LOCUS       NM_001395582            5304 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Rattus norvegicus cyclin-dependent kinase 14 (Cdk14), transcript
            variant 1, mRNA.
ACCESSION   NM_001395582 XM_039107754
VERSION     NM_001395582.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5304)
  AUTHORS   Parmasad,J.A., Ricke,K.M., Nguyen,B., Stykel,M.G., Buchner-Duby,B.,
            Bruce,A., Geertsma,H.M., Lian,E., Lengacher,N.A., Callaghan,S.M.,
            Joselin,A., Tomlinson,J.J., Schlossmacher,M.G., Stanford,W.L.,
            Ma,J., Brundin,P., Ryan,S.D. and Rousseaux,M.W.C.
  TITLE     Genetic and pharmacological reduction of CDK14 mitigates
            synucleinopathy
  JOURNAL   Cell Death Dis 15 (4), 246 (2024)
   PUBMED   38575601
  REMARK    GeneRIF: Genetic and pharmacological reduction of CDK14 mitigates
            synucleinopathy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5304)
  AUTHORS   Yang,H.J., Wang,L., Wang,M., Ma,S.P., Cheng,B.F., Li,Z.C. and
            Feng,Z.W.
  TITLE     Serine/threonine-protein kinase PFTK1 modulates oligodendrocyte
            differentiation via PI3K/AKT pathway
  JOURNAL   J Mol Neurosci 55 (4), 977-984 (2015)
   PUBMED   25355490
  REMARK    GeneRIF: PFTK1 expression is markedly decreased during
            oligodendrocyte differentiation.  PFTK1 overexpression suppresses
            oligodendrocyte differentiation in vitro.
REFERENCE   3  (bases 1 to 5304)
  AUTHORS   Davidson,G., Shen,J., Huang,Y.L., Su,Y., Karaulanov,E.,
            Bartscherer,K., Hassler,C., Stannek,P., Boutros,M. and Niehrs,C.
  TITLE     Cell cycle control of wnt receptor activation
  JOURNAL   Dev Cell 17 (6), 788-799 (2009)
   PUBMED   20059949
REFERENCE   4  (bases 1 to 5304)
  AUTHORS   Jiang,M., Gao,Y., Yang,T., Zhu,X. and Chen,J.
  TITLE     Cyclin Y, a novel membrane-associated cyclin, interacts with PFTK1
  JOURNAL   FEBS Lett 583 (13), 2171-2178 (2009)
   PUBMED   19524571
REFERENCE   5  (bases 1 to 5304)
  AUTHORS   Lazzaro,M.A., Albert,P.R. and Julien,J.P.
  TITLE     A novel cdc2-related protein kinase expressed in the nervous system
  JOURNAL   J Neurochem 69 (1), 348-364 (1997)
   PUBMED   9202329
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Jul 20, 2021 this sequence version replaced XM_039107754.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1582475.1,
                                           SRR26643298.21617.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-594               JAXUCZ010000004.1  29621217-29621810
            595-626             JAXUCZ010000004.1  29628441-29628472
            627-872             JAXUCZ010000004.1  29757147-29757392
            873-967             JAXUCZ010000004.1  29772325-29772419
            968-1047            JAXUCZ010000004.1  29815877-29815956
            1048-1142           JAXUCZ010000004.1  29881538-29881632
            1143-1205           JAXUCZ010000004.1  29915196-29915258
            1206-1329           JAXUCZ010000004.1  29924755-29924878
            1330-1450           JAXUCZ010000004.1  29962690-29962810
            1451-1544           JAXUCZ010000004.1  29986643-29986736
            1545-1608           JAXUCZ010000004.1  30071711-30071774
            1609-1657           JAXUCZ010000004.1  30098567-30098615
            1658-1797           JAXUCZ010000004.1  30130295-30130434
            1798-1941           JAXUCZ010000004.1  30135658-30135801
            1942-5304           JAXUCZ010000004.1  30210289-30213651
