LOCUS       NM_001033867            5500 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus cyclin-dependent kinase 12 (Cdk12), transcript
            variant 1, mRNA.
ACCESSION   NM_001033867
VERSION     NM_001033867.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5500)
  AUTHORS   Liu,M., Fan,H., Li,T., Sihong,L., Qiao,S. and Bi,J.
  TITLE     Low expression of CDK12 in gastric cancer is correlated with
            advanced stage and poor outcome
  JOURNAL   Pathol Res Pract 216 (7), 152962 (2020)
   PUBMED   32534699
REFERENCE   2  (bases 1 to 5500)
  AUTHORS   Wang,C., Wang,H., Lieftink,C., du Chatinier,A., Gao,D., Jin,G.,
            Jin,H., Beijersbergen,R.L., Qin,W. and Bernards,R.
  TITLE     CDK12 inhibition mediates DNA damage and is synergistic with
            sorafenib treatment in hepatocellular carcinoma
  JOURNAL   Gut 69 (4), 727-736 (2020)
   PUBMED   31519701
REFERENCE   3  (bases 1 to 5500)
  AUTHORS   Ji,J., Zhou,C., Wu,J., Cai,Q., Shi,M., Zhang,H., Yu,Y., Zhu,Z. and
            Zhang,J.
  TITLE     Expression pattern of CDK12 protein in gastric cancer and its
            positive correlation with CD8+ cell density and CCL12 expression
  JOURNAL   Int J Med Sci 16 (8), 1142-1148 (2019)
   PUBMED   31523177
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5500)
  AUTHORS   Jeronimo,C., Bataille,A.R. and Robert,F.
  TITLE     The writers, readers, and functions of the RNA polymerase II
            C-terminal domain code
  JOURNAL   Chem Rev 113 (11), 8491-8522 (2013)
   PUBMED   23837720
  REMARK    Review article
REFERENCE   5  (bases 1 to 5500)
  AUTHORS   Egloff,S., Dienstbier,M. and Murphy,S.
  TITLE     Updating the RNA polymerase CTD code: adding gene-specific layers
  JOURNAL   Trends Genet 28 (7), 333-341 (2012)
   PUBMED   22622228
  REMARK    Review article
REFERENCE   6  (bases 1 to 5500)
  AUTHORS   Iorns,E., Martens-de Kemp,S.R., Lord,C.J. and Ashworth,A.
  TITLE     CRK7 modifies the MAPK pathway and influences the response to
            endocrine therapy
  JOURNAL   Carcinogenesis 30 (10), 1696-1701 (2009)
   PUBMED   19651820
REFERENCE   7  (bases 1 to 5500)
  AUTHORS   Chen,H.H., Wang,Y.C. and Fann,M.J.
  TITLE     Identification and characterization of the CDK12/cyclin L1 complex
            involved in alternative splicing regulation
  JOURNAL   Mol Cell Biol 26 (7), 2736-2745 (2006)
   PUBMED   16537916
  REMARK    GeneRIF: CDK12 and cyclin L1/L2 are cyclin-dependent kinase and
            cyclin partners and regulate alternative splicing.
REFERENCE   8  (bases 1 to 5500)
  AUTHORS   Zhang,X.H., Zhang,H., Tu,Y., Gao,X., Zhou,C., Jin,M., Zhao,G.,
            Jing,N., Li,B.M. and Yu,L.
  TITLE     Identification of a novel protein for memory regulation in the
            hippocampus
  JOURNAL   Biochem Biophys Res Commun 334 (2), 418-424 (2005)
   PUBMED   16009348
REFERENCE   9  (bases 1 to 5500)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   10 (bases 1 to 5500)
  AUTHORS   Ko,T.K., Kelly,E. and Pines,J.
  TITLE     CrkRS: a novel conserved Cdc2-related protein kinase that
            colocalises with SC35 speckles
  JOURNAL   J Cell Sci 114 (Pt 14), 2591-2603 (2001)
   PUBMED   11683387
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001033867.1.
