LOCUS       NM_031762               1755 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus cyclin-dependent kinase inhibitor 1B (Cdkn1b),
            mRNA.
ACCESSION   NM_031762
VERSION     NM_031762.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1755)
  AUTHORS   Song,X., Chen,Y., Chen,X., Zhao,X., Zou,Y., Li,L., Zhou,X., Li,M.,
            Zhang,D., Ye,G., Jia,R. and Yin,Z.
  TITLE     Exosomes from tannic acid-stimulated macrophages accelerate wound
            healing through miR-221-3p mediated fibroblasts migration by
            targeting CDKN1b
  JOURNAL   Int J Biol Macromol 244, 125088 (2023)
   PUBMED   37270133
  REMARK    GeneRIF: Exosomes from tannic acid-stimulated macrophages
            accelerate wound healing through miR-221-3p mediated fibroblasts
            migration by targeting CDKN1b.
REFERENCE   2  (bases 1 to 1755)
  AUTHORS   Gao,Q., Guan,L., Hou,R., Meng,R., Li,Q., Liu,J., Jin,Y., Shi,C.,
            Su,D. and Ma,X.
  TITLE     Role of EBAF/Nodal/p27 signaling pathway in development of placenta
            in normal and diabetic rats
  JOURNAL   Dev Biol 481, 172-178 (2022)
   PUBMED   34737126
  REMARK    GeneRIF: Role of EBAF/Nodal/p27 signaling pathway in development of
            placenta in normal and diabetic rats.
REFERENCE   3  (bases 1 to 1755)
  AUTHORS   Chen,D. and Zhang,M.
  TITLE     GAS5 regulates diabetic cardiomyopathy via miR-221-3p/p27
            axis-associated autophagy
  JOURNAL   Mol Med Rep 23 (2) (2021)
   PUBMED   33313941
  REMARK    GeneRIF: GAS5 regulates diabetic cardiomyopathy via miR2213p/p27
            axisassociated autophagy.
REFERENCE   4  (bases 1 to 1755)
  AUTHORS   Guerra,B., Dembic,M., Siddiqui,M.A., Dominguez,I., Ceppi,P. and
            Andresen,B.S.
  TITLE     Down-Regulation of CK2alpha Leads toUp-Regulation of the
            Cyclin-Dependent Kinase Inhibitor p27KIP1 in Conditions Unfavorable
            for the Growth of Myoblast Cells
  JOURNAL   Cell Physiol Biochem 54 (6), 1177-1198 (2020)
   PUBMED   33216476
  REMARK    GeneRIF: Down-Regulation of CK2alpha Leads toUp-Regulation of the
            Cyclin-Dependent Kinase Inhibitor p27(KIP1) in Conditions
            Unfavorable for the Growth of Myoblast Cells.
REFERENCE   5  (bases 1 to 1755)
  AUTHORS   Gao,L., Wang,C., Qin,B., Li,T., Xu,W., Lenahan,C., Ying,G., Li,J.,
            Zhao,T., Zhu,Y. and Chen,G.
  TITLE     6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase Suppresses
            Neuronal Apoptosis by Increasing Glycolysis and 'cyclin-dependent
            kinase 1-Mediated Phosphorylation of p27 After Traumatic Spinal
            Cord Injury in Rats
  JOURNAL   Cell Transplant 29, 963689720950226 (2020)
   PUBMED   32841050
  REMARK    GeneRIF: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
            Suppresses Neuronal Apoptosis by Increasing Glycolysis and
            ''cyclin-dependent kinase 1-Mediated Phosphorylation of p27 After
            Traumatic Spinal Cord Injury in Rats.
REFERENCE   6  (bases 1 to 1755)
  AUTHORS   Kwon,T.K., Nagel,J.E., Buchholz,M.A. and Nordin,A.A.
  TITLE     Characterization of the murine cyclin-dependent kinase inhibitor
            gene p27Kip1
  JOURNAL   Gene 180 (1-2), 113-120 (1996)
   PUBMED   8973354
REFERENCE   7  (bases 1 to 1755)
  AUTHORS   Russo,A.A., Jeffrey,P.D., Patten,A.K., Massague,J. and
            Pavletich,N.P.
  TITLE     Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor
            bound to the cyclin A-Cdk2 complex
  JOURNAL   Nature 382 (6589), 325-331 (1996)
   PUBMED   8684460
REFERENCE   8  (bases 1 to 1755)
  AUTHORS   Poon,R.Y., Toyoshima,H. and Hunter,T.
  TITLE     Redistribution of the CDK inhibitor p27 between different
            cyclin.CDK complexes in the mouse fibroblast cell cycle and in
            cells arrested with lovastatin or ultraviolet irradiation
  JOURNAL   Mol Biol Cell 6 (9), 1197-1213 (1995)
   PUBMED   8534916
REFERENCE   9  (bases 1 to 1755)
  AUTHORS   Toyoshima,H. and Hunter,T.
  TITLE     p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is
            related to p21
  JOURNAL   Cell 78 (1), 67-74 (1994)
   PUBMED   8033213
REFERENCE   10 (bases 1 to 1755)
  AUTHORS   Polyak,K., Lee,M.H., Erdjument-Bromage,H., Koff,A., Roberts,J.M.,
            Tempst,P. and Massague,J.
  TITLE     Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a
            potential mediator of extracellular antimitogenic signals
  JOURNAL   Cell 78 (1), 59-66 (1994)
   PUBMED   8033212
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY623040.1.
