LOCUS       NM_173134               5654 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus CDK5 regulatory subunit associated protein 2
            (Cdk5rap2), mRNA.
ACCESSION   NM_173134 XM_001058949 XM_001059003 XM_001059053
VERSION     NM_173134.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5654)
  AUTHORS   Bouguenina,H., Salaun,D., Mangon,A., Muller,L., Baudelet,E.,
            Camoin,L., Tachibana,T., Cianferani,S., Audebert,S.,
            Verdier-Pinard,P. and Badache,A.
  TITLE     EB1-binding-myomegalin protein complex promotes centrosomal
            microtubules functions
  JOURNAL   Proc Natl Acad Sci U S A 114 (50), E10687-E10696 (2017)
   PUBMED   29162697
REFERENCE   2  (bases 1 to 5654)
  AUTHORS   Gao,F.J., Shi,L., Hines,T., Hebbar,S., Neufeld,K.L. and Smith,D.S.
  TITLE     Insulin signaling regulates a functional interaction between
            adenomatous polyposis coli and cytoplasmic dynein
  JOURNAL   Mol Biol Cell 28 (5), 587-599 (2017)
   PUBMED   28057765
REFERENCE   3  (bases 1 to 5654)
  AUTHORS   Park,J.S., Lee,M.K., Kang,S., Jin,Y., Fu,S., Rosales,J.L. and
            Lee,K.Y.
  TITLE     Species-Specific Expression of Full-Length and Alternatively
            Spliced Variant Forms of CDK5RAP2
  JOURNAL   PLoS One 10 (11), e0142577 (2015)
   PUBMED   26550838
  REMARK    GeneRIF: mouse expresses only one form of CDK5RAP2 that is
            equivalent to the human and rat alternatively spliced variant forms
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5654)
  AUTHORS   Mori,Y., Inoue,Y., Tanaka,S., Doda,S., Yamanaka,S., Fukuchi,H. and
            Terada,Y.
  TITLE     Cep169, a Novel Microtubule Plus-End-Tracking Centrosomal Protein,
            Binds to CDK5RAP2 and Regulates Microtubule Stability
  JOURNAL   PLoS One 10 (10), e0140968 (2015)
   PUBMED   26485573
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5654)
  AUTHORS   Yigit,G., Brown,K.E., Kayserili,H., Pohl,E., Caliebe,A.,
            Zahnleiter,D., Rosser,E., Bogershausen,N., Uyguner,Z.O.,
            Altunoglu,U., Nurnberg,G., Nurnberg,P., Rauch,A., Li,Y., Thiel,C.T.
            and Wollnik,B.
  TITLE     Mutations in CDK5RAP2 cause Seckel syndrome
  JOURNAL   Mol Genet Genomic Med 3 (5), 467-480 (2015)
   PUBMED   26436113
REFERENCE   6  (bases 1 to 5654)
  AUTHORS   Xie,Z., Moy,L.Y., Sanada,K., Zhou,Y., Buchman,J.J. and Tsai,L.H.
  TITLE     Cep120 and TACCs control interkinetic nuclear migration and the
            neural progenitor pool
  JOURNAL   Neuron 56 (1), 79-93 (2007)
   PUBMED   17920017
REFERENCE   7  (bases 1 to 5654)
  AUTHORS   Hassan,M.J., Khurshid,M., Azeem,Z., John,P., Ali,G., Chishti,M.S.
            and Ahmad,W.
  TITLE     Previously described sequence variant in CDK5RAP2 gene in a
            Pakistani family with autosomal recessive primary microcephaly
  JOURNAL   BMC Med Genet 8, 58 (2007)
   PUBMED   17764569
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5654)
  AUTHORS   Andersen,J.S., Wilkinson,C.J., Mayor,T., Mortensen,P., Nigg,E.A.
            and Mann,M.
  TITLE     Proteomic characterization of the human centrosome by protein
            correlation profiling
  JOURNAL   Nature 426 (6966), 570-574 (2003)
   PUBMED   14654843
REFERENCE   9  (bases 1 to 5654)
  AUTHORS   Wang,X., Ching,Y.P., Lam,W.H., Qi,Z., Zhang,M. and Wang,J.H.
