LOCUS       NM_001402171            2529 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus CDK5 regulatory subunit associated protein 1-like
            1 (Cdkal1), transcript variant 1, mRNA.
ACCESSION   NM_001402171
VERSION     NM_001402171.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2529)
  AUTHORS   Peng D, Wang J, Zhang R, Jiang F, Tam CHT, Jiang G, Wang T, Chen M,
            Yan J, Wang S, Yan D, He Z, Ma RCW, Bao Y, Hu C and Jia W.
  TITLE     CDKAL1 rs7756992 is associated with diabetic retinopathy in a
            Chinese population with type 2 diabetes
  JOURNAL   Sci Rep 7 (1), 8812 (2017)
   PUBMED   28821857
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2529)
  AUTHORS   Brambillasca S, Altkrueger A, Colombo SF, Friederich A, Eickelmann
            P, Mark M, Borgese N and Solimena M.
  TITLE     CDK5 regulatory subunit-associated protein 1-like 1 (CDKAL1) is a
            tail-anchored protein in the endoplasmic reticulum (ER) of
            insulinoma cells
  JOURNAL   J Biol Chem 287 (50), 41808-41819 (2012)
   PUBMED   23048041
  REMARK    GeneRIF: CDK5 regulatory subunit-associated protein 1-like 1
            (CDKAL1) is a tail-anchored protein in the endoplasmic reticulum
            (ER) of insulinoma cells.
REFERENCE   3  (bases 1 to 2529)
  AUTHORS   Wei FY, Suzuki T, Watanabe S, Kimura S, Kaitsuka T, Fujimura A,
            Matsui H, Atta M, Michiue H, Fontecave M, Yamagata K, Suzuki T and
            Tomizawa K.
  TITLE     Deficit of tRNA(Lys) modification by Cdkal1 causes the development
            of type 2 diabetes in mice
  JOURNAL   J Clin Invest 121 (9), 3598-3608 (2011)
   PUBMED   21841312
REFERENCE   4  (bases 1 to 2529)
  AUTHORS   Ohara-Imaizumi M, Yoshida M, Aoyagi K, Saito T, Okamura T, Takenaka
            H, Akimoto Y, Nakamichi Y, Takanashi-Yanobu R, Nishiwaki C,
            Kawakami H, Kato N, Hisanaga S, Kakei M and Nagamatsu S.
  TITLE     Deletion of CDKAL1 affects mitochondrial ATP generation and
            first-phase insulin exocytosis
  JOURNAL   PLoS One 5 (12), e15553 (2010)
   PUBMED   21151568
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2529)
  AUTHORS   Arragain S, Handelman SK, Forouhar F, Wei FY, Tomizawa K, Hunt JF,
            Douki T, Fontecave M, Mulliez E and Atta M.
  TITLE     Identification of eukaryotic and prokaryotic methylthiotransferase
            for biosynthesis of 2-methylthio-N6-threonylcarbamoyladenosine in
            tRNA
  JOURNAL   J Biol Chem 285 (37), 28425-28433 (2010)
   PUBMED   20584901
REFERENCE   6  (bases 1 to 2529)
  AUTHORS   Kang ES, Kim MS, Kim CH, Nam CM, Han SJ, Hur KY, Ahn CW, Cha BS,
            Kim SI, Lee HC and Kim YS.
  TITLE     Association of common type 2 diabetes risk gene variants and
            posttransplantation diabetes mellitus in renal allograft recipients
            in Korea
  JOURNAL   Transplantation 88 (5), 693-698 (2009)
   PUBMED   19741467
REFERENCE   7  (bases 1 to 2529)
  AUTHORS   Takeuchi F, Serizawa M, Yamamoto K, Fujisawa T, Nakashima E, Ohnaka
            K, Ikegami H, Sugiyama T, Katsuya T, Miyagishi M, Nakashima N,
            Nawata H, Nakamura J, Kono S, Takayanagi R and Kato N.
  TITLE     Confirmation of multiple risk Loci and genetic impacts by a
            genome-wide association study of type 2 diabetes in the Japanese
            population
  JOURNAL   Diabetes 58 (7), 1690-1699 (2009)
   PUBMED   19401414
REFERENCE   8  (bases 1 to 2529)
  AUTHORS   Cho YM, Kim TH, Lim S, Choi SH, Shin HD, Lee HK, Park KS and Jang
            HC.
  TITLE     Type 2 diabetes-associated genetic variants discovered in the
            recent genome-wide association studies are related to gestational
            diabetes mellitus in the Korean population
  JOURNAL   Diabetologia 52 (2), 253-261 (2009)
   PUBMED   19002430
REFERENCE   9  (bases 1 to 2529)
  AUTHORS   Wu Y, Li H, Loos RJ, Yu Z, Ye X, Chen L, Pan A, Hu FB and Lin X.