            
            Sequence Note: This RefSeq record was created using sequences from
            two different strains, Sprague-Dawley and BN/SsNHsdMCW, because no
            single transcript from the same strain was available for the full
            length of the gene.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY962568.1, SRR26360172.836057.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1108              JAXUCZ010000010.1  83698035-83699142
            1109-1984           JAXUCZ010000010.1  83705981-83706856
            1985-2161           JAXUCZ010000010.1  83716255-83716431
            2162-2301           JAXUCZ010000010.1  83718629-83718768
            2302-2472           JAXUCZ010000010.1  83720163-83720333
            2473-2662           JAXUCZ010000010.1  83724584-83724773
            2663-2719           JAXUCZ010000010.1  83729181-83729237
            2720-2821           JAXUCZ010000010.1  83730183-83730284
            2822-2899           JAXUCZ010000010.1  83735456-83735533
            2900-3016           JAXUCZ010000010.1  83739800-83739916
            3017-3148           JAXUCZ010000010.1  83740944-83741075
            3149-3360           JAXUCZ010000010.1  83743103-83743314
            3361-3813           JAXUCZ010000010.1  83744734-83745186
            3814-5500           JAXUCZ010000010.1  83749264-83750950
FEATURES             Location/Qualifiers
     source          1..5500
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..5500
                     /gene="Cdk12"
                     /gene_synonym="Crk7; Crkrs; Hgn; Pksc"
                     /note="cyclin-dependent kinase 12"
                     /db_xref="GeneID:192350"
                     /db_xref="RGD:621111"
     exon            1..1108
                     /gene="Cdk12"
                     /gene_synonym="Crk7; Crkrs; Hgn; Pksc"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..4520
                     /gene="Cdk12"
                     /gene_synonym="Crk7; Crkrs; Hgn; Pksc"
                     /EC_number="2.7.11.23"
                     /EC_number="2.7.11.22"
                     /note="isoform 1 is encoded by transcript variant 1; cell
                     division cycle 2-related protein kinase 7; cell division
                     protein kinase 12; CDC2-related protein kinase 7;
                     CDC2-related kinase 7; protein kinase for splicing
                     component; Cdc2-related kinase, arginine/serine-rich;
                     hippyragranin"
                     /codon_start=1
                     /product="cyclin-dependent kinase 12 isoform 1"
                     /protein_id="NP_001029039.1"
                     /db_xref="GeneID:192350"
                     /db_xref="RGD:621111"
                     /translation="MPNSERHGGKKDGSGGASGTSQPSSGGGSSNSRERHRLVSKHKR
                     HKSKHSKDMGLVTPEAASLGTIIKPLVEYDDISSDSDTFSDDMAFKSDRRENDERRGT
                     DRSDRLHRHRHHQHRRSRDLLKTKQTEKEKNQEVSKSGSMKDRLSGSSKRSVEGNDDY
                     GKAQLSKSSSKESRSSKMHKEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRR
                     SRSPHRKWSDSSKQDDSPSGASYGQDYDLSPPRSHTSSNYDSYKKSPGSTSRRQSISP
                     PYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSP
                     FLSKRSLSRSPISSRKSMKSRSRSPAYSRHSSSHSKKKRSGSRSRHSSISPVRLPLNS
                     SLGAELSRKKKERAAAAAAAKLDGKESKGSPIILPKKEKFEVKESGLESKKLPRGIKS
                     EKSTPDTELVNVAHSNTEVKNCLDTGKVKLDENLQKHPVKDLKAQGTKDTKPVALKEV