  TITLE     Identification of a common protein association region in the
            neuronal Cdk5 activator
  JOURNAL   J Biol Chem 275 (41), 31763-31769 (2000)
   PUBMED   10915792
REFERENCE   10 (bases 1 to 5654)
  AUTHORS   Ching,Y.P., Qi,Z. and Wang,J.H.
  TITLE     Cloning of three novel neuronal Cdk5 activator binding proteins
  JOURNAL   Gene 242 (1-2), 285-294 (2000)
   PUBMED   10721722
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1 and CB806103.1.
            
            [WARNING] On Mar 18, 2025 this sequence was replaced by
            NM_173134.3.
            
            On or before Dec 25, 2009 this sequence version replaced
            XM_001058949.1, XM_001059003.1, XM_001059053.1, NM_173134.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760386
                              [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               JAXUCZ010000005.1  88975683-88975897   c
            216-283             JAXUCZ010000005.1  88969093-88969160   c
            284-351             JAXUCZ010000005.1  88966558-88966625   c
            352-462             JAXUCZ010000005.1  88946102-88946212   c
            463-539             JAXUCZ010000005.1  88942797-88942873   c
            540-663             JAXUCZ010000005.1  88937564-88937687   c
            664-818             JAXUCZ010000005.1  88934516-88934670   c
            819-981             JAXUCZ010000005.1  88929034-88929196   c
            982-1023            JAXUCZ010000005.1  88927960-88928001   c
            1024-1143           JAXUCZ010000005.1  88927024-88927143   c
            1144-1242           JAXUCZ010000005.1  88924491-88924589   c
            1243-1461           JAXUCZ010000005.1  88919655-88919873   c
            1462-1632           JAXUCZ010000005.1  88901850-88902020   c
            1633-1773           JAXUCZ010000005.1  88897081-88897221   c
            1774-1871           JAXUCZ010000005.1  88888818-88888915   c
            1872-1996           JAXUCZ010000005.1  88883900-88884024   c
            1997-2106           JAXUCZ010000005.1  88882346-88882455   c
            2107-2235           JAXUCZ010000005.1  88880533-88880661   c
            2236-2331           JAXUCZ010000005.1  88873833-88873928   c
            2332-2516           JAXUCZ010000005.1  88871901-88872085   c
            2517-2949           JAXUCZ010000005.1  88863091-88863523   c
            2950-3181           JAXUCZ010000005.1  88858297-88858528   c
            3182-3313           CB806103.1         169-300
            3314-3887           JAXUCZ010000005.1  88849516-88850089   c
            3888-4120           JAXUCZ010000005.1  88847494-88847726   c
            4121-4169           JAXUCZ010000005.1  88840480-88840528   c
            4170-4348           JAXUCZ010000005.1  88837752-88837930   c
            4349-4468           JAXUCZ010000005.1  88833532-88833651   c
            4469-4585           JAXUCZ010000005.1  88830175-88830291   c
            4586-4775           JAXUCZ010000005.1  88827768-88827957   c
            4776-4900           JAXUCZ010000005.1  88826829-88826953   c
            4901-4978           JAXUCZ010000005.1  88823666-88823743   c
            4979-5244           JAXUCZ010000005.1  88822582-88822847   c
            5245-5388           JAXUCZ010000005.1  88819717-88819860   c
