LOCUS       NM_001271295            6124 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus cyclin-dependent kinase 13 (Cdk13), transcript
            variant 1, mRNA.
ACCESSION   NM_001271295 XM_001053539 XM_001053609 XM_225404
VERSION     NM_001271295.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6124)
  AUTHORS   Lu,X.L., Zhan,R., Zhao,G.M., Qian,Z.H., Gong,C.C. and Li,Y.Q.
  TITLE     Expression of CDK13 Was Associated with Prognosis and Expression of
            HIF-1alpha and beclin1 in Breast Cancer Patients
  JOURNAL   J Invest Surg 35 (2), 442-447 (2022)
   PUBMED   33292020
  REMARK    Erratum:[J Invest Surg. 2021 Jan 19;:1. PMID: 33467975]
REFERENCE   2  (bases 1 to 6124)
  AUTHORS   Qi,J.C., Yang,Z., Lin,T., Ma,L., Wang,Y.X., Zhang,Y., Gao,C.C.,
            Liu,K.L., Li,W., Zhao,A.N., Shi,B., Zhang,H., Wang,D.D., Wang,X.L.,
            Wen,J.K. and Qu,C.B.
  TITLE     CDK13 upregulation-induced formation of the positive feedback loop
            among circCDK13, miR-212-5p/miR-449a and E2F5 contributes to
            prostate carcinogenesis
  JOURNAL   J Exp Clin Cancer Res 40 (1), 2 (2021)
   PUBMED   33390186
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6124)
  AUTHORS   van den Akker,W.M.R., Brummelman,I., Martis,L.M., Timmermans,R.N.,
            Pfundt,R., Kleefstra,T., Willemsen,M.H., Gerkes,E.H., Herkert,J.C.,
            van Essen,A.J., Rump,P., Vansenne,F., Terhal,P.A., van Haelst,M.M.,
            Cristian,I., Turner,C.E., Cho,M.T., Begtrup,A., Willaert,R.,
            Fassi,E., van Gassen,K.L.I., Stegmann,A.P.A., de Vries,B.B.A. and
            Schuurs-Hoeijmakers,J.H.M.
  TITLE     De novo variants in CDK13 associated with syndromic ID/DD:
            Molecular and clinical delineation of 15 individuals and a further
            review
  JOURNAL   Clin Genet 93 (5), 1000-1007 (2018)
   PUBMED   29393965
REFERENCE   4  (bases 1 to 6124)
  AUTHORS   Uehara,T., Takenouchi,T., Kosaki,R., Kurosawa,K., Mizuno,S. and
            Kosaki,K.
  TITLE     Redefining the phenotypic spectrum of de novo heterozygous CDK13
            variants: Three patients without cardiac defects
  JOURNAL   Eur J Med Genet 61 (5), 243-247 (2018)
   PUBMED   29222009
REFERENCE   5  (bases 1 to 6124)
  AUTHORS   Hamilton,M.J., Caswell,R.C., Canham,N., Cole,T., Firth,H.V.,
            Foulds,N., Heimdal,K., Hobson,E., Houge,G., Joss,S., Kumar,D.,
            Lampe,A.K., Maystadt,I., McKay,V., Metcalfe,K., Newbury-Ecob,R.,
            Park,S.M., Robert,L., Rustad,C.F., Wakeling,E., Wilkie,A.O.M.,
            Study,T.D.D.D., Twigg,S.R.F. and Suri,M.
  TITLE     Heterozygous mutations affecting the protein kinase domain of CDK13
            cause a syndromic form of developmental delay and intellectual
            disability
  JOURNAL   J Med Genet 55 (1), 28-38 (2018)
   PUBMED   29021403
REFERENCE   6  (bases 1 to 6124)
  AUTHORS   Blazek,D., Kohoutek,J., Bartholomeeusen,K., Johansen,E.,
            Hulinkova,P., Luo,Z., Cimermancic,P., Ule,J. and Peterlin,B.M.
