LOCUS       NM_001107634            5776 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus cyclin-dependent kinase 19 (Cdk19), mRNA.
ACCESSION   NM_001107634 XM_001063700 XM_228203
VERSION     NM_001107634.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5776)
  AUTHORS   Poss ZC, Ebmeier CC and Taatjes DJ.
  TITLE     The Mediator complex and transcription regulation
  JOURNAL   Crit Rev Biochem Mol Biol 48 (6), 575-608 (2013)
   PUBMED   24088064
  REMARK    Review article
REFERENCE   2  (bases 1 to 5776)
  AUTHORS   Liu X, Cheng C, Shao B, Wu X, Ji Y, Lu X and Shen A.
  TITLE     LPS-stimulating astrocyte-conditioned medium causes neuronal
            apoptosis via increasing CDK11(p58) expression in PC12 cells
            through downregulating AKT pathway
  JOURNAL   Cell Mol Neurobiol 33 (6), 779-787 (2013)
   PUBMED   23703121
REFERENCE   3  (bases 1 to 5776)
  AUTHORS   Liu X, Cheng C, Shao B, Wu X, Ji Y, Lu X and Shen A.
  TITLE     The functional interaction between CDK11p58 and
            beta-1,4-galactosyltransferase I involved in astrocyte activation
            caused by lipopolysaccharide
  JOURNAL   Inflammation 35 (4), 1365-1377 (2012)
   PUBMED   22527143
REFERENCE   4  (bases 1 to 5776)
  AUTHORS   Liu X, Cheng C, Shao B, Wu X, Ji Y, Liu Y, Lu X and Shen A.
  TITLE     CDK11(p58) promotes rat astrocyte inflammatory response via
            activating p38 and JNK pathways induced by lipopolysaccharide
  JOURNAL   Neurochem Res 37 (3), 563-573 (2012)
   PUBMED   22120654
REFERENCE   5  (bases 1 to 5776)
  AUTHORS   Duan Y, He X, Yang H, Ji Y, Tao T, Chen J, Hu L, Zhang F, Li X,
            Wang H, Shen A and Lu X.
  TITLE     Cyclin D3/CDK11(p58) complex involved in Schwann cells
            proliferation repression caused by lipopolysaccharide
  JOURNAL   Inflammation 33 (3), 189-199 (2010)
   PUBMED   20066559
REFERENCE   6  (bases 1 to 5776)
  AUTHORS   Ji Y, Xiao F, Sun L, Qin J, Shi S, Yang J, Liu Y, Zhou D, Zhao J
            and Shen A.
  TITLE     Increased expression of CDK11p58 and cyclin D3 following spinal
            cord injury in rats
  JOURNAL   Mol Cell Biochem 309 (1-2), 49-60 (2008)
   PUBMED   18008145
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474051.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001063700.1, XM_228203.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5776
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q12"
     gene            1..5776
                     /gene="Cdk19"
                     /gene_synonym="Cdc2l6; Cdk11"
                     /note="cyclin-dependent kinase 19"
                     /db_xref="GeneID:309804"
                     /db_xref="RGD:1305435"
     exon            1..387
                     /gene="Cdk19"
                     /gene_synonym="Cdc2l6; Cdk11"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..1765
                     /gene="Cdk19"
                     /gene_synonym="Cdc2l6; Cdk11"
                     /EC_number="2.7.11.22"
                     /note="cyclin-dependent kinase (CDC2-like) 11; cell
                     division protein kinase 19; cell division cycle 2-like 6
                     (CDK8-like)"
                     /codon_start=1
                     /product="cyclin-dependent kinase 19"
                     /protein_id="NP_001101104.1"
