LOCUS       NM_017358               4572 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus cell adhesion associated, oncogene regulated
            (Cdon), mRNA.
ACCESSION   NM_017358
VERSION     NM_017358.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4572)
  AUTHORS   Kahn,B.M., Corman,T.S., Lovelace,K., Hong,M., Krauss,R.S. and
            Epstein,D.J.
  TITLE     Prenatal ethanol exposure in mice phenocopies Cdon mutation by
            impeding Shh function in the etiology of optic nerve hypoplasia
  JOURNAL   Dis Model Mech 10 (1), 29-37 (2017)
   PUBMED   27935818
REFERENCE   2  (bases 1 to 4572)
  AUTHORS   Bae,G.U., Domene,S., Roessler,E., Schachter,K., Kang,J.S.,
            Muenke,M. and Krauss,R.S.
  TITLE     Mutations in CDON, encoding a hedgehog receptor, result in
            holoprosencephaly and defective interactions with other hedgehog
            receptors
  JOURNAL   Am J Hum Genet 89 (2), 231-240 (2011)
   PUBMED   21802063
REFERENCE   3  (bases 1 to 4572)
  AUTHORS   Beachy,P.A., Hymowitz,S.G., Lazarus,R.A., Leahy,D.J. and Siebold,C.
  TITLE     Interactions between Hedgehog proteins and their binding partners
            come into view
  JOURNAL   Genes Dev 24 (18), 2001-2012 (2010)
   PUBMED   20844013
  REMARK    Review article
REFERENCE   4  (bases 1 to 4572)
  AUTHORS   Cuadrado,A. and Nebreda,A.R.
  TITLE     Mechanisms and functions of p38 MAPK signalling
  JOURNAL   Biochem J 429 (3), 403-417 (2010)
   PUBMED   20626350
  REMARK    Review article
REFERENCE   5  (bases 1 to 4572)
  AUTHORS   Lu,M. and Krauss,R.S.
  TITLE     N-cadherin ligation, but not Sonic hedgehog binding, initiates
            Cdo-dependent p38alpha/beta MAPK signaling in skeletal myoblasts
  JOURNAL   Proc Natl Acad Sci U S A 107 (9), 4212-4217 (2010)
   PUBMED   20160094
REFERENCE   6  (bases 1 to 4572)
  AUTHORS   Tenzen,T., Allen,B.L., Cole,F., Kang,J.S., Krauss,R.S. and
            McMahon,A.P.
  TITLE     The cell surface membrane proteins Cdo and Boc are components and
            targets of the Hedgehog signaling pathway and feedback network in
            mice
  JOURNAL   Dev Cell 10 (5), 647-656 (2006)
   PUBMED   16647304
REFERENCE   7  (bases 1 to 4572)
  AUTHORS   Zhang,W., Kang,J.S., Cole,F., Yi,M.J. and Krauss,R.S.
  TITLE     Cdo functions at multiple points in the Sonic Hedgehog pathway, and
            Cdo-deficient mice accurately model human holoprosencephaly
  JOURNAL   Dev Cell 10 (5), 657-665 (2006)
   PUBMED   16647303
REFERENCE   8  (bases 1 to 4572)
  AUTHORS   Cole,F., Zhang,W., Geyra,A., Kang,J.S. and Krauss,R.S.
  TITLE     Positive regulation of myogenic bHLH factors and skeletal muscle
            development by the cell surface receptor CDO
  JOURNAL   Dev Cell 7 (6), 843-854 (2004)
   PUBMED   15572127
REFERENCE   9  (bases 1 to 4572)
  AUTHORS   Kang,J.S., Yi,M.J., Zhang,W., Feinleib,J.L., Cole,F. and
            Krauss,R.S.
  TITLE     Netrins and neogenin promote myotube formation
  JOURNAL   J Cell Biol 167 (3), 493-504 (2004)
   PUBMED   15520228
  REMARK    Erratum:[J Cell Biol. 2023 Oct 2;222(10):e20040503909082023c. doi:
            10.1083/jcb.20040503909082023c. PMID: 37702713]
REFERENCE   10 (bases 1 to 4572)
  AUTHORS   Kang,J.S., Gao,M., Feinleib,J.L., Cotter,P.D., Guadagno,S.N. and
            Krauss,R.S.