            
            On Jun 10, 2007 this sequence version replaced NM_031762.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY623040.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132265, SAMD00132277
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1755
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q43"
     gene            1..1755
                     /gene="Cdkn1b"
                     /gene_synonym="Cdki1b; CDKN4; Kip1; p27; P27KIP1"
                     /note="cyclin-dependent kinase inhibitor 1B"
                     /db_xref="GeneID:83571"
                     /db_xref="RGD:69062"
     exon            1..37
                     /gene="Cdkn1b"
                     /gene_synonym="Cdki1b; CDKN4; Kip1; p27; P27KIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            38..551
                     /gene="Cdkn1b"
                     /gene_synonym="Cdki1b; CDKN4; Kip1; p27; P27KIP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..670
                     /gene="Cdkn1b"
                     /gene_synonym="Cdki1b; CDKN4; Kip1; p27; P27KIP1"
                     /note="Cyclin-dependent kinase inhibitor 1B (p27, Kip1);
                     cyclin-dependent kinase inhibitor p27; cyclin-dependent
                     kinase inhibitor p27/Kip1"
                     /codon_start=1
                     /product="cyclin-dependent kinase inhibitor 1B"
                     /protein_id="NP_113950.2"
                     /db_xref="GeneID:83571"
                     /db_xref="RGD:69062"
                     /translation="MSNVRVSNGSPSLERMDARQTEHPKPSACRNLFGPVNHEELTRD
                     LEKHCRDMEEASQRKWNFDFQNHKPLEGRYEWQEVERGSLPEFYYRPPRPPKSACKVP
                     AQESLDVSGSRQAVPSIGSQANSEDRHLVDQMPDSSDSPAGLAEQCPGMRKRPAAEDS
                     SSQNKRANRTEENVSDGSPNAGTVEQTPKKPGLRRQT"
     exon            552..679
                     /gene="Cdkn1b"
                     /gene_synonym="Cdki1b; CDKN4; Kip1; p27; P27KIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            680..1755
                     /gene="Cdkn1b"
                     /gene_synonym="Cdki1b; CDKN4; Kip1; p27; P27KIP1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gactcactcg cggctccgag acttgcgcgg cggcaagaga ggcgaggcgg tggtccacac
       61 ccgcccgggg aggaagatgt caaacgtgag agtgtctaac gggagcccga gcctggagcg
      121 gatggacgcc agacaaaccg agcaccccaa gccttccgcc tgcagaaacc tcttcggccc
      181 ggtcaatcat gaagaactaa cccgggactt ggagaagcac tgccgagata tggaagaagc
      241 gagccagcgc aagtggaatt tcgactttca gaatcataag cccctggagg gcagatacga
      301 gtggcaggag gtggagaggg gcagcttgcc cgagttctac tacagacccc cgcgcccccc
      361 caagagcgcc tgcaaggtgc cggcgcagga gagcttggat gtcagcggga gccgccaggc
      421 ggtgccttca attgggtctc aggcaaactc tgaggaccgg catttggtgg accaaatgcc
      481 tgactcgtca gacagtccgg ctgggttagc ggagcagtgt ccagggatga ggaagcgacc
      541 tgcggcagaa gattcttctt cgcaaaacaa aagggccaac agaacagaag aaaatgtttc
      601 agacggttcc ccgaatgctg gcactgtgga gcagacgccc aagaagcccg gccttcgacg
      661 ccagacgtaa acagctccga attaagaata attccttgtt tattagatac atcactgctt
      721 tatgaagcaa ggaagacata catgaaaaaa tttaaataca tatcgctgac tccattgaat
      781 ggacatcctg tataagcact gagaaagcaa aaacaataac actaaacatt ttaggcactc
      841 ttaaaccatc tgcctctaaa agcattggat gtagcattgc gcaattaggt ttttccttat
      901 ttgcttcatt gtactacctg tgtatatagt ttttatcttt tactatgtag cacataaacg
      961 ttagggatgg gagggcaggg tggggctgag gaatcagcat gggggggagg tgaagaactt
     1021 gcttcagttt gtagcaagga gaaaaaatat ttgacttgca taaagagaag caacttgggt
     1081 ggggggaagg gcttgaattc ctttctttaa agatgtagtg tcctttcggt gagaactgat
     1141 cctttatttt taaaataatc aaaatttgaa taatcgccac agggagttgc tatttacttt
     1201 tacctgaagc atattctcat ttgggagttc cgaagattct gttatgtagc aagaaatggc
     1261 ttaaaaaaat tttttttctt gaaattggaa tttatcagtt aattgtttag cggtaatcac
     1321 ccccagataa cactgggcaa aactctgggg tacatgataa ggaattctga attcttagaa
     1381 ttgactatct cagatcatat ttgctgagaa aatttcttag tgttcttttc acagtgaaca
     1441 taatcctaag tccttggata tttttagaag tcttttaact ttacacaaat aatgaaataa
     1501 tttttttttt aaattcaaag tgtctcaccc tacttgttaa tttgccccca aggaaagttg
     1561 tttttaaaag aaaaaaaaaa aggatacttg tagagtgagt gaaatggata ctacaccttt
     1621 aaacagtgtt tcttcattgc ctgtgtatga gaaaaacttt gaattgtgcc tgtgtatata
     1681 actctgtaaa gacactgaaa attatactaa cttatttatg ttcaaaagat ttttttttta
     1741 atctagacaa tatac
//
