LOCUS       NM_199501               2194 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Rattus norvegicus cyclin dependent kinase 2 (Cdk2), mRNA.
ACCESSION   NM_199501 XM_343145
VERSION     NM_199501.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2194)
  AUTHORS   Kadekawa,K., Nishijima,S., Noguchi,K., Matsumoto,S. and Sugaya,K.
  TITLE     Elucidation of the pathophysiology of interstitial cystitis/bladder
            pain syndrome via experimental autoimmune cystitis rat model
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 327 (2), R250-R260 (2024)
   PUBMED   38842512
REFERENCE   2  (bases 1 to 2194)
  AUTHORS   Matveevsky,S., Chassovnikarova,T., Grishaeva,T., Atsaeva,M.,
            Malygin,V., Bakloushinskaya,I. and Kolomiets,O.
  TITLE     Kinase CDK2 in Mammalian Meiotic Prophase I: Screening for Hetero-
            and Homomorphic Sex Chromosomes
  JOURNAL   Int J Mol Sci 22 (4), 1969 (2021)
   PUBMED   33671248
  REMARK    GeneRIF: Kinase CDK2 in Mammalian Meiotic Prophase I: Screening for
            Hetero- and Homomorphic Sex Chromosomes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2194)
  AUTHORS   Peng,T., Peng,J.J., Miao,G.Y., Tan,Z.Q., Liu,B. and Zhou,E.
  TITLE     miR-125/CDK2 axis in cochlear progenitor cell proliferation
  JOURNAL   Mol Med Rep 23 (2) (2021)
   PUBMED   33300064
  REMARK    GeneRIF: miR125/CDK2 axis in cochlear progenitor cell
            proliferation.
REFERENCE   4  (bases 1 to 2194)
  AUTHORS   Ren,S., Xing,Y., Wang,C., Jiang,F., Liu,G., Li,Z., Jiang,T., Zhu,Y.
            and Piao,D.
  TITLE     Fraxetin inhibits the growth of colon adenocarcinoma cells via the
            Janus kinase 2/signal transducer and activator of transcription 3
            signalling pathway
  JOURNAL   Int J Biochem Cell Biol 125, 105777 (2020)
   PUBMED   32504672
REFERENCE   5  (bases 1 to 2194)
  AUTHORS   Lin,Z., Liu,Z., Wang,X., Qiu,C. and Zheng,S.
  TITLE     MiR-21-3p Plays a Crucial Role in Metabolism Alteration of Renal
            Tubular Epithelial Cells during Sepsis Associated Acute Kidney
            Injury via AKT/CDK2-FOXO1 Pathway
  JOURNAL   Biomed Res Int 2019, 2821731 (2019)
   PUBMED   31223614
  REMARK    GeneRIF: MiR-21-3p mediates metabolism and cell fate alterations of
            tubular epithelial cells (TECs) via manipulating AKT/CDK2-FOXO1
            pathway, and that is crucial in the regulation of energy metabolism
            of TECs during Sepsis and associated acute kidney injury.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2194)
  AUTHORS   Beijersbergen,R.L., Carlee,L., Kerkhoven,R.M. and Bernards,R.
  TITLE     Regulation of the retinoblastoma protein-related p107 by G1 cyclin
            complexes
  JOURNAL   Genes Dev 9 (11), 1340-1353 (1995)
   PUBMED   7797074
REFERENCE   7  (bases 1 to 2194)
  AUTHORS   Hirai,H., Roussel,M.F., Kato,J.Y., Ashmun,R.A. and Sherr,C.J.
  TITLE     Novel INK4 proteins, p19 and p18, are specific inhibitors of the
            cyclin D-dependent kinases CDK4 and CDK6
  JOURNAL   Mol Cell Biol 15 (5), 2672-2681 (1995)
   PUBMED   7739547
REFERENCE   8  (bases 1 to 2194)
  AUTHORS   Kotani,S., Endo,T., Kitagawa,M., Higashi,H. and Onaya,T.
  TITLE     A variant form of cyclin-dependent kinase 2 (Cdk2) in a malignantly
            transformed rat thyroid (FRTL-Tc) cell line
  JOURNAL   Oncogene 10 (4), 663-669 (1995)
   PUBMED   7862443
REFERENCE   9  (bases 1 to 2194)
  AUTHORS   Pagano,M., Pepperkok,R., Verde,F., Ansorge,W. and Draetta,G.
  TITLE     Cyclin A is required at two points in the human cell cycle
  JOURNAL   EMBO J 11 (3), 961-971 (1992)
   PUBMED   1312467
REFERENCE   10 (bases 1 to 2194)
  AUTHORS   Tsai,L.H., Harlow,E. and Meyerson,M.
