LOCUS       NM_080885               1163 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus cyclin-dependent kinase 5 (Cdk5), mRNA.
ACCESSION   NM_080885
VERSION     NM_080885.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1163)
  AUTHORS   Umfress,A., Chakraborti,A., Priya Sudarsana Devi,S., Adams,R.,
            Epstein,D., Massicano,A., Sorace,A., Singh,S., Iqbal Hossian,M.,
            Andrabi,S.A., Crossman,D.K., Kumar,N., Shahid Mukhtar,M., Luo,H.,
            Simpson,C., Abell,K., Stokes,M., Wiederhold,T., Rosen,C., Lu,H.,
            Natarajan,A. and Bibb,J.A.
  TITLE     Cdk5 mediates rotational force-induced brain injury
  JOURNAL   Sci Rep 13 (1), 3394 (2023)
   PUBMED   36854738
  REMARK    GeneRIF: Cdk5 mediates rotational force-induced brain injury.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1163)
  AUTHORS   He,M., Wang,X., Liu,Z., Cui,Q., Chen,Y., Geng,W., Zhu,J. and
            Shen,J.
  TITLE     CDK5 Mediates Proinflammatory Effects of Microglia through
            Activated DRP1 Phosphorylation in Rat Model of Intracerebral
            Hemorrhage
  JOURNAL   Dis Markers 2022, 1919064 (2022)
   PUBMED   35795154
  REMARK    GeneRIF: CDK5 Mediates Proinflammatory Effects of Microglia through
            Activated DRP1 Phosphorylation in Rat Model of Intracerebral
            Hemorrhage.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1163)
  AUTHORS   Zhang,X.X., Wang,Y.M., Su,Y.D., Zuo,F., Wu,B. and Nian,X.
  TITLE     MiR-26a regulated adipogenic differentiation of ADSCs induced by
            insulin through CDK5/FOXC2 pathway
  JOURNAL   Mol Cell Biochem 476 (4), 1705-1716 (2021)
   PUBMED   33423166
  REMARK    GeneRIF: MiR-26a regulated adipogenic differentiation of ADSCs
            induced by insulin through CDK5/FOXC2 pathway.
            Erratum:[Mol Cell Biochem. 2021 Aug;476(8):3217. doi:
            10.1007/s11010-021-04212-3.. PMID: 34156588]
REFERENCE   4  (bases 1 to 1163)
  AUTHORS   Yang,S.H., Huang,C.Y., Hsieh,C.Y. and Chuang,J.I.
  TITLE     CDK4 and CDK5 Inhibition Have Comparable Mild Hypothermia Effects
            in Preventing Drp1-Dependent Mitochondrial Fission and Neuron Death
            Induced by MPP
  JOURNAL   Mol Neurobiol 57 (10), 4090-4105 (2020)
   PUBMED   32666227
  REMARK    GeneRIF: CDK4 and CDK5 Inhibition Have Comparable Mild Hypothermia
            Effects in Preventing Drp1-Dependent Mitochondrial Fission and
            Neuron Death Induced by MPP().
REFERENCE   5  (bases 1 to 1163)
  AUTHORS   Rong,R., Xia,X., Peng,H., Li,H., You,M., Liang,Z., Yao,F., Yao,X.,
            Xiong,K., Huang,J., Zhou,R. and Ji,D.
  TITLE     Cdk5-mediated Drp1 phosphorylation drives mitochondrial defects and
            neuronal apoptosis in radiation-induced optic neuropathy
  JOURNAL   Cell Death Dis 11 (9), 720 (2020)
   PUBMED   32883957
  REMARK    GeneRIF: Cdk5-mediated Drp1 phosphorylation drives mitochondrial
            defects and neuronal apoptosis in radiation-induced optic
            neuropathy.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1163)
  AUTHORS   Sun,D., Leung,C.L. and Liem,R.K.
  TITLE     Phosphorylation of the high molecular weight neurofilament protein
            (NF-H) by Cdk5 and p35
  JOURNAL   J Biol Chem 271 (24), 14245-14251 (1996)
   PUBMED   8662984
REFERENCE   7  (bases 1 to 1163)
  AUTHORS   Hellmich,M.R., Pant,H.C., Wada,E. and Battey,J.F.
  TITLE     Neuronal cdc2-like kinase: a cdc2-related protein kinase with
            predominantly neuronal expression
  JOURNAL   Proc Natl Acad Sci U S A 89 (22), 10867-10871 (1992)
   PUBMED   1279696
REFERENCE   8  (bases 1 to 1163)
  AUTHORS   Xiong,Y., Zhang,H. and Beach,D.
  TITLE     D type cyclins associate with multiple protein kinases and the DNA
            replication and repair factor PCNA
  JOURNAL   Cell 71 (3), 505-514 (1992)
   PUBMED   1358458
REFERENCE   9  (bases 1 to 1163)
  AUTHORS   Meyerson,M., Enders,G.H., Wu,C.L., Su,L.K., Gorka,C., Nelson,C.,
            Harlow,E. and Tsai,L.H.
  TITLE     A family of human cdc2-related protein kinases
  JOURNAL   EMBO J 11 (8), 2909-2917 (1992)
   PUBMED   1639063
REFERENCE   10 (bases 1 to 1163)
  AUTHORS   Eiden,L.E., Huttner,W.B., Mallet,J., O'Connor,D.T., Winkler,H. and
            Zanini,A.
