LOCUS       NM_131902               1433 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cyclin-dependent kinase inhibitor 2C (Cdkn2c),
            mRNA.
ACCESSION   NM_131902
VERSION     NM_131902.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1433)
  AUTHORS   Pei,X.H., Bai,F., Smith,M.D. and Xiong,Y.
  TITLE     p18Ink4c collaborates with Men1 to constrain lung stem cell
            expansion and suppress non-small-cell lung cancers
  JOURNAL   Cancer Res 67 (7), 3162-3170 (2007)
   PUBMED   17409423
REFERENCE   2  (bases 1 to 1433)
  AUTHORS   Tokumoto,Y.M., Apperly,J.A., Gao,F.B. and Raff,M.C.
  TITLE     Posttranscriptional regulation of p18 and p27 Cdk inhibitor
            proteins and the timing of oligodendrocyte differentiation
  JOURNAL   Dev Biol 245 (1), 224-234 (2002)
   PUBMED   11969268
  REMARK    GeneRIF: posttranscriptional regulation
REFERENCE   3  (bases 1 to 1433)
  AUTHORS   Korshunov,A. and Golanov,A.
  TITLE     Immunohistochemical analysis of p18INK4C and p14ARF protein
            expression in 117 oligodendrogliomas: correlation with tumor grade
            and clinical outcome
  JOURNAL   Arch Pathol Lab Med 126 (1), 42-48 (2002)
   PUBMED   11800646
REFERENCE   4  (bases 1 to 1433)
  AUTHORS   Sherr,C.J.
  TITLE     The Pezcoller lecture: cancer cell cycles revisited
  JOURNAL   Cancer Res 60 (14), 3689-3695 (2000)
   PUBMED   10919634
  REMARK    Review article
REFERENCE   5  (bases 1 to 1433)
  AUTHORS   Schreiber,M., Muller,W.J., Singh,G. and Graham,F.L.
  TITLE     Comparison of the effectiveness of adenovirus vectors expressing
            cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D,
            p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis
            and inhibition of tumorigenicity
  JOURNAL   Oncogene 18 (9), 1663-1676 (1999)
   PUBMED   10208428
REFERENCE   6  (bases 1 to 1433)
  AUTHORS   Hirai,H., Roussel,M.F., Kato,J.Y., Ashmun,R.A. and Sherr,C.J.
  TITLE     Novel INK4 proteins, p19 and p18, are specific inhibitors of the
            cyclin D-dependent kinases CDK4 and CDK6
  JOURNAL   Mol Cell Biol 15 (5), 2672-2681 (1995)
   PUBMED   7739547
REFERENCE   7  (bases 1 to 1433)
  AUTHORS   Guan,K.L., Jenkins,C.W., Li,Y., Nichols,M.A., Wu,X., O'Keefe,C.L.,
            Matera,A.G. and Xiong,Y.
  TITLE     Growth suppression by p18, a p16INK4/MTS1- and
            p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb
            function
  JOURNAL   Genes Dev 8 (24), 2939-2952 (1994)
   PUBMED   8001816
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            [WARNING] On Apr 24, 2024 this sequence was replaced by
            NM_131902.5.
            
            On Mar 26, 2021 this sequence version replaced NM_131902.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088864.1, AF474981.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN16676808,
                                           SAMN16676810 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-521               JAXUCZ010000005.1  129644371-129644891 c
            522-661             JAXUCZ010000005.1  129643779-129643918 c
            662-1433            JAXUCZ010000005.1  129639736-129640507 c
FEATURES             Location/Qualifiers
     source          1..1433
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q35"
     gene            1..1433
                     /gene="Cdkn2c"
                     /gene_synonym="p18"
                     /note="cyclin-dependent kinase inhibitor 2C"
                     /db_xref="GeneID:54238"
                     /db_xref="RGD:2325"
     exon            1..521
                     /gene="Cdkn2c"
                     /gene_synonym="p18"
                     /inference="alignment:Splign:2.1.0"
     exon            522..661
                     /gene="Cdkn2c"
                     /gene_synonym="p18"
                     /inference="alignment:Splign:2.1.0"
     CDS             533..1039
                     /gene="Cdkn2c"
                     /gene_synonym="p18"
                     /note="cyclin-dependent kinase inhibitor 2C (p18, inhibits
                     CDK4)"
                     /codon_start=1
                     /product="cyclin-dependent kinase 4 inhibitor C"
                     /protein_id="NP_571977.1"
                     /db_xref="GeneID:54238"
                     /db_xref="RGD:2325"
                     /translation="MAEPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQV
                     MKLGNPEIARRLLLRGANPNLKDRTGFAVIHDAARAGFLDTVQALLEFQADVNIEDNE
                     GNLPLHLAAKEGHLPVVEFLMKHTACNVGHRNHKGDTAFDLARFYGRNEVISLMEANG
                     VGGATSLQ"
     exon            662..1433
                     /gene="Cdkn2c"
                     /gene_synonym="p18"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgtaggcg ggaagttact ggtgagctgg ccgggtgcag gcgcgatgct accgcgagct
       61 gccccagcgg ctggagcccc atagacgctt ccctcttcgc cctacacggt ccccaggctg
      121 ccgggagtcc cgggacccgg cggggccggc atgacgggct tggcgggggt ctgccgcaca
      181 cccaccagcc tccggagacc cgcgccctgc cgggctccca cggcctctga ggctcggcgg
      241 ggctgcggca gcccggccgg cgggctccgg aggctcttct gaagacgccg agcccgcttg
      301 ggagtcgttg agacctgaga gttgagggct tcagaactgc tgctctggtc tgccttcggc
      361 aatcatcttt aaccctcccg agcacgtcag catccagcca gcgcggcgct ttgctagcga
      421 gccgcactct ggactacccc cttctgcgag acggatggaa agtgagccct gcggaggacc
      481 tgactctgaa attctgcctc aagtcaccac tgtgaacaag ggaccctaaa gaatggccga
      541 gccttggggg aacgagttgg cgtccgcagc tgccaggggg gacctagagc aacttactag
      601 tttgttgcaa aataatgtaa acgtcaacgc tcaaaatgga tttgggagaa ctgcgctgca
      661 ggttatgaaa cttgggaatc cggagattgc caggagactt ctcctcagag gtgctaatcc
      721 caatttgaaa gaccgaactg gttttgctgt cattcacgat gctgccagag caggtttcct
      781 ggacactgta caggctttgc tggagttcca agctgatgtt aacatcgaag ataatgaagg
      841 gaacctgccc ttgcacttgg ctgccaaaga aggccacctc cctgtggtgg agttcctaat
      901 gaagcacaca gcctgcaatg tggggcatcg gaaccataag ggggacaccg ccttcgactt
      961 ggccaggttc tatggaagaa atgaggtcat cagcctgatg gaggcgaatg gggttggggg
     1021 agccacgagc ctgcagtgag tgtggtggtc ttttccaccc accgccttct ctttgtccct
     1081 tagttggctg gctgtcctgt tttactatca cttattaaaa tatagggttt cgttttgctt
     1141 tgttttcata ttttaagcag ctagtcaaat ccttcaaaac tgcctaagtg gaaatcttac
     1201 tacaagttta tgaaatattt aaacatcttt ttcactgtca aaattctgat ttctaacatg
     1261 taattgcata tggctatctg tgcctttctt ctggatattt tatctttgat tttttttttc
     1321 tttccttgct taccctttgc cattctcaat gtctgacttg gagactttgt tttaaaaatt
     1381 atttgtcctg atgcatcttt tgcctaatta aaacacattt tttcataaga gga
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