LOCUS       NM_052809               1457 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cysteine dioxygenase type 1 (Cdo1), mRNA.
ACCESSION   NM_052809
VERSION     NM_052809.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1457)
  AUTHORS   Davies,C.G., Fellner,M., Tchesnokov,E.P., Wilbanks,S.M. and
            Jameson,G.N.
  TITLE     The Cys-Tyr cross-link of cysteine dioxygenase changes the optimal
            pH of the reaction without a structural change
  JOURNAL   Biochemistry 53 (50), 7961-7968 (2014)
   PUBMED   25390690
  REMARK    GeneRIF: A pH-dependent kinetic study shows that both cross-linked
            and un-cross-linked CDO are active but the optimal pH decreases
            with the presence of the cross-link.
REFERENCE   2  (bases 1 to 1457)
  AUTHORS   Njeri,C.W. and Ellis,H.R.
  TITLE     Shifting redox states of the iron center partitions CDO between
            crosslink formation or cysteine oxidation
  JOURNAL   Arch Biochem Biophys 558, 61-69 (2014)
   PUBMED   24929188
  REMARK    GeneRIF: redox switch commits CDO towards either formation of the
            Cys93-Tyr157 crosslink or oxidation of the cysteine substrate
REFERENCE   3  (bases 1 to 1457)
  AUTHORS   Souness,R.J., Kleffmann,T., Tchesnokov,E.P., Wilbanks,S.M.,
            Jameson,G.B. and Jameson,G.N.
  TITLE     Mechanistic implications of persulfenate and persulfide binding in
            the active site of cysteine dioxygenase
  JOURNAL   Biochemistry 52 (43), 7606-7617 (2013)
   PUBMED   24084026
  REMARK    GeneRIF: Data suggest that biocatalysis by cysteine dioxygenase
            (CDO1) involves formation of persulfides of both cysteine and
            3-mercaptopropionic acid under reducing conditions; these
            persulfides are stabilized by iron in active site of CDO1.
REFERENCE   4  (bases 1 to 1457)
  AUTHORS   Tchesnokov,E.P., Wilbanks,S.M. and Jameson,G.N.
  TITLE     A strongly bound high-spin iron(II) coordinates cysteine and
            homocysteine in cysteine dioxygenase
  JOURNAL   Biochemistry 51 (1), 257-264 (2012)
   PUBMED   22122511
  REMARK    GeneRIF: Iron dissociation from the CDO active site exhibits an
            extremely slow dissociation rate constant, illustrating the
            stability of the resting state CDO; dioxygenase activity is
            directly proportional to the concentration of iron.
REFERENCE   5  (bases 1 to 1457)
  AUTHORS   Siakkou,E., Rutledge,M.T., Wilbanks,S.M. and Jameson,G.N.
  TITLE     Correlating crosslink formation with enzymatic activity in cysteine
            dioxygenase
  JOURNAL   Biochim Biophys Acta 1814 (12), 2003-2009 (2011)
   PUBMED   21839860
  REMARK    GeneRIF: Correlating crosslink formation with enzymatic activity in
            cysteine dioxygenase.
REFERENCE   6  (bases 1 to 1457)
  AUTHORS   Hosokawa,Y., Matsumoto,A., Oka,J., Itakura,H. and Yamaguchi,K.
  TITLE     Isolation and characterization of a cDNA for rat liver cysteine
            dioxygenase
  JOURNAL   Biochem Biophys Res Commun 168 (2), 473-478 (1990)
   PUBMED   2334417
REFERENCE   7  (bases 1 to 1457)
  AUTHORS   Kuriyama,K., Ida,S. and Ohkuma,S.
  TITLE     Alteration of cerebral taurine biosynthesis in spontaneously
            hypertensive rats
  JOURNAL   J Neurochem 42 (6), 1600-1606 (1984)
   PUBMED   6726227
REFERENCE   8  (bases 1 to 1457)
  AUTHORS   Kuo,S.M. and Stipanuk,M.H.
  TITLE     Changes in cysteine dioxygenase and cysteinesulfinate decarboxylase
            activities and taurine levels in tissues of pregnant or lactating
            rat dams and their fetuses or pups
  JOURNAL   Biol Neonate 46 (5), 237-248 (1984)
   PUBMED   6509133
REFERENCE   9  (bases 1 to 1457)
  AUTHORS   Hosokawa,Y., Yamaguchi,K., Kohashi,N., Kori,Y., Fujii,O. and
            Ueda,I.
  TITLE     Immaturity of the enzyme activity and the response to inducers of
            rat liver cysteine dioxygenase during development
  JOURNAL   J Biochem 88 (2), 389-394 (1980)
   PUBMED   7419499
REFERENCE   10 (bases 1 to 1457)
  AUTHORS   Hosokawa,Y., Yamaguchi,K., Kohashi,N., Kori,Y. and Ueda,I.
