LOCUS       NM_001191861            1505 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus cyclin-dependent kinase 6 (Cdk6), mRNA.
ACCESSION   NM_001191861 XM_342638
VERSION     NM_001191861.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1505)
  AUTHORS   Mudunuru J, Ren C, Taft DR and Maniar M.
  TITLE     Effect of Gender on the Pharmacokinetics of ON 123300, A Dual
            Inhibitor of ARK5 and CDK4/6 for the Treatment of Cancer, in Rats
  JOURNAL   Eur J Drug Metab Pharmacokinet 44 (4), 531-538 (2019)
   PUBMED   30701428
  REMARK    GeneRIF: A small molecule dual inhibitor of the c-MYC activated
            kinases ARK5 and CDK4/6, is being developed.
REFERENCE   2  (bases 1 to 1505)
  AUTHORS   Keutgen XM, Kumar S, Gara SK, Boufraqech M, Agarwal S, Hruban RH,
            Nilubol N, Quezado M, Finney R, Cam M and Kebebew E.
  TITLE     Transcriptional alterations in hereditary and sporadic
            nonfunctioning pancreatic neuroendocrine tumors according to
            genotype
  JOURNAL   Cancer 124 (3), 636-647 (2018)
   PUBMED   29149451
  REMARK    Erratum:[Cancer. 2018 Apr 1;124(7):1518. Gara, Sudheer [corrected
            to Gara, Sudheer Kumar]. PMID: 29574707]
REFERENCE   3  (bases 1 to 1505)
  AUTHORS   Zhang J, Zhao M, Xue ZQ, Liu Y and Wang YX.
  TITLE     miR-377 inhibited tumorous behaviors of non-small cell lung cancer
            through directly targeting CDK6
  JOURNAL   Eur Rev Med Pharmacol Sci 20 (21), 4494-4499 (2016)
   PUBMED   27874949
REFERENCE   4  (bases 1 to 1505)
  AUTHORS   Gu J, Ni Y, Xu L, Xu H and Cai Z.
  TITLE     Nanog interact with CDK6 to regulates astrocyte cells proliferation
            following spinal cord injury
  JOURNAL   Biochem Biophys Res Commun 469 (4), 1097-1103 (2016)
   PUBMED   26707878
  REMARK    GeneRIF: Taken together, these data suggested that both Nanog may
            play important roles in spinal cord pathophysiology via interact
            with CDK6.
REFERENCE   5  (bases 1 to 1505)
  AUTHORS   Yuan W, Tang C, Zhu W, Zhu J, Lin Q, Fu Y, Deng C, Xue Y, Yang M,
            Wu S and Shan Z.
  TITLE     CDK6 mediates the effect of attenuation of miR-1 on provoking
            cardiomyocyte hypertrophy
  JOURNAL   Mol Cell Biochem 412 (1-2), 289-296 (2016)
   PUBMED   26699910
  REMARK    GeneRIF: results reveal that derepression of CDK6 and activation of
            Rb pathway contributes to the effect of attenuation of miR-1 on
            provoking cardiomyocyte hypertrophy
REFERENCE   6  (bases 1 to 1505)
  AUTHORS   Fahraeus R and Lane DP.
  TITLE     The p16(INK4a) tumour suppressor protein inhibits alphavbeta3
            integrin-mediated cell spreading on vitronectin by blocking
            PKC-dependent localization of alphavbeta3 to focal contacts
  JOURNAL   EMBO J 18 (8), 2106-2118 (1999)
   PUBMED   10205165
REFERENCE   7  (bases 1 to 1505)
  AUTHORS   Russo AA, Tong L, Lee JO, Jeffrey PD and Pavletich NP.
  TITLE     Structural basis for inhibition of the cyclin-dependent kinase Cdk6
            by the tumour suppressor p16INK4a
  JOURNAL   Nature 395 (6699), 237-243 (1998)
   PUBMED   9751050
REFERENCE   8  (bases 1 to 1505)
  AUTHORS   Costello JF, Plass C, Arap W, Chapman VM, Held WA, Berger MS, Su
            Huang HJ and Cavenee WK.
  TITLE     Cyclin-dependent kinase 6 (CDK6) amplification in human gliomas
            identified using two-dimensional separation of genomic DNA
  JOURNAL   Cancer Res 57 (7), 1250-1254 (1997)
   PUBMED   9102208
REFERENCE   9  (bases 1 to 1505)
  AUTHORS   Hirai H, Roussel MF, Kato JY, Ashmun RA and Sherr CJ.
  TITLE     Novel INK4 proteins, p19 and p18, are specific inhibitors of the
            cyclin D-dependent kinases CDK4 and CDK6
  JOURNAL   Mol Cell Biol 15 (5), 2672-2681 (1995)
   PUBMED   7739547
REFERENCE   10 (bases 1 to 1505)
  AUTHORS   Meyerson M and Harlow E.
  TITLE     Identification of G1 kinase activity for cdk6, a novel cyclin D
            partner
  JOURNAL   Mol Cell Biol 14 (3), 2077-2086 (1994)
   PUBMED   8114739
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000141.1.