  TITLE     The Cyclin K/Cdk12 complex maintains genomic stability via
            regulation of expression of DNA damage response genes
  JOURNAL   Genes Dev 25 (20), 2158-2172 (2011)
   PUBMED   22012619
REFERENCE   7  (bases 1 to 6124)
  AUTHORS   Bartkowiak,B., Liu,P., Phatnani,H.P., Fuda,N.J., Cooper,J.J.,
            Price,D.H., Adelman,K., Lis,J.T. and Greenleaf,A.L.
  TITLE     CDK12 is a transcription elongation-associated CTD kinase, the
            metazoan ortholog of yeast Ctk1
  JOURNAL   Genes Dev 24 (20), 2303-2316 (2010)
   PUBMED   20952539
REFERENCE   8  (bases 1 to 6124)
  AUTHORS   Chen,H.H., Wong,Y.H., Geneviere,A.M. and Fann,M.J.
  TITLE     CDK13/CDC2L5 interacts with L-type cyclins and regulates
            alternative splicing
  JOURNAL   Biochem Biophys Res Commun 354 (3), 735-740 (2007)
   PUBMED   17261272
REFERENCE   9  (bases 1 to 6124)
  AUTHORS   Even,Y., Durieux,S., Escande,M.L., Lozano,J.C., Peaucellier,G.,
            Weil,D. and Geneviere,A.M.
  TITLE     CDC2L5, a Cdk-like kinase with RS domain, interacts with the
            ASF/SF2-associated protein p32 and affects splicing in vivo
  JOURNAL   J Cell Biochem 99 (3), 890-904 (2006)
   PUBMED   16721827
REFERENCE   10 (bases 1 to 6124)
  AUTHORS   Lapidot-Lifson,Y., Patinkin,D., Prody,C.A., Ehrlich,G., Seidman,S.,
            Ben-Aziz,R., Benseler,F., Eckstein,F., Zakut,H. and Soreq,H.
  TITLE     Cloning and antisense oligodeoxynucleotide inhibition of a human
            homolog of cdc2 required in hematopoiesis
  JOURNAL   Proc Natl Acad Sci U S A 89 (2), 579-583 (1992)
   PUBMED   1731328
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Feb 11, 2021 this sequence version replaced NM_001271295.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.254933.1,
                                           SRR26643293.72178.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1420              JAXUCZ010000017.1  51946701-51948120
            1421-2077           JAXUCZ010000017.1  51976064-51976720
            2078-2248           JAXUCZ010000017.1  51982255-51982425
            2249-2388           JAXUCZ010000017.1  51983764-51983903
            2389-2559           JAXUCZ010000017.1  51985386-51985556
            2560-2749           JAXUCZ010000017.1  52002352-52002541
            2750-2806           JAXUCZ010000017.1  52003625-52003681
            2807-2908           JAXUCZ010000017.1  52013896-52013997
            2909-2986           JAXUCZ010000017.1  52014095-52014172
            2987-3103           JAXUCZ010000017.1  52025609-52025725
            3104-3235           JAXUCZ010000017.1  52026559-52026690
            3236-3441           JAXUCZ010000017.1  52032679-52032884
            3442-3891           JAXUCZ010000017.1  52034153-52034602
            3892-6124           JAXUCZ010000017.1  52035025-52037257
FEATURES             Location/Qualifiers
     source          1..6124
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q11"
     gene            1..6124
                     /gene="Cdk13"
                     /gene_synonym="Cdc2l5"
                     /note="cyclin-dependent kinase 13"
                     /db_xref="GeneID:306998"
