LOCUS       NM_001004132            3115 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Rattus norvegicus cyclin-dependent kinase 16 (Cdk16), transcript
            variant 1, mRNA.
ACCESSION   NM_001004132 XM_006256618
VERSION     NM_001004132.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3115)
  AUTHORS   Shehata,S.N., Hunter,R.W., Ohta,E., Peggie,M.W., Lou,H.J.,
            Sicheri,F., Zeqiraj,E., Turk,B.E. and Sakamoto,K.
  TITLE     Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1
            kinase
  JOURNAL   Cell Signal 24 (11), 2085-2094 (2012)
   PUBMED   22796189
REFERENCE   2  (bases 1 to 3115)
  AUTHORS   Chen,X.Y., Gu,X.T., Saiyin,H., Wan,B., Zhang,Y.J., Li,J.,
            Wang,Y.L., Gao,R., Wang,Y.F., Dong,W.P., Najjar,S.M., Zhang,C.Y.,
            Ding,H.F., Liu,J.O. and Yu,L.
  TITLE     Brain-selective kinase 2 (BRSK2) phosphorylation on PCTAIRE1
            negatively regulates glucose-stimulated insulin secretion in
            pancreatic beta-cells
  JOURNAL   J Biol Chem 287 (36), 30368-30375 (2012)
   PUBMED   22798068
REFERENCE   3  (bases 1 to 3115)
  AUTHORS   Mikolcevic,P., Sigl,R., Rauch,V., Hess,M.W., Pfaller,K.,
            Barisic,M., Pelliniemi,L.J., Boesl,M. and Geley,S.
  TITLE     Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin
            Y and is essential for spermatogenesis
  JOURNAL   Mol Cell Biol 32 (4), 868-879 (2012)
   PUBMED   22184064
REFERENCE   4  (bases 1 to 3115)
  AUTHORS   Wu,K., Li,S., Bodhinathan,K., Meyers,C., Chen,W.,
            Campbell-Thompson,M., McIntyre,L., Foster,T.C., Muzyczka,N. and
            Kumar,A.
  TITLE     Enhanced expression of Pctk1, Tcf12 and Ccnd1 in hippocampus of
            rats: Impact on cognitive function, synaptic plasticity and
            pathology
  JOURNAL   Neurobiol Learn Mem 97 (1), 69-80 (2012)
   PUBMED   21982980
  REMARK    GeneRIF: Behavioral experiments suggested that overexpression of
            Pctk1 produces a deficit in learning and memory.
REFERENCE   5  (bases 1 to 3115)
  AUTHORS   Fu,W.Y., Cheng,K., Fu,A.K. and Ip,N.Y.
  TITLE     Cyclin-dependent kinase 5-dependent phosphorylation of Pctaire1
            regulates dendrite development
  JOURNAL   Neuroscience 180, 353-359 (2011)
   PUBMED   21335063
REFERENCE   6  (bases 1 to 3115)
  AUTHORS   Mokalled,M.H., Johnson,A., Kim,Y., Oh,J. and Olson,E.N.
  TITLE     Myocardin-related transcription factors regulate the Cdk5/Pctaire1
            kinase cascade to control neurite outgrowth, neuronal migration and
            brain development
  JOURNAL   Development 137 (14), 2365-2374 (2010)
   PUBMED   20534669
REFERENCE   7  (bases 1 to 3115)
  AUTHORS   Liu,Y., Cheng,K., Gong,K., Fu,A.K. and Ip,N.Y.
  TITLE     Pctaire1 phosphorylates N-ethylmaleimide-sensitive fusion protein:
            implications in the regulation of its hexamerization and exocytosis
  JOURNAL   J Biol Chem 281 (15), 9852-9858 (2006)
   PUBMED   16461345
  REMARK    GeneRIF: Pctaire1 phosphorylates N-ethylmaleimide-sensitive fusion
            protein
REFERENCE   8  (bases 1 to 3115)
  AUTHORS   Hirose,T., Kawabuchi,M., Tamaru,T., Okumura,N., Nagai,K. and
            Okada,M.
  TITLE     Identification of tudor repeat associator with PCTAIRE 2 (Trap). A
            novel protein that interacts with the N-terminal domain of PCTAIRE
            2 in rat brain
  JOURNAL   Eur J Biochem 267 (7), 2113-2121 (2000)
   PUBMED   10727952
REFERENCE   9  (bases 1 to 3115)
  AUTHORS   Gao,C.Y., Chauthaiwale,V.M., Rampalli,A.M. and Zelenka,P.S.
