LOCUS       XP_038968993             342 aa            linear   ROD 22-FEB-2024
DEFINITION  cyclin-dependent kinase-like 4 isoform X1 [Rattus norvegicus].
ACCESSION   XP_038968993
VERSION     XP_038968993.1
DBLINK      BioProject: PRJNA1074393
DBSOURCE    REFSEQ: accession XM_039113065.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_086024) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Jul 25, 2024 this sequence was replaced by
            NP_001419048.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_036323735.1-RS_2024_02
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 02/09/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..342
                     /organism="Rattus norvegicus"
                     /strain="BN/NHsdMcwi"
                     /bio_material="RGD 61498"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /sex="male"
                     /tissue_type="kidney, spleen, liver"
                     /geo_loc_name="USA: Wisconsin, Milwaukee"
                     /lat_lon="43.05 N 88.04 W"
                     /collected_by="Rebecca Schilling, Melinda Dwinell"
     Protein         1..342
                     /product="cyclin-dependent kinase-like 4 isoform X1"
                     /calculated_mol_wt=39215
     Region          2..286
                     /region_name="STKc_CDKL1_4"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Cyclin-Dependent protein Kinase Like 1 and 4; cd07847"
                     /db_xref="CDD:270837"
     Site            order(10..14,18,31,33,50,64,80..83,86,88..89,126,128,
                     130..131,133,144,147,158,160..163,165,203)
                     /site_type="active"
                     /db_xref="CDD:270837"
     Site            order(10..14,18,31,33,64,80..83,86,126,128,130..131,133,
                     144)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270837"
     Site            order(50,88,126,128,147,158,160..163,165,203)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270837"
     Site            order(143..152,153..154,156..165)
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270837"
     CDS             1..342
                     /gene="Cdkl4"
                     /coded_by="XM_039113065.2:1065..2093"
                     /db_xref="GeneID:503009"
                     /db_xref="RGD:1583704"
ORIGIN      
        1 mekyeklaki gegsygvvfk crnkssgqvv aikkfvesed dpvvrkialr eirmlkqlkh
       61 pnlvnlievf rrkrkmhlvf eycdhtllne lernpngvsd gviksvlwqt lqalnfchkh
      121 ncihrdvkpe niliakqgvi kicdfgfari lipgdaytdy vatrwyrape llvgdtkygs
      181 svdiwavgcv faelltgqpl wpgksdvdql yliirtlgkl iprhqsifks nqffrgisip
      241 epedmetlee kfsnvqpmal sfmkgclkmd pderltcaql ldstyfesfq edqmkrkars
      301 egrsrrrqqn qllplipgsh isptpdgrkq avqlkfdhlp ni
//
