LOCUS       NM_001025752            2145 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cyclin-dependent kinase 20 (Cdk20), mRNA.
ACCESSION   NM_001025752 XM_344563
VERSION     NM_001025752.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2145)
  AUTHORS   Qiu,H., Dai,H., Jain,K., Shah,R., Hong,C., Pain,J., Tian,B.,
            Vatner,D.E., Vatner,S.F. and Depre,C.
  TITLE     Characterization of a novel cardiac isoform of the cell
            cycle-related kinase that is regulated during heart failure
  JOURNAL   J Biol Chem 283 (32), 22157-22165 (2008)
   PUBMED   18508765
  REMARK    GeneRIF: heart expresses a splice variant of CCRK, which promotes
            cardiac cell growth and survival; differs from the generic isoform
            in protein-protein interactions, substrate specificity and
            regulation of cell cycle; and is down-regulated in heart failure
REFERENCE   2  (bases 1 to 2145)
  AUTHORS   Yu,Y., Kranzler,H.R., Panhuysen,C., Weiss,R.D., Poling,J.,
            Farrer,L.A. and Gelernter,J.
  TITLE     Substance dependence low-density whole genome association study in
            two distinct American populations
  JOURNAL   Hum Genet 123 (5), 495-506 (2008)
   PUBMED   18438686
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC098838.1.
            
            On Feb 26, 2008 this sequence version replaced NM_001025752.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760433,
                              SAMN12840110 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-773               BC098838.1         1-773
            774-2145            BC098838.1         1339-2710
FEATURES             Location/Qualifiers
     source          1..2145
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..2145
                     /gene="Cdk20"
                     /gene_synonym="Ccrk"
                     /note="cyclin-dependent kinase 20"
                     /db_xref="GeneID:364666"
                     /db_xref="RGD:1305219"
     exon            1..285
                     /gene="Cdk20"
                     /gene_synonym="Ccrk"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..1251
                     /gene="Cdk20"
                     /gene_synonym="Ccrk"
                     /EC_number="2.7.11.22"
                     /note="cell cycle-related kinase; cell division protein
                     kinase 20"
                     /codon_start=1
                     /product="cyclin-dependent kinase 20"
                     /protein_id="NP_001020923.2"
                     /db_xref="GeneID:364666"
                     /db_xref="RGD:1305219"
                     /translation="MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGI
                     PNQALREIKALQEIEDSQYVVQLKAVFPHGAGFVLAFEFMLSDLAEVVRHAQRPLAPA
                     QVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGGRLY
                     THQVATRWYRAPELLYGARQYDQGVDLWAVGCIMGELLNGSPLFPGENDIEQLCCVLR
                     ILGTPSPRVWPEITELPDYNKISFKEQAPVPLEEVLPDASHQALDLLGQFLLYPPRQR
                     IAASQALLHQYFFTAPLPAHPSELPIPQRPGGPTPKAHPGPPHVHDFHVDRPLEESLL
                     NPELIRPFIPEG"
     exon            286..399
                     /gene="Cdk20"
                     /gene_synonym="Ccrk"
                     /inference="alignment:Splign:2.1.0"
     exon            400..588
                     /gene="Cdk20"
                     /gene_synonym="Ccrk"
                     /inference="alignment:Splign:2.1.0"
