LOCUS       NM_053593               1340 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus cyclin-dependent kinase 4 (Cdk4), transcript
            variant 1, mRNA.
ACCESSION   NM_053593
VERSION     NM_053593.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1340)
  AUTHORS   Pedraza,N., Monserrat,M.V., Ferrezuelo,F., Torres-Rosell,J.,
            Colomina,N., Miguez-Cabello,F., Parraga,J.P., Soto,D.,
            Lopez-Merino,E., Garcia-Vilela,C., Esteban,J.A., Egea,J. and
            Gari,E.
  TITLE     Cyclin D1-Cdk4 regulates neuronal activity through phosphorylation
            of GABAA receptors
  JOURNAL   Cell Mol Life Sci 80 (10), 280 (2023)
   PUBMED   37684532
  REMARK    GeneRIF: Cyclin D1-Cdk4 regulates neuronal activity through
            phosphorylation of GABAA receptors.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1340)
  AUTHORS   Zhang,J.Y., Lv,D.B., Su,Y.N., Wang,X.L., Sheng,W.C., Yang,G.,
            Li,L.X., Gao,X., Gao,Y.Z. and Li,J.T.
  TITLE     LncRNA SNHG1 attenuates neuropathic pain following spinal cord
            injury by regulating CDK4 level
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (23), 12034-12040 (2020)
   PUBMED   33336721
  REMARK    GeneRIF: LncRNA SNHG1 attenuates neuropathic pain following spinal
            cord injury by regulating CDK4 level.
REFERENCE   3  (bases 1 to 1340)
  AUTHORS   Yang,S.H., Huang,C.Y., Hsieh,C.Y. and Chuang,J.I.
  TITLE     CDK4 and CDK5 Inhibition Have Comparable Mild Hypothermia Effects
            in Preventing Drp1-Dependent Mitochondrial Fission and Neuron Death
            Induced by MPP
  JOURNAL   Mol Neurobiol 57 (10), 4090-4105 (2020)
   PUBMED   32666227
  REMARK    GeneRIF: CDK4 and CDK5 Inhibition Have Comparable Mild Hypothermia
            Effects in Preventing Drp1-Dependent Mitochondrial Fission and
            Neuron Death Induced by MPP().
REFERENCE   4  (bases 1 to 1340)
  AUTHORS   Sadek,K., Abouzed,T., Nasr,S. and Shoukry,M.
  TITLE     Licochalcone B Ameliorates Liver Cancer via Targeting of Apoptotic
            Genes, DNA Repair Systems, and Cell Cycle Control
  JOURNAL   Iran J Pharm Res 19 (4), 372-386 (2020)
   PUBMED   33841550
REFERENCE   5  (bases 1 to 1340)
  AUTHORS   Mudunuru,J., Ren,C., Taft,D.R. and Maniar,M.
  TITLE     Effect of Gender on the Pharmacokinetics of ON 123300, A Dual
            Inhibitor of ARK5 and CDK4/6 for the Treatment of Cancer, in Rats
  JOURNAL   Eur J Drug Metab Pharmacokinet 44 (4), 531-538 (2019)
   PUBMED   30701428
  REMARK    GeneRIF: A small molecule dual inhibitor of the c-MYC activated
            kinases ARK5 and CDK4/6, is being developed.
REFERENCE   6  (bases 1 to 1340)
  AUTHORS   Smith,E., Frenkel,B., Schlegel,R., Giordano,A., Lian,J.B.,
            Stein,J.L. and Stein,G.S.
  TITLE     Expression of cell cycle regulatory factors in differentiating
            osteoblasts: postproliferative up-regulation of cyclins B and E
  JOURNAL   Cancer Res 55 (21), 5019-5024 (1995)
   PUBMED   7585545
REFERENCE   7  (bases 1 to 1340)
  AUTHORS   Medema,R.H., Herrera,R.E., Lam,F. and Weinberg,R.A.
  TITLE     Growth suppression by p16ink4 requires functional retinoblastoma
            protein
  JOURNAL   Proc Natl Acad Sci U S A 92 (14), 6289-6293 (1995)
   PUBMED   7603984
REFERENCE   8  (bases 1 to 1340)
  AUTHORS   Hirai,H., Roussel,M.F., Kato,J.Y., Ashmun,R.A. and Sherr,C.J.
  TITLE     Novel INK4 proteins, p19 and p18, are specific inhibitors of the
            cyclin D-dependent kinases CDK4 and CDK6
  JOURNAL   Mol Cell Biol 15 (5), 2672-2681 (1995)
   PUBMED   7739547
REFERENCE   9  (bases 1 to 1340)
  AUTHORS   Bem,Z. and Birecka,A.
  TITLE     [A rare type of bone involvement in scleroderma (author's transl)]
  JOURNAL   Pol Przegl Radiol Med Nukl 42 (2), 115-117 (1978)
   PUBMED   704385
REFERENCE   10 (bases 1 to 1340)
  AUTHORS   Gattringer,B.
