LOCUS       NM_001012035            4185 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cyclin dependent kinase like 2 (Cdkl2), mRNA.
ACCESSION   NM_001012035 XM_006250737 XM_239920
VERSION     NM_001012035.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4185)
  AUTHORS   Hasson,S.A., Kane,L.A., Yamano,K., Huang,C.H., Sliter,D.A.,
            Buehler,E., Wang,C., Heman-Ackah,S.M., Hessa,T., Guha,R.,
            Martin,S.E. and Youle,R.J.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On or before Dec 16, 2022 this sequence version replaced
            XM_006250737.4, NM_001012035.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.53767.1,
                                           SRR26643299.54186.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-502               JAXUCZ010000014.1  16312938-16313439
            503-701             JAXUCZ010000014.1  16315985-16316183
            702-896             JAXUCZ010000014.1  16319818-16320012
            897-1075            JAXUCZ010000014.1  16323695-16323873
            1076-1188           JAXUCZ010000014.1  16324271-16324383
            1189-1334           JAXUCZ010000014.1  16326526-16326671
            1335-1423           JAXUCZ010000014.1  16330120-16330208
            1424-1553           JAXUCZ010000014.1  16332895-16333024
            1554-1849           JAXUCZ010000014.1  16334550-16334845
            1850-1943           JAXUCZ010000014.1  16335355-16335448
            1944-2067           JAXUCZ010000014.1  16336930-16337053
            2068-2174           JAXUCZ010000014.1  16337180-16337286
            2175-2263           JAXUCZ010000014.1  16344685-16344773
            2264-4185           JAXUCZ010000014.1  16345603-16347524
FEATURES             Location/Qualifiers
     source          1..4185
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..4185
                     /gene="Cdkl2"
                     /note="cyclin dependent kinase like 2"
                     /db_xref="GeneID:305242"
                     /db_xref="RGD:1309625"
     exon            1..502
                     /gene="Cdkl2"
                     /inference="alignment:Splign:2.1.0"
     exon            503..701
                     /gene="Cdkl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             534..2240
                     /gene="Cdkl2"
                     /EC_number="2.7.11.22"
                     /note="cyclin-dependent kinase-like 2 (CDC2-related
                     kinase)"
                     /codon_start=1
                     /product="cyclin-dependent kinase-like 2"
                     /protein_id="NP_001012035.2"
                     /db_xref="GeneID:305242"
                     /db_xref="RGD:1309625"
                     /translation="MEKYENLGLVGEGSYGMVMKCRNKDSGRIVAIKKFLESDDDKMV
                     KKIAMREIKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLKLFPNGLDYQV
                     VQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTD
                     YVATRWYRAPELLVGDVKYGKAVDIWAIGCLVIEMLMGQPLFPGESDIDQLHHIMTCL
                     GNLIPRHQELFYKNPVFAGVRLPEIKDIEAEPLESRYPKLPEVVISLAKKCLHIDPDK
                     RPLCADLLHHDFFQMDGFAERFSQELQLKIEKDARNNSLPKKFQIRKKEKDDALGEER
                     KTLVVQDTNADPKTKDSKVLKVKGSKIDVEKTEKGTRASNGSCLHDNGTSHKGLSSTS