  TITLE     Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE
            genes are associated with type 2 diabetes and impaired fasting
            glucose in a Chinese Han population
  JOURNAL   Diabetes 57 (10), 2834-2842 (2008)
   PUBMED   18633108
REFERENCE   10 (bases 1 to 2529)
  AUTHORS   Lee YH, Kang ES, Kim SH, Han SJ, Kim CH, Kim HJ, Ahn CW, Cha BS,
            Nam M, Nam CM and Lee HC.
  TITLE     Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B,
            IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean
            population
  JOURNAL   J Hum Genet 53 (11-12), 991-998 (2008)
   PUBMED   18991055
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000289.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001402171.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132293,
                              SAMD00132294 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                JACYVU010000289.1  3621813-3621892
            81-124              JACYVU010000289.1  3622509-3622552
            125-294             JACYVU010000289.1  3627080-3627249
            295-407             JACYVU010000289.1  3630876-3630988
            408-492             JACYVU010000289.1  3707196-3707280
            493-589             JACYVU010000289.1  3774210-3774306
            590-638             JACYVU010000289.1  3783006-3783054
            639-759             JACYVU010000289.1  3800524-3800644
            760-863             JACYVU010000289.1  3864753-3864856
            864-1030            JACYVU010000289.1  3942810-3942976
            1031-1176           JACYVU010000289.1  3970345-3970490
            1177-1357           JACYVU010000289.1  4015892-4016072
            1358-1420           JACYVU010000289.1  4046880-4046942
            1421-1504           JACYVU010000289.1  4136469-4136552
            1505-1669           JACYVU010000289.1  4139566-4139730
            1670-2529           JACYVU010000289.1  4173529-4174388
FEATURES             Location/Qualifiers
     source          1..2529
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p12"
     gene            1..2529
                     /gene="Cdkal1"
                     /note="CDK5 regulatory subunit associated protein 1-like
                     1"
                     /db_xref="GeneID:361243"
                     /db_xref="RGD:1310246"
     exon            1..80
                     /gene="Cdkal1"
                     /inference="alignment:Splign:2.1.0"
     exon            81..124
                     /gene="Cdkal1"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..1861
                     /gene="Cdkal1"
                     /EC_number="2.8.4.5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     threonylcarbamoyladenosine tRNA methylthiotransferase"
                     /codon_start=1
                     /product="threonylcarbamoyladenosine tRNA
                     methylthiotransferase isoform 1"
                     /protein_id="NP_001389100.1"
                     /db_xref="GeneID:361243"
                     /db_xref="RGD:1310246"
                     /translation="MPSASCDVLLDDIEDIISQEDSKPQDRHFSRKHVFPKVRRRNTQ
                     KYLQEEPSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAYGYKITENASDADL
                     WLLNSCTVKNPAEDHFRNSIKKAHEENKKVVLAGCVPQAQPRQDYLKGLSIIGVQQID
                     RVVEVVEETIKGHSVRLLGQKKESGKRLGGARLDLPKIRKNPLIEIISINTGCLNACT
                     YCKTKHARGNLASYPIDELVERAKQSFQEGVCEIWLTSEDTGAYGRDIGTDLPTLLWK
                     LVEVIPEGAMLRLGMTNPPYILEHLEEMAKILNHPRVYAFLHIPVQSASDSVLMDMKR
                     EYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQ
                     FYPRPGTPAAKAKQVPAHVKKQRTKDLSRVFHSYNPYDHKIGERQQVLVTEESFDSKF
                     YVAHNRFYEQVLVPKNPAFMGKMVEVDIYESGKHFLKGQPVSETRVYTPSICKPLAKG
                     EVSGLTTEFRNRLGDRLNSTSGTCPAPPQGSACSRMALQTSQYDCALKVAAGLALIAL
                     LLHFWPESMFTM"
     exon            125..294
                     /gene="Cdkal1"
                     /inference="alignment:Splign:2.1.0"
     exon            295..407
                     /gene="Cdkal1"
                     /inference="alignment:Splign:2.1.0"
     exon            408..492
                     /gene="Cdkal1"
                     /inference="alignment:Splign:2.1.0"