            5389-5515           JAXUCZ010000005.1  88812938-88813064   c
            5516-5562           JAXUCZ010000005.1  88807902-88807948   c
            5563-5654           JAXUCZ010000005.1  88807402-88807493   c
FEATURES             Location/Qualifiers
     source          1..5654
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q31"
     gene            1..5654
                     /gene="Cdk5rap2"
                     /note="CDK5 regulatory subunit associated protein 2"
                     /db_xref="GeneID:286919"
                     /db_xref="RGD:708451"
     exon            1..215
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..5619
                     /gene="Cdk5rap2"
                     /note="CDK5 activator-binding protein C48"
                     /codon_start=1
                     /product="CDK5 regulatory subunit-associated protein 2"
                     /protein_id="NP_775157.2"
                     /db_xref="GeneID:286919"
                     /db_xref="RGD:708451"
                     /translation="MMDSGMEEDVTLPGTLSGCSGLHPVLPSDLDVISDTTGLGNGVL
                     PIMSEEKVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERIQQEFAGPTEHIYKK
                     NIELKVEVESLKRELQERDQLLVKASKAVESLAEGGGSEIQRVKEDARKKVQQVEELL
                     TKRIHLLEEDVKAAQAELEKAFAGTETEKALRLSLESKLSAMKKMQEGDLEMTLALEE
                     KDRLIEELKLSLKSKEALIQCLKEEKSQMASPDENVSSGELRGLSATLREEKERDAEE
                     RQKERNHFEERIQALQEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKEVEELN
                     SIIKELTADSTQSREAPLKTQVSEFEVRESENCEAALAEKEALLAKLHSENVTKNTEN
                     HRLLRNVKKVTQELNDLKKEKLRLERDLEEAHREGNRGARTIHDLRNEVEKLRKEVCE
                     REKAVEKHYKSLPGESSSKFHSQEQVVKGLTESASQEDLLLQKSNEKDLEAIQQNCYL
                     MTAEELKFGSDGLITEKCSQQSPDSKLIFSKEKQQSEYEGLTGDLKTEQNVYAHLAKN
                     LQDTDSKLQAELKRVLALRKQLEQDVLAYRNLQTALQEQLSEIRKREEEPFSFYSDQT
                     SYLSICLEEHSQFQLEHFSQEEIKKKVIDLIQLVKDLHADNQHLKKTIFDISCMGVQG
                     NDRLESTKQAELMASKADEDTLKFKADDENHFQSDQHLEQSREIMEDYAEGGGKDGYV
                     RHMDSNILDHDGAHTPDTSEDHSLEDELLSLLATFFSKKATPSLESRPDLLKALGALL
                     LERICLAEQGSPGDHSDSKAEKALEQVAVRLRDELGHSCLANSFSKSHSELKSPRGTW
                     LVKTGDEAKVELKSVSVQTMTIEDSTRGFKPERKREAWAGKPEEAVFSTELESEALGE
                     MPGLQATHLSFPSAIDKDDQKTGLLIQLKTPELLENLYNLPASQEVVAQLQGQVLELQ
                     KELKEYKIRNKQLLDKLILAEAMMEGMAVPNSTPVNVPAAQAVVRTAFQGKPGEQEGH
                     ETTHSAGRDKEVDSDQYTSFEIDSEICPPDDLALLPACKENLEDFLGPPSIATYLDSK
                     SQLSVKVSVVGTDQSENINLPDDTEALKQKIHDLQTELEGYRNIIVQLQKHSQCSEAI
                     ITVLCGTEGAQDGLNKPKGHIDEEEMTFSSLHQVRYVKHMKILRPLTPEIIDGKMLES
                     LKQQLVEQEQELQKEQDLNLELFGEIHNLQNKFRDLSPSRYDSLVQSQARELSLQRQQ
                     IKDSHDICVVCHQHMSTMIKAFEELLQASDVDSCVAEGFREQLTQCAGLLEQLEKLFL
                     HGKSARVEPHTQTELLRRLRTEEDNLPYQHLLPESPEPSASHALSDDEMSEKSFLSRE
                     PKPDSETEKYPTIASRFPQDLLMEHIQEIRTLRKHLEESIKTNEKLRKQLERQGCETD
                     QGSTNVSAYSSELHNSLTSEIQFLRKQNEALSTMLEKGSKEKQKENEKLRESLARKTE
                     SLEHLQLEYASVREENERLRRDISEKERQNQQLTQEVCSSLQELSRVQEEAKSRQQLL
                     LQKDELLQSLQMELKVYEKLAEEHQKLQQDVNKCPEASDNSFDLFESTQAMAPKSASE
                     TPVLSGTDVDSLSCDSTSSATSPSCMPCLVAGRHLWASKSGHHMLCLIEDYDALYKQI
