LOCUS       NM_021772               1731 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus cyclin-dependent kinase-like 3 (Cdkl3), mRNA.
ACCESSION   NM_021772
VERSION     NM_021772.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1731)
  AUTHORS   Liu,Z., Xu,D., Zhao,Y. and Zheng,J.
  TITLE     Non-syndromic mild mental retardation candidate gene CDKL3
            regulates neuronal morphogenesis
  JOURNAL   Neurobiol Dis 39 (3), 242-251 (2010)
   PUBMED   20347982
REFERENCE   2  (bases 1 to 1731)
  AUTHORS   Haq,R., Randall,S., Midmer,M., Yee,K. and Zanke,B.
  TITLE     NKIATRE is a novel conserved cdc2-related kinase
  JOURNAL   Genomics 71 (2), 131-141 (2001)
   PUBMED   11161806
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Mar 27, 2010 this sequence version replaced NM_021772.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF112183.1, SRR26360190.2002974.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               JAXUCZ010000010.1  36767908-36768019
            113-292             JAXUCZ010000010.1  36768470-36768649
            293-487             JAXUCZ010000010.1  36775455-36775649
            488-666             JAXUCZ010000010.1  36783329-36783507
            667-779             JAXUCZ010000010.1  36784756-36784868
            780-919             JAXUCZ010000010.1  36787364-36787503
            920-1008            JAXUCZ010000010.1  36790521-36790609
            1009-1168           JAXUCZ010000010.1  36791419-36791578
            1169-1731           JAXUCZ010000010.1  36791669-36792231
FEATURES             Location/Qualifiers
     source          1..1731
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..1731
                     /gene="Cdkl3"
                     /gene_synonym="Nkiatre; Nkiatreb"
                     /note="cyclin-dependent kinase-like 3"
                     /db_xref="GeneID:60396"
                     /db_xref="RGD:619874"
     exon            1..112
                     /gene="Cdkl3"
                     /gene_synonym="Nkiatre; Nkiatreb"
                     /inference="alignment:Splign:2.1.0"
     exon            113..292
                     /gene="Cdkl3"
                     /gene_synonym="Nkiatre; Nkiatreb"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..1501
                     /gene="Cdkl3"
                     /gene_synonym="Nkiatre; Nkiatreb"
                     /EC_number="2.7.11.22"
                     /note="serine/threonine protein kinase NKIATRE;
                     serine/threonine kinase NKIATRE beta"
                     /codon_start=1
                     /product="cyclin-dependent kinase-like 3"
                     /protein_id="NP_068540.1"
                     /db_xref="GeneID:60396"
                     /db_xref="RGD:619874"
                     /translation="MEMYETLGKVGEGSYGTVMKCKHKDTGRIVAIKIFYEKPEKSVN
                     KIATREIKFLKQFRHENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRL
                     RKYLFQILRAIEYLHNNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDVYTDY
                     VATRWYRAPELVLKDTTYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVG
                     NLTPHLHNIFSKSPIFAGVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPAERIS
                     STDLLHHDYFTRDGFIEKFIPELRAKLLQEAKVNSFIKPKENFKENEPVRDEKKPVFT
                     NPLLYGNPTLYGKEVDRDKRAKELKVRVIKAKGGKGDVPDLKKTESEGEHRQQGTAED
                     THPTSLDRKPSVSELTNPVHPSANSDTVKEDPHSGGCMIMPPINLTSSNLLAANPSSN
                     LSHPNSR"
     exon            293..487
                     /gene="Cdkl3"
                     /gene_synonym="Nkiatre; Nkiatreb"
                     /inference="alignment:Splign:2.1.0"
     exon            488..666
                     /gene="Cdkl3"
                     /gene_synonym="Nkiatre; Nkiatreb"
                     /inference="alignment:Splign:2.1.0"
     exon            667..779
                     /gene="Cdkl3"
                     /gene_synonym="Nkiatre; Nkiatreb"
                     /inference="alignment:Splign:2.1.0"
     exon            780..919
                     /gene="Cdkl3"
                     /gene_synonym="Nkiatre; Nkiatreb"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1008
                     /gene="Cdkl3"
                     /gene_synonym="Nkiatre; Nkiatreb"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1168
                     /gene="Cdkl3"
                     /gene_synonym="Nkiatre; Nkiatreb"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1731
                     /gene="Cdkl3"
                     /gene_synonym="Nkiatre; Nkiatreb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaggtcggc caggactgga ggtgtggtgt cccgcgtccg gctgggactt ccacgcagcc
       61 gggccggcgg gactacagga tgggctgagg cggcggcgat tctcaggacg agaagccagg
      121 cttgaaaatg gagatgtatg aaacccttgg aaaagtagga gagggaagtt atggaacggt
      181 catgaaatgc aagcataagg atactgggcg gatagtggcc attaagatat tctatgagaa
      241 accagaaaaa tctgtcaaca aaattgcaac gagagaaata aagtttctaa agcaatttcg
      301 tcatgaaaac ctggtcaatc tgattgaagt ttttagacaa aaaaagaaaa tccatttggt
      361 atttgagttt attgaccaca cggtcttaga tgagttacag cattattgtc acggattaga
      421 gagtaagcga ctaagaaagt acctgttcca gatcctccga gcgatcgagt atctgcacaa
      481 caacaacatt atccaccgag atataaagcc tgagaatatt ttagtctccc agtcaggaat
      541 tacaaagctc tgcgattttg ggtttgcgcg gacactagca gctcctggag acgtttacac
      601 agactacgtg gccacccgct ggtacagagc tccagagctg gtgttgaaag acaccaccta
      661 tggaaaacca gtggatatct gggctttggg ctgtatgatc attgaaatgg ccactggcaa
      721 tccctacctt cctagcagtt ccgatttgga tttgctccac aagattgttt taaaagtagg
      781 caacctgacc ccgcacctgc acaatatttt ttccaagagt cccatctttg ctggggtggt
      841 tcttcctcaa gttcaacatc ccaaaaacgc aagaaagaaa tacccaaagc tcaacggatt
      901 gctggcagat atagttcatg cttgtttaca aattgatcct gctgagagga tatcatccac
      961 cgatcttttg catcacgatt actttactag agatggattt attgagaaat ttataccaga
     1021 gctgagagct aagttattac aggaagcaaa ggttaattca tttataaagc caaaagagaa
     1081 ttttaaggaa aatgaacctg tgagagatga gaaaaaacca gtttttacca accctctgct
     1141 ctatggaaac ccaacacttt atggaaagga agtggacaga gacaaaaggg ccaaggagct
     1201 caaagtcaga gtcattaagg ccaaaggggg aaaaggagac gtcccagacc tgaagaagac
     1261 agagagtgaa ggtgaacacc gccagcaggg cacagctgag gacacacacc ccacatcact
     1321 ggacaggaag ccttctgtct cggaactaac aaaccctgtc catcccagtg cgaattctga
     1381 cactgtcaaa gaagacccac actctggggg ctgtatgata atgccaccta tcaacctgac
     1441 aagcagtaat ttgttggccg caaatcccag ttcaaacctc tcccacccca attcacggtg
     1501 agctagagtg agaggaggct tgattaagta aggcgtcctc ctgtgcggcg cattgcagac
     1561 acacgtgtac gatgtcagta tggaccggac ctgaaaagga tcttctcaag ttgcagtcaa
     1621 gtagtaacag ggcattccct gaggagttct tgggaatgtt atgtgagaag tgtttttctt
     1681 agctatatag gtattaaact tttttttgag acaaattgcc acagagccca g
//