  TITLE     CDO: an oncogene-, serum-, and anchorage-regulated member of the
            Ig/fibronectin type III repeat family
  JOURNAL   J Cell Biol 138 (1), 203-213 (1997)
   PUBMED   9214393
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            [WARNING] On Jul 19, 2024 this sequence was replaced by
            NM_017358.3.
            
            On Nov 26, 2020 this sequence version replaced NM_017358.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF004840.1, SRR26643429.29701.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               JAXUCZ010000008.1  42064002-42064103
            103-375             JAXUCZ010000008.1  42064550-42064822
            376-522             JAXUCZ010000008.1  42066253-42066399
            523-666             JAXUCZ010000008.1  42067227-42067370
            667-957             JAXUCZ010000008.1  42068370-42068660
            958-1227            JAXUCZ010000008.1  42069219-42069488
            1228-1581           JAXUCZ010000008.1  42074785-42075138
            1582-1871           JAXUCZ010000008.1  42080763-42081052
            1872-2046           JAXUCZ010000008.1  42081884-42082058
            2047-2178           JAXUCZ010000008.1  42084111-42084242
            2179-2382           JAXUCZ010000008.1  42088118-42088321
            2383-2564           JAXUCZ010000008.1  42089039-42089220
            2565-2670           JAXUCZ010000008.1  42089677-42089782
            2671-2793           JAXUCZ010000008.1  42094361-42094483
            2794-3015           JAXUCZ010000008.1  42097629-42097850
            3016-3296           JAXUCZ010000008.1  42099753-42100033
            3297-3376           JAXUCZ010000008.1  42102739-42102818
            3377-3636           JAXUCZ010000008.1  42115028-42115287
            3637-4572           JAXUCZ010000008.1  42115915-42116850
FEATURES             Location/Qualifiers
     source          1..4572
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q21"
     gene            1..4572
                     /gene="Cdon"
                     /gene_synonym="Cdo"
                     /note="cell adhesion associated, oncogene regulated"
                     /db_xref="GeneID:50938"
                     /db_xref="RGD:708433"
     exon            1..102
                     /gene="Cdon"
                     /gene_synonym="Cdo"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..3800
                     /gene="Cdon"
                     /gene_synonym="Cdo"
                     /note="immunoglobulin superfamily member; cell adhesion
                     molecule-related/down-regulated by oncogenes; Cdon
                     homolog"
                     /codon_start=1
                     /product="cell adhesion molecule-related/down-regulated by
                     oncogenes precursor"
                     /protein_id="NP_059054.2"
                     /db_xref="GeneID:50938"
                     /db_xref="RGD:708433"
                     /translation="MHPDLGPLWKLLYVLVILCSSVSSDLAPYFISEPLSAVQKLGRP
                     VVLHCSAKPVTARISWLHNGKRLDRNTEQIKIHRGTLTILSLNPSLSGCYQCVANNSV
                     GAVVSGPATVSAAALADFDSSTMHVITAEEKNTGFIGCRVPESNPKAEVRYKIRGKWL
                     MYSTGNYIILPSGNLQILNVSSKDKGSYKCAAYNPVTSELKVEPAGRKLLVSRPSSDG