FEATURES             Location/Qualifiers
     source          1..5304
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q13"
     gene            1..5304
                     /gene="Cdk14"
                     /gene_synonym="Pftk1"
                     /note="cyclin-dependent kinase 14"
                     /db_xref="GeneID:362316"
                     /db_xref="RGD:1305544"
     exon            1..594
                     /gene="Cdk14"
                     /gene_synonym="Pftk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             504..1913
                     /gene="Cdk14"
                     /gene_synonym="Pftk1"
                     /EC_number="2.7.11.22"
                     /note="isoform 1 is encoded by transcript variant 1; cell
                     division protein kinase 14; PFTAIRE protein kinase 1"
                     /codon_start=1
                     /product="cyclin-dependent kinase 14 isoform 1"
                     /protein_id="NP_001382511.1"
                     /db_xref="GeneID:362316"
                     /db_xref="RGD:1305544"
                     /translation="MCDLIEPQPAEKIGKMKKLRRTLSESFSRIALKKDDTTFDEICV
                     TKMSTRNCQGMDSVIKHLDTIPEDKKVRVQRTQSTFDPFEKPANQVKRVHSENNACIN
                     FKSSAAGKESPKVRRHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKL
                     VALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLC
                     QYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFG
                     LARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPG
                     MKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTVYSSKSLRQAWNKLSYVNHA
                     EDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAGES
                     MRAFGKNNSYGKSLSNSKH"
     exon            595..626
                     /gene="Cdk14"
                     /gene_synonym="Pftk1"
                     /inference="alignment:Splign:2.1.0"
     exon            627..872
                     /gene="Cdk14"
                     /gene_synonym="Pftk1"
                     /inference="alignment:Splign:2.1.0"
     exon            873..967
                     /gene="Cdk14"
                     /gene_synonym="Pftk1"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1047
                     /gene="Cdk14"
                     /gene_synonym="Pftk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1142
                     /gene="Cdk14"
                     /gene_synonym="Pftk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1205
                     /gene="Cdk14"
                     /gene_synonym="Pftk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1329
                     /gene="Cdk14"
                     /gene_synonym="Pftk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1450
                     /gene="Cdk14"
                     /gene_synonym="Pftk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1544
                     /gene="Cdk14"
                     /gene_synonym="Pftk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1608
                     /gene="Cdk14"
                     /gene_synonym="Pftk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1657
                     /gene="Cdk14"
                     /gene_synonym="Pftk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1797
                     /gene="Cdk14"
                     /gene_synonym="Pftk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1941
