LOCUS       NM_024488               1891 bp    mRNA    linear   ROD 31-JUL-2024
DEFINITION  Rattus norvegicus CDK5 regulatory subunit associated protein 3
            (Cdk5rap3), mRNA.
ACCESSION   NM_024488
VERSION     NM_024488.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1891)
  AUTHORS   Chen,Y., Zheng,Y., Iyer,S.R., Harders,G.E., Pan,S., Chen,H.H.,
            Ichiki,T., Burnett,J.C. Jr. and Sangaralingham,S.J.
  TITLE     C53: A novel particulate guanylyl cyclase B receptor activator that
            has sustained activity in vivo with anti-fibrotic actions in human
            cardiac and renal fibroblasts
  JOURNAL   J Mol Cell Cardiol 130, 140-150 (2019)
   PUBMED   30954448
  REMARK    GeneRIF: The current findings advance innovation in drug discovery
            and highlight C53 as a novel pGC-B activator with sustained in vivo
            activity and anti-fibrotic actions in vitro.
REFERENCE   2  (bases 1 to 1891)
  AUTHORS   Wu,J., Jiang,H., Luo,S., Zhang,M., Zhang,Y., Sun,F., Huang,S. and
            Li,H.
  TITLE     Caspase-mediated cleavage of C53/LZAP protein causes abnormal
            microtubule bundling and rupture of the nuclear envelope
  JOURNAL   Cell Res 23 (5), 691-704 (2013)
   PUBMED   23478299
REFERENCE   3  (bases 1 to 1891)
  AUTHORS   Zhang,Y., Zhang,M., Wu,J., Lei,G. and Li,H.
  TITLE     Transcriptional regulation of the Ufm1 conjugation system in
            response to disturbance of the endoplasmic reticulum homeostasis
            and inhibition of vesicle trafficking
  JOURNAL   PLoS One 7 (11), e48587 (2012)
   PUBMED   23152784
REFERENCE   4  (bases 1 to 1891)
  AUTHORS   Lemaire,K., Moura,R.F., Granvik,M., Igoillo-Esteve,M.,
            Hohmeier,H.E., Hendrickx,N., Newgard,C.B., Waelkens,E., Cnop,M. and
            Schuit,F.
  TITLE     Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect
            pancreatic beta cells from ER stress-induced apoptosis
  JOURNAL   PLoS One 6 (4), e18517 (2011)
   PUBMED   21494687
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1891)
  AUTHORS   An,H., Lu,X., Liu,D. and Yarbrough,W.G.
  TITLE     LZAP inhibits p38 MAPK (p38) phosphorylation and activity by
            facilitating p38 association with the wild-type p53 induced
            phosphatase 1 (WIP1)
  JOURNAL   PLoS One 6 (1), e16427 (2011)
   PUBMED   21283629
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1891)
  AUTHORS   Yin,X., Warner,D.R., Roberts,E.A., Pisano,M.M. and Greene,R.M.
  TITLE     Novel interaction between nuclear co-activator CBP and the CDK5
            activator binding protein - C53
  JOURNAL   Int J Mol Med 16 (2), 251-256 (2005)
   PUBMED   16012757
REFERENCE   7  (bases 1 to 1891)
  AUTHORS   Jiang,H., Luo,S. and Li,H.
  TITLE     Cdk5 activator-binding protein C53 regulates apoptosis induced by
            genotoxic stress via modulating the G2/M DNA damage checkpoint
  JOURNAL   J Biol Chem 280 (21), 20651-20659 (2005)
   PUBMED   15790566
REFERENCE   8  (bases 1 to 1891)
  AUTHORS   Chen,J., Liu,B., Liu,Y., Han,Y., Yu,H., Zhang,Y., Lu,L., Zhen,Y.
            and Hui,R.
  TITLE     A novel gene IC53 stimulates ECV304 cell proliferation and is
            upregulated in failing heart
  JOURNAL   Biochem Biophys Res Commun 294 (1), 161-166 (2002)
   PUBMED   12054757
REFERENCE   9  (bases 1 to 1891)
  AUTHORS   Wang,X., Ching,Y.P., Lam,W.H., Qi,Z., Zhang,M. and Wang,J.H.