                     IVTSKETETSEKEALPPLPTITSPPPLPSTTPPPQTPPLPPLPPLPAVPLQPPLPPPQ
                     PPFSQVPVSNTSTLPSSPHPRTSTLSSQTNSQPLVQVSMKTQLSVTAAIPHLKTSTLP
                     PLPLPPLLPGDDDMDSPKEMLPSKPAKKEKEQRTRHLLTDLPLPPELPGGDPSPPDSP
                     EPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKA
                     KDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLVHQSVVNMKEIVTDKQDALDF
                     KKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLDYCHKKNFLHRDI
                     KCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAID
                     VWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKK
                     QYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLP
                     HWQDCHELWSKKRRRQRQSGIVIEEQPPSKASRKETTSGTAAEPVKNSSPAPPQPAPV
                     KAEPGPGDAVGLGDITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQL
                     EALNQSISALTEASSQQQDSESIAPEESLKEVPSVSVVLPPAEQTTPEASNTPADMQN
                     MLAVLLSQLMKTQEPAGNLEENTSDKNSGPQGPRRTPTMPQEEAAACPPHILPPEKRP
                     PEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALR
                     PMEYSTRSHPNRTYGNTDGPETGFSATDTDERSSGPALTESLVQTLVKNRTFSGSVSH
                     LGESNSYQGTGSVQFPGDQDLRFTRVPLALHSVVGQPFLKSEGNSNSVVHAETKLQNY
                     GELGPGTTGANSSGTTLQWGGPAQSFGKPYRGAARVPPRGGRGRGVPY"
     exon            1109..1984
                     /gene="Cdk12"
                     /gene_synonym="Crk7; Crkrs; Hgn; Pksc"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2161
                     /gene="Cdk12"
                     /gene_synonym="Crk7; Crkrs; Hgn; Pksc"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2301
                     /gene="Cdk12"
                     /gene_synonym="Crk7; Crkrs; Hgn; Pksc"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2472
                     /gene="Cdk12"
                     /gene_synonym="Crk7; Crkrs; Hgn; Pksc"
                     /inference="alignment:Splign:2.1.0"
     exon            2473..2662
                     /gene="Cdk12"
                     /gene_synonym="Crk7; Crkrs; Hgn; Pksc"
                     /inference="alignment:Splign:2.1.0"
     exon            2663..2719
                     /gene="Cdk12"
                     /gene_synonym="Crk7; Crkrs; Hgn; Pksc"
                     /inference="alignment:Splign:2.1.0"
     exon            2720..2821
                     /gene="Cdk12"
                     /gene_synonym="Crk7; Crkrs; Hgn; Pksc"
                     /inference="alignment:Splign:2.1.0"
     exon            2822..2899
                     /gene="Cdk12"
                     /gene_synonym="Crk7; Crkrs; Hgn; Pksc"
                     /inference="alignment:Splign:2.1.0"
     exon            2900..3016
                     /gene="Cdk12"
                     /gene_synonym="Crk7; Crkrs; Hgn; Pksc"
                     /inference="alignment:Splign:2.1.0"
     exon            3017..3148
                     /gene="Cdk12"
                     /gene_synonym="Crk7; Crkrs; Hgn; Pksc"
                     /inference="alignment:Splign:2.1.0"
     exon            3149..3360
                     /gene="Cdk12"
                     /gene_synonym="Crk7; Crkrs; Hgn; Pksc"
                     /inference="alignment:Splign:2.1.0"
     exon            3361..3813
                     /gene="Cdk12"
                     /gene_synonym="Crk7; Crkrs; Hgn; Pksc"
                     /inference="alignment:Splign:2.1.0"
     exon            3814..5500
                     /gene="Cdk12"