                     /gene="Cdk14"
                     /gene_synonym="Pftk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..5304
                     /gene="Cdk14"
                     /gene_synonym="Pftk1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggagggcgg cggaggcctc ggagtcggag tcggaacgcg gcgcggggtc gcgcctgggt
       61 cccgggcgcc aggcctctgg ccagggcagt cgcgggtctc cgtgcagcgc cgcccctcgg
      121 gctggggaac ttgtcccgcg cgcctcgcct gcagccgcct gcgcctcctc ggccgcgccg
      181 cccccgtctc cggtcgcggc cgcgcggctc tggcttacaa aggagggaaa atgcggcggg
      241 cagcggcgca gcgcgggggc ccccgggcgg cggggatcgc ggccgccccc ggcaccacgt
      301 aagacgcccc cgcgcgccca gcctcggccc aggcccgagc cccgcaggca ggcgagcgct
      361 gcgcgtcgcc cgcggcccgc gaggaggcgg aggagcagga cgaggcgccg ccttccccgc
      421 gccgcgcgcc ctcgcccgcc gttgtctgcg ctgcgctgcg ctggaccagt ttcgcgaagt
      481 tgcccgggcc ccgcgtcgcc cagatgtgcg acctcattga accgcagccg gccgagaaga
      541 tcggcaagat gaagaagttg aggagaactt tgtccgagag tttcagccgc atcgctctga
      601 agaaagacga caccaccttt gatgagatat gtgtcacaaa gatgtctaca cggaactgcc
      661 agggaatgga ttcagtgatc aagcacctgg acacgattcc tgaagataaa aaagtcaggg
      721 ttcagaggac gcagagcacc tttgacccat tcgagaaacc ggccaatcag gtcaaaaggg
      781 tacactcaga gaacaatgct tgcattaact ttaagtcctc cgctgctggc aaagagtcac
      841 ctaaagtcag gcggcattcc agccccagct cgccaacaag tcccaaattt ggaaaagctg
      901 actcatacga aaaactggaa aaactagggg aaggatcata tgcaacagta tacaaaggga
      961 aaagcaaggt aaacggaaag ctggtggctc taaaggtgat caggctgcag gaggaagagg
     1021 gtacgccttt cacagccatc agagaagctt ctctgctgaa aggattaaag catgcaaaca
     1081 tcgtgcttct tcatgacatc atccacacca aggaaacact gacacttgtc tttgaatatg
     1141 tgcacactga tttatgtcag tacatggaca agcaccctgg aggactccat ccagataatg
     1201 tgaagttgtt tttatttcag ttgctgcgag ggctgtctta catccaccag cgttatattt
     1261 tgcacagaga cctgaaaccg cagaaccttc tcatcagtga cacgggggag ttgaagctgg
     1321 cagatttcgg tctggcaaga gcaaaatccg tccctagcca cacgtactcc aatgaagtgg
     1381 ttaccttgtg gtacagacct ccagacgttc tcctgggctc tacagagtac tccacctgcc
     1441 tggacatgtg gggagtcggc tgtatctttg ttgagatgat ccaaggagtc gctgcatttc
     1501 caggaatgaa agacattcag gatcaacttg aacggatatt tctggttctt ggaacaccaa
     1561 acgaggacac gtggcctgga gttcattctt taccacattt taagccagaa cgatttaccg
     1621 tgtacagctc taaaagcctt agacaagcat ggaataagct cagctatgta aatcacgccg
     1681 aggacctggc ctccaagctt ctacagtgtt ccccaaagaa caggctgtca gcacaggccg
     1741 ccttgagcca cgagtatttc agcgatctgc ccccgcggct atgggagctg accgatatgt
     1801 cttctatttt tactgtccca aatgtgagat tgcaacccga agctggagag agcatgaggg
     1861 cctttggaaa aaacaatagt tacgggaaaa gtctatcgaa cagcaagcac tgacgagccc
     1921 agcatcctcg ggagagcaca ggattaagtc gtcatcattc tgggaagaaa aagaggaaga
     1981 agaaaaataa ataaataaat aaatacataa ataaataaat aaataccact aataaagtgg
     2041 tcacccgtgc aagggatccc tggatcggtt ctcttctgct ccctgcagtg gatttcactg
     2101 acaggaaaac tgaagctgga agaccccgtt tcctctgcag ttcatttaaa accttgcacg
     2161 catttggata ccttgtgatt tccaagaacg tacgtgaaga ttaagcttcg cttactgata
     2221 cgtggcatgt atccctttcg gtcttttgtg tctgattccg tttgatttcc ccctgccaca
     2281 cagtgtctct tgtgaagggt tttcctgctt tcagcagcct cgtcttaaat acatgaagac
     2341 agcacatttg ctgtccacat ttcctccatc gtgtctgcac ttgaaagcca cacggtggca
     2401 ggaaacagtg cgtgtgtttt ccccgagagc ggagtgcatt ctgcaaccac caggaaggac
     2461 attctttctg ctaaaacaaa ccccatgttt tctgacggac tagacagcat gttcccaggc
     2521 agcagggccc tacctgtcgc ttgccttgga ggacgtttgg aaacgtgagg tttttttttt
