LOCUS       NM_001109061            2467 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus cyclin-dependent kinase 8 (Cdk8), mRNA.
ACCESSION   NM_001109061 XM_001061556 XM_573350
VERSION     NM_001109061.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2467)
  AUTHORS   Zhang R, Zhong Y, Long SY, Yang QN, Zhou B and Rao L.
  TITLE     Association between CDK8 gene polymorphisms and dilated
            cardiomyopathy in a Chinese Han population
  JOURNAL   Cardiovasc Diagn Ther 11 (5), 1036-1046 (2021)
   PUBMED   34815954
REFERENCE   2  (bases 1 to 2467)
  AUTHORS   Dou P, Tan G, Fan Z, Xiao J, Shi C and Lin Z.
  TITLE     MicroRNA-9 facilitates hypoxia-induced injury and apoptosis in H9c2
            cells via targeting CDK8
  JOURNAL   J Biosci 46 (2021)
   PUBMED   33737500
  REMARK    GeneRIF: MicroRNA-9 facilitates hypoxia-induced injury and
            apoptosis in H9c2 cells via targeting CDK8.
REFERENCE   3  (bases 1 to 2467)
  AUTHORS   Jeronimo C, Bataille AR and Robert F.
  TITLE     The writers, readers, and functions of the RNA polymerase II
            C-terminal domain code
  JOURNAL   Chem Rev 113 (11), 8491-8522 (2013)
   PUBMED   23837720
  REMARK    Review article
REFERENCE   4  (bases 1 to 2467)
  AUTHORS   Poss ZC, Ebmeier CC and Taatjes DJ.
  TITLE     The Mediator complex and transcription regulation
  JOURNAL   Crit Rev Biochem Mol Biol 48 (6), 575-608 (2013)
   PUBMED   24088064
  REMARK    Review article
REFERENCE   5  (bases 1 to 2467)
  AUTHORS   Porter DC, Farmaki E, Altilia S, Schools GP, West DK, Chen M, Chang
            BD, Puzyrev AT, Lim CU, Rokow-Kittell R, Friedhoff LT,
            Papavassiliou AG, Kalurupalle S, Hurteau G, Shi J, Baran PS,
            Gyorffy B, Wentland MP, Broude EV, Kiaris H and Roninson IB.
  TITLE     Cyclin-dependent kinase 8 mediates chemotherapy-induced
            tumor-promoting paracrine activities
  JOURNAL   Proc Natl Acad Sci U S A 109 (34), 13799-13804 (2012)
   PUBMED   22869755
REFERENCE   6  (bases 1 to 2467)
  AUTHORS   Egloff S, Dienstbier M and Murphy S.
  TITLE     Updating the RNA polymerase CTD code: adding gene-specific layers
  JOURNAL   Trends Genet 28 (7), 333-341 (2012)
   PUBMED   22622228
  REMARK    Review article
REFERENCE   7  (bases 1 to 2467)
  AUTHORS   Jang MK, Mochizuki K, Zhou M, Jeong HS, Brady JN and Ozato K.
  TITLE     The bromodomain protein Brd4 is a positive regulatory component of
            P-TEFb and stimulates RNA polymerase II-dependent transcription
  JOURNAL   Mol Cell 19 (4), 523-534 (2005)
   PUBMED   16109376
REFERENCE   8  (bases 1 to 2467)
  AUTHORS   Malik S, Guermah M, Yuan CX, Wu W, Yamamura S and Roeder RG.
  TITLE     Structural and functional organization of TRAP220, the
            TRAP/mediator subunit that is targeted by nuclear receptors
  JOURNAL   Mol Cell Biol 24 (18), 8244-8254 (2004)
   PUBMED   15340084
  REMARK    Erratum:[Mol Cell Biol. 2022 Nov 17;42(11):e0035922. PMID:
            36255214]
REFERENCE   9  (bases 1 to 2467)
  AUTHORS   Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens
            L, Zybailov B, Washburn MP, Brower CS, Conaway RC and Conaway JW.