  TITLE     Decrease of rat liver cysteine dioxygenase (cysteine oxidase)
            activity mediated by glucagon
  JOURNAL   J Biochem 84 (2), 419-424 (1978)
   PUBMED   212416
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Nov 26, 2020 this sequence version replaced NM_052809.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M35266.1, BC070509.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676785, SAMN16676787
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-359               JAXUCZ010000018.1  41633361-41633719   c
            360-437             JAXUCZ010000018.1  41629099-41629176   c
            438-592             JAXUCZ010000018.1  41626390-41626544   c
            593-762             JAXUCZ010000018.1  41621219-41621388   c
            763-1457            JAXUCZ010000018.1  41619076-41619770   c
FEATURES             Location/Qualifiers
     source          1..1457
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..1457
                     /gene="Cdo1"
                     /note="cysteine dioxygenase type 1"
                     /db_xref="GeneID:81718"
                     /db_xref="RGD:69262"
     exon            1..359
                     /gene="Cdo1"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..792
                     /gene="Cdo1"
                     /EC_number="1.13.11.20"
                     /note="cytosolic cysteine dioxygenase 1; cysteine
                     dioxygenase, type I; CDO; CDO-I; cysteine dioxygenase 1,
                     cytosolic"
                     /codon_start=1
                     /product="cysteine dioxygenase type 1"
                     /protein_id="NP_434696.1"
                     /db_xref="GeneID:81718"
                     /db_xref="RGD:69262"
                     /translation="MERTELLKPRTLADLIRILHELFAGDEVNVEEVQAVLEAYESNP
                     AEWALYAKFDQYRYTRNLVDQGNGKFNLMILCWGEGHGSSIHDHTDSHCFLKLLQGNL
                     KETLFDWPDKKSNEMIKKSERTLRENQCAYINDSIGLHRVENVSHTEPAVSLHLYSPP
                     FDTCHAFDQRTGHKNKVTMTFHSKFGIRTPFTTSGSLENN"
     exon            360..437
                     /gene="Cdo1"
                     /inference="alignment:Splign:2.1.0"
     exon            438..592
                     /gene="Cdo1"
                     /inference="alignment:Splign:2.1.0"
     exon            593..762
                     /gene="Cdo1"
                     /inference="alignment:Splign:2.1.0"
     exon            763..1457
                     /gene="Cdo1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagggtttag gctggtctcc ggtgacctcc tagtcctaaa tcttgatacc cttgcaagag
       61 ctttgagcgt gtggggtccc gggcgttcgg ggtcccgggt gtgtgcggtt tgtatagcct
      121 gaagccgggg tcctccgcgc tcgcgtcctc cgcagctgga ctgaagagac gcgtcccagc
      181 cctgcgggga tggaacggac cgagctgctg aagccccgga ccctggccga cctcatccga
      241 atcttgcatg agctcttcgc cggggacgaa gtcaatgtgg aggaggtgca ggctgtgctg
      301 gaagcctacg agagcaatcc tgccgagtgg gctttgtatg ccaaattcga tcaatacagg
      361 tatactcgaa accttgtgga tcaaggaaat gggaagttta atctgatgat tctgtgctgg
      421 ggtgaagggc atggcagcag tattcacgat cacacggact cccactgctt tttgaagctg
      481 ctgcaaggaa atctaaagga gacattgttt gactggcctg acaagaaatc caacgagatg
      541 atcaagaagt ctgaaagaac tttgagggaa aatcagtgtg cctacattaa tgattctatt
      601 ggcttacatc gagtagagaa cgtcagccac acagagcctg ctgtgagcct tcacttgtac
      661 agtccacctt tcgatacatg ccatgccttt gaccaacgaa cagggcataa aaacaaagtc
      721 accatgacat tccacagcaa atttggaatc agaactccat ttacaacttc aggttcactg
      781 gagaacaact aagacctgcc aagcctttca aagttttgct tctgggtcgt tggaatgttt
      841 taccttggat aagagaggcc acccatcatt tgctgtccag ttatacattt taataagtcc
      901 atgctcagtg tgtatactaa ggaagcaaac catcccctga gctatgcagg agaaaaatcc
      961 cactaaagaa aaagtcactt gatttttaat agccaaatca ccttgctccc agttcttctg
     1021 tcttctaact ccatggaaat tctattggga gttctcagtg gggttttttt tcaaccttag
     1081 gaaacacttc tggtctctga actctaataa tcaataagta aaaatgaaga aaccacaagc
     1141 tatcacatgt ctgttttcat acctggaagt ctaagtgtgg aaatctttaa tttactttgt
     1201 atgttcttaa tgtttgacaa gaattttttt aaatcttggt tttcagtttt ttcaaccctg
     1261 tttgacaaat tcctatgctg tggagactag ggatgcagat agcagtttgg tgtttggtag
     1321 tgaacagcag tggggccaga aatgtgcatg tatccagacc tcctgcaaat aaaaactgaa
     1381 actcatgtgt aatgtgtgcc accaccttaa gctgccacca aaattgccaa acgactttaa
     1441 taaaactgga tttgaga
//
