LOCUS       NM_031550                706 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cyclin-dependent kinase inhibitor 2A (Cdkn2a),
            mRNA.
ACCESSION   NM_031550 XM_346744
VERSION     NM_031550.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 706)
  AUTHORS   Bartkowiak,E., Piwowarczyk,K., Bodnar,M., Kosikowski,P., Chou,J.,
            Wozniak,A. and Wierzbicka,M.
  TITLE     Expression of p16Ink4a protein in pleomorphic adenoma and carcinoma
            ex pleomorphic adenoma proves diversity of tumour biology and
            predicts clinical course
  JOURNAL   J Clin Pathol 75 (9), 605-611 (2022)
   PUBMED   33941588
  REMARK    GeneRIF: Expression of p16(Ink4a) protein in pleomorphic adenoma
            and carcinoma ex pleomorphic adenoma proves diversity of tumour
            biology and predicts clinical course.
REFERENCE   2  (bases 1 to 706)
  AUTHORS   Teramoto,N., Ikeda,M., Sugihara,H., Shiga,T., Matsuwaki,T.,
            Nishihara,M., Uchida,K. and Yamanouchi,K.
  TITLE     Loss of p16/Ink4a drives high frequency of rhabdomyosarcoma in a
            rat model of Duchenne muscular dystrophy
  JOURNAL   J Vet Med Sci 83 (9), 1416-1424 (2021)
   PUBMED   34334511
  REMARK    GeneRIF: Loss of p16/Ink4a drives high frequency of
            rhabdomyosarcoma in a rat model of Duchenne muscular dystrophy.
REFERENCE   3  (bases 1 to 706)
  AUTHORS   Yoo,K.H., Yim,H.E. and Bae,E.S.
  TITLE     Angiotensin inhibition and cellular senescence in the developing
            rat kidney
  JOURNAL   Exp Mol Pathol 117, 104551 (2020)
   PUBMED   33010296
  REMARK    GeneRIF: Angiotensin inhibition and cellular senescence in the
            developing rat kidney.
REFERENCE   4  (bases 1 to 706)
  AUTHORS   Okazaki,Y., Misawa,N., Akatsuka,S., Kohyama,N., Sekido,Y.,
            Takahashi,T. and Toyokuni,S.
  TITLE     Frequent homozygous deletion of Cdkn2a/2b in tremolite-induced
            malignant mesothelioma in rats
  JOURNAL   Cancer Sci 111 (4), 1180-1192 (2020)
   PUBMED   32080953
  REMARK    GeneRIF: the loss of Cdkn2a/2b, which are the most frequently lost
            foci in human MM, were observed in 8 cases of rat MM (homozygous
            deletion [5/8] and loss of heterozygosity [3/8]) by array-based
            comparative genomic hybridization techniques.
REFERENCE   5  (bases 1 to 706)
  AUTHORS   Altun,E., Yazici,H., Arslan,E., Tulaci,K.G. and Erken,H.A.
  TITLE     The Impact of Type II Diabetes on Tongue Dysplasia and p16-Related
            Aging Process: An Experimental Study
  JOURNAL   Anal Cell Pathol (Amst) 2019, 3563215 (2019)
   PUBMED   31687322
  REMARK    GeneRIF: streptozotocin-induced experimental diabetes mellitus
            induced p16 expression but did not show any difference in p53,
            Bcl-2, and Ki67 levels.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 706)
  AUTHORS   Herman,J.G., Jen,J., Merlo,A. and Baylin,S.B.
  TITLE     Hypermethylation-associated inactivation indicates a tumor
            suppressor role for p15INK4B
  JOURNAL   Cancer Res 56 (4), 722-727 (1996)
   PUBMED   8631003
REFERENCE   7  (bases 1 to 706)
  AUTHORS   Quelle,D.E., Ashmun,R.A., Hannon,G.J., Rehberger,P.A., Trono,D.,
            Richter,K.H., Walker,C., Beach,D., Sherr,C.J. and Serrano,M.
  TITLE     Cloning and characterization of murine p16INK4a and p15INK4b genes
  JOURNAL   Oncogene 11 (4), 635-645 (1995)
   PUBMED   7651726
REFERENCE   8  (bases 1 to 706)
  AUTHORS   Medema,R.H., Herrera,R.E., Lam,F. and Weinberg,R.A.
  TITLE     Growth suppression by p16ink4 requires functional retinoblastoma
            protein
  JOURNAL   Proc Natl Acad Sci U S A 92 (14), 6289-6293 (1995)
   PUBMED   7603984
REFERENCE   9  (bases 1 to 706)
  AUTHORS   Hirai,H., Roussel,M.F., Kato,J.Y., Ashmun,R.A. and Sherr,C.J.