  TITLE     Expression of alternatively spliced PCTAIRE-1 mRNA in PC12 cells
            and neonatal rat brain
  JOURNAL   Gene 176 (1-2), 243-247 (1996)
   PUBMED   8918260
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On or before Nov 23, 2022 this sequence version replaced
            XM_006256618.4, NM_001004132.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887621.79377.1,
                                           SRR22399481.2013189.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-390               JAXUCZ010000021.1  4056991-4057380     c
            391-598             JAXUCZ010000021.1  4052444-4052651     c
            599-732             JAXUCZ010000021.1  4051819-4051952     c
            733-858             JAXUCZ010000021.1  4051595-4051720     c
            859-915             JAXUCZ010000021.1  4051453-4051509     c
            916-1030            JAXUCZ010000021.1  4051252-4051366     c
            1031-1125           JAXUCZ010000021.1  4050570-4050664     c
            1126-1188           JAXUCZ010000021.1  4050413-4050475     c
            1189-1312           JAXUCZ010000021.1  4050050-4050173     c
            1313-1433           JAXUCZ010000021.1  4049724-4049844     c
            1434-1531           JAXUCZ010000021.1  4049547-4049644     c
            1532-1637           JAXUCZ010000021.1  4049356-4049461     c
            1638-1680           JAXUCZ010000021.1  4049232-4049274     c
            1681-1771           JAXUCZ010000021.1  4048989-4049079     c
            1772-1849           JAXUCZ010000021.1  4047676-4047753     c
            1850-3115           JAXUCZ010000021.1  4046330-4047595     c
FEATURES             Location/Qualifiers
     source          1..3115
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq11"
     gene            1..3115
                     /gene="Cdk16"
                     /gene_synonym="Pctk1"
                     /note="cyclin-dependent kinase 16"
                     /db_xref="GeneID:81741"
                     /db_xref="RGD:620584"
     exon            1..390
                     /gene="Cdk16"
                     /gene_synonym="Pctk1"
                     /inference="alignment:Splign:2.1.0"
     exon            391..598
                     /gene="Cdk16"
                     /gene_synonym="Pctk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             397..1887
                     /gene="Cdk16"
                     /gene_synonym="Pctk1"
                     /EC_number="2.7.11.22"
                     /note="serine/threonine-protein kinase PCTAIRE-1; cell
                     division protein kinase 16; PCTAIRE-1 protein kinase,
                     alternatively spliced; PCTAIRE-motif protein kinase 1;
                     PCTAIRE protein kinase 1"
                     /codon_start=1
                     /product="cyclin-dependent kinase 16"
                     /protein_id="NP_001004132.1"
                     /db_xref="GeneID:81741"
                     /db_xref="RGD:620584"
                     /translation="MDRMKKIKRQLSMTLRGGRGIDKTNGVPEQIGLDESGGGGGSDL
                     GEAPTRVAPGELRSIRGPLSSAPEIVHEDMKMGSDGESDQASATSSDEVQSPVRVRMR
                     NHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFG
                     KLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDL
                     KHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNVINMHNVKLFLFQLLRGLAY
                     CHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILL
                     GSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEDTWPGILSN
                     EEFRTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLG
                     ERIHKLPDTTSIFALKEVQLQKEANIRSTSMPDSGRPAFRVVDTEF"
     exon            599..732
                     /gene="Cdk16"
                     /gene_synonym="Pctk1"
                     /inference="alignment:Splign:2.1.0"
     exon            733..858
                     /gene="Cdk16"
                     /gene_synonym="Pctk1"
                     /inference="alignment:Splign:2.1.0"
     exon            859..915
                     /gene="Cdk16"
                     /gene_synonym="Pctk1"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1030
                     /gene="Cdk16"
                     /gene_synonym="Pctk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1125
                     /gene="Cdk16"
                     /gene_synonym="Pctk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1188
                     /gene="Cdk16"
                     /gene_synonym="Pctk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1312
                     /gene="Cdk16"
                     /gene_synonym="Pctk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1433
                     /gene="Cdk16"