  TITLE     Identification of a common protein association region in the
            neuronal Cdk5 activator
  JOURNAL   J Biol Chem 275 (41), 31763-31769 (2000)
   PUBMED   10915792
REFERENCE   10 (bases 1 to 1891)
  AUTHORS   Ching,Y.P., Qi,Z. and Wang,J.H.
  TITLE     Cloning of three novel neuronal Cdk5 activator binding proteins
  JOURNAL   Gene 242 (1-2), 285-294 (2000)
   PUBMED   10721722
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1 and BC081793.1.
            
            On May 5, 2015 this sequence version replaced NM_024488.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081793.1, AF177476.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                JAXUCZ010000010.1  82399914-82400001   c
            89-1891             BC081793.1         1-1803
FEATURES             Location/Qualifiers
     source          1..1891
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..1891
                     /gene="Cdk5rap3"
                     /gene_synonym="C53"
                     /note="CDK5 regulatory subunit associated protein 3"
                     /db_xref="GeneID:80278"
                     /db_xref="RGD:620002"
     exon            1..103
                     /gene="Cdk5rap3"
                     /gene_synonym="C53"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1612
                     /gene="Cdk5rap3"
                     /gene_synonym="C53"
                     /note="CDK5 activator-binding protein C53"
                     /codon_start=1
                     /product="CDK5 regulatory subunit-associated protein 3"
                     /protein_id="NP_077814.2"
                     /db_xref="GeneID:80278"
                     /db_xref="RGD:620002"
                     /translation="MQDHQHVPIDIQTSKLLDWLVDRRHCNLKWQSLVLTIREKINTA
                     IQDMPESQEIAQLLSGSYIHYFHCLRIVDLLKGTEASTKNIFGRYSSQRMKDWQEIIS
                     LYEKDNTYLVELSSLLVRNVNYEIPSLKKQIAKCQQLQQDYSRKEEEGQAGAAEMREQ
                     FYHSCKQYGITGDNVRRELLALVKDLPSQLAEIGAGAQSLGEAIDLYQACVEFVCDSP
                     TEQVLPMLRYVQKKGNSTVYEWRTGTEPSVVERPQLEDPPEQVQEDEIDWGDFGLEAV
                     SDSGNIISAETPGIDWGISLESESKDAGADKIDWGDNAVASEITVLETGTEAPEGVAR
                     GSDALTLLEYPETRNQFIDELMELEIFLSQRAVEMSEEADILSVSQFQLAPAILQGQT
                     KEKMLSLVSTLQHLIGQLTSLRMQHLFMILASPRYVDRVTELLQQKLKQSQLLALKKD
                     LMVEKQQEALQEQAALEPKLDLLLEKTRELQKLIEADISKRYNGRPVNLMGTSV"
     exon            104..149
                     /gene="Cdk5rap3"
                     /gene_synonym="C53"
                     /inference="alignment:Splign:2.1.0"
     exon            150..281
                     /gene="Cdk5rap3"
                     /gene_synonym="C53"
                     /inference="alignment:Splign:2.1.0"
     exon            282..382
                     /gene="Cdk5rap3"
                     /gene_synonym="C53"
                     /inference="alignment:Splign:2.1.0"
     exon            383..431
                     /gene="Cdk5rap3"
                     /gene_synonym="C53"
                     /inference="alignment:Splign:2.1.0"
     exon            432..610
                     /gene="Cdk5rap3"
                     /gene_synonym="C53"
                     /inference="alignment:Splign:2.1.0"
     exon            611..747
                     /gene="Cdk5rap3"
                     /gene_synonym="C53"
