LOCUS       NM_080782               1872 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus cyclin-dependent kinase inhibitor 1A (Cdkn1a),
            mRNA.
ACCESSION   NM_080782
VERSION     NM_080782.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1872)
  AUTHORS   Swinford-Jackson SE, Fant B, Wimmer ME, Chan D, Knouse MC,
            Sarmiento M, Thomas AS, Huffman PJ, Mankame S, Worobey SJ and
            Pierce RC.
  TITLE     Cocaine-Induced Changes in Sperm Cdkn1a Methylation Are Associated
            with Cocaine Resistance in Male Offspring
  JOURNAL   J Neurosci 42 (14), 2905-2916 (2022)
   PUBMED   35232758
  REMARK    GeneRIF: Cocaine-Induced Changes in Sperm Cdkn1a Methylation Are
            Associated with Cocaine Resistance in Male Offspring.
REFERENCE   2  (bases 1 to 1872)
  AUTHORS   Yoo KH, Yim HE and Bae ES.
  TITLE     Angiotensin inhibition and cellular senescence in the developing
            rat kidney
  JOURNAL   Exp Mol Pathol 117, 104551 (2020)
   PUBMED   33010296
  REMARK    GeneRIF: Angiotensin inhibition and cellular senescence in the
            developing rat kidney.
REFERENCE   3  (bases 1 to 1872)
  AUTHORS   Guo Q, Liu Y, Sun R, Yang F, Qiao P, Zhang R, Song L, E L and Liu
            H.
  TITLE     Mechanical stimulation induced osteogenic differentiation of BMSCs
            through TWIST/E2A/p21 axis
  JOURNAL   Biosci Rep 40 (5) (2020)
   PUBMED   32309849
  REMARK    GeneRIF: Mechanical stimulation induced osteogenic differentiation
            of BMSCs through TWIST/E2A/p21 axis.
REFERENCE   4  (bases 1 to 1872)
  AUTHORS   Herrmann J, Babic M, Tolle M, Eckardt KU, van der Giet M and
            Schuchardt M.
  TITLE     A Novel Protocol for Detection of Senescence and Calcification
            Markers by Fluorescence Microscopy
  JOURNAL   Int J Mol Sci 21 (10), 3475 (2020)
   PUBMED   32423114
  REMARK    GeneRIF: A Novel Protocol for Detection of Senescence and
            Calcification Markers by Fluorescence Microscopy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1872)
  AUTHORS   Zhuang W, Lian G, Huang B, Du A, Gong J, Xiao G, Xu C, Wang H and
            Xie L.
  TITLE     CPT1 regulates the proliferation of pulmonary artery smooth muscle
            cells through the AMPK-p53-p21 pathway in pulmonary arterial
            hypertension
  JOURNAL   Mol Cell Biochem 455 (1-2), 169-183 (2019)
   PUBMED   30511343
  REMARK    GeneRIF: CPT1 regulates the proliferation of pulmonary artery
            smooth muscle cells through the AMPK-p53-p21 pathway in pulmonary
            arterial hypertension.
REFERENCE   6  (bases 1 to 1872)
  AUTHORS   Martens U, Lennartsson P, Hogberg J and Stenius U.
  TITLE     Low expression of the WAF1/CIP1 gene product, p21, in
            enzyme-altered foci induced in rat liver by diethylnitrosamine or
            phenobarbital
  JOURNAL   Cancer Lett 104 (1), 21-26 (1996)
   PUBMED   8640740
REFERENCE   7  (bases 1 to 1872)
  AUTHORS   Beauchamp RD, Sheng HM, Shao JY, Thompson EA and Ko TC.
  TITLE     Intestinal cell cycle regulations. Interactions of cyclin D1, Cdk4,
            and p21Cip1
  JOURNAL   Ann Surg 223 (5), 620-628 (1996)
   PUBMED   8651753
REFERENCE   8  (bases 1 to 1872)
  AUTHORS   Belinsky SA, Middleton SK, Picksley SM, Hahn FF and Nikula KJ.
  TITLE     Analysis of the K-ras and p53 pathways in X-ray-induced lung tumors
            in the rat
  JOURNAL   Radiat Res 145 (4), 449-456 (1996)
   PUBMED   8600505
REFERENCE   9  (bases 1 to 1872)
  AUTHORS   Healy E, Reynolds NJ, Smith MD, Harrison D, Doherty E, Campbell C
            and Rees JL.
  TITLE     Up-regulation of p21WAF1/CIP1 in psoriasis and after the
            application of irritants and tape stripping
  JOURNAL   J Invest Dermatol 105 (2), 274-279 (1995)
   PUBMED   7636313
REFERENCE   10 (bases 1 to 1872)
  AUTHORS   el-Deiry WS, Tokino T, Waldman T, Oliner JD, Velculescu VE, Burrell
            M, Hill DE, Healy E, Rees JL, Hamilton SR et al.
  TITLE     Topological control of p21WAF1/CIP1 expression in normal and
            neoplastic tissues
  JOURNAL   Cancer Res 55 (13), 2910-2919 (1995)
   PUBMED   7796420
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000324.1.
            
            [WARNING] On Mar 30, 2024 this sequence was replaced by
            NM_080782.5.