  TITLE     A mammalian mediator subunit that shares properties with
            Saccharomyces cerevisiae mediator subunit Cse2
  JOURNAL   J Biol Chem 279 (7), 5846-5851 (2004)
   PUBMED   14638676
REFERENCE   10 (bases 1 to 2467)
  AUTHORS   Brower CS, Sato S, Tomomori-Sato C, Kamura T, Pause A, Stearman R,
            Klausner RD, Malik S, Lane WS, Sorokina I, Roeder RG, Conaway JW
            and Conaway RC.
  TITLE     Mammalian mediator subunit mMED8 is an Elongin BC-interacting
            protein that can assemble with Cul2 and Rbx1 to reconstitute a
            ubiquitin ligase
  JOURNAL   Proc Natl Acad Sci U S A 99 (16), 10353-10358 (2002)
   PUBMED   12149480
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474012.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_573350.2, XM_001061556.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2467
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12p11"
     gene            1..2467
                     /gene="Cdk8"
                     /gene_synonym="RGD1560888"
                     /note="cyclin-dependent kinase 8"
                     /db_xref="GeneID:498140"
                     /db_xref="RGD:1560888"
     exon            1..142
                     /gene="Cdk8"
                     /gene_synonym="RGD1560888"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1409
                     /gene="Cdk8"
                     /gene_synonym="RGD1560888"
                     /codon_start=1
                     /product="cyclin-dependent kinase 8"
                     /protein_id="NP_001102531.1"
                     /db_xref="GeneID:498140"
                     /db_xref="RGD:1560888"
                     /translation="MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGK
                     DDKDYALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEH
                     DLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVM
                     GEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIW
                     AIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEH
                     STLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPY
                     FLEDPLPTSDVFAGCQIPYPKREFLTEEEPDEKGDKKNQQQQQGNNHTNGTGHPGNQD
                     SGHAQGPPLKKVRVVPPTTTSGGLIMTSDYQRSNPHAAYPNPGPSTSQPQSSMGYSAT
                     SQQPPQYSHQTHRY"
     exon            143..218
                     /gene="Cdk8"
                     /gene_synonym="RGD1560888"
                     /inference="alignment:Splign:2.1.0"
     exon            219..329
                     /gene="Cdk8"
                     /gene_synonym="RGD1560888"
                     /inference="alignment:Splign:2.1.0"
     exon            330..470
                     /gene="Cdk8"
                     /gene_synonym="RGD1560888"
                     /inference="alignment:Splign:2.1.0"
     exon            471..528
                     /gene="Cdk8"
                     /gene_synonym="RGD1560888"
                     /inference="alignment:Splign:2.1.0"
     exon            529..660
                     /gene="Cdk8"
                     /gene_synonym="RGD1560888"
                     /inference="alignment:Splign:2.1.0"
     exon            661..804
                     /gene="Cdk8"
                     /gene_synonym="RGD1560888"
                     /inference="alignment:Splign:2.1.0"
     exon            805..874
                     /gene="Cdk8"
                     /gene_synonym="RGD1560888"
                     /inference="alignment:Splign:2.1.0"
     exon            875..947
                     /gene="Cdk8"
                     /gene_synonym="RGD1560888"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1045