                     /db_xref="RGD:1311226"
     exon            1..1420
                     /gene="Cdk13"
                     /gene_synonym="Cdc2l5"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..4742
                     /gene="Cdk13"
                     /gene_synonym="Cdc2l5"
                     /EC_number="2.7.11.22"
                     /note="isoform 1 is encoded by transcript variant 1; cell
                     division protein kinase 13; cell division cycle 2-like 5
                     (cholinesterase-related cell division controller)"
                     /codon_start=1
                     /product="cyclin-dependent kinase 13 isoform 1"
                     /protein_id="NP_001258224.2"
                     /db_xref="GeneID:306998"
                     /db_xref="RGD:1311226"
                     /translation="MPSSSDTALGGGGGLSWAEKKLEERRKRRRFLSPQQPPLLLPLL
                     QPQLLQPPPPPPPLLFLAAPGAAAAAAAAAAASSSCFSPGPPLEVKRLARGKRRPGGR
                     QKRRRGPRAGQEAEKRRVFSLPQPQQDGGGGASSGGGVTPLVEYEDVSSQSEQGLLLG
                     GASAATAATAAGGTGGNGGSPASSSGTQRRAEGSERRPRRDRRSSSGRSKERHREHRR
                     RDGTRSGSEASKARSRHGHSGEERAEAAKSGSSSSSGGRRKSASATSSSSSSRKDRDL
                     KAHRSRTKSSKEPPSAYKEPPKAYREDKSEPKAYRRRQRSLSPLGGRDESPVSHRASQ
                     SLRSRKSPSPAGGGSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSS
                     WRRSRSPYSPVLRRSAKSRSRSPYSSRHSRSRSRHRLSRSRSRHSSISPSTLTLKSSL
                     AAELNKNKKARAAEAARAAEAAKAAEAAKAAEAAAKAAKASSVSTPTKGNTETGASVS
                     QTNHVKEVKKLKTEHAPSPSSGGTVKSDKTKTKPPLQVTKVDNNLIVEKATKKTVVGK
                     ESKPAATKEEPVSTKEKTKPLTPSVGAKEKEQHVALVTSTLPPLPLPPMLPEDKDADS
                     LRGNISVKAVKKEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKKTATQLHSKRRPKI
                     CGPRYGEIKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDN
                     EKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDL
                     MGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADF
                     GLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIF
                     QANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAAL
                     DLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWSKKRRRQKQ
                     MGMTDDLSTIKAPRKDLSLGLDDSRTSTPQGVLPPAQLKSQNSSSGAPVITGPGQPLN
                     HSELAILLNLLQSKSSVNMADFVQVLNIKVNSETQQQLNKINLPAGILATGEKQTDPS
                     TPQQESSKSLGGVQPSQSIQPKVETDAAQAAVQSAFAVLLTQLIKAQQSKQKDAMLEE
                     RENGSGHDAPVQLRPPPEPSTPASGQDDLIQHQDRRILELTPEPERPRILPPDQRPPE
                     PPEPPPVTEEDLDYRTENQHGPTTSSSLTDPHAGVKAALLQLLAQHQPQDDPKREGGI
                     DYSTGDTYVPSSDYKDNFGASFSAAPYVSSDGLGSSSAAAPLEARSFIGNSDIQSLDN
                     YSTASSHTGGPPQTSAFTESFPSSVAGYGDIYLNAGPMLFSGDKDHRFEYSHGPITVL
                     TNSSDPSTGPESTHPLPAKIHNYNYGGNLQENPGGPSLMHGQTWTSPAQGPGYSQGYR
                     GHISTSAGRGRGRGLPY"
     exon            1421..2077
                     /gene="Cdk13"
                     /gene_synonym="Cdc2l5"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2248
                     /gene="Cdk13"