     exon            589..710
                     /gene="Cdk20"
                     /gene_synonym="Ccrk"
                     /inference="alignment:Splign:2.1.0"
     exon            711..773
                     /gene="Cdk20"
                     /gene_synonym="Ccrk"
                     /inference="alignment:Splign:2.1.0"
     exon            774..897
                     /gene="Cdk20"
                     /gene_synonym="Ccrk"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1053
                     /gene="Cdk20"
                     /gene_synonym="Ccrk"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..2119
                     /gene="Cdk20"
                     /gene_synonym="Ccrk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttaaagtta gttcaagatg gagtgactgc tgaaggcagc ggaaaggtgc tgcctagagg
       61 gcatgcagat tcctgactga gctcagcacc ggtctttccg gtcacgtgct ttatggagca
      121 gctgctagac gcgttattgc taggcaacgc ttgcaggctc cttgctaggt tagatccccg
      181 cagtgtggga tctgggcgcc gcgggccgac atggatcagt attgcatcct cggtcgcatc
      241 ggggagggcg cccacggcat cgtctttaaa gccaagcacg tagagactgg cgagatcgtt
      301 gccctcaaga aggtggccct gcggcggctg gaggatggta ttcctaacca ggccctcagg
      361 gaaatcaagg ctctgcagga gatcgaggac agtcaatatg tggtacagct gaaggctgtg
      421 ttcccacatg gtgcaggctt tgtgctggct ttcgagttta tgctgtcgga cctggcggag
      481 gtggtgcgcc atgcccagag gccactagcc ccagcacagg ttaagagcta cctgcagatg
      541 ctgctcaaag gtgttgcatt ttgccatgcc aacaacatcg tgcatcggga cctgaagcct
      601 gccaacctgc tcatcagtgc ctcaggccag ctcaagatag ctgactttgg actggcccgg
      661 gtcttctctc cagatggtgg tcgcctctac acacatcagg tggccaccag gtggtaccga
      721 gctcctgagc tcctgtacgg tgctcggcag tatgaccagg gtgttgacct atgggctgta
      781 ggctgtatta tgggagagct gttgaatgga tcccccctat tcccgggaga aaacgacatt
      841 gaacaactgt gctgtgtgct tcgaatcctg ggtaccccga gtcctcgagt ctggccggag
      901 atcacagagc tgcctgacta caacaagatc tccttcaagg agcaggcacc agtgcccctg
      961 gaggaggtgc tgcctgatgc ctctcaccag gccctggacc tgctgggtca gttcctcctt
     1021 taccctccac gacagcgtat tgcagcctcc caggcccttc tgcatcagta tttcttcaca
     1081 gctcctctgc ctgcccatcc gtctgagctg ccaattcctc agcgcccagg gggacccaca
     1141 cccaaggctc atccagggcc cccccatgtc catgacttcc atgtggatcg tcctcttgag
     1201 gagtcactgt tgaatccaga actgatccgg cccttcatcc cagagggctg agatgctggt
     1261 ccagtccttc ctgctcaacc caggtgcacc gagacagcta ctcttctgcc tcatcctgat
     1321 tggcccccat ggcctcccca tggctatatg taccacaccc ggttctgctt cttagcgtgc
     1381 ttgagggctg ggctctgaca ggcagaacca tgaagatgtt caccgcagca gagaaagaga
     1441 ctcacagccc ccagaaactg ccatctgtgt tcttctctgg ggccatctct cagtggtgct
     1501 acctggcctt agagagattc tcagggtctg tctcctcttc aaggacattg atactacagc
     1561 accacctcgg ggaagcacag agaataagct gtcttcatat ggggacacag ctgggaagtc
     1621 agacatgctt tggctttggc ttcactgggt cagactttga gattcatata aaagccctgg
     1681 gtgtttctgc ctgtatttgc accttgtctg ttgttgttag ggaaagggcc ttaattcgta
     1741 ggggtcaggt acccagatgg tgcctctagt aagggccatt tgggttctga gacttcctgt
     1801 gctcttcatg ggacttgaga gctcacatgg gagtgaggtc cagaagttga ggcccagcaa
     1861 tgggcagtgc agttcccaaa gcacactttc cacatgttgg gtgttagtca gtgagccaga
     1921 gcctgctgtg cagattcgaa gcaggctttc ctggaattca ctcggtaagt agattccagt
     1981 gtgactcagc cagcttgatt tttatttcat aggaatatat taagatgagt ctaaaaggcg
     2041 gttctctact tcccagtgct gcaaccccgt aatacagttc tccccccaac aataaaatta
     2101 tttttgtcat gctttgtaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