                     LRDCSNVTIDHPRNPGTAIPPLTHNLSAVAPGINAAMGTIPGVQNYRVDEKTKKYCNP
                     FVKPSQPSPSGIYNMNVSASVSGEKYLLQANKKRKEYPKVDVRLPELNYNHLPELRAL
                     EGIARNSRLIKKENKCLSESRIPSLAAIDLHASSVASHQGAGSPVSDESEADLPRMEH
                     QH"
     exon            702..896
                     /gene="Cdkl2"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1075
                     /gene="Cdkl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1188
                     /gene="Cdkl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1334
                     /gene="Cdkl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1423
                     /gene="Cdkl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1553
                     /gene="Cdkl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1849
                     /gene="Cdkl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1943
                     /gene="Cdkl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2067
                     /gene="Cdkl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2174
                     /gene="Cdkl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..2263
                     /gene="Cdkl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2264..4185
                     /gene="Cdkl2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcgggtga gagccgcccc ttgcagctgg ccaacgcctt cgcccagggc tacttgacga
       61 ggtgctgctt cccggagatg agcgacccga gggcttttga caggcggtgt tctctttccc
      121 cagttcgttt ctctgcagct cttggccgtg acaggtgcta gtgtccgtgc ctgtcacaga
      181 cgcattctga ctcgggccct tcccctctct ctctggagac tgcctatggc tggggaccga
      241 gtgaggtcgt tgccttgacg acggcagcat gcggccggca gtcctcggaa gtgtgagctt
      301 gcggagggca gaagccaatc tgcctccctg cctgcttcac ctaggaccag taactgcgtc
      361 cgcagaggaa atcccagtac tgggattgct agtttgctag tcagcatctt tttagatctg
      421 ctagcgagat gcatatcacc tcaaatttgt ttccaagttg aaaacctttg gctctttcca
      481 tgtgaagggt ttggaagaaa tacaagaaaa attcctactg gttttgaagc aaaatggaaa
      541 agtatgagaa cctaggattg gttggagagg ggagttacgg aatggtgatg aagtgtagga
      601 acaaagacag tggaagaatt gtggccatta agaagttctt agagagcgat gacgataaaa
      661 tggttaagaa gatcgctatg cgagaaatca agttactaaa gcaactgcgg catgaaaatt
      721 tggtgaacct gttggaagtg tgtaagaaaa agaagcgttg gtacttagtc tttgaatttg
      781 ttgaccacac gattcttgat gacttgaaac tcttcccaaa tggactagac tatcaagtag
      841 ttcaaaagta tttgtttcag atcattaatg gaattggatt ttgccatagt cacaatatca
      901 tacacagaga tataaaaccc gagaatatat tagtctcaca gtctggcgtt gtaaaattat
      961 gtgactttgg attcgcacgg acattggcgg ctcctgggga ggtttacact gactatgtgg
     1021 ccacccggtg gtacagagct ccagaactgc tggtcggtga tgtcaagtac ggcaaggctg
     1081 ttgatatctg ggccattggt tgtctggtca ttgagatgct tatggggcaa ccactatttc
     1141 caggagaatc cgatattgat cagctgcatc atattatgac atgtttaggt aatttaattc
     1201 caagacacca ggagctattt tataaaaatc ctgtgtttgc tggagtaagg ttgcctgaga
     1261 tcaaagacat agaagcagag cctctcgaga gccgctatcc gaagctccct gaagttgtga
     1321 tcagtttagc aaagaaatgc ttgcacattg atccagacaa aaggcccttg tgtgctgacc
     1381 ttctacacca tgatttcttt caaatggatg gatttgctga gaggttttct caagaattgc
     1441 agttaaaaat agagaaagat gccaggaata attctttacc taaaaagttt caaatcagaa
     1501 agaaagaaaa agacgatgcc ttaggtgaag aaagaaaaac acttgtggta caggatacca