                     FHILHPALSQALAVLPHSPVTLECVVSGVPASQVYWLKDGQDALSGSNWRRLYSHLAT
                     ASIDPADSGNYSCVVGNNRSGDVKHVTYTVNVLEHASISKGLHDQKVSLGATVRFTCE
                     VHGNPAPNRTWFHNAQPIRPSSRHLTEGSVLKITGVIMEDSGLYQCMADNGIGFMQST
                     GRLQIEQDSGQRPVIVTAPANVEVTDGDFVTLSCNATGEPVPVIHWYGRHGLITSHPS
                     QVLRSKSRKSHLFRPGDLDPEPVYLIMSQAGSSSLSIQAVTWEHAGKYTCEAVNKHGS
                     TQSEAFLTVVPFETNTKAEPVTPSEASQNDERDPRDGSESGLLNLFPVKVHSGGVELP
                     AEKNASVPDAPNILSPPQTHMPDTYTLVWRAGRDGGMPINAYFVKYRKLDDGSGAVGS
                     WHTVRVPGSESELHLTELEPSSLYEVLMVARSAVGEGQPAMLTFRTSKEKMASSKNTQ
                     ASFPPVGIPKRPVTSEASNSNFGVVLTDSSRHSGVPEAPDRPTISMASETSVYVTWIP
                     RANGGSPITAFKVEYKRMKSSDWLVAAEDIPPSKLSVEVRSLEPGSIYKFRVIAINHY
                     GESFRSSASRPYQVAGFPNRFSNRPITGPHIAYTEAVSDTQIMLKWTYIPSSNNNTPI
                     QGFYIYYRPTDSDNDSDYKRDVVEGSKQWHTIGHLQPETSYDIKMQCFNEGGESEFSN
                     VMICETKVKRVPGASEYPMKELSTPPSSSGNGGNVGPATSPARSSDMLYLIVGCVLGV
                     MVLILLVFIALCLWKSRQQSAIQKYDPPGYLYQGSEINGQMVEYTTLSGTARINGSVH
                     GGFLSKGSLSNGCSHLHHKGPNGVNGILNGTINGGLYSAHTSSLTRTCVEFEHPHHLV
                     NGGAVYTAVPQMDPLECINCRNCRNNNRCFTKTNSPLPVVPVVASYPQDGLEMKPLGV
                     MKFPVCPVSTVPDGGQIPEECLKDSVAPAPTQRTCRQDNTSDINSDSTEDTAEFNRGD
                     SSGHSEAEDKVFSWSPLILSPVLEDCSEKTAWSPPGPPLDGLSVVLQQAQET"
     exon            103..375
                     /gene="Cdon"
                     /gene_synonym="Cdo"
                     /inference="alignment:Splign:2.1.0"
     exon            376..522
                     /gene="Cdon"
                     /gene_synonym="Cdo"
                     /inference="alignment:Splign:2.1.0"
     exon            523..666
                     /gene="Cdon"
                     /gene_synonym="Cdo"
                     /inference="alignment:Splign:2.1.0"
     exon            667..957
                     /gene="Cdon"
                     /gene_synonym="Cdo"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1227
                     /gene="Cdon"
                     /gene_synonym="Cdo"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1581
                     /gene="Cdon"
                     /gene_synonym="Cdo"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1871
                     /gene="Cdon"
                     /gene_synonym="Cdo"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..2046
                     /gene="Cdon"
                     /gene_synonym="Cdo"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2178
                     /gene="Cdon"
                     /gene_synonym="Cdo"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2382
                     /gene="Cdon"
                     /gene_synonym="Cdo"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2564
                     /gene="Cdon"
                     /gene_synonym="Cdo"
                     /inference="alignment:Splign:2.1.0"
     exon            2565..2670
                     /gene="Cdon"
                     /gene_synonym="Cdo"
                     /inference="alignment:Splign:2.1.0"
     exon            2671..2793
                     /gene="Cdon"
                     /gene_synonym="Cdo"
                     /inference="alignment:Splign:2.1.0"