                     /db_xref="GeneID:309804"
                     /db_xref="RGD:1305435"
                     /translation="MDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGK
                     DEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEH
                     DLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVM
                     GEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIW
                     AIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEY
                     PTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPY
                     FQEDPLPTLDVFAGCQIPYPKREFLNEDEPEEKGDKNQPQQQNPHQQPVAPQQQAAAP
                     TQAPPPQQSSAQTNGTAGGATTGGGAAGAGLQHSQDSGLNQVPPNKKPRIGPSGANSG
                     GPVMPSDYQHSSSRLNYQSSVQGSSQSQGTLGYSSSQQSTQYHPSHQAHRY"
     exon            388..463
                     /gene="Cdk19"
                     /gene_synonym="Cdc2l6; Cdk11"
                     /inference="alignment:Splign:2.1.0"
     exon            464..574
                     /gene="Cdk19"
                     /gene_synonym="Cdc2l6; Cdk11"
                     /inference="alignment:Splign:2.1.0"
     exon            575..715
                     /gene="Cdk19"
                     /gene_synonym="Cdc2l6; Cdk11"
                     /inference="alignment:Splign:2.1.0"
     exon            716..773
                     /gene="Cdk19"
                     /gene_synonym="Cdc2l6; Cdk11"
                     /inference="alignment:Splign:2.1.0"
     exon            774..905
                     /gene="Cdk19"
                     /gene_synonym="Cdc2l6; Cdk11"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1049
                     /gene="Cdk19"
                     /gene_synonym="Cdc2l6; Cdk11"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1119
                     /gene="Cdk19"
                     /gene_synonym="Cdc2l6; Cdk11"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1192
                     /gene="Cdk19"
                     /gene_synonym="Cdc2l6; Cdk11"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1290
                     /gene="Cdk19"
                     /gene_synonym="Cdc2l6; Cdk11"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1369
                     /gene="Cdk19"
                     /gene_synonym="Cdc2l6; Cdk11"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1636
                     /gene="Cdk19"
                     /gene_synonym="Cdc2l6; Cdk11"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..5776
                     /gene="Cdk19"
                     /gene_synonym="Cdc2l6; Cdk11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaaaacaag gaaatgaagg gaggaggcgg gactgtgggt gcctgcggga gccgccgccg
       61 ccgccgcgga ggaggaggag gcggaggagg tggctgccgc ggccgccgag gagtcccttg
      121 ctgaaggcag accgcggagc ggcgggcggc gcgcgcgcgc ccgagcgacg gctgttcgag
      181 aagtggagcg gcggcggcgg aggagggact gagtggcggc ggcccccgcg tcccggtttc
      241 tctatggggg aagcagacaa tggattatga tttcaaggcg aagctggcgg cggagcggga
      301 gcgggtggag gatctgtttg agtacgaagg gtgcaaagtg ggacgcggca cctacgggca
      361 cgtctacaag gcgaggcgga aagatggaaa agatgaaaag gaatatgcac ttaagcaaat
      421 cgaaggcaca ggaatatcta tgtcggcttg tagagagatt gcacttttga gagaactgaa
      481 gcaccctaat gtgatcgcac tgcagaaggt gttcctttct cacagcgata ggaaggtgtg