                     SWGQTLLAKMDIQTQEALSPTSQKLGPKASFSVPLSKFLSSMNTAKLILEKASRLLKL
                     FWRVSVPTNGQCSLHCDQIGEMKAEITKLHKKLFEQEKKLQNTAKLLQQSKHQEKIIF
                     DQLVITHQVLRKARGNLELRPRAAHPGTSSPSRPGS"
     exon            216..283
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            284..351
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            352..462
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            463..539
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            540..663
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            664..818
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            819..981
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1023
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1143
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1242
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1461
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1632
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1773
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1871
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..1996
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..2106
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2235
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            2236..2331
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2516
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            2517..2949
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            2950..3181
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            3182..3313
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            3314..3887
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            3888..4120
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            4121..4169
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            4170..4348
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            4349..4468
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            4469..4585
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            4586..4775
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            4776..4900
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            4901..4978
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            4979..5244
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            5245..5388
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            5389..5515
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            5516..5562
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
     exon            5563..5654
                     /gene="Cdk5rap2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatggcggcg gctgcggttt gaattccagc ggcgccgctt gactgagaac aagagctggg
       61 ttggaggggg cgggacctgg ggaaccgagc gcgccgcgac tgcggggtaa ccagtggcgc
      121 tgctgctgca gacaccggtg ccacctcttt gtgttcatga tggactcagg gatggaagag
      181 gacgtcaccc tgcctgggac cctcagcggc tgcagtggcc ttcaccctgt tctaccaagt
      241 gatctggatg tcatcagtga cactactggc ttgggaaatg gagtgctccc aatcatgtca
      301 gaagaaaagg tctctcccac cagagcccgg aacatgaagg actttgaaaa ccaaatcact
      361 gagctgaaga aggagaactt caatctaaag ctccggatct acttccttga ggagaggata