     exon            2794..3015
                     /gene="Cdon"
                     /gene_synonym="Cdo"
                     /inference="alignment:Splign:2.1.0"
     exon            3016..3296
                     /gene="Cdon"
                     /gene_synonym="Cdo"
                     /inference="alignment:Splign:2.1.0"
     exon            3297..3376
                     /gene="Cdon"
                     /gene_synonym="Cdo"
                     /inference="alignment:Splign:2.1.0"
     exon            3377..3636
                     /gene="Cdon"
                     /gene_synonym="Cdo"
                     /inference="alignment:Splign:2.1.0"
     exon            3637..4572
                     /gene="Cdon"
                     /gene_synonym="Cdo"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttcccagcct acttctgtaa ttgggcgata tgcatccaga cctcggaccc ttatggaaac
       61 tgctgtatgt tcttgtgatt ctgtgttctt ctgtgagctc agacttggca ccttatttta
      121 tttctgagcc actctctgct gtccagaagc ttggcagacc cgtggtccta cattgttctg
      181 ctaaacctgt tactgcccga atctcatggt tgcataatgg aaaacgattg gacagaaaca
      241 cagaacagat aaagatccac cgggggactt tgaccattct gtctctcaac ccttcccttt
      301 ctggttgcta ccagtgtgtg gccaacaaca gtgttggggc tgttgtcagt ggccctgcca
      361 cagtgtccgc tgcagccctg gctgatttcg attcatcaac aatgcatgtt attactgcag
      421 aagagaaaaa cacgggtttc attggctgca gggtacctga gagtaacccc aaagctgagg
      481 tgcgctacaa gatccgggga aagtggctga tgtattccac agggaactac ataatccttc
      541 cctcaggaaa tcttcagatt ttgaatgtat cctcgaagga taagggatcc tacaagtgtg
      601 ctgcctataa tcctgtcacc agtgaactga aagttgaacc cgctggccgg aagctccttg
      661 tgagtcgtcc ttcctcggat ggttttcaca ttcttcaccc tgctctttct caggcattag
      721 ctgtccttcc gcacagccct gttaccttgg agtgtgtagt gagtggggtc cccgcctcac
      781 aagtgtattg gctgaaggac gggcaggatg ctctgtcagg aagcaactgg agaaggctgt
      841 actctcacct ggccacagct agcatcgacc cagcggattc cgggaactat tcctgtgtgg
      901 tgggcaacaa caggtccgga gatgttaaac acgtcactta cacagtcaac gtactggagc
      961 acgcttcaat ttctaaaggg ctgcacgatc agaaggtgtc cctgggggcc accgtacgtt
     1021 ttacctgcga agttcacggg aacccagccc ccaaccgcac ctggtttcat aacgcacagc
     1081 ccatccgccc ctcctcacgg catctgacgg aaggaagtgt tctgaagatc accggggtca
     1141 tcatggagga ttctgggttg tatcagtgca tggcagacaa tgggattgga tttatgcaat
     1201 ctactggaag acttcaaatt gaacaagaca gtggacagag gcctgtcata gtcaccgccc
     1261 cagcaaacgt agaggtgacg gacggagact tcgtgacttt gtcttgcaat gccacaggag
     1321 agcctgtccc ggtcattcat tggtacggcc gccatggatt gataaccagc catccatctc
     1381 aggtccttag gtccaaatct cgaaagtccc acctcttccg acctggggac ctggacccgg
     1441 agcctgtcta cctcatcatg tcccaagcgg gctcgagctc tctgtccatc caggcagtga
     1501 cttgggagca tgctgggaaa tacacttgcg aagctgtgaa caaacatggc agcacacagt
     1561 cagaagcgtt cctcacagtc gttccttttg aaacaaacac aaaggcagag ccagtcacac
     1621 cctccgaagc ttctcagaac gatgaacgag acccacgaga cggttcagag tccggcttgc
     1681 tgaacttgtt tccagtgaag gtgcattccg gtggagtgga attgccagca gagaaaaatg
     1741 cctctgtccc cgatgctcct aacatactga gccccccaca gacccacatg ccagacacat
     1801 acaccctggt gtggagggcg gggagggatg gcggaatgcc catcaacgcc tatttcgtga
     1861 agtaccgaaa gctggacgac ggcagtggtg cggtaggcag ctggcacacg gttcgcgtcc
     1921 cagggagtga gagcgagctg catctaaccg aactggagcc ttcaagcctt tatgaagttt
