LOCUS       NM_001007743            1699 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cyclin-dependent kinase 9 (Cdk9), mRNA.
ACCESSION   NM_001007743 XM_342413
VERSION     NM_001007743.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1699)
  AUTHORS   Wang,C., Chen,R., Zhu,X., Zhang,X. and Lian,N.
  TITLE     Long noncoding RNA small nucleolar RNA host gene 5 facilitates
            neuropathic pain in spinal nerve injury by promoting SCN9A
            expression via CDK9
  JOURNAL   Hum Cell 37 (2), 451-464 (2024)
   PUBMED   38167752
  REMARK    GeneRIF: Long noncoding RNA small nucleolar RNA host gene 5
            facilitates neuropathic pain in spinal nerve injury by promoting
            SCN9A expression via CDK9.
REFERENCE   2  (bases 1 to 1699)
  AUTHORS   Martin,R.D., Sun,Y., MacKinnon,S., Cuccia,L., Page,V., Hebert,T.E.
            and Tanny,J.C.
  TITLE     Differential Activation of P-TEFb Complexes in the Development of
            Cardiomyocyte Hypertrophy following Activation of Distinct G
            Protein-Coupled Receptors
  JOURNAL   Mol Cell Biol 40 (14), e00048-20 (2020)
   PUBMED   32341082
  REMARK    GeneRIF: Differential Activation of P-TEFb Complexes in the
            Development of Cardiomyocyte Hypertrophy following Activation of
            Distinct G Protein-Coupled Receptors.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1699)
  AUTHORS   Blank,M.F., Chen,S., Poetz,F., Schnolzer,M., Voit,R. and Grummt,I.
  TITLE     SIRT7-dependent deacetylation of CDK9 activates RNA polymerase II
            transcription
  JOURNAL   Nucleic Acids Res 45 (5), 2675-2686 (2017)
   PUBMED   28426094
REFERENCE   4  (bases 1 to 1699)
  AUTHORS   Jeronimo,C., Bataille,A.R. and Robert,F.
  TITLE     The writers, readers, and functions of the RNA polymerase II
            C-terminal domain code
  JOURNAL   Chem Rev 113 (11), 8491-8522 (2013)
   PUBMED   23837720
  REMARK    Review article
REFERENCE   5  (bases 1 to 1699)
  AUTHORS   Kwak,H. and Lis,J.T.
  TITLE     Control of transcriptional elongation
  JOURNAL   Annu Rev Genet 47, 483-508 (2013)
   PUBMED   24050178
  REMARK    Review article
REFERENCE   6  (bases 1 to 1699)
  AUTHORS   Yeo,M., Lin,P.S., Dahmus,M.E. and Gill,G.N.
  TITLE     A novel RNA polymerase II C-terminal domain phosphatase that
            preferentially dephosphorylates serine 5
  JOURNAL   J Biol Chem 278 (28), 26078-26085 (2003)
   PUBMED   12721286
REFERENCE   7  (bases 1 to 1699)
  AUTHORS   Simone,C., Bagella,L., Bellan,C. and Giordano,A.
  TITLE     Physical interaction between pRb and cdk9/cyclinT2 complex
  JOURNAL   Oncogene 21 (26), 4158-4165 (2002)
   PUBMED   12037672
REFERENCE   8  (bases 1 to 1699)
  AUTHORS   Simone,C., Stiegler,P., Bagella,L., Pucci,B., Bellan,C., De
            Falco,G., De Luca,A., Guanti,G., Puri,P.L. and Giordano,A.
  TITLE     Activation of MyoD-dependent transcription by cdk9/cyclin T2
  JOURNAL   Oncogene 21 (26), 4137-4148 (2002)
   PUBMED   12037670
REFERENCE   9  (bases 1 to 1699)
  AUTHORS   Nguyen,V.T., Kiss,T., Michels,A.A. and Bensaude,O.
  TITLE     7SK small nuclear RNA binds to and inhibits the activity of
            CDK9/cyclin T complexes
  JOURNAL   Nature 414 (6861), 322-325 (2001)
   PUBMED   11713533
REFERENCE   10 (bases 1 to 1699)
  AUTHORS   Peng,J., Zhu,Y., Milton,J.T. and Price,D.H.
  TITLE     Identification of multiple cyclin subunits of human P-TEFb
  JOURNAL   Genes Dev 12 (5), 755-762 (1998)
   PUBMED   9499409
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC082037.1.
