LOCUS       NM_130812               2326 bp    mRNA    linear   ROD 16-FEB-2024
DEFINITION  Rattus norvegicus cyclin-dependent kinase inhibitor 2B (Cdkn2b),
            mRNA.
ACCESSION   NM_130812
VERSION     NM_130812.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2326)
  AUTHORS   Okazaki,Y., Misawa,N., Akatsuka,S., Kohyama,N., Sekido,Y.,
            Takahashi,T. and Toyokuni,S.
  TITLE     Frequent homozygous deletion of Cdkn2a/2b in tremolite-induced
            malignant mesothelioma in rats
  JOURNAL   Cancer Sci 111 (4), 1180-1192 (2020)
   PUBMED   32080953
  REMARK    GeneRIF: the loss of Cdkn2a/2b, which are the most frequently lost
            foci in human MM, were observed in 8 cases of rat MM (homozygous
            deletion [5/8] and loss of heterozygosity [3/8]) by array-based
            comparative genomic hybridization techniques.
REFERENCE   2  (bases 1 to 2326)
  AUTHORS   Wang,F. and Zhang,L.
  TITLE     p15(INK4b) regulates cell cycle signaling in hippocampal astrocytes
            of aged rats
  JOURNAL   Aging Clin Exp Res 28 (5), 813-821 (2016)
   PUBMED   26526028
REFERENCE   3  (bases 1 to 2326)
  AUTHORS   Hong,Q., Li,Y., Chen,X., Ye,H., Tang,L., Zhou,A., Hu,Y., Gao,Y.,
            Chen,R., Xia,Y. and Duan,S.
  TITLE     CDKN2B, SLC19A3 and DLEC1 promoter methylation alterations in the
            bone marrow of patients with acute myeloid leukemia during
            chemotherapy
  JOURNAL   Exp Ther Med 11 (5), 1901-1907 (2016)
   PUBMED   27168825
REFERENCE   4  (bases 1 to 2326)
  AUTHORS   Yu,C. and Wang,W.
  TITLE     Relationship Between P15 Gene Mutation and Formation and Metastasis
            of Malignant Osteosarcoma
  JOURNAL   Med Sci Monit 22, 656-661 (2016)
   PUBMED   26921270
  REMARK    GeneRIF: The P15 gene mutation was significantly correlated with
            osteosarcoma formation and metastasis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2326)
  AUTHORS   Zhang,L., Ruan,M., Liu,X.M., Zhang,J.Y., Guo,Y., Yang,W.Y., Liu,F.,
            Liu,T.F., Wang,S.C., Chen,X.J., Zou,Y., Chen,Y.M. and Zhu,X.F.
  TITLE     [Methylation of the genes in the 9P21 region in children with acute
            myeloid leukemia]
  JOURNAL   Zhongguo Dang Dai Er Ke Za Zhi 17 (1), 6-10 (2015)
   PUBMED   25616284
REFERENCE   6  (bases 1 to 2326)
  AUTHORS   Tsubari,M., Tiihonen,E. and Laiho,M.
  TITLE     Cloning and characterization of p10, an alternatively spliced form
            of p15 cyclin-dependent kinase inhibitor
  JOURNAL   Cancer Res 57 (14), 2966-2973 (1997)
   PUBMED   9230210
REFERENCE   7  (bases 1 to 2326)
  AUTHORS   Schwaller,J., Pabst,T., Koeffler,H.P., Niklaus,G., Loetscher,P.,
            Fey,M.F. and Tobler,A.
  TITLE     Expression and regulation of G1 cell-cycle inhibitors (p16INK4A,
            p15INK4B, p18INK4C, p19INK4D) in human acute myeloid leukemia and
            normal myeloid cells
  JOURNAL   Leukemia 11 (1), 54-63 (1997)
   PUBMED   9001419
REFERENCE   8  (bases 1 to 2326)
  AUTHORS   Hino,O., Kobayashi,E., Hirayama,Y., Kobayashi,T., Kubo,Y.,
            Tsuchiya,H., Kikuchi,Y. and Mitani,H.
  TITLE     Molecular genetic basis of renal carcinogenesis in the Eker rat
            model of tuberous sclerosis (Tsc2)
  JOURNAL   Mol Carcinog 14 (1), 23-27 (1995)
   PUBMED   7546221
REFERENCE   9  (bases 1 to 2326)
  AUTHORS   Knapek,D.F., Serrano,M., Beach,D., Trono,D. and Walker,C.L.
  TITLE     Association of rat p15INK4B/p16INK4 deletions with monosomy 5 in
            kidney epithelial cell lines but not primary renal tumors
  JOURNAL   Cancer Res 55 (8), 1607-1612 (1995)
   PUBMED   7712460
REFERENCE   10 (bases 1 to 2326)
  AUTHORS   Hannon,G.J. and Beach,D.
  TITLE     p15INK4B is a potential effector of TGF-beta-induced cell cycle
            arrest
  JOURNAL   Nature 371 (6494), 257-261 (1994)
   PUBMED   8078588
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000162.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_130812.5.
