LOCUS       NM_001037543             624 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus cerebral dopamine neurotrophic factor (Cdnf),
            mRNA.
ACCESSION   NM_001037543 XM_341561
VERSION     NM_001037543.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 624)
  AUTHORS   Stepanova,P., Srinivasan,V., Lindholm,D. and Voutilainen,M.H.
  TITLE     Cerebral dopamine neurotrophic factor (CDNF) protects against
            quinolinic acid-induced toxicity in in vitro and in vivo models of
            Huntington's disease
  JOURNAL   Sci Rep 10 (1), 19045 (2020)
   PUBMED   33154393
  REMARK    GeneRIF: Cerebral dopamine neurotrophic factor (CDNF) protects
            against quinolinic acid-induced toxicity in in vitro and in vivo
            models of Huntington's disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 624)
  AUTHORS   Wang,L., Wang,Z., Xu,X., Zhu,R., Bi,J., Liu,W., Feng,X., Wu,H.,
            Zhang,H., Wu,J., Kong,W., Yu,B. and Yu,X.
  TITLE     Recombinant AAV8-mediated intrastriatal gene delivery of CDNF
            protects rats against methamphetamine neurotoxicity
  JOURNAL   Int J Med Sci 14 (4), 340-347 (2017)
   PUBMED   28553166
  REMARK    GeneRIF: Results demonstrated that CDNF overexpression in the brain
            could attenuate the METH-induced dopamine and tyrosine hydroxylase
            loss in the striatum but could not lower METH-induced hyperthermia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 624)
  AUTHORS   Liu,H., Zhao,C., Zhong,L., Liu,J., Zhang,S., Cheng,B. and Gong,L.
  TITLE     Key subdomains in the C-terminal of cerebral dopamine neurotrophic
            factor regulate the protein secretion
  JOURNAL   Biochem Biophys Res Commun 465 (3), 427-432 (2015)
   PUBMED   26271594
  REMARK    GeneRIF: In all, these findings suggest that helix-7 in the
            C-terminal is important for CDNF secretion, which maybe potential
            affect CDNF function in ER stress.
REFERENCE   4  (bases 1 to 624)
  AUTHORS   Cheng,L., Zhao,H., Zhang,W., Liu,B., Liu,Y., Guo,Y. and Nie,L.
  TITLE     Overexpression of conserved dopamine neurotrophic factor (CDNF) in
            astrocytes alleviates endoplasmic reticulum stress-induced cell
            damage and inflammatory cytokine secretion
  JOURNAL   Biochem Biophys Res Commun 435 (1), 34-39 (2013)
   PUBMED   23624196
  REMARK    GeneRIF: Data show that overexpression of conserved dopamine
            neurotrophic factor (CDNF) in astrocytes alleviated cell damage and
            proinflammatory cytokine secretion, which may represent a promising
            strategy for neuroprotection in the central nervous system (CNS).
REFERENCE   5  (bases 1 to 624)
  AUTHORS   Sun,Z.P., Gong,L., Huang,S.H., Geng,Z., Cheng,L. and Chen,Z.Y.
  TITLE     Intracellular trafficking and secretion of cerebral dopamine
            neurotrophic factor in neurosecretory cells
  JOURNAL   J Neurochem 117 (1), 121-132 (2011)
   PUBMED   21235575
  REMARK    GeneRIF: Disruption of the helix-1 domain of cerebral dopamine
            neurotrophic factor significantly reduces its secretion in
            endoplasmic reticulum.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Dec 1, 2005 this sequence version replaced XM_341561.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ128463.1, FQ121633.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               JAXUCZ010000017.1  79637626-79637800   c
            176-303             JAXUCZ010000017.1  79628695-79628822   c
            304-445             JAXUCZ010000017.1  79626994-79627135   c
            446-624             JAXUCZ010000017.1  79623728-79623906   c
FEATURES             Location/Qualifiers
     source          1..624
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.3"
     gene            1..624
                     /gene="Cdnf"
                     /gene_synonym="Armetl1"
                     /note="cerebral dopamine neurotrophic factor"
                     /db_xref="GeneID:361276"
                     /db_xref="RGD:1307600"
     exon            1..175
                     /gene="Cdnf"
                     /gene_synonym="Armetl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..624
                     /gene="Cdnf"
                     /gene_synonym="Armetl1"
                     /note="ARMET-like protein 1; conserved dopamine
                     neurotrophic factor; arginine-rich protein mutated in
                     early stage tumors-like 1; arginine-rich, mutated in early
                     stage tumors-like 1"
                     /codon_start=1
                     /product="cerebral dopamine neurotrophic factor precursor"
                     /protein_id="NP_001032632.1"
                     /db_xref="GeneID:361276"
                     /db_xref="RGD:1307600"
                     /translation="MRCTSPAALVTFCAGLWISNHVLAQGLEAGVRSRADCEVCKEFL
                     NRFYNSLLTRGIDFSVDTIEEELISFCADTKGKENRLCYYLGATKDSATKILGEVTRP
                     MSVHMPTVKICEKLKKMDSQICELKYEKKLDLESVDLWKMRVAELKQILHSWGEECRA
                     CAEKHDYVNLIKELAPKYVETRPQTEL"
     exon            176..303
                     /gene="Cdnf"
                     /gene_synonym="Armetl1"
                     /inference="alignment:Splign:2.1.0"
     exon            304..445
                     /gene="Cdnf"
                     /gene_synonym="Armetl1"
                     /inference="alignment:Splign:2.1.0"
     exon            446..624
                     /gene="Cdnf"
                     /gene_synonym="Armetl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caagaggcaa cctccgctac tgtaagcaag gtgtgggaag ttcccggtcc caggctcagc
       61 atgcggtgca ccagtccggc tgccctggtg actttttgcg ccgggctttg gatctccaac
      121 catgtgctgg cacagggcct ggaggccggt gtgcgatcga gggctgactg tgaagtatgc
      181 aaagagttct taaaccgatt ctacaactcc ttgctaacca gaggaataga cttttctgtg
      241 gataccatag aggaagagct gatcagcttt tgcgcggaca ccaagggaaa agaaaaccgc
      301 ctgtgctatt atctaggagc taccaaagac tcggccacca agatcctagg tgaagtcact
      361 cgtcccatga gtgtacacat gcccacggtg aagatttgtg agaagctgaa gaagatggac
      421 agccagatct gcgagctgaa atatgagaag aaattggact tggaatctgt ggacctgtgg
      481 aaaatgaggg ttgcagagct gaagcagatc cttcacagct ggggggaaga gtgcagggcc
      541 tgcgcggaga agcatgacta cgtgaacctc attaaagaac tggcccccaa atacgtagag
      601 acgcgccccc aaacagagct ctga
//