                     /gene_synonym="Pctk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1531
                     /gene="Cdk16"
                     /gene_synonym="Pctk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1637
                     /gene="Cdk16"
                     /gene_synonym="Pctk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1680
                     /gene="Cdk16"
                     /gene_synonym="Pctk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1771
                     /gene="Cdk16"
                     /gene_synonym="Pctk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1849
                     /gene="Cdk16"
                     /gene_synonym="Pctk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..3115
                     /gene="Cdk16"
                     /gene_synonym="Pctk1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagagcgcg gcgcgcgcgg ctgttgggcc gctggttagg gggccctggg atctgctgcg
       61 tctccgctag ctgtctgccg tgagtcacga gccgccgtga acacccggat tccagcggga
      121 gcttgcgagc acgggggcat cgcccgcagt ggccaagctc atggctggct gagcgggacg
      181 ccgccgccgc ctcagccgcc gccgccgccg ccgcctcttc ctcctcagcc ggcggcggcc
      241 cgggcccaac agccatggct gaagactact gggacgggcg cctgcggcga actggaggaa
      301 aaggaggtcg cgcggcctca tcctgggccg ccgccccagg cgccaccgcg ccggccccgc
      361 ggctctgagg ttactcgcgc gccccctccg gtcgccatgg atcggatgaa gaagatcaaa
      421 cggcagctgt caatgacact ccgagggggc cgaggcatag acaagaccaa tggtgtccct
      481 gagcagatag gcctagatga gagtggtggt ggtggtggca gtgaccttgg agaagctccc
      541 acccgtgttg cccctgggga acttcgctct attcggggcc cactcagctc tgcaccagag
      601 attgtgcatg aagacatgaa gatgggatct gatggggaga gtgaccaggc ttcagccaca
      661 tcctcagatg aggtgcagtc tccagtgaga gtgcgcatgc gcaaccaccc cccacgcaag
      721 atctccactg aggatatcaa caaacgcctg tcactaccag ctgacatacg gctgcctgag
      781 ggctaccttg agaagctgac actcaatagt cccatctttg ataagcctct tagccggcgc
      841 ctccgccgtg tcagcttgtc tgagattggc tttggaaaac tggagaccta catcaaacta
      901 gacaagctgg gtgagggtac ctatgccact gtctacaaag gcaaaagcaa gctcacagac
      961 aaccttgtag cacttaagga gatcagactg gaacacgaag aaggggcacc ttgcactgct
     1021 atccgggaag tgtctctgct caaggacctc aagcatgcca acatcgtcac actacatgac
     1081 attatccaca cagagaagtc cctcaccctt gtctttgaat acttggacaa ggacctgaag
     1141 cagtacctgg atgactgtgg aaatgtcatc aacatgcaca atgtgaaact gttcctgttc
     1201 cagttgctcc gtggcctggc ctactgccac aggcagaagg tgctacatcg agacctcaag
     1261 ccccagaacc tactcatcaa cgagagggga gagctcaaac tggcagactt tggcctggct
     1321 cgtgccaagt caattcctac taaaacatac tccaacgaag tggtgacact gtggtaccgg
     1381 ccccccgaca tcttacttgg gtccacagac tactctaccc aaattgacat gtggggtgtt
     1441 ggctgcatct tttatgagat ggccacaggc cggcccctct tcccaggctc cacagtggaa
     1501 gaacagctgc acttcatctt ccgcattttg ggaaccccaa ctgaggacac atggccaggt
     1561 atcctgtcca atgaagagtt tagaacatac aactacccca agtaccgagc tgaggccctt
     1621 ctgagccatg caccccgact tgatagcgat ggagctgacc tcctcaccaa gctgctgcag
     1681 tttgagggtc gcaatcggat ctctgctgag gatgccatga aacatccatt ctttctcagc
     1741 ttgggggagc ggatccacaa acttcctgac actacttcca tatttgcact aaaggaggta
     1801 cagctacaaa aggaggccaa cattcggtcc acttctatgc ctgactcagg caggccagct
     1861 ttccgtgtgg tggataccga gttctaagcc aagttttaag ccacagacca aggccccagc
     1921 aggcagcggc tggagggatg ccacacccct cacaggacag cccccatctg caatcctccc
     1981 tgcttgttgc ctgcttacct gcctgagcca cactcccctg ccaacttgtc ccctgccacc
     2041 tgtccaaaca ccgaactact ggcctggcct gttaacccaa ccactggcct gtctgctggg
     2101 tgctaacaaa gctctcacca ctactttgct tgatgtgtct gtctctgtct tggtagatgc
     2161 tggtggaccg aatggccgtg ccagctttcc acactaaggc taggccttcc cctcttcatc
     2221 acactctctc ccaggaccac taccccatgg ccaaccaggg gtttggagct agcccaggcc
     2281 aggctctcaa tcgactttga ctagaaggta gtgatgcctt gggtctgagg tatcatttgc
     2341 ctgcttccca tctgtcccac ttgcctctgt tgtatgggct tttttttagt ttcttttatt
     2401 gttttttatt attttaaatg aggttctcac tttttaatgc aatatctctg tatacagact
     2461 ggttgggcac tactccctga gtgtggccct cccacagtat tttgtgcaat gaagtcccac
     2521 tcccaccctt tgagaggtag ggacccagac cctattcaga tcctgaccat cactagaccc
     2581 tggaattggc tatgggaaag catgcctcag ccactcacct tcctccccta cctagcgttc
     2641 ccagctatag ggggacccag aactaccaga gagtgggaga tggacatggt ggggcctact
     2701 ttttccctcc ttcagtcccg tagccagggc ctccttcctt ctcagggtct tcccagccca
     2761 gctctgccta gccctcctgc cctgtcctac tcggtgctgt tgagtagggg ctctgccagg
     2821 aatcgagcag cttagtgagg agccatatat aatatgtata tgtgcacaag caggaggaca
     2881 tgtgggagct tgtgcccaat tgttacaccc caatccctag gagggtcagg caggccaagg
     2941 acagtctcct ggatggatgg tttgctcccc ttcctccacc ttaagccttg ggacccttaa
     3001 gcagggtggg agggcaaggg agggtgccct cctagtgggg tttggggggg gattgggttc
     3061 ctgaatgcac cataatcgct gtatgaaata ttaaaaaaaa agtctaaagt gaaaa
//