            
            On Feb 10, 2021 this sequence version replaced NM_130812.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB584075.1, AF474979.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-317               JACYVU010000162.1  18568033-18568349   c
            318-2326            JACYVU010000162.1  18562662-18564670   c
FEATURES             Location/Qualifiers
     source          1..2326
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q32"
     gene            1..2326
                     /gene="Cdkn2b"
                     /gene_synonym="p15"
                     /note="cyclin-dependent kinase inhibitor 2B"
                     /db_xref="GeneID:25164"
                     /db_xref="RGD:2324"
     exon            1..317
                     /gene="Cdkn2b"
                     /gene_synonym="p15"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..578
                     /gene="Cdkn2b"
                     /gene_synonym="p15"
                     /note="Cyclin dependent kinase inhibitor 2B (p15, inhibits
                     CDK4); cyclin-dependent kinase inhibitor 2B (p15, inhibits
                     CDK4); p14-INK4b; p15-INK4b"
                     /codon_start=1
                     /product="cyclin-dependent kinase 4 inhibitor B"
                     /protein_id="NP_570825.1"
                     /db_xref="GeneID:25164"
                     /db_xref="RGD:2324"
                     /translation="MLGGGSDAGLATAAARGQVETVRQLLEAGADPNAVNRFGRRPIQ
                     VMMMGSAQVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLMVLHKAGARLDVCD
                     AWGRLPVDLAEEQGHRDIARYLHAATGD"
     exon            318..2326
                     /gene="Cdkn2b"
                     /gene_synonym="p15"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctccccacc cggcacaagt cagctgtgcc tgaggtgcgg ttcccaggcg ctagggctcg
       61 agcgtttccc cggacgctca ccacagctgc tgggtcccca gagaggagga gcggctcaga
      121 gacgaggctg taacaatctc aaggccggcg gaggaccatt tctgccacgg accggggaca
      181 agggcatgtt gggcggcggc agtgacgcgg gcctggccac cgccgcggcg cggggacagg
      241 tggagacggt gcggcagctc ctggaagccg gcgcagatcc caacgccgtc aaccgcttcg
      301 ggaggcgccc gatccaggtc atgatgatgg gcagcgccca ggtggcagag ctgttgctcc
      361 tccacggagc agaacccaac tgcgccgatc ctgccaccct caccagacct gtgcatgatg
      421 cagctcgaga gggcttcctg gacacgctaa tggtgctgca caaggcaggg gcacggctgg
      481 atgtgtgtga cgcctggggc cgcctgccgg tagacttagc tgaagagcag ggccaccgtg
      541 atattgcgag gtatctgcac gctgccactg gagattgatt gcagggtccc tcagcctcct
      601 gcaaggacca tttttttttc tccccagccc tatctaggaa gactgtaaac gtggagagga
      661 tcagcagcgc acagcctgct ggccttccag aaccccaccc tacccaggaa ggcaaagcca
      721 atcagaaata acttcctaag tgttttctga agcttggtct ggcccttgat cctcaccctg
      781 aagccagggg atcaccaagg agatttagta ttgtatgaag ttctgggacc ctctatcttt
      841 caggacatgg tgtaaaatag caagggaaat tcttgaatct ccacaagaag ctgctgcttc
      901 ggggaattga gaaagcttga cattggctgg gagcagtcag taccttcccc tgtgaactga
      961 aaatgcagaa gatccacagg ctagagggaa aacctggaga gtagatgtga ggcactgaag
     1021 tgggtttatg cactgtcctg tgtggtgatt cacctgcaaa atgacatgta tagaaaccaa
     1081 ggagtcacct gcacctctac aaggaaaata gtgaaattga agacaacaga tctctgctaa
     1141 acggtgaccc agttcccttg aggcctgggt cctgacagac tctacatgca caatgtccaa
     1201 tgatgaattg tagtgtatag cagtttgctc tatgcaaaat agtttaataa cccctttaga
     1261 aatttcctac atttgagttg ctctttagta actgtattta atgaggaaaa cttttaactg
     1321 tgtgtgtaac tgctcttcag aggtgagact gaagggcaac ttgtttttgt ggttggttgg
     1381 ttagttggtt ggtcttttcc tcttttcttc cttttctagg cagtgttttc cttttcaagg
     1441 tagtccctca agtccagcta ccactgcctt agtctcctta agtactggcc tgatagcctg
     1501 catccttctg aaatacagct tctcatgaaa ctatgacagt ctgcacactc ctagtggcaa
     1561 agagcacttt gcttttatct ttaagctgtt tacttctctg ttcattgttt ctgtacagtg
     1621 tctcggggag ctattctagg tgtcctgtta gatggctggt gtgtttatct agtcagttac
     1681 cttgggctac gtcccaaagt ttactaaaaa ggaaattgag tatgaactaa ctgaaatcaa
     1741 atgatgactc atgggctgta ttgctgtcta ctgaacaatt gtggatgcac tctggggggc
     1801 tccagtgtgg cttggttcat tttgcattga aacaattgat atatcattat tttaataaag
     1861 aataaacatt tccaagatgt ggaaatgttg gtactaaagc atatttccag gctggctcat
     1921 aaccacctat aactccagtt tcaaggagga tcaaaacctc tgcctctaga gaaacctgca
     1981 ttcttgattc ttgtgcatat acatccctaa cacacacaca cacacacaca cacacacaca
     2041 cacacacaca cacacacaat tattaaaaaa aacaaaaaca aaaaaagtgg agcctgaaga
     2101 gatttccatg gttgttaaga gcctttgctg ttcttcagag ttcagttccc agcaatcgta
     2161 acaggtccag gatattatga cctctgcagg cacccataca tggcatacac tcatattttc
     2221 acacaaataa tttaaaagta ttttcatgca tctaacacta actcccaaat gttaaaagat
     2281 tcaaaagtat tcactgcttg tcctttttaa taaatataaa tctata
//
