052.2)"
     Site            96..116
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O35052.2)"
     Region          123..457
                     /region_name="CTP_transf_1"
                     /note="Cytidylyltransferase family; cl21502"
                     /db_xref="CDD:451277"
     Site            149..169
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O35052.2)"
     Site            183..203
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O35052.2)"
     Site            230..250
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O35052.2)"
     Site            279..299
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O35052.2)"
     Site            357..377
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O35052.2)"
     CDS             1..461
                     /gene="Cds1"
                     /coded_by="NM_031242.2:60..1445"
                     /db_xref="GeneID:81925"
                     /db_xref="RGD:621185"
ORIGIN      
        1 mlelrhrggc pgpggagtpp pregeaaggd hetestsdke tdiddrygdl dargdsdvpe
       61 vppssdrtpe ilkkalsgls srwknwwirg iltltmislf fliiymgsfm lmllvlgiqv
      121 kcfqeiitig yrvyhsydlp wfrtlswyfl lcvnyffyge tvadyfatfv qreeqlqfli
      181 ryhrfisfal ylagfcmfvl slvkkhyrlq fymfawthvt llitvtqshl viqnlfegmi
      241 wflvpissvi cnditaylfg fffgrtplik lspkktwegf iggffstvif gfiaayvlsk
      301 yqyfvcpvey rsdvnsfvte cepselfqlq nyslppflqa vlsretvsly pfqihsials
      361 tfasligpfg gffasgfkra fkikdfanti pghggimdrf dcqylmatfv hvyitsfirg
      421 pnpskvlqql lvlqpeqqln iyrtlkihlt ekgilqptwk v
//