      421 cagcaggagt ttgctggccc cacagagcac atctacaaga agaacattga actcaaggtg
      481 gaagtggaaa gtctgaagcg tgagctccag gagagagatc agttgctcgt caaagcctcc
      541 aaagccgtgg agagcctagc agaagggggt ggttctgaaa tccagcgggt gaaagaagat
      601 gcaaggaaga aggtgcagca ggtggaagaa ctcctaacta aaaggataca tcttctagaa
      661 gaagatgtga aagccgccca agcagaactg gagaaggcct ttgcagggac agaaacagag
      721 aaggctcttc ggctcagctt agaaagcaag ctctcggcga tgaagaagat gcaggagggg
      781 gacctggaga tgactctggc tctggaagag aaggacagac tgattgagga gttgaagctg
      841 tctttgaaga gcaaagaagc tttaattcag tgccttaaag aggaaaaatc tcagatggca
      901 tctcctgacg agaacgtgtc atctggagaa ctccgaggac tttctgccac tctaagagaa
      961 gaaaaagaga gagacgctga ggaacggcag aaggagagaa accactttga agagaggatc
     1021 caggcacttc aggaggacct gagagagaag gaaagagaaa ttgctacaga gaagaaaaat
     1081 agcttaaaga gggataaagc cattcagggt ctaaccatgg cattaaaatc aaaggaaaaa
     1141 gaggttgaag aacttaattc cataatcaaa gaactcactg ctgactccac ccaaagtaga
     1201 gaggctccct tgaaaaccca ggtctccgaa ttcgaggtaa gagagtctga gaactgtgag
     1261 gctgcgctgg cagagaagga agccctgttg gccaagctgc actcggaaaa tgtcacaaag
     1321 aatactgaga accataggtt gctcaggaat gttaaaaagg tcacccagga gttgaatgac
     1381 ctgaagaagg agaagctgag actagagcgg gacctggagg aagcccaccg agaagggaac
     1441 agaggagccc gaaccatcca tgaccttaga aatgaagttg agaaactacg caaggaagtg
     1501 tgtgagagag agaaggctgt ggagaagcat tacaagagtc ttccaggcga aagcagttca
     1561 aagttccatt ctcaagaaca agtggtcaaa ggtctgacag aaagtgccag tcaggaggac
     1621 ctgctgctgc agaaatccaa tgaaaaagat ttggaagcaa tacagcagaa ctgttattta
     1681 atgactgcag aggagctcaa gtttgggagc gatggcttaa taacagaaaa gtgttctcag
     1741 cagtcaccag acagcaaact catcttctcc aaggaaaagc aacaatcaga gtatgaaggg
     1801 ctgactgggg acttaaagac agaacagaac gtctatgccc atctggcaaa gaatctgcag
     1861 gacacagaca gcaaactgca ggctgaattg aaaagggttc ttgccctccg gaagcagctg
     1921 gagcaggatg tgcttgccta tcggaatctg cagacggccc tgcaggagca gctcagtgaa
     1981 attcggaagc gggaagaaga gccgttttca ttttatagcg atcaaacatc atatctaagt
     2041 atttgccttg aagagcacag tcagtttcaa ttggagcatt tttctcaaga agaaatcaag
     2101 aaaaaggtca ttgacctcat acagcttgtg aaggacctgc atgcagacaa ccagcacctg
     2161 aagaaaacca tttttgatat ctcttgcatg ggtgtccagg gaaatgacag acttgagtca
     2221 acaaaacaag cagagcttat ggctagcaag gcggatgagg acacactcaa attcaaagca
     2281 gatgatgaga atcatttcca gagtgaccag catttggagc agagtagaga gatcatggag
     2341 gactatgctg agggtggcgg caaggatgga tatgtaaggc acatggattc caatatttta
     2401 gaccatgatg gggcccacac acctgatacc tctgaagacc atagcctaga ggatgagctc
     2461 ctgagcctac tcgccacttt cttcagtaag aaggctacac cgtcgctgga gtccaggccg
     2521 gatctgctga aagcacttgg tgccctgctt ttggaacgga tatgcttggc agaacaggga
     2581 agtcctggag atcactctga tagtaaagct gagaaggcac ttgagcaagt agctgttcgg
     2641 ttgagagatg aacttggcca ttcctgccta gccaactcat tctccaagtc acacagtgag
     2701 ctcaagtcac cgcggggcac ctggctagta aagacaggtg atgaagccaa ggtggagctg
     2761 aagagtgtct cagtgcagac catgaccata gaggacagca cccgtggatt caaacctgag
     2821 aggaagagag aagcttgggc agggaaacca gaagaggccg ttttcagcac tgagcttgag
     2881 tcagaggcgt tgggtgagat gccagggcta caggccactc acctctcatt ccccagtgcc
     2941 atcgacaagg atgaccagaa gacaggcttg ctgatccaat taaaaacacc tgagttattg
     3001 gaaaatttgt ataatcttcc tgcctcccaa gaggtggtag ctcaactcca gggccaggtt