     1981 tgatggtggc cagaagtgca gtcggcgaag gacagcctgc catgcttacc ttccggacca
     2041 gcaaagaaaa gatggcatca tcaaaaaaca cccaggcgtc ctttccacct gtgggcatcc
     2101 ctaagcggcc tgtaacttcg gaggcttcca acagcaattt tggagttgtg cttacggatt
     2161 cctctaggca tagtggagtc ccagaggcac cagatcgacc tactatctcg atggcatcgg
     2221 agacctcagt ctatgtcacc tggattcccc gtgcaaatgg cggctctccc atcactgcct
     2281 tcaaggtgga atataagcgg atgaaaagta gtgactggct ggtggctgct gaagacatcc
     2341 ctccttccaa actctctgtg gaagtccgga gtttagagcc aggttcgata tacaaattta
     2401 gggtcattgc tatcaaccat tacggtgaga gttttcggag ctcggcgtcc cgtccctacc
     2461 aggtggctgg cttcccaaat cgcttttcca atcgccccat aactggacct cacatcgcat
     2521 acacagaggc tgtcagcgat actcagatca tgctaaaatg gacgtatatt ccatcaagta
     2581 acaataacac tcccattcaa ggattctata tctattaccg gccaacagac agtgacaatg
     2641 acagtgatta caagagggat gttgtggaag gttcaaagca gtggcacacc attggtcacc
     2701 tgcagccaga gacctcctat gacattaaga tgcagtgctt taatgaagga ggagagagtg
     2761 agttcagcaa cgtgatgatc tgcgagacta aagtgaaacg agttcccgga gcatcggagt
     2821 atcccatgaa agagttgagc actcctccca gttcttcagg gaacggaggg aacgtggggc
     2881 ctgcaaccag ccctgccagg agcagcgaca tgctgtacct catcgtcggc tgtgtgcttg
     2941 gggttatggt cctcattctt ctggtcttca ttgcactgtg tctgtggaag agtcgccaac
     3001 agagcgccat acagaaatat gatcctccag gatatctcta ccaggggtca gagattaatg
     3061 ggcagatggt agagtatacc actctctcag gaacagcccg gatcaatggg agtgttcacg
     3121 gaggcttcct cagcaaaggc agtctcagca atggctgctc tcacctccac cacaaaggcc
     3181 ccaacggagt caatgggatc ctgaatggaa ccataaatgg ggggctttat tctgcacaca
     3241 ccagctccct aaccaggacg tgtgtggagt tcgaacatcc tcaccatcta gtgaacggtg
     3301 gagcagtgta cacggctgtc cctcagatgg acccactgga atgcattaat tgtcggaatt
     3361 gccggaacaa caataggtgt ttcaccaaaa ccaacagtcc ccttcctgtg gtcccagtgg
     3421 tagcctctta tcctcaggat ggactggaaa tgaagcccct cggtgtcatg aagttcccag
     3481 tgtgtccagt ttccacagtt cctgatggtg gccagatacc tgaggagtgc ctcaaggaca
     3541 gcgtggcacc agcacctacc cagcgtacat gccgccagga caacacaagc gacatcaatt
     3601 ctgattccac agaagacaca gcagagttca acagaggaga cagcagcggt cattcagaag
     3661 cagaggacaa agttttcagt tggagtcctc ttattttatc acctgtcttg gaggactgca
     3721 gtgagaagac agcgtggtct cctcctggcc cccctctaga cgggctgtca gtggtccttc
     3781 agcaagccca agagacctga gaggaatgtg agcaggcctc ccactgcaag ccagtaactg
     3841 caccacacag gcctggggac aaactgtgtg aaggacatta attcaaatca gagaaaacca
     3901 ttatttattt tttggtagta gtaatgtcat gaatgtatct taaaatgtgc gcccttttat
     3961 attatttatg ccttatgttt tcccttcccc atttcttcct ccccctattt ttttttaatg
     4021 cagagttttt ttaatcgtct ggagagcagg ggatcattct gtgtcttctg gggccttcag
     4081 ttggcaggct tccatcttct ggcctgttca gttgtgggga gaggattgcc cacgccattt
     4141 cacatttgtc accagtcgtt cctagatgga aaaactgtta cctctcccat gtcgtcagac
     4201 ttttgggaac atttaaaaat caaccatagt tgtgatcata tgtttataat agccaaccca
     4261 gctgacacac ttttgagtac cttccagaaa aatactaata ctgacttatt ttctctctgt
     4321 gcctgggtac aagtagcgat caatcttcta ggtatcaaat tagccagtgt tgttatgaac
     4381 acagaaacat gtaaagtctg tttggattat tgtattatat agaaagggaa ccagattcag
     4441 aaggaaaagt aatgccttca tggtccactg ctcctattat cttaatttac aaaatggcca
     4501 ccacgagttc ttcgcactac ttgcagaggt atataataaa tacaaaagta aggcctttaa
     4561 actgatagtt tg
//