                     /gene_synonym="Crk7; Crkrs; Hgn; Pksc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggagggtgg ggctttttgg agtgctgggg aactttttcc ccttcttcag gaccggggaa
       61 agggaatgcc caattcagag agacatgggg gcaagaagga cgggagtgga ggagcttctg
      121 gaacttcgca gccgtcatcg ggaggcggca gctccaacag cagggagcgt caccgcttgg
      181 tgtcgaagca caagcggcat aagtccaagc actccaaaga catggggttg gtaacccccg
      241 aagcggcatc tttgggtaca ataatcaaac cattggtgga gtatgatgac atcagctctg
      301 attcagacac cttctcagat gacatggcct tcaaatcaga caggagggag aacgatgaac
      361 gtcgtggaac ggatcggagt gaccgcctgc acagacatcg tcaccaccag caccggcggt
      421 cccgagactt gttaaaaact aaacagaccg aaaaggaaaa aaaccaggaa gtctccaaat
      481 ctggatcgat gaaggaccgg ttatcaggta gttcgaaacg ttcagtggag gggaacgatg
      541 attatgggaa ggcacaatta tccaaaagca gcagcaagga atccaggtcg tccaaaatgc
      601 acaaagagaa gacccggaaa gaacgagagt taaagtctgg acacaaggac cgtagtaaaa
      661 gtcatcggaa aagggaaaca cccaaaagtt acaaaacggt ggatagcccc aaacggagat
      721 ctaggagtcc ccataggaaa tggtctgaca gttccaagca agatgacagc ccttctggag
      781 cttcttatgg ccaagattac gatcttagcc ccccaaggtc tcatacttct agcaattatg
      841 actcctacaa gaagagtccg ggaagtacct caagaaggca gtcaatcagc ccaccttata
      901 aagagccttc tgcttaccag tccagcactc ggtcacccag tccctacagc cgacgacaga
      961 ggtcagtgag cccctatagc cggagacggt catccagcta tgaaaggagc ggttcttaca
     1021 gcgggagatc acccagcccc tatggccgaa ggcgatctag cagccctttc ttgagcaaga
     1081 ggtctctgag tcggagtcca atctccagta ggaaatccat gaagtccaga agtagaagtc
     1141 ctgcatattc aagacactca tcttcacata gtaaaaagaa gcgatccggg tcacgaagtc
     1201 gtcattccag catctcacct gtcaggcttc cattgaattc cagcctggga gctgaactca
     1261 gtagaaaaaa gaaggaaaga gcagctgctg cagcagcagc aaaattggat ggaaaagaat
     1321 ctaagggttc acctataatt ttgcctaaaa aagagaaatt tgaggtgaag gagtcagggt
     1381 tagagtctaa aaagttaccc agaggtataa agtcagaaaa atctacccca gatactgaac
     1441 tggtaaatgt agcacattca aacacagagg taaaaaattg tttagataca gggaaagtaa
     1501 agttggatga gaacttgcag aagcatcctg ttaaggattt gaaagcacag ggaacaaagg
     1561 acaccaaacc tgtagcactg aaggaggtga ttgttacttc aaaggagaca gagacatcag
     1621 aaaaggaggc ccttccacct ctccccacaa taacttctcc acccccttta ccatctacta
     1681 ctcctccacc tcagacaccc cctttgccac ctttgcctcc actaccagct gttccactgc
     1741 agccaccttt gcctcctccc caaccaccat ttagtcaagt tcctgtttca aatacttcaa
     1801 ctttaccctc ttctcctcac ccaaggacat ctactttatc ctctcagaca aattctcagc
     1861 cccttgtaca ggtttctatg aagactcaat tatctgtaac agctgctatt ccacacctga
     1921 aaacttcaac attgcctcct ctgcccctcc ctcccctatt acctggagat gatgacatgg
     1981 atagtccaaa agaaatgctt ccttcaaagc ctgcaaagaa agagaaagag cagaggactc
     2041 gccacttact cacagacttg cctcttcctc ctgagctacc aggtggagat ccatctcccc
     2101 cagattctcc agagccaaag gcaattacac cacctcaaca accatataaa aagagaccaa
     2161 aaatttgttg tccacgttat ggagaaagaa gacaaacaga aagtgattgg gggaagcgct
     2221 gcgtggacaa gtttgacatt attgggatta ttggagaagg aacctatggc caagtatata
     2281 aagccaagga caaagacaca ggagaacttg tagctctgaa gaaggttcgg ctagacaatg
     2341 agaaagaggg cttcccaatc acagccatcc gggagattaa gattcttcgt cagttagttc
     2401 atcaaagtgt tgtaaacatg aaggagattg tcacagacaa acaagatgca ctggatttca
     2461 agaaggacaa aggtgccttt taccttgtat ttgaatatat ggaccatgac ttaatgggac
     2521 tgctagaatc aggtttggtg cacttttctg aggaccatat caagtcattc atgaaacagc
     2581 taatggaagg actggattac tgtcacaaaa agaatttcct ccatcgggat attaaatgtt
     2641 ctaacatttt gctgaataac agtgggcaaa tcaaactggc agattttggc cttgctcggc