     exon            493..589
                     /gene="Cdkal1"
                     /inference="alignment:Splign:2.1.0"
     exon            590..638
                     /gene="Cdkal1"
                     /inference="alignment:Splign:2.1.0"
     exon            639..759
                     /gene="Cdkal1"
                     /inference="alignment:Splign:2.1.0"
     exon            760..863
                     /gene="Cdkal1"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1030
                     /gene="Cdkal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1176
                     /gene="Cdkal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1357
                     /gene="Cdkal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1420
                     /gene="Cdkal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1504
                     /gene="Cdkal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1669
                     /gene="Cdkal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..2529
                     /gene="Cdkal1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acaagtgtca tggcgcgctc catctgaagc ctgtgcagtt tcctgacagt ggcttgtggt
       61 ttttctctca gtttggacag attcatcttt caagaggact tgagaccaat ttcagataat
      121 caagatgcct tctgcatcct gtgatgtact gctggatgac atagaagata tcatatcaca
      181 ggaagattca aagccacaag atagacattt ctcaagaaag catgtgtttc ctaaagtacg
      241 gaggcggaat acccaaaaat atttgcaaga agagcccagc ccaccaagtg acagcacgat
      301 tccaggcata cagaaaattt ggatacgaac atggggctgc tcacataata attcagatgg
      361 agaatacatg gctggacagc ttgctgccta tggctataaa attacagaaa atgcatcaga
      421 tgcagatctg tggctcctga acagctgcac tgtgaagaac ccagctgaag accacttcag
      481 aaactcaatc aaaaaagctc acgaggagaa taagaaagtt gtcctcgctg gctgtgttcc
      541 ccaagcccag cctcgtcagg attacctcaa aggactgagc atcattgggg ttcagcagat
      601 agatcgtgtg gtagaagttg tggaggaaac aataaaaggt cactccgtga ggctcctggg
      661 ccagaagaaa gaaagtggga agcggttggg tggagcgaga ctggatttgc caaagatcag
      721 gaagaatccg ctgatagaaa tcatatccat caacacgggg tgtctcaatg cttgtaccta
      781 ctgcaaaact aaacatgcca gaggaaacct ggccagctat cccattgatg aacttgtaga
      841 gagagccaag cagtcctttc aagagggtgt ttgtgagata tggctgacca gcgaggacac
      901 cggggcctat ggcagagaca ttggcacaga tctccccaca ctcctgtgga agctggtgga
      961 agtgattcct gagggagcca tgctgaggct tggcatgaca aatccaccgt atattttaga
     1021 gcatctggag gaaatggcaa aaatcctcaa ccaccccaga gtctacgctt ttctccacat
     1081 cccggtgcag tctgcctctg acagtgtgct catggacatg aagagagagt actgcgtggc
     1141 cgacttcaaa agagttgtgg attttctcaa ggagaaggtt cctggaataa cgattgctac
     1201 ggatattatc tgtggttttc ctggagaaac cgatcaggat tttcaagaaa ccgtgaaact
     1261 tgttgaagag tacaaatttc caagcctctt catcaaccag ttctatccaa gacccggaac
     1321 ccccgctgca aaagccaaac aagtcccagc acacgtgaaa aaacaaagaa caaaagatct
     1381 atctcgggtg tttcattcct acaacccata tgatcacaag attggcgaaa gacaacaagt
     1441 gttagtcaca gaagagtctt ttgactccaa gttttatgtt gcacataacc gattctatga
     1501 gcaggtctta gtgccaaaga accctgcatt catgggaaaa atggttgagg tcgacattta
     1561 tgaatcagga aaacacttct tgaaaggaca gccagtatca gaaaccagag tctatacacc
     1621 ctccatctgc aagccgctgg ccaagggaga agtctcaggt ttgacaacgg aattcagaaa
     1681 tagacttggg gatcgtctga attcaacttc gggcacctgt cctgcacctc cacagggctc
     1741 ggcctgttcc agaatggcgc tgcagacgtc ccagtatgac tgtgcactga aggtggctgc
     1801 aggcctggct ctcatcgctc tccttctgca tttctggcct gagtctatgt ttacaatgta
     1861 accaagtaaa gcatctgtaa ggattaagtt tctaaataaa atcttcaatg gacaggagag
     1921 caacagcacc agttctcaag agacagtcct ctgaactgga cacactgcct tgtctggatc
     1981 ccttcttact gcgctcacac tgagctgagc cctttgacct cagaccagat cacagcttct
     2041 gagcatgtct ttctcatcaa actccttttg actccttttt aacaacaaac acaagtggta
     2101 ggattttttt tctccagtca tttaagtccc agtctaagtt cacagtggct ctgcccaccc
     2161 gtggctctgc ccaccctttc cttgtgagga agaacatcca gccttaataa acattctccg
     2221 ggctgtgttt ggagtccccg tgctacaaac atctttttca cagcagatgt gttcctgaaa
     2281 cgtttatata gaaacctatt ttgagaactt ggacccaagt ctgccactta aaggactctt
     2341 cctggtgttc tagcaaatgt gaagattcca tgcctgtggc acccacaaac tttcaaaaca
     2401 aaccatgatc ctttcctgac acaccccggc cagacatgct gcatttatca ttctgcccca
     2461 gcaccatcag cagtctgaac agctgcaatg acctctttca caataaacgg aatcggtgca
     2521 gtaagaaaa
//