  TITLE     Novel INK4 proteins, p19 and p18, are specific inhibitors of the
            cyclin D-dependent kinases CDK4 and CDK6
  JOURNAL   Mol Cell Biol 15 (5), 2672-2681 (1995)
   PUBMED   7739547
REFERENCE   10 (bases 1 to 706)
  AUTHORS   Serrano,M., Hannon,G.J. and Beach,D.
  TITLE     A new regulatory motif in cell-cycle control causing specific
            inhibition of cyclin D/CDK4
  JOURNAL   Nature 366 (6456), 704-707 (1993)
   PUBMED   8259215
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 27, 2020 this sequence version replaced NM_031550.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L81167.1, AY679728.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               JAXUCZ010000005.1  109107786-109107956 c
            172-485             JAXUCZ010000005.1  109102564-109102877 c
            486-706             JAXUCZ010000005.1  109100765-109100985 c
FEATURES             Location/Qualifiers
     source          1..706
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q32"
     gene            1..706
                     /gene="Cdkn2a"
                     /gene_synonym="Arf; INK4A; MTS1; p16; p16Cdkn2a; p19ARF"
                     /note="cyclin-dependent kinase inhibitor 2A"
                     /db_xref="GeneID:25163"
                     /db_xref="RGD:2323"
     exon            1..171
                     /gene="Cdkn2a"
                     /gene_synonym="Arf; INK4A; MTS1; p16; p16Cdkn2a; p19ARF"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..525
                     /gene="Cdkn2a"
                     /gene_synonym="Arf; INK4A; MTS1; p16; p16Cdkn2a; p19ARF"
                     /note="Cyclin dependent kinase inhibitor 2A (p16, inhibits
                     CDK4); cell cycle regulator; cyclin-dependent kinase
                     inhibitor 2a p19Arf; alternative reading frame; cell cycle
                     inhibitor; cyclin-dependent kinase inhibitor 2a p16Ink4a;
                     CDK4I; p16-INK4; p16-INK4a; cyclin-dependent kinase 4
                     inhibitor A"
                     /codon_start=1
                     /product="cyclin-dependent kinase inhibitor 2A"
                     /protein_id="NP_113738.1"
                     /db_xref="GeneID:25163"
                     /db_xref="RGD:2323"
                     /translation="MESSADRLARAAALGREHEVRALLEAGASPNAPNTFGRTPIQVM
                     MMGNVKVAALLLSYGADSNCEDPTTLSRPVHDAAREGFLDTLVVLHQAGARLDVRDAW
                     GRLPLDLALERGHHDVVRYLRYLLSSAGNVSRVTDRHNFCSSTPRCLGLRGQPPKQR"
     exon            172..485
                     /gene="Cdkn2a"
                     /gene_synonym="Arf; INK4A; MTS1; p16; p16Cdkn2a; p19ARF"
                     /inference="alignment:Splign:2.1.0"
     exon            486..706
                     /gene="Cdkn2a"
                     /gene_synonym="Arf; INK4A; MTS1; p16; p16Cdkn2a; p19ARF"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atctccgaga ggaaggcgaa ctcgaggaga gcgatccgga gcagcatgga gtcctctgca
       61 gatagactag ccagggcagc ggccctgggc cgtgagcacg aggtgcgggc actgctggaa
      121 gccggggctt caccaaacgc cccgaacact ttcggtcgta ccccgataca ggtgatgatg
      181 atgggcaacg tcaaagtggc agctctcctg ctctcctatg gtgcagattc gaactgcgag
      241 gaccccacca ccctctcccg accggtgcac gacgcagcgc gggagggctt cctagacact
      301 ctggtagtac tgcaccaggc aggggcgcgg ctggatgtgc gcgatgcctg gggtcgcctg
      361 ccgctcgacc tggccctaga gcggggacat cacgacgtcg tgcggtattt gcggtatcta
      421 ctctcctccg ctgggaacgt ttcccgggtc accgacaggc ataacttctg ctcaagcacg
      481 cccaggtgcc taggacttcg aggccaaccc ccaaagcagc gctaagttag gcctcagccc
      541 tcctttttct ccttggcttc acttctggca acgcgagact agcatatggc tttaaaaaaa
      601 tacataatgc tttttgcaat cacgcggggt gggtgggggg aggttagcag agggagggag
      661 ggacagagtg gactattaaa aaaagattaa atacttttta aaaatg
//
