LOCUS       NM_001033758            2045 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus cyclin-dependent kinase inhibitor 1C (Cdkn1c),
            transcript variant 2, mRNA.
ACCESSION   NM_001033758
VERSION     NM_001033758.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2045)
  AUTHORS   Meng Q, Liu Y, Huo X, Sun H, Wang Y and Bu F.
  TITLE     MicroRNA-221-3p contributes to cardiomyocyte injury in H2O2-treated
            H9c2 cells and a rat model of myocardial ischemia-reperfusion by
            targeting p57
  JOURNAL   Int J Mol Med 42 (1), 589-596 (2018)
   PUBMED   29693157
  REMARK    GeneRIF: miR2213p exacerbated the hydrogen peroxideinduced
            myocardial damage in H9c2 cells and myocardial ischemiareperfusion
            injury in the rat model by modulating p57.
REFERENCE   2  (bases 1 to 2045)
  AUTHORS   Aguilar R, Bustos FJ, Saez M, Rojas A, Allende ML, van Wijnen AJ,
            van Zundert B and Montecino M.
  TITLE     Polycomb PRC2 complex mediates epigenetic silencing of a critical
            osteogenic master regulator in the hippocampus
  JOURNAL   Biochim Biophys Acta 1859 (8), 1043-1055 (2016)
   PUBMED   27216774
  REMARK    GeneRIF: The results indicate enrichment of repressive chromatin
            histone marks and of the Polycomb PRC2 complex at the Runx2/p57
            promoter region during epigenetic silencing of a critical
            osteogenic master regulator in the hippocampus.
REFERENCE   3  (bases 1 to 2045)
  AUTHORS   Guo H, Jing L, Cheng Y, Atsaves V, Lv Y, Wu T, Su R, Zhang Y, Zhang
            R, Liu W, Rassidakis GZ, Wei Y, Nan K and Claret FX.
  TITLE     Down-regulation of the cyclin-dependent kinase inhibitor p57 is
            mediated by Jab1/Csn5 in hepatocarcinogenesis
  JOURNAL   Hepatology 63 (3), 898-913 (2016)
   PUBMED   26606000
REFERENCE   4  (bases 1 to 2045)
  AUTHORS   Jiang X, Zhang F and Ning Q.
  TITLE     Losartan reverses the down-expression of long noncoding
            RNA-NR024118 and Cdkn1c induced by angiotensin II in adult rat
            cardiac fibroblasts
  JOURNAL   Pathol Biol (Paris) 63 (3), 122-125 (2015)
   PUBMED   25979571
  REMARK    GeneRIF: The decrease of Cdkn1c induced by Ang II is mediated by
            AT1 receptors not AT2 receptors, since it is reversed by losartan.
REFERENCE   5  (bases 1 to 2045)
  AUTHORS   Er H, Acar N, Kipmen-Korgun D, Celik-Ozenci C, Ustunel I, Asar M
            and Korgun ET.
  TITLE     Determination of PCNA, cyclin D3, p27, p57 and apoptosis rate in
            normal and dexamethasone-induced intrauterine growth restricted rat
            placentas
  JOURNAL   Acta Histochem 117 (2), 137-147 (2015)
   PUBMED   25596037
  REMARK    GeneRIF: Dexamethasone induced placental and embryonal
            abnormalities which could be associated with reduced expressions of
            PCNA and cyclin D3, increased expressions of p27 and p57 and
            increased rate of apoptosis in IUGR placentas
REFERENCE   6  (bases 1 to 2045)
  AUTHORS   Hiromura K, Haseley LA, Zhang P, Monkawa T, Durvasula R, Petermann
            AT, Alpers CE, Mundel P and Shankland SJ.