      541 gctgctgttt gactatgcag aacatgacct ttggcatatt attaagtttc accgtgcatc
      601 aaaagcaaat aaaaagccca tgcagttacc aagatccatg gttaagtcgc tgctgtacca
      661 gatcctcgat ggtatccatt acctccacgc aaactgggtg ctccacaggg acctgaaacc
      721 agcaaatatc ctagtaatgg gagaaggtcc tgaaaggggg agagtcaaaa tagctgacat
      781 gggttttgcc agattattca attctcctct aaagccactt gcagatttgg atccagtagt
      841 cgtgacattt tggtatcggg ctccagaact tttactcggt gccaggcatt acacaaaggc
      901 catcgacatc tgggcaatag gctgcatatt cgctgagctc ttgacttccg aacccatttt
      961 tcactgtcgt caggaagata taaaaacaag caatcctttt catcacgatc aactggatcg
     1021 aatatttagt gtcatggggt ttcctgcaga taaagactgg gaagatatta gaaaaatgcc
     1081 agagtaccca acacttcaaa aagactttcg aagaacaacg tatgccaaca gcagcctcat
     1141 aaagtacatg gagaaacaca aggtcaagcc tgacagcaaa gtgttccttc tgcttcagaa
     1201 actcctcacc atggatccaa ccaagagaat tacctcagag caggctctgc aggaccctta
     1261 cttccaggaa gaccccctgc caacattaga tgtgttcgct ggctgccaga ttccataccc
     1321 caaaagagag ttcctcaatg aagatgaacc ggaagagaaa ggtgacaaga accagccaca
     1381 gcagcagaac ccacatcagc agcctgtagc cccccaacag caggcagcag cccccacaca
     1441 ggctcctcca ccacagcaga gcagtgccca gaccaatgga actgctgggg gagccactac
     1501 cggtggcggg gccgctggag ccggtctgca gcacagccag gactctgggc tgaatcaggt
     1561 gcctccaaac aagaagcccc ggattgggcc ttcgggtgca aactcaggcg ggcctgttat
     1621 gccatcggat tatcagcact ccagttctcg cctgaattac caaagcagcg ttcaggggtc
     1681 ctctcagtcc cagggtaccc taggctactc gtcatctcag cagagtaccc agtaccaccc
     1741 gtctcaccag gcccaccggt actgacccac tgcccgcttg gcctcgggga gcacagagcc
     1801 ggcggcaggg tggtttctgc aatacaaaga accccacgct gaagactgac gtcatgcaaa
     1861 gcgcagatgt gtgagaggga acctttgcat gctaagtatt ttgaaggacg aatatctctt
     1921 cttcgttgac ttaaagaaga gtcttgtgaa gtgtccccag ccctcttccc cgcatgaatt
     1981 cctctctgac tttcctgatg aagcgtcttt tctaccccag cacttctgca tccttcagca
     2041 gtctctggag gagtttctgg tgcacctttc tcacgctgta gcaatcatta taatttatct
     2101 tgtcttagga tctcaatgtt ctaggaacag ggctccagtg ctgtaaagtt ttgtacttca
     2161 tgaactgatc tagcaacacc agtcaaatgc accttttaaa gcactacaca gtcttcacag
     2221 actaactgct ttgctcttgg aagtcttaaa aagaaactgt tactgtccca aagtacttta
     2281 ctattatgtt ctatttatct ctttcaggga aggttagtga aagacacgtg tgggacagac
     2341 cgtgcccaca accaaaaaca gcttaggtct ttgcagctac ctgcttatgc tatgaagaac
     2401 tgaagtactt ggtggttttt atataatcat tcatggggaa ctcagttccc agaatcatca
     2461 tattctgaat aatattcagt gattaaaatt ataattttaa cttcatgtag ctaagtctac
     2521 tttaaaagag gtttcaagag ctttgatgga atccagtcct ttgggactca cctggaagtc
     2581 tgaagagact gtttcctgca ctaggacctc acaaggagtc atgctgatca aagcgcgctt
     2641 cgtccacttg agggaaaagc tttttccatg tacatctcgg agcttctctc aaggcgctgc
     2701 tggttcttca gtctcttcat gtctggtcag catgagtaac tttgtttcat aatcaaggat
     2761 gctcagatag aagcctgtta actcatctgc agtgttctcc atttgtatgg acagagcata
     2821 aagtgactat ttttaaagca tgttaaactt ttaggtttca ttcatgttcg aagtgtgtat
     2881 tatgtatgca taattttgct gttactgaga cttaacgctg tcaagaacct tttttattgc
     2941 actgaatgct ttcttttgcc cctaggaaga aacttaataa ttgtgcctac gaactatggg
     3001 cagatagtgt gaagtagatg aggtgaagat ttgcatttcc gtgatctacg aattagaggg
     3061 ggtccttcct tagctccttc tgaggacccc cacacacctc cagagtcgag gaaacgtaaa
     3121 ggcttagcac tcccattgca gtgcagggcc aggataccct gttctgatgc ccctgcagtg