     2581 tcttttcttt tatccttgga aatgagcaca taggagacca aaatccactt aacatttcaa
     2641 tagcatgact gtttctgagc aggtcttagg tagagagaca agtaccgaaa acaaagacag
     2701 ggtgaatgaa ggttgataat tattattttt ttaagcctgt agaaagcaag gcaacttttt
     2761 acatgtgttc tgggtcttgt caacatcttc cttttttcca tcaactctgt attattaaac
     2821 tgttatactc tgtatttttt taactggaga aaatagtaag gaatagcatt cttaaaactt
     2881 gggtgcaaag aaaaaaaaga gtctgtcagg ataggtcccg aaagcagtct tggctgatta
     2941 aagcttaaaa atcaaattta aaaattatcc agagttaaaa atttgcttgc ttatggcgaa
     3001 ggacctttga ttgttcagaa acattccaag ctatccagaa ggcatcaccg gatatggact
     3061 ttaaacgagt cttcagtagc aactgttcaa aggcagatct tataagcaat gcaggagttt
     3121 tgcttaaaga ataaaaatgg caaagcaagg cccttgtttt aaggacctct gggaccttgc
     3181 acgtttaggg caagtctgtg ccactgggag agagggatgc cctagcatac attgaccatt
     3241 ggtctgaggc agctgcccag tgcccgctac taccacaggc agcctcactg ctgaatccca
     3301 ggaaagcggg cccaaggagc aggtaggcag cttcatgtga agtatgccct ttgctcctcc
     3361 tgacacaaat ccccatggaa atgcaatgca tctgtgtaca gtggtctgtg ttttattctt
     3421 cccaagaaag aggagaagct acaagctgga aacgttgcac acaattttag gatcaggact
     3481 aaaaatcaca atgcagtttc acaagggttt tctgattctc caatggggaa gaagcttcct
     3541 tgtagtcaaa tccagtgcat cctgggaagt agatcgaggt tccaggaagt agattaaact
     3601 ttcaaaggca tcgggtctga gtaagaggtg taactgatcc cccagcctat cagaggggtc
     3661 actcagtgtg atgtcacaaa cgctaaacaa ggaactcctt tcagaatggt ttgaaagaaa
     3721 gcaaaggaca cccaaggtga cagtgtttac tcttcactac ctgggaatcc tttctcgttc
     3781 ctcttttgta cattccttcc acgggaagtc tttgcaggga ttttgattta aagtatagtt
     3841 aaattgggag ttctttaagt ggggagaaaa ctttatgtgt aattaagaac agcctcccct
     3901 gtgatttgaa tcgtccattc atctgggggc agggaagagg ttgtgtttgg atttcactaa
     3961 gtgtaagtca ggagctccat actaatgtcg aaaggtttca ataagaacat aaaggcagct
     4021 agaggtccag gcccttgtct agacagcttc tcctgggaag taagacataa cactgctcgg
     4081 tgtggggtct gcctttcgac aggcacgcct ctcaggttta aagggtttca gtttcctgtc
     4141 cttgtcatca aggaaggaaa tccaaagtgt ctgaccctcc ccctccaccc aacatggtca
     4201 cagccccctt ccctggcttt actctccttg cctctctaag ggcgtcatga aaatcagtgc
     4261 agactttgtt cgttaccacg tccttgtacc gttgagagag cactggaatg tttggtgaga
     4321 ttatttttct atgaagcttg agtttggaca gctgctaaga atagcaccaa taccttggca
     4381 cagcaattgt atcaaagcaa cctcactgca cacagtattt ggaaaggaag catgggactt
     4441 agtttccatc ttcttaaggg gaaccgttta attaattaag aaatacaaca ctacatagga
     4501 caggaaaatg tgtttgctgt aaaattagaa gtatgaggca ggggcagcta tctgcccacc
     4561 atgcaaggat gaacacctgt ttctagctct cgagtgacta aaggtttcca agggagtcag
     4621 tgggactgtg ggaaaccagg gcctcttggt accctctcct cagtgtgtgt gacacccacc
     4681 gtaatcagta ctctatgtat gcatccgtag cagacactca tctgtgaata tcgctgggtt
     4741 tgtaatcttt tgttctgtaa gaagatgttt aggctgtaca tactggggta gaccattgcc
     4801 tgcccctcta catagaaata tgctgcataa ttgtgcataa cttccttctc cgttgctggc
     4861 ttatagacag aggaaactga aggctaccat acggtttcct cgtataccag actgaaaact
     4921 cttaaatctc aaatgaagta agcaagttcc tagtctcact gccccctttc acagcagcat
     4981 aaattagagg cacatttaaa agggaaaaaa aaatctttgt tttgtaagtg ggctttcggt
     5041 tttttcttgt ttctttttct tcctcccctc ctcccccacg ggtttataca atgcgctgag
     5101 atgtgtacct tttaatgggg ttagaaccgc agagactcat cgtgcttcag cacagcacat
     5161 agccaggaga atggaatact acatgttgca tacgtgttgc caattgtaat ttgtctgtac
     5221 tacgaaggat gtaatggttt gtcagctgcc attgttgttt tctgtaacat gatatggaat
     5281 aaagtatagc cgaatctgca tata
//