  TITLE     Podocyte expression of the CDK-inhibitor p57 during development and
            disease
  JOURNAL   Kidney Int 60 (6), 2235-2246 (2001)
   PUBMED   11737597
REFERENCE   7  (bases 1 to 2045)
  AUTHORS   Kassem SA, Ariel I, Thornton PS, Hussain K, Smith V, Lindley KJ,
            Aynsley-Green A and Glaser B.
  TITLE     p57(KIP2) expression in normal islet cells and in hyperinsulinism
            of infancy
  JOURNAL   Diabetes 50 (12), 2763-2769 (2001)
   PUBMED   11723059
REFERENCE   8  (bases 1 to 2045)
  AUTHORS   Sherr CJ.
  TITLE     The Pezcoller lecture: cancer cell cycles revisited
  JOURNAL   Cancer Res 60 (14), 3689-3695 (2000)
   PUBMED   10919634
  REMARK    Review article
REFERENCE   9  (bases 1 to 2045)
  AUTHORS   Zhang P, Wong C, DePinho RA, Harper JW and Elledge SJ.
  TITLE     Cooperation between the Cdk inhibitors p27(KIP1) and p57(KIP2) in
            the control of tissue growth and development
  JOURNAL   Genes Dev 12 (20), 3162-3167 (1998)
   PUBMED   9784491
REFERENCE   10 (bases 1 to 2045)
  AUTHORS   Sugioka,Y., Fujii-Kuriyama,Y., Kitagawa,T. and Muramatsu,M.
  TITLE     Changes in polypeptide pattern of rat liver cells during chemical
            hepatocarcinogenesis
  JOURNAL   Cancer Res 45 (1), 365-378 (1985)
   PUBMED   3965145
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY351679.1 and BC098646.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY351679.1, DY309199.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               AY351679.1         1-172
            173-1075            AY351679.1         174-1076
            1076-2045           BC098646.1         939-1908
FEATURES             Location/Qualifiers
     source          1..2045
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q42"
     gene            1..2045
                     /gene="Cdkn1c"
                     /gene_synonym="Kip2; p57; p57KIP2"
                     /note="cyclin-dependent kinase inhibitor 1C"
                     /db_xref="GeneID:246060"
                     /db_xref="RGD:727892"
     exon            1..1179
                     /gene="Cdkn1c"
                     /gene_synonym="Kip2; p57; p57KIP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             282..1313
                     /gene="Cdkn1c"
                     /gene_synonym="Kip2; p57; p57KIP2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     cyclin-dependent kinase inhibitor p57; p57KIP2 A3sh"
                     /codon_start=1
                     /product="cyclin-dependent kinase inhibitor 1C isoform 2"
                     /protein_id="NP_001028930.1"
                     /db_xref="GeneID:246060"
                     /db_xref="RGD:727892"
                     /translation="MGMSDVYLRSRTAMERLASSDTFPVIARSSACRSLFGPVDHEEL
                     GRELRMRLAELNAEDQNRWDFNFQQDVPLRGPGRLQWMEVDSESVPAFYRETVQVGRC
                     RLQLGPRPPPVAVAVIPRSGPPAGEGPDGLEEAPEQPPSAPASAVVAEPTPPATPAPA
                     SDLTSDPIPDVTPVATSDSTPDPIPDVATQDGEEQVPEQVSEQVSEQGEESGAEPGDE