  TITLE     A nomenclature proposal for the chromogranin/secretogranin proteins
  JOURNAL   Neuroscience 21 (3), 1019-1021 (1987)
   PUBMED   3627430
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 26, 2020 this sequence version replaced NM_080885.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L02121.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               JAXUCZ010000004.1  11647124-11647254
            132-220             JAXUCZ010000004.1  11647818-11647906
            221-288             JAXUCZ010000004.1  11647982-11648049
            289-349             JAXUCZ010000004.1  11648153-11648213
            350-406             JAXUCZ010000004.1  11648314-11648370
            407-502             JAXUCZ010000004.1  11649713-11649808
            503-577             JAXUCZ010000004.1  11649961-11650035
            578-674             JAXUCZ010000004.1  11650191-11650287
            675-744             JAXUCZ010000004.1  11650465-11650534
            745-805             JAXUCZ010000004.1  11650958-11651018
            806-886             JAXUCZ010000004.1  11651122-11651202
            887-1163            JAXUCZ010000004.1  11651330-11651606
FEATURES             Location/Qualifiers
     source          1..1163
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..1163
                     /gene="Cdk5"
                     /note="cyclin-dependent kinase 5"
                     /db_xref="GeneID:140908"
                     /db_xref="RGD:70514"
     exon            1..131
                     /gene="Cdk5"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..973
                     /gene="Cdk5"
                     /EC_number="2.7.11.1"
                     /note="cell division protein kinase 5; TPKII catalytic
                     subunit; serine/threonine-protein kinase PSSALRE; tau
                     protein kinase II catalytic subunit; cyclin-dependent-like
                     kinase 5"
                     /codon_start=1
                     /product="cyclin-dependent kinase 5"
                     /protein_id="NP_543161.1"
                     /db_xref="GeneID:140908"
                     /db_xref="RGD:70514"
                     /translation="MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGV
                     PSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEI
                     VKSLLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSA
                     EVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRL
                     LGTPTEEQWPAMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRIS
                     AEEALQHPYFSDFCPP"
     exon            132..220
                     /gene="Cdk5"
                     /inference="alignment:Splign:2.1.0"
     exon            221..288
                     /gene="Cdk5"
                     /inference="alignment:Splign:2.1.0"
     exon            289..349
                     /gene="Cdk5"
                     /inference="alignment:Splign:2.1.0"
     exon            350..406
                     /gene="Cdk5"
                     /inference="alignment:Splign:2.1.0"
     exon            407..502
                     /gene="Cdk5"
                     /inference="alignment:Splign:2.1.0"
     exon            503..577
                     /gene="Cdk5"
                     /inference="alignment:Splign:2.1.0"
     exon            578..674
                     /gene="Cdk5"
                     /inference="alignment:Splign:2.1.0"
     exon            675..744
                     /gene="Cdk5"
                     /inference="alignment:Splign:2.1.0"
     exon            745..805
                     /gene="Cdk5"
                     /inference="alignment:Splign:2.1.0"
     exon            806..886
                     /gene="Cdk5"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1163
                     /gene="Cdk5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggggctg gagctttggg taccacctcc tctgcaacgc cggggccggg agtcttagaa
       61 ccgagggccc gcaggggtcc ccgtggccgc tgcgatgcag aaatacgaga aactggagaa
      121 gattggggaa ggcacctacg gaactgtgtt caaggccaaa aaccgggaaa cccatgagat
      181 tgtggctctg aagcgagtca ggctggacga tgacgatgag ggtgtgccaa gttcagccct
      241 ccgggagatc tgtctactca aagaactgaa gcacaaaaac attgtcaggc ttcatgatgt
      301 cctgcatagt gacaagaagc tcacattggt gtttgagttc tgtgatcagg acctgaagaa
      361 atattttgac agctgcaatg gtgacctgga ccctgagatt gtgaagtcac tcctcttcca
      421 gctgctgaaa ggcctgggat tctgtcacag ccgtaacgtg ctgcacaggg acctgaagcc
      481 ccagaatctg ctcattaaca ggaatgggga actgaaattg gctgattttg gcctggcccg
      541 agcctttggt atcccagtcc gctgctactc tgctgaggtg gtcacgctgt ggtaccgccc
      601 accggatgtc ctctttgggg ccaagctgta ctccacgtcc atcgacatgt ggtcagccgg
      661 ctgcatcttt gcagagctgg ccaatgcagg gcgacctctc ttccccggca atgatgtgga
      721 tgaccagctg aagaggatct ttcgactgct agggacaccg actgaggaac agtggcctgc
      781 catgaccaaa ctgccagact ataagcccta cccaatgtac ccagctacaa catccttggt
      841 gaatgtcgtg cccaaactca atgccacggg gagagacctg ttgcagaacc tgttgaagtg
      901 taacccagtg cagcgcatct cggcagagga ggccttgcag cacccctatt tctctgactt
      961 ctgtcccccg tagactctct gaccctggcg gccaggctgg ggcctgacct atttaagcct
     1021 ccctcccagg agggtgggag agtggggtat gggatgctga gtaccagctg tgctgggccc
     1081 agccaggggc gagttaccct ggtccgcggt ttccctccct ccatggactt tatttaattt
     1141 cataaattgg ttcctttccc aca
//