            
            On Nov 29, 2004 this sequence version replaced XM_342413.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082037.1, EV772266.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840117 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1699
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p11"
     gene            1..1699
                     /gene="Cdk9"
                     /note="cyclin-dependent kinase 9"
                     /db_xref="GeneID:362110"
                     /db_xref="RGD:1359638"
     exon            1..136
                     /gene="Cdk9"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..1163
                     /gene="Cdk9"
                     /EC_number="2.7.11.23"
                     /EC_number="2.7.11.22"
                     /note="cell division protein kinase 9; cyclin-dependent
                     kinase 9 (CDC2-related kinase)"
                     /codon_start=1
                     /product="cyclin-dependent kinase 9"
                     /protein_id="NP_001007744.1"
                     /db_xref="GeneID:362110"
                     /db_xref="RGD:1359638"
                     /translation="MAKQYDSVECPFCDEVTKYEKLAKIGQGTFGEVFKAKHRQTGQK
                     VALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLV
                     FDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRD
                     GVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCI
                     MAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDKYELFEKLELVKGQKRKVK
                     DRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTS
                     MFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF"
     exon            137..218
                     /gene="Cdk9"
                     /inference="alignment:Splign:2.1.0"
     exon            219..309
                     /gene="Cdk9"
                     /inference="alignment:Splign:2.1.0"
     exon            310..476
                     /gene="Cdk9"
                     /inference="alignment:Splign:2.1.0"
     exon            477..648
                     /gene="Cdk9"
                     /inference="alignment:Splign:2.1.0"
     exon            649..797
                     /gene="Cdk9"
                     /inference="alignment:Splign:2.1.0"
     exon            798..1675
                     /gene="Cdk9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggcggcgg cggcggcggc ggcggcggcg cgctggaggc ggccatggcc aagcagtacg
       61 actcagtgga atgcccgttt tgcgatgagg tcaccaagta cgagaaactt gccaagatcg
      121 gccaaggcac attcggggaa gtatttaaag ccaagcaccg tcagaccggc cagaaggtgg
      181 ctctgaagaa agtgttgatg gagaatgaga aggaggggtt ccccatcaca gccttgcggg
      241 aaatcaagat tctacagctc ctaaagcacg agaatgtggt caacctgatt gagatttgtc
      301 gaaccaaagc ttcaccctat aaccgctgca aaggcagcat ctatctggtg ttcgacttct
      361 gtgagcatga cctcgctggg ctgctgagca atgtcttagt gaagttcacg ttgtctgaga
      421 tcaagagagt aatgcagatg ctgctgaatg gcctctacta catccacagg aacaagatcc
      481 tgcacaggga catgaaggct gccaacgtgc tcattacccg agatggggtc ctaaagctgg
      541 cagattttgg gctggctcgc gccttcagcc tagctaagaa tagccagccc aaccgataca
      601 ccaaccgtgt ggtgacattg tggtaccgac ctccggagct cctgctcgga gagcgggact
      661 acggcccgcc cattgacctg tggggtgctg ggtgcatcat ggcagagatg tggacccgca
      721 gccccatcat gcagggcaac acagagcagc accagcttgc cctcatcagc cagctctgtg
      781 gctccatcac tccagaggtg tggccaaacg tggacaagta tgagctgttc gaaaagctgg
      841 aactggtcaa gggccagaag cggaaggtga aggaccgtct gaaggcctac gtccgggacc
      901 cctatgctct ggacctcatt gacaagctgc tggtgctgga ccctgcacag cggattgaca
      961 gtgatgatgc cctcaaccat gacttcttct ggtcggaccc catgccctcg gacctcaagg
     1021 gcatgctgtc tactcacttg acgtctatgt ttgagtacct ggccccacca cgacggaagg
     1081 gtagccagat cacccagcag tccaccaacc agagccgaaa tcccgccact accaaccaga
     1141 cggaatttga acgtgtcttc tgaggctgtc gctggccggt gttcttaggt taggggtgga
     1201 ttgcttctgc tctgacttgc atgaacatgt gacatgatgg gacgtttgag attttctcct
     1261 ccagtacata tcaactccac cctggcgctg ggaacagctg cctgagtgga ctggggcaga
     1321 gcattggctg caagccctga gggtcctggg gctgtcctgc ctgcctctct ctggaggtct
     1381 cagcatggat acgaagtggg gtgggagaag ctcacccact gtgactttta agaactcctg
     1441 tgtgatggga ggaaggtaca ggttcctcac catccccagc ccttcctctg gatgaggatg
     1501 tgaaggacag aggcatctcc aaaatgggct acttttggta tagaccttag gagtgtgggg
     1561 ctggtgtaag ctcttggttc ctttaaaagg agaattttat tttgttttgt tcagtttaga
     1621 cattcctgga tgcagtttga ttggttaaat taaaagttga tttttttttc cagtaaaaaa
     1681 aaaaaaaaaa aaaaaaaaa
//