                     /gene_synonym="Cdc2l5"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..2388
                     /gene="Cdk13"
                     /gene_synonym="Cdc2l5"
                     /inference="alignment:Splign:2.1.0"
     exon            2389..2559
                     /gene="Cdk13"
                     /gene_synonym="Cdc2l5"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..2749
                     /gene="Cdk13"
                     /gene_synonym="Cdc2l5"
                     /inference="alignment:Splign:2.1.0"
     exon            2750..2806
                     /gene="Cdk13"
                     /gene_synonym="Cdc2l5"
                     /inference="alignment:Splign:2.1.0"
     exon            2807..2908
                     /gene="Cdk13"
                     /gene_synonym="Cdc2l5"
                     /inference="alignment:Splign:2.1.0"
     exon            2909..2986
                     /gene="Cdk13"
                     /gene_synonym="Cdc2l5"
                     /inference="alignment:Splign:2.1.0"
     exon            2987..3103
                     /gene="Cdk13"
                     /gene_synonym="Cdc2l5"
                     /inference="alignment:Splign:2.1.0"
     exon            3104..3235
                     /gene="Cdk13"
                     /gene_synonym="Cdc2l5"
                     /inference="alignment:Splign:2.1.0"
     exon            3236..3441
                     /gene="Cdk13"
                     /gene_synonym="Cdc2l5"
                     /inference="alignment:Splign:2.1.0"
     exon            3442..3891
                     /gene="Cdk13"
                     /gene_synonym="Cdc2l5"
                     /inference="alignment:Splign:2.1.0"
     exon            3892..6124
                     /gene="Cdk13"
                     /gene_synonym="Cdc2l5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccctgagg cctctgcgca cacacggcga ctagaaacgg ggacgcgcgt cccgacccgg
       61 attatcgtgg cgcgactccc ggccggccct gctgctcgct acccctccgc cgcggctgcc
      121 gtcccccttc ccggcggggg acatggccag ggtctgaccc cggaggaggc cgcacccgcg
      181 ccgcactctg cggcgggctc taggcgatgc cgagcagctc ggacacggcg ctggggggag
      241 gcgggggcct gagctgggcc gagaagaagt tggaggagcg ccgcaagcgg aggcgattcc
      301 tgtcccctca gcagccgccg ctgctgttgc cgctcctgca gccgcagctc ctgcaaccgc
      361 cgccgccccc gccgcctctg ctcttcctgg ctgcccccgg cgcggccgcc gccgcagccg
      421 ccgccgccgc ggcctcctcc tcctgcttca gcccgggccc tcctttggag gtcaagcggc
      481 tggcgagagg caagaggcgc cccggagggc ggcagaagcg gcgccgcggg ccccgcgccg
      541 ggcaggaggc ggagaagcgc cgggtcttct cgctgcccca gccgcagcag gacggcggtg
      601 gcggtgccag tagcggcggg ggtgtgaccc cgctggtgga gtatgaggat gtaagctccc
      661 agtccgagca ggggctgctg ctggggggcg ccagcgcggc aacggcggcg acggctgccg
      721 ggggaacggg gggcaacggc gggagtccgg cctcctcctc cggcacgcag aggcgcgcgg
      781 aggggtcgga gcgcaggccg cgccgggacc gccgcagcag cagcggtcgc agtaaggagc
      841 gccatcgcga gcaccggcgg cgggacggga cgcgcagtgg cagcgaggcc tcaaaggccc
      901 gcagccgcca cggacacagc ggcgaggagc gggccgaggc cgccaagagc ggcagtagca
      961 gcagcagcgg cggccgccgc aaaagtgcat cggctacgtc cagcagtagt agcagccgca
     1021 aggatcggga cctcaaggcc catcgcagcc ggactaagtc gtccaaggag ccgccctcgg