            
            [WARNING] On Mar 28, 2024 this sequence was replaced by
            NM_001191861.3.
            
            On Feb 10, 2021 this sequence version replaced NM_001191861.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760434 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-233               JACYVU010000141.1  20446769-20447001   c
            234-369             JACYVU010000141.1  20396213-20396348   c
            370-537             JACYVU010000141.1  20357366-20357533   c
            538-647             JACYVU010000141.1  20318219-20318328   c
            648-698             JACYVU010000141.1  20272681-20272731   c
            699-834             JACYVU010000141.1  20268648-20268783   c
            835-1505            JACYVU010000141.1  20266681-20267351   c
FEATURES             Location/Qualifiers
     source          1..1505
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q13"
     gene            1..1505
                     /gene="Cdk6"
                     /note="cyclin-dependent kinase 6"
                     /db_xref="GeneID:114483"
                     /db_xref="RGD:621121"
     CDS             1..981
                     /gene="Cdk6"
                     /EC_number="2.7.11.22"
                     /note="cell division protein kinase 6"
                     /codon_start=1
                     /product="cyclin-dependent kinase 6"
                     /protein_id="NP_001178790.1"
                     /db_xref="GeneID:114483"
                     /db_xref="RGD:621121"
                     /translation="MEKDSLSRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKR
                     VRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD
                     QDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIK
                     LADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAELFRRKPL
                     FRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDL
                     LLKCLTFNPAKRISAYGALNHPYFQDLERYKDNLHSHLSSSQSTSELNTA"
     exon            1..233
                     /gene="Cdk6"
                     /inference="alignment:Splign:2.1.0"
     exon            234..369
                     /gene="Cdk6"
                     /inference="alignment:Splign:2.1.0"
     exon            370..537
                     /gene="Cdk6"
                     /inference="alignment:Splign:2.1.0"
     exon            538..647
                     /gene="Cdk6"
                     /inference="alignment:Splign:2.1.0"
     exon            648..698
                     /gene="Cdk6"
                     /inference="alignment:Splign:2.1.0"
     exon            699..834
                     /gene="Cdk6"
                     /inference="alignment:Splign:2.1.0"
     exon            835..1505
                     /gene="Cdk6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggagaagg acagcctgag tcgcgccgac cagcagtatg agtgcgtggc ggagatcggg
       61 gaaggcgcct acgggaaggt gttcaaggcc cgcgacctga agaacggcgg ccgcttcgtg
      121 gctctgaagc gcgtgcgagt gcagaccgga gaggagggca tgccgctctc caccatccgc
      181 gaggtggcgg tgctgaggca cctggagacc tttgagcacc ccaacgtggt caggttgttt
      241 gacgtgtgca cagtgtcacg gacagacaga gaaactaaac ttacgctagt gtttgagcat
      301 gttgatcaag acttgaccac ttacttggat aaagttccag aacccggtgt gcccacagag
      361 accataaagg atatgatgtt tcagcttctc cgaggtctgg acttcctcca ttctcacaga
      421 gtagtgcatc gtgacctgaa gccacagaac attctggtga ccagcagtgg acaaataaaa
      481 ctggctgact tcggccttgc ccgcatctac agttttcaga tggcccttac ctcggtggtc
      541 gtcacgctgt ggtaccgagc cccggaagtc ctgctccagt ccagctacgc cacccccgtg
      601 gacctctgga gtgttggctg catctttgca gaactgtttc gcagaaagcc tctttttcgt
      661 ggaagttcag acgtggatca actagggaaa atcttggacg tcatcggact cccaggagaa
      721 gaagactggc ctagggatgt tgctcttccc agacaggctt ttcactccaa atctgcccaa
      781 cccatcgaga agtttgtgac agacatcgac gagctaggca aagacctcct tctgaaatgc
      841 ttgacgttta atccagctaa aagaatatcc gcttatggcg ccctgaatca cccgtacttc
      901 caagacctgg agagatacaa ggacaacctg cattctcacc tgtcgtccag ccagagcacc
      961 tcggagctga acacagcctg aggctccccg gggatgccgc tagctcgtca tctgaacaca
     1021 ctggtgtccc ccaggcaagc cttgcagagc agttacagac tgctggctga ggacccttct
     1081 agctgccagc ttctgggtgg gctctgcctc accaaggaaa ccacctagtt tactgttcag
     1141 agatcaatgc aagagcgatt gcagctttac gttcatacac gtgtttgttt gtctgtctgt
     1201 ttcaagaacc tggaagactt ccagaagaga agctgctgac caattgtgct gccatttcgt
     1261 tttctaacct tgaatgctgc cagtgtagaa tggggatcca ggcccagcgg agttatgatg
     1321 taatctgcct gcagctgctg ggcctgcttt ggtacttgtg tgtgtgtgtg tgtgtgtgtg
     1381 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtaagag acgggggaag ggagagagaa
     1441 agatccctga tctcgtaaag tgttactttt tcgtagacaa gaagaataaa tgaattttaa
     1501 agaaa
//