     1561 atgctgatcc caaaactaag gattctaaag tgttaaaagt aaaggggtca aaaatcgatg
     1621 tcgagaaaac tgaaaaagga actagagctt caaatggcag ctgtctccat gacaacggga
     1681 caagccacaa aggcttgtct tccacaagcc tcagagattg cagcaatgtc accattgatc
     1741 acccaaggaa tccaggcaca gcgattcctc ccctcacaca caatctttct gcagttgctc
     1801 ctggtatcaa cgctgcaatg gggactattc ctggagttca gaattacaga gtggacgaga
     1861 aaactaagaa atactgtaat ccttttgtta aaccaagcca gccttctcca tcagggattt
     1921 ataatatgaa tgtgagcgca tccgtctcag gggaaaagta ccttcttcag gcaaacaaga
     1981 aaaggaagga atatcccaaa gtcgacgtgc gattgcctga actaaactat aaccatcttc
     2041 ctgaactgag agctttagaa ggcatagctc gaaattctag gctaataaag aaagagaaca
     2101 aatgtctttc agaatctcga attccctctc tggctgccat tgacctgcat gcatccagtg
     2161 ttgcatcaca ccagggagca ggatcacctg tgtcagatga gtccgaggct gacttgcctc
     2221 gaatggagca ccagcactga gacccatttt aatcctgaac aggatgctgc cagcacttga
     2281 gatgacgtcc tcttgcacga gagcactgat gccccagagg agatctgcgg tttgactgtt
     2341 tccttctgga aacctacgct ttctaagaaa ggctttgcag aagaagggaa gacagacttc
     2401 caaagacctc aaaggaagat tgaacaagtg ccccttcacc tttccaacct atgatgctat
     2461 ttcaagatat atccgtggaa cgatagtgac atggttcttg ttacatgaat gtgtatttga
     2521 tattagtaga ttgtgtattt aaagttatct gagattaaaa gtcagtaaaa aaggagagaa
     2581 tcattataaa aagtcatgat tttatgcatt gaactttgta ttatctatat aagtgtttac
     2641 agttgaagaa aatgaaaaga agctaggatc tgtgagataa aagtttcctt taccttaact
     2701 ataagaacac attttaaaag cttgcttcta ggtgtgagtg gtgtgagact atggtcgcgc
     2761 tgtctttgtt ttctgtcatt gttaattgct gatctaagaa ctgtgctatt gcaacttttg
     2821 ttactagtga cggtgatgtt ggtaagtctt ccacactgag aggttctggt gctgatgtcc
     2881 ttcctgaaag gacatgatgg aagtcgcagg ggtttgtggg cacacctgta agtgaacaac
     2941 tgagcttctc cttgagggaa aaggtataat atatatatat atggagaggt gggagcaggc
     3001 agaactgcct gtctatctgt ctgtctgtct ctccaggcta gggcagtagg cactgaatta
     3061 ccccaccaaa gaggctttta gaggctttgg tggagtccac tcttgtctct ggtcgtttga
     3121 ggttagtggt ggacaaccca cagcagttga ttgccctctc acctcaaatg cttagcctta
     3181 cccagaagcc ttgtcccaag gcggaaggtc gtttacgtgt attccacata cgctctctga
     3241 tgcacagctt caccacctct taggtgggag gattggacca tttggattcc aggtctcagt
     3301 gtccgggctc tcagccatgc tcccacttat cattggagaa aacagttgtt caggggcctg
     3361 aatttgcgtg gtggttttgc attaaccaac gaatggaacc tttttattta aagctgttgg
     3421 ctacaactta gcctaagact tgaacaagag ttcttcattc ccttggggga cttaaaaatg
     3481 aaatcctaat ctggacacta cgagtagaca ttcaggatga ggcaaaataa agggttccaa
     3541 cataaaaaaa tctgctggta gtaggtgaat aaatattttt tatttaaaag ctgtatttta
     3601 agcctctgac taagggtttt cctaggctag taagactaac atgctgataa aactcactat
     3661 gtcagtagta attggctctc tactaaaata ccactattaa ttgttatttt gaaaaacatt
     3721 gcacagccag cagcataggg aggagtcagt acctgaaact aagcagcacc cagttaattt
     3781 caggctgttc tcatgtcaag gccagtgtga ggatatcggc ctgacaacgg gggtctgcct
     3841 cagctcgctt atgatttgta tccttgagtt tggtatcttt ggcctattaa gacacattat
     3901 gaactttaca attaagactt taaaaatcat ttcttgagtc cttactgata tctgaagatc
     3961 atattttgtt agaccttggt gtggaactaa agaagtaaac actgctccaa cgaagtctgg
     4021 aggtactaaa ccgacatatt ctcttttcag tgcgcgggtg gtgagtctct tcccccaaga
     4081 atgtgatgta cgcagacatg ctcatgtgaa accagtttct gtacttttgg gagacgatgg
     4141 gctgctgtgc ccacctgtgt ttaataaata ttatctaacc aagca
//