     1081 cctacaagga gccgcccaag gcctaccggg aggacaagag cgaaccgaag gcctacaggc
     1141 ggcggcagcg gtccctgagc ccgctgggag gccgggacga aagcccggtg tcccacaggg
     1201 cctcgcagag cctccggagc cgcaagtccc ccagcccggc gggaggtggc agcagtccct
     1261 attcccggcg gttgccgcgc tccccgagcc cctacagccg gcgccgctcg cccagctaca
     1321 gccgccacag ctcctacgag cggggcggcg acgtatcccc cagcccgtac agcagcagca
     1381 gctggcggcg ctcgcgcagt ccctacagtc cagtactcag acgatctgcc aaatcccgaa
     1441 gcagaagccc ctattcatct aggcactcaa gatctcgtag caggcacaga ttgtctagat
     1501 cccgaagtcg tcattcaagc atttctccta gcacactaac tctgaagagt agcctggcag
     1561 ctgaattaaa caagaataaa aaggcacgag ctgcagaggc agcaagagct gcagaggcag
     1621 ccaaagctgc agaagctgct aaggctgctg aggcagctgc caaagctgca aaagcctcta
     1681 gtgtttctac acctaccaag gggaacacag aaactggtgc cagtgtctca cagacaaacc
     1741 atgtgaagga agtcaaaaaa cttaaaactg agcatgcacc ttctccttca agtggtggga
     1801 ctgtcaaaag tgacaagaca aaaacaaagc caccgcttca agtaacaaaa gtagacaata
     1861 atttgattgt agagaaagct accaagaaaa cagttgttgg gaaagagagt aaacctgctg
     1921 ctacaaagga agaaccagtg tctactaaag agaaaaccaa gccactcaca ccaagtgtag
     1981 gagccaagga gaaggagcaa catgtggctt tagtgacctc tacattacca ccattacctt
     2041 tgcctcccat gttgcctgaa gataaagatg ctgatagttt aagaggcaat atttctgtaa
     2101 aagcagttaa aaaagaagta gaaaagaaac tccggtgtct gcttgctgat ttaccattgc
     2161 cccctgagtt accaggagga gatgatcttt ccaagagtcc agaggagaag aaaacagcaa
     2221 cacagttaca tagcaaaaga aggcctaaaa tatgtgggcc tcgctatggt gaaatcaaag
     2281 aaaaagatat tgactggggg aaacgctgcg tggataaatt tgatatcatc ggaattattg
     2341 gagaaggtac ttatggacaa gtttacaaag ccagggacaa agacactgga gaaatggtag
     2401 ccttaaagaa agtacgtctg gataatgaaa aggagggttt cccaattaca gcaattagag
     2461 aaattaaaat tcttcggcaa cttacccatc agagtatcat caatatgaag gaaatagtga
     2521 ctgataaaga agatgctttg gattttaaga aagacaaagg tgcattttac ctggtgtttg
     2581 aatatatgga ccatgatctg atgggactgc tggagtcagg cttggttcat tttaatgaaa
     2641 accatataaa atcttttatg agacagctca tggaaggcct ggattattgt cataagaaga
     2701 actttttgca cagagatatt aaatgttcaa atatccttct aaataataga ggacagataa
     2761 aacttgcaga ttttggactt gctcgtttat atagctcaga agaaagccgt ccatatacta
     2821 acaaggtcat tactttgtgg tatcgtccac ctgaactgct cttgggagaa gaacgatata
     2881 caccggccat tgatgtatgg agctgtggat gtatccttgg ggaactcttc actaaaaagc
     2941 ctatatttca agcaaaccag gaacttgcac aactagagct aataagtcgt atatgtggga
     3001 gtccgtgtcc tgcagtatgg cctgatgtaa tcaaactgcc atatttcaac accatgaaac
     3061 caaagaagca atatcggcgg aagttaagag aagagtttgt ttttatccct gcagctgcac
     3121 tcgacttatt tgattacatg cttgccttgg atcccagtaa gcgctgcact gccgagcagg
     3181 ctcttcagtg tgagttcctg cgagacgtgg aaccctccaa aatgcctcca ccagaccttc
     3241 ctttgtggca agattgtcat gaattatgga gtaaaaagag aagaagacag aaacagatgg
     3301 gcatgactga tgatctttcc acaatcaaag cccccagaaa ggacttgtct ctgggcttag
     3361 atgacagcag aactagcacg ccccagggtg tgctgccacc tgcacagcta aagtctcaga
     3421 acagctccag tggagcacct gtaataacag gccctggaca gccgttaaac cacagtgaat
     3481 tggcaattct tctaaaccta ctacaatcta aatcaagtgt taatatggct gattttgtcc
     3541 aagtgttgaa cattaaggta aactctgaga ctcaacagca gctaaataaa ataaaccttc