     3061 ctagagctgc agaaagagct gaaagagtat aagatccgca acaagcaact ccttgataag
     3121 ctaattctgg cagaggcaat gatggagggg atggcagtgc ccaactctac tccggtaaac
     3181 gtgcctgcag cccaggctgt tgtgagaaca gccttccaag gcaagccagg cgagcaagaa
     3241 ggacatgaaa ccacacattc tgccggaaga gacaaggaag tagacagtga ccaatataca
     3301 agctttgaga ttgattctga aatctgccca cctgatgacc ttgccttatt accagcatgc
     3361 aaagagaacc ttgaagactt cttaggccca ccctccatag ccacttacct ggattccaag
     3421 agtcagctct ctgttaaagt cagtgtggtt ggaactgacc agtctgagaa tatcaatctc
     3481 cctgatgata cagaagcctt aaaacagaaa atccatgact tgcaaactga gctggaaggc
     3541 taccggaaca tcattgtcca gctacagaag cattctcagt gcagtgaggc tattattaca
     3601 gttttgtgtg ggacagaagg ggcccaagat ggcctgaaca agcctaaggg ccacatcgat
     3661 gaagaagaga tgacattttc aagtttgcac caagtaagat atgtgaagca catgaaaatc
     3721 ctccgtccac taaccccaga aataattgat ggcaagatgc tagagagcct caagcagcag
     3781 ctggtagaac aggagcagga gctacagaag gagcaggatt tgaacttgga acttttcggt
     3841 gaaatccata acctgcagaa caagttccga gacctctcgc catcaagata cgattcattg
     3901 gttcagtccc aagcaaggga gctctctctt cagcggcagc aaattaagga tagtcatgat
     3961 atctgtgtcg tttgccatca acacatgagc accatgatca aggcatttga ggaacttctg
     4021 caggccagtg atgtggacag ttgtgtggct gagggcttcc gcgagcagct aacacagtgt
     4081 gctggactgc tagagcaact ggagaagctg tttctccatg gaaagtcagc cagagtggaa
     4141 ccacataccc agactgaact gctaaggagg ttaagaactg aagaagacaa cttaccttac
     4201 caacatctcc tgcctgaatc tcctgagcct tctgcctctc atgctctgtc agatgatgaa
     4261 atgtctgaga agtccttcct gtccagagaa ccgaagccag acagtgagac tgagaagtac
     4321 ccaacaatag cgagccgttt tcctcaagac ttactaatgg aacacataca ggaaattcga
     4381 actttgagaa agcatttgga agaatctatt aaaacaaatg agaagctccg gaaacagctg
     4441 gaacggcagg gatgtgagac tgaccaaggc tctacaaatg tttctgctta cagctcagaa
     4501 ctgcataatt ctctgacatc agaaatacag ttcctgagga agcagaatga ggccctcagt
     4561 acgatgctcg agaaggggtc caaagaaaaa cagaaagaga atgaaaaatt gcgtgagtcc
     4621 ctggccagga agactgagag tcttgagcac cttcagctag agtatgccag tgtaagggaa
     4681 gaaaatgaaa gactgcggag agacatcagt gagaaggaga gacaaaacca gcagttgact
     4741 caggaggtct gcagcagcct ccaagagctg agcagggtac aggaagaggc aaagtcaaga
     4801 cagcagctgc tcttacagaa agacgagctg cttcagtccc tccaaatgga gcttaaggtg
     4861 tatgagaagc tggccgagga gcatcagaag ctacagcaag atgtcaacaa atgtcctgag
     4921 gccagcgata attcatttga tctatttgaa tctacccagg caatggcacc taaatcagct
     4981 tctgagactc ctgtcctttc tggaactgat gttgattccc tctcctgtga cagtaccagt
     5041 tctgccacca gcccctcttg catgccctgc ctggttgctg gccgccacct gtgggccagc
     5101 aagagtggcc accacatgct gtgcctgatt gaggactatg atgccctcta taagcagatc
     5161 agctggggcc agacactgct tgccaagatg gatattcaaa cccaagaggc tctgagcccc
     5221 acaagtcaga agctgggacc aaaggcttca ttctctgtgc ctctgagcaa gtttctctcc
     5281 agcatgaaca cagccaagct gatcctggaa aaagcctcca ggttgctgaa gctcttctgg
     5341 agggtctctg tccccaccaa cggccagtgt tcccttcact gtgaccagat tggagaaatg
     5401 aaggcagaga tcaccaaact acacaaaaaa ttgtttgaac aagaaaagaa gctgcagaac
     5461 acagcaaaac ttctgcagca gagcaagcac caggagaaaa tcatctttga tcagttggtc
     5521 atcacccacc aagtccttcg gaaagccagg ggaaacctgg agctcaggcc tagagctgcc
     5581 catccaggaa catccagtcc cagcagaccg ggctcatgag aagagctttc agctaataaa
     5641 gcttgtgatc ctga
//