            
            On Nov 27, 2020 this sequence version replaced NM_080782.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100620.1, DN947728.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                JACYVU010000324.1  2873164-2873193
            31-486              JACYVU010000324.1  2881182-2881637
            487-1872            JACYVU010000324.1  2882220-2883605
FEATURES             Location/Qualifiers
     source          1..1872
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1872
                     /gene="Cdkn1a"
                     /gene_synonym="Cip1; UV96; Waf1"
                     /note="cyclin-dependent kinase inhibitor 1A"
                     /db_xref="GeneID:114851"
                     /db_xref="RGD:69328"
     exon            1..30
                     /gene="Cdkn1a"
                     /gene_synonym="Cip1; UV96; Waf1"
                     /inference="alignment:Splign:2.1.0"
     exon            31..486
                     /gene="Cdkn1a"
                     /gene_synonym="Cip1; UV96; Waf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..536
                     /gene="Cdkn1a"
                     /gene_synonym="Cip1; UV96; Waf1"
                     /note="cyclin-dependent kinase inhibitor 1A (P21);
                     cyclin-dependent kinase inhibitor 1A (p21, Cip1)"
                     /codon_start=1
                     /product="cyclin-dependent kinase inhibitor 1"
                     /protein_id="NP_542960.1"
                     /db_xref="GeneID:114851"
                     /db_xref="RGD:69328"
                     /translation="MSDPGDVRPVPHRSKVCRRLFGPVDSEQLSRDCDALMASCLQEA
                     RERWNFDFATETPLEGNYVWERVRSPGLPKIYLSPGSRRRDDLGGDKRPSTSSALLQG
                     PGPAPEDHVALSLSCTLVSHAPERPEDSPGGTGTSQGRKRRQTSLTDFYHSKRRLVFC
                     KRKP"
     exon            487..1872
                     /gene="Cdkn1a"
                     /gene_synonym="Cip1; UV96; Waf1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggatgcatc tatcttgtga tatgtaccag ccacaggcac catgtccgat cctggtgatg
       61 tccgacctgt tccacacagg agcaaagtat gccgtcgtct gttcggtccc gtggacagtg
      121 agcagttgag ccgcgattgc gatgcgctca tggcgagctg tctccaggag gcccgagaac
      181 ggtggaactt tgacttcgcc actgagacgc cactggaggg caactacgtc tgggagcgtg
      241 ttcggagccc agggctgccc aagatctacc tgagccctgg gtcccgccgc cgtgatgacc
      301 tgggagggga caagaggccc agtacctcct cggccctgct gcaggggcca gggccagctc
      361 cggaggacca cgtggccttg tcgctgtctt gcactctggt gtctcacgcc cctgagaggc
      421 ctgaagactc cccgggcggg accgggacat ctcagggccg aaaacggagg cagaccagcc
      481 taacagattt ctatcactcc aagcgccgat tggtcttctg caagagaaag ccctgaagtg
      541 cccacgggag gctcgccttc ttctgctgtg ggtcaggagg cctcttcccc atcttctgcc
      601 ttagccttca ttcagtgtgt cttaattatt atttgtgttt taatttaaac ttctcctgta
      661 tatactctgc ctgccccctc ccagcctcca aacttagtta tttaaaaaac aaaacaaaac
      721 aatgaaatta gtaggacggt aggctcctta gtgctgtttt tttttttttt tttttttttt
      781 tttttatgta gaccattatt taagtccttc tcaacccaag ctgtgtttct gatcctggcg
      841 ggatggtcct ggcgggatgg tcgcactggc ctcatgccat ctgcatctcg catctcgccc
      901 aatccccgcc cctcccccct aactcctccc ccgcccccac tccctgcctg gttccttgcc
      961 acttcttacc tgggggcgat cctcagacct gaatagcact ttggacaact gagtaggact
     1021 tcggggtctc cttgtcacct ctaaggcccg ctaggatgac agtgaagcag tcacagccta
     1081 gaacaaagat gcccggttag gacctaagcg taccgtccag agccttgaca tttactcaga
     1141 cctgtgaaga tcctttgcca ctcctgggga ccccgcctcc cctgtgggtc tctgccagct
     1201 gcccctctat ttttgagggt taatctggtg atctgctgct ctcccttcct cagacccttc
     1261 ccctccccag gttggcagga ggcatccttt ccctcgccac ggctcagtgg accagaaggg
     1321 aacgggtaca cagggtacac taagtggggt ttcctggtcc tacctcaggc agctccagtg
     1381 gcaactgccc ttcttatggg tctagggtag gtccttggtg acgagacggg cttcccagag
     1441 catccctgtg tgtgtggtat gtggtggtgg tggggggtgg acttatctgg gatggggacc
     1501 ccagccgctg aagtcctcag tgacttgtcc catttcttag tagttgtaca aggagtcagg
     1561 ccaagatggt gcctcggggg ctgagggagc tcacaggaac tgagcagtga ctggtccttt
     1621 cccagtattg aatactgagc ccctgtgggt gtcgaagcac ttagtgggtc tggccccaac
     1681 cccaaacacc cctgtttctg taacaccctg agctggactg tttatcttta gccgggagaa
     1741 catgtatttt ggtcccttcc ctgtctccgc tcagattgta aacctcccac gtgtggggat
     1801 cacaccctgc actgtcccga atctttacac cctatcccaa agctggtgct caataaatac
     1861 ttctagatga tt
//