     3601 ctgctggaat tttggcaaca ggtgaaaaac agacagatcc atcaacacca caacaggagt
     3661 cttcaaaatc attgggagga gttcagcctt cacagagcat ccagcctaaa gtggaaactg
     3721 acgctgcgca ggctgcagtg cagagtgcat ttgcagtcct cctgactcag ttaataaagg
     3781 cccagcagtc aaaacagaaa gatgccatgc tggaggagag ggagaatgga tcaggacatg
     3841 acgctccagt gcaactcagg ccgcctccag aacccagcac tcctgcctct gggcaagatg
     3901 acctcatcca acaccaagac aggaggatat tggagctgac accagagcca gagcggcctc
     3961 ggattctgcc tcctgatcaa cgacctcctg aacctcctga accaccacca gtcactgagg
     4021 aggacctgga ttatcggaca gaaaaccagc atggacctac tactagttct tcattaactg
     4081 acccacatgc tggagtgaag gcagccctct tacagctgct tgctcaacat cagccccagg
     4141 atgatcccaa aagagaaggt ggtattgatt attccacagg agacacgtac gtgcccagtt
     4201 cagactataa agacaacttt ggagcgtctt tctctgccgc cccttatgtg agcagtgatg
     4261 gtctggggag tagctctgct gctgcaccgt tggaggcgcg cagtttcatc ggaaactcag
     4321 atattcagtc tctggataac tacagtactg cttcatctca cactggtggt ccacctcaga
     4381 cttctgcctt caccgagtca tttcccagtt cagtagctgg atacggagac atttacctca
     4441 atgctggtcc catgctgttt agtggagaca aggaccatag atttgagtac agccatggtc
     4501 ctatcacggt cctcacaaac agcagtgacc cttccacagg gccggagagt actcacccct
     4561 tgccagcaaa gatacacaac tataactatg gtggtaactt acaggaaaat ccaggtggcc
     4621 ccagcctcat gcatggacag acctggactt ctcctgccca aggacctgga tactcacaag
     4681 gatacagggg acacattagc acatcagctg gcagaggtcg aggcagaggg ttaccatact
     4741 gagtatctgt ttttcctcag gcacatcatt tttatctgga aagacttttc tagctgcaat
     4801 ttcaggcagc aatccaagag acttgaataa tattaattca acaacagctt tatttttatg
     4861 tggaaagggt cttgcataca atagtgaaaa aagaaaacaa caaaaaaaaa tctttgctta
     4921 aattcatgct gttcttaaaa ctagctctat tgattgtaca tcgtcacaga ttttagttaa
     4981 cagttttatt ttgtattctt gcagttttaa gtggatgcta acattaggga cataatgttt
     5041 ttatggccct cttgcagatc ttctgaacta tgcacacttg tgcttttttt gtaagtttgg
     5101 accaactttt atgtaaacaa cctacccctt tccctcaacc ctcccagttt tacagcaatc
     5161 agaaagggca ctgatttctt tggtattttc tttttacaaa gctaccttta gtcaaaggtc
     5221 actgtcagtc tttgcacctg ctttcagtgt tattgtgaaa ggtgtacttt gtgctcattt
     5281 cagaaaataa aacacaacct ttctcttgat gcaacagttt tatataaaac aaatggttaa
     5341 cattattttt gttttgtttt gttttgtttt tttcaggtta ccataaccca gcaaaattca
     5401 ttcaaatgaa atagtggttt ttatatgaaa actatgggtc gggtggggag gggttcgagt
     5461 aagtgcctta acaggtatgc ttcaggactg cggatgaagt tagcctttcc accactgtct
     5521 ttccaaggga gtctgcactg tgctgaaggg gcacgaagct ctccattttt aggagttgtt
     5581 tggtcagttc tgttaggtcc atcccctctg cttgtcacac ggtccttttc tgcctgtctt
     5641 ttggctgtta actttcactg ttaccttctc acggtaggag tgtaagagaa aaagaaaggg
     5701 agaactcggt accttttgtt acttctggga agtactaatt tttttttttt tttttgatca
     5761 gttaagttgt tgaaagtaat agctgaatga gaattttagt gtgtttcttt ctttctggct
     5821 gtcatactaa cccagtttct atttggaggg caggggtttg aatcaaatat gtataacaat
     5881 tcacaaaata aaatcatatg atacataata aatatattaa agctcacaga aggagggtgg
     5941 caaacaccat atttaaagtt atataattat tttaagaaaa tgtcaagtta cgtagcaaaa
     6001 agaaaactca aagagaaaac taccttttcc tttcaatttt gtgaaattta ctgtaatttc
     6061 tgccagatta gagcagtgct attaggtcat ttttattcta ttaaaatcaa ccaagaaaga
     6121 ataa
//