  TITLE     Isolation of the human cdk2 gene that encodes the cyclin A- and
            adenovirus E1A-associated p33 kinase
  JOURNAL   Nature 353 (6340), 174-177 (1991)
   PUBMED   1653904
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 27, 2020 this sequence version replaced NM_199501.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061832.1, SRR26360176.1411493.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676785 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-266               JAXUCZ010000007.1  1721613-1721878     c
            267-344             JAXUCZ010000007.1  1720839-1720916     c
            345-465             JAXUCZ010000007.1  1720620-1720740     c
            466-636             JAXUCZ010000007.1  1719299-1719469     c
            637-738             JAXUCZ010000007.1  1717972-1718073     c
            739-942             JAXUCZ010000007.1  1715897-1716100     c
            943-2194            JAXUCZ010000007.1  1714392-1715643     c
FEATURES             Location/Qualifiers
     source          1..2194
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..2194
                     /gene="Cdk2"
                     /note="cyclin dependent kinase 2"
                     /db_xref="GeneID:362817"
                     /db_xref="RGD:70486"
     exon            1..266
                     /gene="Cdk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..1047
                     /gene="Cdk2"
                     /EC_number="2.7.11.22"
                     /note="cell division protein kinase 2; cyclin dependent
                     kinase 2-alpha"
                     /codon_start=1
                     /product="cyclin-dependent kinase 2"
                     /protein_id="NP_955795.1"
                     /db_xref="GeneID:362817"
                     /db_xref="RGD:70486"
                     /translation="MENFQKVEKIGEGTYGVVYKAKNKLTGEVVALKKIRLDTETEGV
                     PSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLP
                     LIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAEGSIKLADFGLARAFGVPVRTYT
                     HEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRT
                     LGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS
                     AKAALAHPFFQDVTKPVPHLRL"
     exon            267..344
                     /gene="Cdk2"
                     /inference="alignment:Splign:2.1.0"
     exon            345..465
                     /gene="Cdk2"
                     /inference="alignment:Splign:2.1.0"
     exon            466..636
                     /gene="Cdk2"
                     /inference="alignment:Splign:2.1.0"
     exon            637..738
                     /gene="Cdk2"
                     /inference="alignment:Splign:2.1.0"
     exon            739..942
                     /gene="Cdk2"
                     /inference="alignment:Splign:2.1.0"
     exon            943..2194
                     /gene="Cdk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caagagctga gctctgcttg cgttccatcc cgagctaggg ctgccgtgct cacccgggcc
       61 cccaggtcct ccgctccgag tgtccggccc gctttcgtca gggttcccgg gccccgctcc
      121 cgggggcctg agccgcctca ctagcgctcc atggagaact tccaaaaggt ggagaagatt
      181 ggagagggca cgtacggagt ggtgtacaaa gccaaaaaca agttgacggg agaagttgtg
      241 gcgcttaaga aaatccggct cgacactgag actgaaggtg tgcccagtac tgccatccga
      301 gagatctccc tccttaagga gctcaatcac cctaacatcg tcaagctgct ggatgtcatc
      361 cacacagaaa ataagcttta tctggtgttt gaattcctgc accaggacct caagaagttt
      421 atggatgctt ctgctctcac tggcattcct cttcccctca tcaagagcta tctgttccag
      481 ctgctccagg gcctagcatt ctgccattct caccgtgtcc tgcaccgaga ccttaagccc
      541 cagaacctgc ttatcaacgc agaggggtcc atcaagctgg ctgactttgg actagcaaga
      601 gcctttggag tccctgtccg tacttacact catgaggtgg tgaccctctg gtaccgagca
      661 ccggagattc ttctgggctg caagtactac tccacagccg tggacatctg gagcctgggc
      721 tgcatctttg ccgaaatggt gacccgcagg gccctattcc ctggagactc tgagattgac
      781 caactcttcc ggatctttcg gactctgggg accccagatg aggtggtttg gccaggagtt
      841 acttctatgc ctgattataa gccaagtttc cccaagtggg ctcggcagga ttttagcaag
      901 gttgtgcctc ccctggatga agacggacgg agcttgttat ctcaaatgct gcactatgac
      961 cccaacaagc ggatttcagc caaagcagcc ctggctcacc ctttcttcca ggatgtgact
     1021 aaaccagtgc cccaccttcg actctgatgt ccttcccaaa gccctcttca cctgtggtct
     1081 gacctgatcc tgggcctttt ggacacaggt cagccttctg ctgttttctg gctgtcttag
     1141 ccttttctct gggccagccg gttctgggga ttcagaggtg cagagaagga ttaggtgaaa
     1201 agggagaaag ttttggcatt agatgcactt aacccgactt ccagcttctc tccctcttcc
     1261 cagtcatcac tgagaaggat tagtattgaa gcaaaactga cagttctccc cagtgtcaga
     1321 ttttgccatc ccaaccttaa gactgtctca tagttaccgt gttgagggaa atgcccccag
     1381 actcctgctg acaatgtttt ctaaactaat gagcagaagc ctaagttggg acagttcaga
     1441 accaagcaag aggggtccat tttaatgaat tagagtaaaa aaatagacct aagccatttg
     1501 taccttagtc ttagtgtttg gcctcatcta gcaaccaagg aagcctggtt ggagaaacag
     1561 aagaaatgat tccctccaga gccctgtctc ccttccccag gcaagaagag ccaggagggc
     1621 acaggcttac gcttcactct gatctgtgtg cttcacaggg caaggtgaaa gacacttgaa
     1681 tttccctttt tagcaatctt actgttttct ggtgctgccg gctgaaccca ggaccttgcc
     1741 ctcactaagc aaatgtacct accaccagtg agccagattt cgttcgagcc ctcctttggg
     1801 aagttcagtt cttcagttgt cagagagcct tattaccatc ttcctctgag agccaccctc
     1861 actcctagta gtggaagcga gctaggagac atttcgagaa tgctgatact ttttaaaggc
     1921 tgggttaggt cattggggga aattttctat aaaagagtga acaattatat ttatattttc
     1981 aagttagaat agtttggata tttcaatggt tttttgtttg ttgtttcttt ttttcttttt
     2041 tgtcagtgtg gatggatttg ttaccatgtg cactttggga tttttttttt aattgtttaa
     2101 agaaaatatt tcttttatga tttccttctc ccaccccgtg ttgttaatat tatttgtaat
     2161 ttagtttgta attcattaaa agaaaatatt ctca
//