     2701 tctataactc tgaagagagt cgcccttaca caaacaaagt cattactctg tggtatcgac
     2761 ctccagagct gcttcttgga gaggaaagat acacaccagc cattgatgtt tggagctgtg
     2821 ggtgcatcct tggggaactg ttcacaaaga aacctatttt tcaagccaat ttggaactgg
     2881 ctcagctaga actgatcagt cgtctctgtg gtagtccttg tccagcagtg tggcctgatg
     2941 ttatcaagct gccctacttc aacaccatga aaccgaaaaa gcaatacagg agacgcctaa
     3001 gagaagaatt ctctttcatt ccttcagcgg cacttgatct gttggaccac atgctgacac
     3061 tggatcctag caagcgctgc acagcggaac aaaccctaca gagtgacttt cttaaagatg
     3121 tggaactcag caaaatggca cctccagacc tacctcactg gcaggattgc catgaattgt
     3181 ggagtaagaa acgtcgacgg caacgacaaa gtggtattgt gatagaagag caacctccat
     3241 ccaaagcttc tcgaaaagaa actacctcag ggacagcagc tgagcctgtg aagaacagta
     3301 gcccagcacc acctcaacct gctcctgtca aggcagagcc tggtccaggg gatgcagtag
     3361 ggcttggtga catcacacag cagttgaatc aaagtgaatt ggcagtgtta ttaaacctgc
     3421 ttcagagcca aactgacctg agcatccctc agatggcaca attgcttaac atccactcca
     3481 atccagagat gcaacagcag cttgaagccc tgaatcagtc tattagtgca ctgactgaag
     3541 ccagttccca gcagcaagac tcagaatcca tagccccaga ggaatcattg aaggaggtac
     3601 cttctgtatc tgtggtcctg cctcctgctg aacagacaac tcctgaagct tcaaacacac
     3661 cagctgacat gcagaatatg ttggcagttc tcttgagtca gctgatgaaa acccaagagc
     3721 cagcaggtaa cctggaggaa aacaccagtg acaagaatag tgggccacag gggccccgaa
     3781 gaacccctac aatgccacag gaggaggcag cagcatgtcc tcctcacatt cttccaccag
     3841 agaagaggcc ccctgaaccc cctggacctc caccgccgcc acctccaccc cctctggttg
     3901 aaggcgatct ttccagcgcc ccccaggagt tgaatcccgc cgtgacagcc gccttgctgc
     3961 aacttttatc ccagcctgaa gcagagcctc ctggccacct gccacatgag caccaggcct
     4021 tgagaccaat ggagtactcc actcgatccc atccaaacag gacttacgga aatactgatg
     4081 ggcctgaaac agggttcagt gccactgaca ctgatgaacg cagttctggt ccagccttga
     4141 cagaatcttt ggttcagacc ctggtgaaga acaggacctt ctcaggctct gtgagccacc
     4201 ttggggagtc caacagttac cagggcacag ggtcagtgca gttcccaggg gaccaggacc
     4261 tccgttttac tagggttccc ttagcattac actcagtggt tgggcaacca ttcctgaagt
     4321 ctgagggaaa tagcaactct gtggtacatg cagagaccaa attgcaaaac tatggggagc
     4381 tgggaccagg aaccactggg gccaacagct caggaacaac ccttcagtgg gggggcccag
     4441 ctcagtcttt tggaaaaccc taccgagggg ctgcaagagt cccaccacga gggggaagag
     4501 ggagaggggt tccttattaa cacagaaaca tcaaatgccc tgaaagattc cttccctatc
     4561 catctttcca tctagttctc tgaaccttta atgaaatcac ttgccagagc aaggtaatca
     4621 tctgcatttg gctactgcaa tgctgtctgt ttttttcctt gctcacttgc tgctagcagg
     4681 cgagtcaatg atgttggcac cagttcttcc aaaaatgggc aatagccaga atatttactt
     4741 ctctatgtag gagctgtagt agaaaatatg gagaaaaaga cacattcaac tgaaaagtaa
     4801 ttgttgcatt agctcattgc ctgcacttga gcagaagaaa actatcctgt tttgagatgg
     4861 ctctggagag gctttgattt ttaaaagttt gttggttttt tttcctgtgt gtgtatgtgt
     4921 gtgtgtgtat atatagtttc ttttgaattt ttatttagtt tcccacccca accctcccca
     4981 catccccctt taaagagaat agtgttcaca aagtctgagc tcctcttagg ccttcgctag
     5041 aagggtaaca gtggactggc tggcttaaat gtttccttcc tctctaccat ctcatatttg
     5101 tgagcactcc ctttacccct gttgagcatc ttgtacatac ctttttccaa ataaatcatc
     5161 cttaggtttg ctcagtttga cagagttctg tccctcttcc tgcagacaca gcaggctgta
     5221 gacaacggca ttcttgggca agtaggaagc ctacccagtc tttgattttt gcttgtttac
     5281 ttttttctcc ttcccctctc tccttgtcac cccctctttt ctttttcctc cttcctccct
     5341 tgtgtgttca cttctattat tctctttctc tgtatctttt tgaggcattt gtttggaaaa
     5401 aaaaatgcat agtagagatg cccaagaacc tggaataata ccttccctct ttcttttttt
     5461 cctttttttt ttaataaagg aaaggaaatg caaactccta
//
