LOCUS       NM_001401040             797 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus cyclin-dependent kinase inhibitor 3 (Cdkn3),
            transcript variant 1, mRNA.
ACCESSION   NM_001401040 XM_006251791
VERSION     NM_001401040.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 797)
  AUTHORS   Dai,W., Miao,H., Fang,S., Fang,T., Chen,N. and Li,M.
  TITLE     CDKN3 expression is negatively associated with pathological tumor
            stage and CDKN3 inhibition promotes cell survival in hepatocellular
            carcinoma
  JOURNAL   Mol Med Rep 14 (2), 1509-1514 (2016)
   PUBMED   27314282
REFERENCE   2  (bases 1 to 797)
  AUTHORS   Lin,W.R., Lai,M.W. and Yeh,C.T.
  TITLE     Cyclin-dependent kinase-associated protein phosphatase is
            overexpressed in alcohol-related hepatocellular carcinoma and
            influences xenograft tumor growth
  JOURNAL   Oncol Rep 29 (3), 903-910 (2013)
   PUBMED   23292002
REFERENCE   3  (bases 1 to 797)
  AUTHORS   Xing,C., Xie,H., Zhou,L., Zhou,W., Zhang,W., Ding,S., Wei,B.,
            Yu,X., Su,R. and Zheng,S.
  TITLE     Cyclin-dependent kinase inhibitor 3 is overexpressed in
            hepatocellular carcinoma and promotes tumor cell proliferation
  JOURNAL   Biochem Biophys Res Commun 420 (1), 29-35 (2012)
   PUBMED   22390936
REFERENCE   4  (bases 1 to 797)
  AUTHORS   Yeh,C.T., Lu,S.C., Chao,C.H. and Chao,M.L.
  TITLE     Abolishment of the interaction between cyclin-dependent kinase 2
            and Cdk-associated protein phosphatase by a truncated KAP mutant
  JOURNAL   Biochem Biophys Res Commun 305 (2), 311-314 (2003)
   PUBMED   12745075
REFERENCE   5  (bases 1 to 797)
  AUTHORS   Lee,S.W., Reimer,C.L., Fang,L., Iruela-Arispe,M.L. and
            Aaronson,S.A.
  TITLE     Overexpression of kinase-associated phosphatase (KAP) in breast and
            prostate cancer and inhibition of the transformed phenotype by
            antisense KAP expression
  JOURNAL   Mol Cell Biol 20 (5), 1723-1732 (2000)
   PUBMED   10669749
REFERENCE   6  (bases 1 to 797)
  AUTHORS   Gyuris,J., Golemis,E., Chertkov,H. and Brent,R.
  TITLE     Cdi1, a human G1 and S phase protein phosphatase that associates
            with Cdk2
  JOURNAL   Cell 75 (4), 791-803 (1993)
   PUBMED   8242750
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Feb 1, 2022 this sequence version replaced XM_006251791.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC167026.1, BQ201635.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                JAXUCZ010000015.1  22502398-22502455
            59-141              JAXUCZ010000015.1  22504457-22504539
            142-197             JAXUCZ010000015.1  22506380-22506435
            198-242             JAXUCZ010000015.1  22506857-22506901
            243-465             JAXUCZ010000015.1  22509350-22509572
            466-497             JAXUCZ010000015.1  22511060-22511091
            498-601             JAXUCZ010000015.1  22511975-22512078
            602-797             JAXUCZ010000015.1  22513530-22513725
FEATURES             Location/Qualifiers
     source          1..797
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p14"
     gene            1..797
                     /gene="Cdkn3"
                     /note="cyclin-dependent kinase inhibitor 3"
                     /db_xref="GeneID:289993"
                     /db_xref="RGD:1307781"
     exon            1..58
                     /gene="Cdkn3"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..688
                     /gene="Cdkn3"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     kinase-associated phosphatase; CDK2-associated
                     dual-specificity phosphatase"
                     /codon_start=1
                     /product="cyclin-dependent kinase inhibitor 3 isoform 1"
                     /protein_id="NP_001387969.1"
                     /db_xref="GeneID:289993"
                     /db_xref="RGD:1307781"
                     /translation="MKPPISIQASEFDSSDEEPADDEQTPIQISWLPLSRVNCSQFLG
                     LCALPGCKFKDVRRNIQKDTEELKSSGIQDVFVFCTRGELSKYRVPNLLDLYQQYGIV
                     THHHPIPDGGTPDIGSCWEIMEELATCLKNNRKTLIHCYGGLGRSCLVAACLLLYLSD
                     SISPQQAIDSLRDVRGSGAIQTIKQYNYLHEFRDKLAAYLSSRDSLSRSVSR"
     exon            59..141
                     /gene="Cdkn3"
                     /inference="alignment:Splign:2.1.0"
     exon            142..197
                     /gene="Cdkn3"
                     /inference="alignment:Splign:2.1.0"
     exon            198..242
                     /gene="Cdkn3"
                     /inference="alignment:Splign:2.1.0"
     exon            243..465
                     /gene="Cdkn3"
                     /inference="alignment:Splign:2.1.0"
     exon            466..497
                     /gene="Cdkn3"
                     /inference="alignment:Splign:2.1.0"
     exon            498..601
                     /gene="Cdkn3"
                     /inference="alignment:Splign:2.1.0"
     exon            602..797
                     /gene="Cdkn3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggatgctgt gagggcggcg gcactggtta ctgcgtgtgg cggcccgcga tgaagccgcc
       61 catttcaata caagcaagcg agtttgattc ttcagacgaa gagcctgctg acgacgagca
      121 gactccaatt caaatttcat ggctacctct gtcacgagtg aattgttctc agtttctcgg
      181 tttatgtgct cttccaggtt gtaaatttaa agatgttaga agaaacattc aaaaagatac
      241 agaggaacta aagagctctg ggatccaaga cgtatttgtt ttctgcacca gaggggaact
      301 gtcaaaatat agagtcccaa accttctgga cctctaccaa caatatggaa ttgtcaccca
      361 tcatcatccg atcccagatg gagggactcc cgacattggc agctgctggg aaatcatgga
      421 ggagctggcc acctgcctta aaaacaaccg aaaaaccctg atacactgtt atggaggact
      481 tggaagatct tgtcttgtag ctgcttgtct cctcctatac ttgtctgact caatttcacc
      541 acagcaagcc atagacagcc ttcgagatgt caggggatct ggggcgatac agaccatcaa
      601 gcaatataac tatcttcatg aattccggga caagttagct gcctatctgt catcaagaga
      661 ttcactgtca agatccgtgt ccagataagg aagagcccag acacgcagcc gcagctgaag
      721 ttccaagttc tctagcgtaa tctgtattgg agtgctactg ccatcctgaa cataaatgtt
      781 atgtgcagac ttctaaa
//