                     LGAEPVSEQGKQQGAEPVEEKDEEPVEEQGAEPVEEKDEEPVEGQNGELVEEQDENQE
                     LKDQPLSGIPGRPAAGTAAANANDFFAKRKRTAQENKASNDVPAGCPSPNVAPGVGAV
                     EQTPRKRLR"
     exon            1180..1318
                     /gene="Cdkn1c"
                     /gene_synonym="Kip2; p57; p57KIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..2018
                     /gene="Cdkn1c"
                     /gene_synonym="Kip2; p57; p57KIP2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcgctgtgc tcgaggggtg ccggctaggc ccgactgaga gcaagcgaac aggcaggcaa
       61 gctccgaggg ggcgcggccc aagctggaca ggacaaacga tcgagacgca ggagccgtcc
      121 atcaccaatt agccaggtag ccgccgcgtc cctaggctga ggtggacgcg ggctgtgcaa
      181 ggggtctcac ccacgcccag cctccgccct cctcctctcc cctcttcctt ctcctcccgt
      241 tcccttcttt ctcgctgccc gcgtttgcac agccttcgac catgggcatg tccgacgtgt
      301 acctccgcag cagaacagcg atggaacgct tggcctccag cgacaccttc ccagtgatag
      361 cgcgcagcag cgcctgccgc agcctcttcg ggcctgtaga ccacgaggag ctgggccgcg
      421 agctgcggat gcgcctggcg gagctgaacg ccgaggacca gaaccgctgg gacttcaact
      481 tccagcagga tgtgcctctt cgaggccctg gtcgtctgca gtggatggag gtggacagcg
      541 agtctgtgcc cgccttctac cgcgagacgg tgcaggtggg gcgctgtcgc ctgcagctgg
      601 ggccccggcc acctccggtg gctgtggctg tcatcccgcg ttctgggccg ccggctggcg
      661 agggccccga cggcctagag gaggcgcctg agcagccgcc cagcgcccca gcctcggccg
      721 tggtcgcgga gcccacccca cccgcgaccc cggccccggc ctcagatctg acctcagacc
      781 cgattccgga cgtgaccccg gtcgcgacct cggactcgac tccagacccg atcccagacg
      841 tggcgactca ggacggcgag gaacaggtcc ctgagcaggt ctctgagcag gtctctgagc
      901 agggcgagga gtcgggtgct gagccgggtg atgagctggg agctgagccg gtctctgagc
      961 agggcaagca gcagggcgcg gagccggtcg aggagaagga cgaggagccg gtggaggagc
     1021 agggcgcaga gccggtcgag gagaaggacg aggagccagt cgaggggcag aacggggagc
     1081 tggtcgagga gcaggacgag aatcaggagc tgaaggacca gcctctctcg gggattccag
     1141 gacgtcctgc agccgggact gctgcggcca atgcgaacga cttcttcgcc aagcgcaaga
     1201 gaactgcgca ggagaacaag gcgtcgaacg atgtccctgc agggtgtccc tctcctaacg
     1261 tggctcctgg ggtgggcgcg gtggagcaga ccccgcgcaa acgtctgcga tgagttagtt
     1321 tagagcctaa cggccagaga gaacttgctg ggcatctggg cagcggacga tggaagaact
     1381 ctgggcttcg gctgggacct ttcattcatg tagcaggaac cggagatggc tgcgcagagc
     1441 agcccacggt tttgtggaaa tctgaaaact gtgcaatgta ttgagaacac tctgtaccat
     1501 gtgcaaggag tacgctggtc ccaaggtgta aagctttaaa tcatttatgt aaaatgttta
     1561 atctctactc gctctcagtg caaaaagata aaaagaaaaa aagagagaga aactagaaaa
     1621 tgtagaacga aggaaaaaga cgagaaaaag gaaaaacatg tatatttgta caaaaagtta
     1681 aaaattatgc taatttaatg tttgtattta tccatgcgtg gatccctctg ccgcgcaact
     1741 gctggcttat tgattattac caaaggcact agaaatcacc agcttcagat tacccacaaa
     1801 tgtaaatcta cttttgtatt agactctaga ggaatggttg ttgagtaaaa gcccccacac
     1861 attcatcttc agttagctga cagtgtcctc cacattatta gattgctctt aaacttggtg
     1921 accagactgt cgaaaaatgg ttcctgtact gcccatacca actgcccagg gctcctcgtc
     1981 cgccaggttc taaataaaga ggcccaacaa aaatcacaaa aaaaaaaaaa aaaaaaaaaa
     2041 aaaaa
//