  TITLE     [Retrospective study of one year of family therapy in a
            neurological practice (author's transl)]
  JOURNAL   Nervenarzt 48 (6), 326-330 (1977)
   PUBMED   70761
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Mar 11, 2022 this sequence version replaced NM_053593.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070956.1, FQ219275.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               JAXUCZ010000007.1  64771453-64771593
            142-375             JAXUCZ010000007.1  64772049-64772282
            376-511             JAXUCZ010000007.1  64772414-64772549
            512-679             JAXUCZ010000007.1  64772662-64772829
            680-789             JAXUCZ010000007.1  64772979-64773088
            790-840             JAXUCZ010000007.1  64773795-64773845
            841-976             JAXUCZ010000007.1  64773934-64774069
            977-1340            JAXUCZ010000007.1  64774528-64774891
FEATURES             Location/Qualifiers
     source          1..1340
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..1340
                     /gene="Cdk4"
                     /note="cyclin-dependent kinase 4"
                     /db_xref="GeneID:94201"
                     /db_xref="RGD:621120"
     exon            1..141
                     /gene="Cdk4"
                     /inference="alignment:Splign:2.1.0"
     exon            142..375
                     /gene="Cdk4"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..1069
                     /gene="Cdk4"
                     /EC_number="2.7.11.22"
                     /note="isoform 1 is encoded by transcript variant 1; cell
                     division protein kinase 4; PSK-J3"
                     /codon_start=1
                     /product="cyclin-dependent kinase 4 isoform 1"
                     /protein_id="NP_446045.1"
                     /db_xref="GeneID:94201"
                     /db_xref="RGD:621120"
                     /translation="MATTRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGA
                     AGGGLPVSTVREVALLRRLEAFEHPNVVRLMDVCATSRTDRDIKVTLVFEHIDQDLRT
                     YLDKAPPPGLPVETIKDLMRQFLSGLDFLHANCIVHRDLKPENILVTSNGTVKLADFG
                     LARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNS
                     EADQLGKIFDLIGLPPEDDWPREVSLPRGAFSPRGPRPVQSVVPEMEESGAQLLLEML
                     TFNPLKRISAFRALQHSYLHKEESDPE"
     exon            376..511
                     /gene="Cdk4"
                     /inference="alignment:Splign:2.1.0"
     exon            512..679
                     /gene="Cdk4"
                     /inference="alignment:Splign:2.1.0"
     exon            680..789
                     /gene="Cdk4"
                     /inference="alignment:Splign:2.1.0"
     exon            790..840
                     /gene="Cdk4"
                     /inference="alignment:Splign:2.1.0"
     exon            841..976
                     /gene="Cdk4"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1340
                     /gene="Cdk4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctctagct cgcggcctgt gtctatggtc tggcccgaag cgtccagctg cccgggaccg
       61 atccccggtg tatggcgccg caggaaacgg ctcccgggcc cagataaagg gccacctccg
      121 cagctcttgg ccgagcgtaa gatcccctgc tccgagaatg gctaccactc gatatgaacc
      181 cgtggctgaa attggtgtcg gtgcctatgg gacggtgtac aaagcccgag atccccacag
      241 tggccacttt gtggctctca agagtgtgag agttcctaat ggaggagcag ctggaggggg
      301 ccttcccgtc agcacagttc gtgaggtggc cttgttaaga aggctggagg cctttgaaca
      361 tcccaatgtt gtacggctga tggatgtctg tgctacttcc cgaactgatc gggacatcaa
      421 ggtcacctta gtgtttgagc atatagacca ggacctacgg acatacctgg acaaagcacc
      481 tccgccgggc ttgcctgttg agaccattaa ggatctgatg cgccagtttc taagcggcct
      541 agatttcctt catgcaaact gcattgttca ccgggacctg aagccagaga acattctagt
      601 gacaagtaat gggacagtta agctggccga ctttggccta gccagaatct acagctacca
      661 gatggccctc acgcctgtgg ttgttacgct ctggtaccgg gctcctgaag ttcttctgca
      721 gtctacatat gcaacgcctg tggatatgtg gagtgttggc tgtatcttcg cagagatgtt
      781 tcgccggaag cctctcttct gtgggaactc tgaggctgac cagctgggca aaatctttga
      841 tctcattgga ttgcctccag aagacgactg gcctcgagag gtctctcttc ctcgaggagc
      901 cttttccccc agaggacctc ggccagtgca gtcagtggtg ccggagatgg aggaatctgg
      961 agcgcagttg ctgctggaaa tgctgacctt taatccactt aagcgaatct ctgccttccg
     1021 agccctgcag cactcttacc tgcacaagga ggaaagtgac ccggagtgag gagaggggct
     1081 gccttttcca gtttccggac gctgtgtgga aagaaccttg ctgaagtggc agcctctgcc
     1141 ttcccctgag gctatggaga gtcctccggt ttagccttaa atgacaattc cctacctctc
     1201 cttatgaggt ttaccccacc cccaccctcc tgtttctcta cactaaaggg caggcattat
     1261 ctgtcttctt ccctccctga tttatattgg gatctttttt atacaggaaa acaaaacaag
     1321 acaaagaagt atggtcttta
//