                     /gene="Cdk8"
                     /gene_synonym="RGD1560888"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1124
                     /gene="Cdk8"
                     /gene_synonym="RGD1560888"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1283
                     /gene="Cdk8"
                     /gene_synonym="RGD1560888"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..2467
                     /gene="Cdk8"
                     /gene_synonym="RGD1560888"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggaggctgt gacaatggac tatgacttta aagtgaagct gagcagcgag cgggagcggg
       61 tcgaggacct gtttgaatac gagggctgca aagttggtcg aggcacttac gggcatgtct
      121 acaaggcgaa gaggaaagat gggaaggacg ataaagacta cgctttaaaa caaatagaag
      181 gaactggaat ttctatgtcg gcatgcagag agatagcatt acttcgagag cttaagcacc
      241 caaacgtcat ctctcttcag aaggtgtttc tgtctcatgc tgatcggaaa gtatggcttc
      301 tctttgacta tgctgaacat gacctctggc atataattaa gtttcacaga gcttcgaaag
      361 ccaacaagaa gcccgttcag ttacctcggg gaatggtgaa gtcactgttg taccagatcc
      421 tagatgggat tcactatctt catgccaact gggtgttgca cagggatttg aaacctgcta
      481 atattttagt tatgggtgaa ggtcctgagc gaggaagagt aaaaattgct gacatgggct
      541 ttgcccgatt atttaattca cctttgaagc ctttagcaga tttggatcca gtggttgtaa
      601 cattctggta ccgagctcca gaattactcc tcggagccag acactatacc aaagcaattg
      661 atatttgggc tatagggtgt atatttgcag aactactaac gtcagagcca atatttcact
      721 gtcgacaaga ggacatcaaa actagtaatc cttatcacca tgaccagctg gacagaatat
      781 tcaatgtaat gggattccct gcagataaag attgggaaga tataaaaaag atgcccgaac
      841 attcaacatt aatgaaagat ttcagaagaa atacgtacac caattgcagc cttatcaagt
      901 acatggaaaa gcataaagtt aaacctgaca gtaaagcatt ccacttgctt cagaagttgc
      961 tcactatgga cccaataaag cgaattacct cagagcaggc catgcaggat ccctacttcc
     1021 tagaagaccc actccccacg tcagatgttt tcgccggttg tcagatccct tatcccaaac
     1081 gagagttttt gacagaagaa gagcctgatg agaaaggaga caaaaagaac cagcagcagc
     1141 agcagggcaa taaccacact aatggaaccg gccatcccgg gaaccaggac agcggccacg
     1201 cacaggggcc ccccttgaaa aaagtgagag ttgtccctcc taccactacc tcaggtgggc
     1261 tcatcatgac ctccgactat cagcgttcca atccacatgc tgcttatccc aaccctggac
     1321 caagcacatc acagccccag agcagcatgg gatactcagc tacctcccag cagcctccac
     1381 agtactcaca tcagacacat cggtactgag ctgtgctgga gtctgtccgt gcactgttgc
     1441 tcatgctgca ggactggctg cagcactctg cgggaacctg gtgtgggcca tgcgaatgta
     1501 ctgtacaacc acatcttcac aatgtccagt agccgagttc cacagttgtc acagatcggg
     1561 gcggtagctt ccaggttgta cctaagtttg gagttagact tgaaatgaaa gtgctagcac
     1621 agttgtggtg tgggtttgct ccttccatag tttacttgac atggttcaga ctgaccaagc
     1681 atagttttca gtgacagtct gtagcagttg aagctgtgaa atgtgctagg gcgagcattt
     1741 gtcctcatgt gtggtgactt tcagtgtaac agcgttatct gaccaatagt acacacagac
     1801 gcaaggttta actggtactt gaaacacaga ttatgttaac aaaataaccg agacttaaag
     1861 attattttgg tatactttct ttttagtgtc ttatcagtgg gttgattcat cttctacata
     1921 aatcagtgtt ttatgaccaa gaatattgct tggattgttt tgaaagtaca aaagaaccac
     1981 atagtttcta ctgacaggtt tcagaactcc caaagattaa tttccaactt agaggtctgt
     2041 ttttattttc aacctatgac ttgactggtc ctaaagctgc tatttgatta atatgttgtc
     2101 attgatagaa gcctgttggt tccgcaaact gaaatgattg tcgcagacag tgtttccttt
     2161 ttcttgttgg tgttgctgat ttgtgagcat gctttctgat tacaaaagcg tgagtggcga
     2221 cctccgtgag gcacggcatc agtgtgcact cttctgtcct gatttaagct gcctagtgta
     2281 gtgctattac agttttgttc agttaacttt ctttttaaaa agttgttcgc acatttttag
     2341 ggtgccctta cttcagaaag gagagggagt aggagagcct tagaactttt gaggggaaaa
     2401 taaaaagcta taacatacaa cgtactgtat caaactattt tacatgaatg acacaagtat
     2461 tctgaat
//