                     /inference="alignment:Splign:2.1.0"
     exon            748..892
                     /gene="Cdk5rap3"
                     /gene_synonym="C53"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1000
                     /gene="Cdk5rap3"
                     /gene_synonym="C53"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1079
                     /gene="Cdk5rap3"
                     /gene_synonym="C53"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1168
                     /gene="Cdk5rap3"
                     /gene_synonym="C53"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1374
                     /gene="Cdk5rap3"
                     /gene_synonym="C53"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1546
                     /gene="Cdk5rap3"
                     /gene_synonym="C53"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1866
                     /gene="Cdk5rap3"
                     /gene_synonym="C53"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccggtttg tttctgaatt gaggctcagg cacgccggct caggattggt gctgggccgg
       61 gccggggtct ttggccggaa gcggaagtgg aaaaaggatg caggaccatc agcacgtgcc
      121 catcgacatc cagaccagca agctgctcga ttggctggtg gacagaagac actgcaactt
      181 aaaatggcaa agcctggtgc tgaccatccg ggaaaagatc aacaccgcca tccaggacat
      241 gccagagagc caagagattg cccagctgct ctctggttcc tacatccact acttccactg
      301 cctaagaata gtggaccttc ttaaaggtac cgaggcttcc accaaaaata tttttggccg
      361 ctactcttca cagcggatga aggattggca ggagatcata agcctgtatg agaaggacaa
      421 cacctattta gtggaactct ctagcctcct ggttcggaat gtcaactatg agatcccctc
      481 tctgaagaag cagattgcca agtgccagca actgcagcaa gactacagcc gcaaggagga
      541 ggagggccag gctggggctg ctgagatgcg agagcagttc taccactcct gcaaacagta
      601 cggcatcacg ggagacaatg tccgacgaga gcttctggcc ctggtgaagg acctgccaag
      661 tcagctggct gagataggag cgggagctca gtccctgggg gaagccatcg acctgtacca
      721 ggcctgtgtg gagtttgtat gtgacagccc cacagagcag gtgctgccca tgctgcggta
      781 cgttcagaag aagggaaact ccacggtgta tgagtggagg acagggacag agccctctgt
      841 ggtagagcgg ccacaactgg aggaccctcc cgagcaggtg caagaagacg agatcgactg
      901 gggcgacttt ggcctggagg ctgtttctga ctctggaaac atcatctctg ctgagacccc
      961 tgggatagac tggggtatct ccctggagtc agagtccaag gatgctgggg ctgacaagat
     1021 agactggggt gacaatgctg ttgcttcgga gatcaccgtg ctggagacag gaacggaggc
     1081 tccagagggt gttgctaggg gctcagacgc tctgactctc cttgaatacc ctgagactcg
     1141 gaatcagttc atcgatgagc tcatggagct tgagatcttc ttgtctcaga gagcagtaga
     1201 gatgagtgag gaggctgaca tcctgtccgt gagccagttc cagctggctc ctgccatcct
     1261 tcagggccag accaaggaga agatgctcag cctggtgtcc acactgcagc atctgattgg
     1321 ccagctcacc agtctccgga tgcagcacct gtttatgatt ctggcctcac cgaggtatgt
     1381 ggaccgggtg acagagctcc tccagcagaa gctgaagcag tcccagctgt tggctctgaa
     1441 gaaggacctg atggtggaga agcagcagga ggcgcttcag gagcaggcag cgctggagcc
     1501 caagctggac ctgctgctgg agaagaccag agagctgcag aagctgattg aagctgacat
     1561 ctccaagaga tacaacggcc gtcctgtgaa cctgatgggg acctctgtgt gacgtgctcc
     1621 ctctgtgtcc tccacccagc ttcctggtgg ggggtgggac agcccaggct ggtattgctg
     1681 gacctcacca gcaagaagcc agcagacctg gaggcagagc cacaaggaag ggccacctga
     1741 gtggtggcac cagcattcat tgtgacctct gcaagaagtc tgagtggctc tgtggctctc
     1801 agcctaaggc acagttgctt cttctggtta tcaaggaagg cttaataaaa aaaggaagtg
     1861 actctcaaaa aaaaaaaaaa aaaaaaaaaa a
//