     3181 cccagccttg ttctccatgg ttgttgagct agaataaaat agccagttgt tgtatatgca
     3241 aactatatga tttttaaaaa ctattcttgt gaacctatct acctggttct gatactctgg
     3301 ggtccatata caagtaaact aggatttttt agaagccagt atacattttg cactattgat
     3361 gtaatactgt agccagccag gatcatactg atttcagcat atttatgctt ataaatagta
     3421 atacaggctt atagtgacaa gcataccagg gccgaacatg aaggcatcga cacgtgacat
     3481 gcttcgttgg gaggaatttc tgaccgtctc cttagatttc tttttatccc ttatatcttt
     3541 tttaaaataa ggatcagcct actgcatcgt gttgctatcc atataaagtt ctgtcccgtg
     3601 ccctggagcc ctttgtccag ggccactgtt cccttatcac aggcccagtg ctctgctggg
     3661 tgggaaaaca gagagcagga gacatttcct tgttacagcc aatcccgtga caataaactc
     3721 atgtgggagt gtcaggtgcc atgaaggtcc ttttgtttac ttctgaaccc acttggataa
     3781 ccaagcttcc ttctgcattt tatggtaaac agtgttacgg ggaagcaggt ctgtctgacc
     3841 actgaggaga aagccggtga tgagccgtca cacaggcatc tatgcatatt tgagttcaca
     3901 gcagcaggca gcagcaggtg gtggcccctg tggatagcgt attgtactag gtggttgtgg
     3961 aaagtgacaa tgaaaacaag ccctgctctg gccctcgagt aagctccata gtaacaggca
     4021 ttagaccagt ctgtgtgtat ccatagtaac aggcattaga ccagtctgtg tgtatccata
     4081 ggtatatatt aggacagtgc tctacacaga ctggatccac agttcggcca tgtgcactca
     4141 cacattcata ggactgttct ggtaaaactg actcacacag ggcactttgt cattcgctcc
     4201 cagtatctgt tttccaggac aaagccagaa accttcgctg tatatacaac tgggctccac
     4261 atcgctgcac tgattctgac cctttgagtg tcccttcttc ctcagggtgg gtgatgcgta
     4321 cctgtgccca gtactctcag aaatgatttc tgtttgtcct ttcctttctc tgtcaaggaa
     4381 gcaaagcctt ttgtattcat taaggccata gtccatgggt tgggacctct aataggacca
     4441 tgggacccat ggagctcctt aagggtggag tttacctccg tgagccttga gtgatggtat
     4501 ttctctttga ccgtttatta gatactattt tattctctag ggacacaggg aggcaccctc
     4561 tgacttaggg gagctcgagt ctagggaggg attgaagggt tgagttgaaa ggtttctgtt
     4621 ctttatatta aaagtcactt ttacccgtag ctttgtggca aggtgtttga gggaaaagat
     4681 tgaggcgttt gcgaacagag tagctcaaag taaggtagcg tgagtcggta acttgaggct
     4741 gaagcaatcc ctttgatgaa gtaaaccatg aagtgagatg cagaaatcaa ggaggggaca
     4801 agtctacttt ttatgtctgc gctttggaaa ccttaggact taagagctct gacatgctgc
     4861 actctgtaac acggcttcat ggcgggaagg gagggcctca cgtccacaca cgctggctgc
     4921 ctcgttcctg gctgtcccta gctgtcccta gctgtccctg agatgatgct gtgcttcact
     4981 aggaggaaaa gcagttggag agtaagactt gcggcttgct tgcttctgag atatagcaac
     5041 agccacatgc tgctccctcg gtgaccgaga aagaccatga agggccgttg ggcttatgga
     5101 gaccggaaga agtccagcac gagtaataac tttatacaag gtgtagcagt ttaggtcctc
     5161 ttaatcatca agaatagtta gatacagccc cagtctcaga agtgtatggt ccccgaggcg
     5221 gtacttacct tccaagccgt tttcaacagg gagtgacgct agcgtgttat atgggaaata
     5281 cctaaggcac tgttaccacc cacatagtga gtaaattaat actatttcat ttaaaaaaaa
     5341 aaaaaaagct ttgtctgggt agacactaaa agcattatat aaagccaaga ctgagatgtc
     5401 ctttttaata acaactgata gtccttttat atatgttaca cagtatgtcc tttctaaact
     5461 agtttgtatt cctgataatt cctgtttgtg aagtgtacct ctctctcact ttggtcattt
     5521 tctgcacgca ccccctctgt atgatcgtag atactgccgc ggctctcctt gctctgctgt
     5581 gatgtgtgta ccccaagccc actgcccccc gaagcccact ctggggatgc agggtgtgtg
     5641 gcctcggcgt cttcagaact gggtgcttct gctctggagt tacccggcca ccctcctcag
     5701 aatggctgtt ccagctatga tgagttacgt cacatttatt ttgtattctt ggttgaaata
     5761 aaatttaatt gacttt
//
